Ese umuvuduko w'umutima wawe uhindagurika? Reka twige kuri Dofetilide!

Ese muganga yakubwiye ko hari ikibazo mu mikorere y'umutima wawe, ni ukuvuga umuvuduko w'umutima wawe? Ugomba kuba warumvise ufite ubwoba gato, si byo se? Dofetilide ni ubwoko bw'umuti utangwa muri ibyo bihe. Rero, uyu munsi turaganira kuri uyu muti witwa Dofetilide, nk'aho twabibwira inshuti.

Dofetilide ni iki?

Mu magambo make, Dofetilide ni umuti urwanya arrhythm . Ibi bivuze ko ufasha mu kuvugurura imikorere y'umutima wawe. Akenshi uza mu ishusho ya capsule. Akenshi uyifata rimwe cyangwa kabiri ku munsi. Ushobora kuba warayibonye ku izina rya Tikosyn®.

Ariko hari ikintu kimwe ugomba kwibuka. Igipimo cy'uyu muti, ni ukuvuga ingano uhabwa yo kunywa, gishobora gutandukana bitewe n'umuntu ku wundi . Niba inshuti yawe ifata uyu muti, ntuzahabwa ingano imwe n'iyo ahawe. Muganga azasuzuma uburwayi bwawe maze akugenere igipimo gikwiye (nk'umuti wa `125 mcg, 250 mcg` cyangwa `500 mcg`). `(mcg)` bisobanura mikorogarama.

Ni mu bihe bihe Dofetilide ikoreshwa?

Uyu muti ukoreshwa cyane cyane mu kuvura ibibazo bimwe na bimwe by’umutima no kubikumira ko bitazongera kubaho.

Indwara z'umutima

• Gucura imitsi mu mutima (Afib): Iki ni cyo gihe icyumba cyo hejuru cy'umutima wawe (cyanone cyitwa atria) gitera cyane kandi mu buryo butari bwo, aho gukubita mu buryo busanzwe. Tekereza nk'ingoma igomba gucurangwa mu buryo runaka, ariko igacuranga mu buryo butari bwo ikagenda isa n'iyasaze. Ibi byitwa "Afib".
• Gutera kw'umutima mu buryo budasanzwe: Iyi ni indi miterere idasanzwe y'umutima ibaho mu cyumba cyo hejuru cy'umutima. Isa gato na ``Afib``, ariko hari itandukaniro rito.

Icy'ingenzi: Muri izi ndwara zombi, imikorere y'umutima iba idahwitse, bityo amaraso ashobora kudashyirwamo neza. Ibi bishobora gutera ingorane zitandukanye. Bityo, uyu muti ukora ukosora iyo mikorere idahwitse no gutuma umutima wongera gukora neza.

Imikoreshereze ya "Off-label"

Hari igihe abaganga batanga Dofetilide ku zindi ndwara z'umutima zitari izo yakoreshejwe mbere. Ibi byitwa "gukoresha umuti utari uwo mu bwoko bwa "off-label". Ni ukuvuga ko abaganga bazi ko umuti ushobora gufasha muri izo ndwara, ariko mbere ntabwo wemejwe kuri izo ndwara.

Izindi ndwara zisa n'izo zifata umutima ni izi:

• Tachycardia yo mu mitsi: Muri ibi, icyumba cyo hasi cy'umutima gitera vuba cyane.
• Supraventricular Tachycardias: Iyi ni kandi umutima utera vuba cyane ugaragara mu byumba byo hejuru by'umutima. Hariho ubundi bwoko uretse `(Afib)` na `(Atrial Flutter).`
• Syndrome ya Wolff-Parkinson-White: Iyi ni indwara umutima utera cyane bitewe n'inzira y'amashanyarazi mu mutima.

Ni gute watangira Dofetilide?

Ibi ni ibintu bidasanzwe gato. Iyo utangiye gufata Dofetilide, ugomba kumara iminsi itatu cyangwa ine mu bitaro . Ibi bishobora kumvikana nk'ibidasanzwe, sibyo? Impamvu ni uko abaganga bashaka kureba uburyo umuti ugira ingaruka ku mikorere y'umutima wawe ndetse no kureba niba hari ikindi kibazo gishya wahura nacyo. Bazakoresha kandi iki gihe kugira ngo bagushakire urugero rukwiye. Mu gihe uri mu bitaro, bashobora guhindura ingano y'umuti uhabwa. Ntugahangayike, ibi byose ni ukugira ngo ubone umutekano.

