Unoziva here kuti endothelin iri mumuviri wako? Inokanganisa sei BP yedu!

Wakambonzwa here izwi rekuti 'Endothelin'? Ungave wakanzwa chiremba achikutaurira zita iri kana mumwe munhu wemumhuri mako paanenge achitaura nezvemushonga, kana kuti ungave wakamboriona pane imwe nzvimbo paanenge achiverenga nezvechirwere. Kunyangwe ichi chiri chinhu chidiki chinogadzirwa mumiviri yedu, chinoita basa guru rekuchengetedza BP yedu, kana kuti 'pressure' sezvatinoiziva tese, padanho rakakodzera. Zvisinei, kana endothelin iyi ikawedzera mumuviri kupfuura zvinodiwa, matambudziko akasiyana-siyana ehutano anogona kuitika. Saka, nhasi tichataura nezve endothelin iyi uye zvainoita kumuviri wedu nenzira iri nyore yaunogona kunzwisisa.

Saka chii chinonzi endothelin iyi?

Zvichitaurwa zviri nyore, endothelin ipuroteni diki inobatsira kudzikamisa tsinga dzeropa mumiviri yedu. Kutaura chokwadi, ipeptide. Mapeptidi macheni mapfupi emapuroteni anoumbwa nezvinhu zvidiki zvinonzi maamino acids. Izvi zvinobatsirawo kuvaka mapuroteni makuru mumiviri yedu.

Unoziva here kuti ndiani anogadzira endothelin iyi? Kune masero mukati metsinga dzedu dzeropa. Inonzi endothelium. Iyi ndiyo nzvimbo huru mumuviri wedu inogadzira endothelin.

Chii chinonzi endothelium? Ungatsanangura zvishoma here?

Funga nezvetsinga dzeropa mumiviri yedu senzvimbo ine mapaipi anotakura mvura. Mukati memapaipi iwayo, parutivi panofamba ropa, makafukidzwa nechikamu chakatetepa chemasero. Chikamu ichocho chemasero chinonzi endothelium . Kunyange zvazvo zvingaita sezvinoshamisa, chinoonekwawo seimwe yenhengo huru mumuviri wedu!

Masero aya endothelial anoburitsa zvinhu zvakasiyana-siyana. Zvinhu izvi zvinodzora kukura nekudzika kwetsinga dzedu dzeropa, izvo zvinonzi vascular tone . Iyi vascular tone ndiyo inosarudza kuti mwoyo yedu inofanira kuoma sei kupomba ropa uye kuti inoshanda zvakaoma sei kutenderera ropa mumuviri wese.

Endothelium ne endothelin zvinoshanda pamwe chete kuti zviite mamwe mabasa akakosha:

• Zvinobatsira kuti ropa rigwambe. Izvi zvakakosha zvikuru kuti ropa rimire kubuda kana wava neronda.
• Inodzora huwandu hwemvura nemunyu (electrolytes) muropa redu.
• Zvinobatsirawo kudzora kuzvimba nekudzivirira chepfu kuti dzisapinde munyama dzedu.

Saka endothelin inoitei kumuviri?

Tatotaura kuti endothelin chinhu chinobatsira kudzikamisa tsinga dzeropa. Kutaura zvazviri, endothelin ndiyo vasoconstrictor ine simba zvikuru mumuviri wedu. Ngatitsanangure zvishoma nezveshoko iri:

• Chikamu che "Vaso" chinoreva mitsipa yeropa iri muhurongwa hwedu hwemwoyo.
• "Constrictor" kana "constriction"Kudzikira kweropa zvinoreva kuti tsinga dzeropa dzinodzikira kana kuti dzinodzikira. Izvi zvinoderedza kufamba kweropa, uye dzimwe nguva zvinotomisa kufamba kwaro.

Saka, zvinoitwa ne endothelin kuwedzera BP yedu. Kana tsinga dzeropa dzikava dzakamanikana, mwoyo unofanirwa kushanda nesimba kuti upombe ropa. Ndosaka BP ichiwedzera.