Ni gute wafata Dofetilide mu rugo?

Umaze kugera mu rugo uvuye kwa muganga, icyapa cy'umuti uhawe kizagaragaza neza umubare w'umuti ugomba gufata n'inshuro ugomba gufata ku munsi.

Ni ingenzi cyane kwibuka izi ngingo:

• Fata umuti neza neza nk'uko muganga yabikubwiye. Ntukongere cyangwa ngo ugabanye urugero.
• Fata umuti ku gihe kimwe buri munsi. Niba ari mu gitondo, uwufate mu gitondo, niba ari nijoro, uwufate nijoro. Ntugahindure isaha.
• Nubwo waba wumva umeze neza, ntugahagarike gufata umuti. Komeza uwufate igihe cyose muganga wawe akubwira.
• Ushobora gufata uyu muti uri mu biryo cyangwa utabiriye.
• Ntugacike imiti yawe.
• Fata gusa ingano yanditswe na muganga.

Niba ufite ikibazo icyo ari cyo cyose kijyanye n'imiti yawe cyangwa uburyo bwo kongeramo imiti, ntutinye kubaza muganga wawe cyangwa umufarumasiye. Niba hari ikintu udasobanukiwe, saba ko bagusobanurira.

Ni iki nabwira muganga wanjye mbere yo gufata Dofetilide?

Mbere yo kukwandikira uyu muti, ni ngombwa kubwira muganga wawe ibi bikurikira:

• Ese wigeze ugira ikibazo cyo kugira ubwivumbure kuri dofetilide? Niba ari uko bimeze, sobanura uko byagenze.
• Andika imiti yose ufata ubu (kwandikirwa na muganga, kugurishwa mu mabwiriza ya muganga (OTC), vitamine, n'inyongeramusaruro z'ibimera). Ntugatangire imiti mishya cyangwa inyongeramusaruro utabanje kugisha inama muganga wawe.
• Tubwire niba ufite indwara y'umutima, cyane cyane indwara y'umutima yitwa 'Long QT Syndrome' , cyangwa niba ufite indwara y'impyiko cyangwa umwijima, cyangwa niba ufite potasiyumu cyangwa manyeziyumu nke mu maraso yawe.
• Menya neza ko utubwire niba utwite, ugerageza gutwita, cyangwa wonsa .

Ni iyihe miti idakwiye gufatwa hamwe na Dofetilide?

Niba ufata iyi miti, gufata Dofetilide bishobora guteza akaga gakomeye.Bityo rero, niba ukoresha umuti nk'uyu, ugomba kubibwira muganga wawe. Hanyuma ntazaguha Dofetilide.

• Cimetidine (urugero: Tagamet®)
• Cisapride
• Dolutegravir (`Dolutegravir` - urugero:` Tivicay®`)
• Verapamil (`Verapamil` - urugero` Calan®`)
• Ketoconazole
• Itraconazole (urugero: Sporanox®)
• Trimethoprim (`Trimethoprim` - urugero `Proloprim®`)
• Trimethoprim hamwe na sulfamethoxazole (urugero: Bactrim®, Septra®)
• Hydrochlorothiazide (`Hydrochlorothiazide` - urugero `Microzide®`)
• Ziprasidone
• Imiti igabanya ubukana bwa tricyclic nka amitriptyline
• Promethazine
• Prochlorperazine (urugero: Compro®)
• Quinidine
• Disopyramide (urugero, Norpace®)
• Sotalol (`Sotalol` - urugero` Betapace®`)

Indi miti ishobora kugira ingaruka kuri Dofetilide

Hari indi miti ishobora kugira ingaruka ku miti ya Dofetilide. Ibi bivuze ko iyo uyifashe hamwe, ishobora guhindura uburyo Dofetilide ikora cyangwa ikongera ingaruka mbi zayo. Kubwibyo, niba ufata imwe muri iyi miti iri hano hepfo, vugana na muganga wawe mbere yo gutangira Dofetilide.

• Amiodarone (`Amiodarone` - urugero` Cordarone®`)
• Digoxin (`Digoxin` - urugero `Lanoxin®`)
• Metformin (`Metformin` - urugero `Glucophage®`)
• Megestrol
• Diltiazem (urugero: Cardizem®)
• Zafirlukast
• Quinine
• Fluconazole
• Erythromycin (`Erythromycin` - urugero `PCE®`)
• Clarithromycin
• Antibiyotike za Fluoroquinolone nka Norfloxacin na Moxifloxacin
• SSRI (Selective Serotonin Reuptake Inhibitors) nka Fluoxetine, Sertraline, Paroxetine (urugero: Paxil®)
• Imiti igabanya amazi mu mubiri nka Furosemide, Triamterene, na Amiloride
• Imiti igabanya ubukana bwa poroteyine (imiti ivura indwara nka virusi itera SIDA) nka Indinavir

Gusa icyo ugomba kumenya: Kimwe n'imiti imwe n'imwe, kunywa umutobe w'imbuto z'umuhondo (imbuto isa n'imbuto z'umuhondo) bishobora kongera urugero rw'umuti wa dofetilide mu mubiri wawe. Ibi bishobora guteza akaga. Baza muganga wawe niba nta kibazo kunywa umutobe w'imbuto z'umuhondo mu gihe ufata uyu muti.

Wakora iki niba wabuze dose y'umuti?

Niba ibi bibaye, fata dose yabuze ukimara kwibuka . Ariko, niba igihe cyo gufata dose ikurikira kigeze, jya usimbuka dose yabuze hanyuma ufate dose ikurikira ku gihe cyagenwe. Ntukigere ufata dose ebyiri. Niba utazi icyo wakora, vugana na muganga wawe cyangwa umufarumasiye.

Ni izihe nyungu za Dofetilide?

Dofetilide ishobora gufasha mu kugenzura zimwe mu ndwara z’umutima zidakora neza, ibyo bikaba byakoroshya ubuzima bwawe. Ariko, ni ngombwa kwibuka ko idakiza indwara burundu.

Ni izihe ngaruka mbi za Dofetilide?

Kimwe n'indi miti yose, Dofetilide ishobora gutera ingaruka zimwe na zimwe. Si buri wese uzibona, ariko ni byiza kuzimenya.

Ingaruka mbi nke zishobora kubaho:

• Kubabara mu gatuza
• Kuribwa umutwe (umutwe)
• Kuzungera (vertigo)
• Isesemi (kumva ushaka kuruka)
• Impiswi (kubabara mu gifu)
• Kubabara mu gifu

Ikintu cyo kwitondera cyane:

Dofetilide itangwa kugira ngo ikosore umutima utari mwiza, ariko hari ibyago byo kongera gutera umutima utari mwiza ukoresheje uyu muti. By'umwihariko, umutima utera vuba mu cyumba cyo hasi cy'umutima (`ventricular tachycardia`) witwa ``Torsades de Pointes``` ushobora kubaho.

Iyi ni yo mpamvu nyamukuru ituma ugomba kujya mu bitaro no gutangira gufata imiti! Abaganga barashaka kugukurikiranira hafi iyi ndwara y'umutima iteye akaga kandi idasanzwe.

Ni ryari nzongera kumva meze neza nyuma yo gutangira imiti?

Dofetilide ifata amasaha abiri cyangwa atatu kugira ngo itangire gukora. Ariko, nubwo waba wumva umeze neza, ntugahagarike gufata umuti kugeza igihe muganga wawe agutegetse. Komeza kuwufata.

Ni gute nakwita ku buzima bwanjye mu gihe nfata Dofetilide?

Hari ibintu bike ugomba gukora ku ruhande rwawe mu gihe ufata uyu muti.