Chii chinoitika kana mazinga e endothelin akawedzera?

Kazhinji, endothelin inoshanda nenzira inobatsira miviri yedu. Zvisinei, kana nekuda kwechimwe chikonzero huwandu hwe endothelin hukawedzera mumuviri, hunogona kukonzera zvirwere zvakawanda zvinokuvadza mwoyo nemapapu edu . Fungidzira zvinoitika kana pombi yemvura ikanyanya kuvharika. Ndizvo zvakaita.

Zvimwe zvezvirwere zvinogona kukonzerwa nekuwedzera kwemazinga e endothelin ndeizvi:

• Atherosclerosis (chirwere chetsinga): Muizvi, mafuta anounganidzwa mukati metsinga dzeropa , zvichiita kuti tsinga dzitete .
• Chirwere chemwoyo chakatyoka: Kushaya simba kwemoyo nekuda kwekushushikana kamwe kamwe.
• Mhando dzakasiyana dzegomarara .
• Cardiomyopathy : Kushaya simba kwetsandanyama yemwoyo.
• Zvirwere zvemwoyo (mwoyo) uye kutadza kushanda zvakanaka kwemoyo.
• Chirwere chetsinga dzeropa , pamwe chete nechirwere chinonzi endothelial dysfunction .
• Kukwira kweropa uye preeclampsia .
• Chirwere cheitsvo uye kutadza kushanda zvakanaka kweitsvo .
• Kuora kwemapapu (pulmonary fibrosis) uye kukwira kweropa mumapapu .
• Scleroderma : Kukora kweganda nenyama dzinobatana.

Fungidzira, Nimal ave nenguva aine BP yakakwira. Chiremba akati mitsipa yake yeropa yakadzikira zvishoma, uye kuti huwandu hwe endothelin yake hunogona kunge huri kuikanganisa. Akanyeverawo kuti kana akasatora mushonga wake nemazvo, zvinogona kukonzera chirwere chemwoyo. Saka, hazvina kunaka kutora nyaya iyi ye endothelin zvishoma.

Kune mhando dze endothelin here?

Ehe, kune marudzi eendothelin. Vaongorori vezvekurapa vakatanga kuaona muna 1987. Kune marudzi matatu makuru eendothelin, ayo anoumbwa nemaamino acid peptides mana. Ose matatu anobatsira mukuderedza kushushikana kweropa.

Rudzi rwe endothelin runonyanya kushandiswa uye rune simba mumiviri yedu ndi endothelin-1 (ET-1). Vatsvakurudzi vachiri kudzidza kuti mamwe marudzi maviri, endothelin-2 (ET-2) uye endothelin-3 (ET-3), anokanganisa sei miviri yedu. Parizvino, pfungwa huru iri paET-1.

Chii chinonzi endothelin receptors?

Nhengo dzese dzemuviri wedu dzine ma-endothelin receptors. Ma-receptor aya akafanana nema-doorknobs. Kana mamorekuru e-endothelin auya obatana nema-receptor aya, anotumira meseji kumasero iwayo kuti aite chimwe chinhu. Aya ndiwo matauriro anoita endothelin nemasero mumiviri yedu yese.

Mazinga e endothelin anoyerwa sei?

Kana vanachiremba vachida kuziva kuti endothelin yako yakawanda sei, vanozoongorora ropa . Izvi zvinoyera huwandu hwe endothelin-1 (ET-1). Inowanikwa muchikamu cheropa chinonzi plasma. Plasma chikamu cheropa chinosara mushure mekunge masero matsvuku eropa, masero machena eropa, uye maplatelet abviswa.

Kuongororwa kweropa uku kunogona kuitwa kuhofisi yachiremba wako, kuchipatara, kana murabhoritari. Mamwe marudzi e endothelin akaoma kuyera muropa nenzira iyi.

Chiyero che endothelin i picograms pa milliliter (pg/mL).

• Huwandu hweET-1 muplasma yemunhu mukuru hunenge 1 pg/mL kusvika 2 pg/mL.
• Mazinga eET-1 muvana vadiki akakwira zvishoma.
• Uyewo, panogona kunge paine mutsauko mudiki padanho iri pakati pemapoka akasiyana emadzinza.

Kazhinji, vanhu vane mamwe matambudziko emwoyo kana mapapu, akadai se pulmonary arterial hypertension, vane ET-1 levels yakakwira. Uyewo, mamwe marapirwo emwoyo, akadai se balloon angioplasty, anogona kuwedzera mazinga e endothelin kwenguva pfupi.

Chii chinonzi Endothelin Receptor Antagonists (ERA)?

Iyi imhando yemishonga inopihwa kana huwandu hwe endothelin hwawedzera. Endothelin Receptor Antagonists (ERA) inoshanda nekuderedza huwandu hwe endothelin mumuviri wedu.

Iyi mishonga ndeyemhando yekurapa inonzi "targeted therapy." Kureva kuti, mishonga iyi inoenda chaizvo uye inorwisa masero ane matambudziko chete, pasina kukonzera kukuvara kukuru kumasero ane hutano. Kufanana nepfuti inopfura, inobaya chaizvo chinangwa. Mishonga yeERA inonyanya kushandiswa kurapa mamwe marudzi eBP yakakwira mumapapu (pulmonary arterial hypertension).

Pane migumisiro yakaipa here pamishonga iyi yeERA?

Kufanana nemishonga chero ipi zvayo, mishonga yeERA inogona kukonzera mimwe migumisiro yakaipa.

• Vakadzi vane pamuviri kana vakadzi vari kuedza kubata pamuviri havafanirwe kutora mishonga iyi yeERA. Izvi zvinodaro nekuti mishonga iyi inogona kukonzera matambudziko ekuzvarwa kwemwana asati aberekwa. Iyi inyaya yakakosha zvikuru.
• Kashoma, mushonga uyu unogona kukonzera kukuvara kwechiropa. Saka, chiremba wako anogona kuraira kuongororwa kweropa kuti aongorore hutano hwechiropa chako nguva nenguva.
• Mimwe migumisiro inogona kuitika ndeiyi:
• Kuzvimba.
• Kuzvimba kwechiso (edema) kana kusviba.
• Musoro .
• Kusvotwa nekurutsa.
• Kurova kwemwoyo nekukurumidza uye kurova kwemoyo.

Kana uchinzwa chimwe chinhu chakadai, unofanira kuudza chiremba wako nekukasika kuitira kuti atore matanho anodiwa.

Saka, ndezvipi zvinhu zvatinofanira kurangarira kubva munyaya iyi? (Mharidzo Yekuenda Kumba)

Zvakanaka, tataura zvakawanda nezve endothelin. Muchidimbu:

• Endothelin ipuroteni inokosha inogadzirwa mumuviri inobatsira kuomesa tsinga dzeropa uye kudzora BP.
• Izvi zvinogadzirwa nerukoko rwemasero anonzi endothelium rwuri mukati metsinga dzedu dzeropa.
• Kana huwandu hwe endothelin hukanyanya kukwira, mitsipa yeropa inogona kuvharika zvakanyanya, zvichikonzera matambudziko akadai seBP, chirwere chemwoyo, uye chirwere chemapapu .
• Huwandu hweEndothelin-1 (ET-1) muropa hunogona kuyerwa nekuongororwa kweropa .
• Mishonga inoderedza huwandu hwe endothelin receptor antagonists (ERAs) inoshandiswa kunyanya pakurapa BP yakakwira mumapapu.
• Kana uri kutora mushonga weERA, unofanira kungwarira zvikuru panguva yekuzvitakura uye nehutano hwechiropa chako.

Saka, kana iwe kana mumwe munhu waunoziva aine dambudziko neEndothelin, zvakanaka kutsvaga mazano echiremba. Ndinovimba chinyorwa chino chakupa rumwe ruzivo. Ramba uine hutano hwakanaka!

Endothelin , BP, chirwere chemwoyo, chirwere chemapapu, endothelium, mapeptides