• Menya neza ko ujya mu nama zawe zose hamwe na muganga wawe, harimo n'ibizamini byo muri laboratwari. Icyo gihe ni bwo ushobora kubona uburyo imiti ikugiraho ingaruka.
• Ushobora gukenera gupimwa umutima (electrocardiogram) rimwe mu mezi atandatu . Ibi bizagenzura umuvuduko n'uburyo umutima wawe utera.
• Bashobora kandi gutegeka ko bapima amaraso kugira ngo barebe niba ingano y'imiti igomba guhindurwa.
• Buri gihe soma agapapuro k'amakuru kazanwa n'imiti yawe, cyane cyane niba hari impinduka ziherutse kubaho ku miti yawe cyangwa ku buzima bwawe. Baza umufarumasiye wawe niba ufite ikibazo.

Ibindi bintu ushobora gukora:

• Niba urimo kubagwa, kuvurwa amenyo, cyangwa kuvurwa byihutirwa, bwira umuganga cyangwa umuganga w'amenyo ko urimo gufata Dofetilide.
• Ushobora kandi kwambara ikarita iranga umuntu ivuga ko ufata Dofetilide.
• Ntugahagarike gufata uyu muti utabanje kubibaza muganga wawe.
• Kurikiza inama za muganga wawe ku bijyanye n'ibiribwa n'ibinyobwa, cyane cyane ibinyobwa bisindisha.
• Buri gihe fata imiti ihagije . Mbere yo kujya mu biruhuko cyangwa mu rugendo, reba niba imiti yawe igenda igabanuka. Bitabaye ibyo, ushobora kutayibona mu gihe cyihutirwa.

Ni ryari ukwiye kujya kwa muganga?

Niba ubonye kimwe muri ibi bimenyetso, hamagara muganga wawe ako kanya cyangwa ujye mu cyumba cy’ubutabazi bw’ibanze:

• Umutima utera vuba cyangwa utari umeze neza.
• Kumva umutima wawe urimo gutera cyane, kumva umutima wawe urimo kwihuta cyane.
• Kubabara mu gituza.
• Kuzungera cyangwa kumva ufite umutwe udafite umutwe (`lightheadedness`).
• Kugorwa no guhumeka.
• Impiswi ikomeye.
• Kuruka no kubura ubushake bwo kurya.
• Kubira ibyuya bidasanzwe.
• Inyota y'amazi yiyongera.
• Uduheri ku ruhu.

Nubwo hari ingaruka mbi nke nk'izi, vugana na muganga wawe niba zikubangamiye:

• Umutwe.
• Kubura ibitotsi.
• Izindi ngaruka mbi zose zikubangamira.

Ni hehe nagura Dofetilide?

Dofetilide ntabwo iboneka muri farumasi zose. Kubwibyo, hamagara farumasi ikwegereye kugira ngo urebe niba bayifite. Niba ufite ikibazo cyo kubona umuti, vugana na muganga wawe.

Ni gute wabika Dofetilide?

• Bika Dofetilide mu gikoresho gifunze neza, ku bushyuhe bw'icyumba, ahantu humutse .
• Ntukayishyire ahantu hashyushye cyangwa ku zuba ryinshi.
• Ntubike uyu muti ahantu hari ubushuhe bwinshi, nko mu bwiherero. Ubushuhe bushobora kwangiza imiterere y'umuti.
• Ntugashyire uyu muti kure y'abana gusa, ahubwo n'indi miti yose.
• Ntuzigere usangiza undi muntu uwo ari we wese umuti wawe.
• Ntukigere ukoresha imiti yarengeje igihe. Hari imiti ipakiyeho yanditseho itariki ntarengwa. Cyangwa, niba utazi neza imyaka y'umuti, hamagara farumasi yawe uyibaze.

Amaherezo, ibintu byo kwibuka

Bishobora kugutera agahinda cyane kumenya ko ufite ikibazo cy’umutima utera cyane. Ariko, niba muganga wawe yakwandikiye Dofetilide, irashobora kugufasha. Icy'ingenzi ni ugukurikiza amabwiriza ya muganga n'amabwiriza ari ku ipaki y'imiti neza. Niba ufite ibindi bibazo cyangwa impungenge kuri uyu muti, ntutindiganye kubaza muganga wawe cyangwa umufarumasiye wawe. Bazagufasha.

Dofetilide , Gutera cyane k'umutima, Arrhythmia, Atrial fibrillation, Atrial flutter, Tikosyn, Indwara z'umutima