Pane mumwe munhu mumhuri yako, pamwe ambuya kana sekuru, akambova nechirwere cheAlzheimer here? Kana izvozvo zvikaitika, zvakajairika kuva nekutya mupfungwa dzako, "Oh, ndichabatwawo nechirwere ichi here?" Ndipo panotanga kutaurwa nezvekuedzwa kwemajini eAPOE. Kunogona here kufanotaura remangwana redu? Ngatitaurei nezvezvinhu zvese zviri nyore uye zvakajeka.
Chii chinonzi bvunzo iyi yeAPOE gene?
Zvichitaurwa zviri nyore, bvunzo yeAPOE gene bvunzo yezvemajini inotarisa genotype yejini inonzi apolipoprotein E. Kana uine mamwe marudzi ejini iri, unogona kunge uri panjodzi yakakura yekubatwa nechirwere cheAlzheimer kupfuura mamwe .
Asi chinonyanya kukosha apa ndechekuti. Kungoti une njodzi yakakura hazvirevi kuti ucharwara zvechokwadi. Fungidzira kuti kune makore matema mudenga. Izvi zvinoreva kuti pane mukana wemvura, asi hazvirevi kuti ichanaya zvechokwadi. Ndizvo zvazviri. Hutano hwedu hunokanganiswa kwete chete nemajini edu, asiwo nezvimwe zvinhu zvakawanda, zvakaita sezvatinodya, kungave tichiita maekisesaizi, uye mararamiro edu.
Saka, zvakakosha zvikuru kutaura nachiremba wako kuti unzwisise mhedzisiro yebvunzo iyi.
Zvakanaka, saka chii chinonzi gene reAPOE iri?
Jini reAPOE rinoudza masero emuviri wedu kuti agadzire puroteni yakakosha inonzi apolipoprotein E. Puroteni iyi inoita basa rakakosha zvikuru. Inobatanidzwa nemafuta (lipids) mumuviri wedu uye inotakura zvinhu zvakaita secholesterol kuenda kwazvinoda kuva muropa, semutyairi wetekisi. Tinozvidaidza kuti lipoprotein.
Kune mhando nhatu huru, kana kuti ma alleles, ejini reAPOE mumiviri yedu.
| Mhando yemajini (Allele) | Tsananguro |
|---|---|
| APOE-e2 (APOE2) | Kazhinji mhando isingawanzoitiki. |
| APOE-e3 (APOE3) | Mhando yakajairika iyo vanhu vazhinji vane. |
| APOE-e4 (APOE4) | Mhando iyi inobatanidzwa nenjodzi yekubatwa nechirwere cheAlzheimer. |
Tose tinogara nhaka makopi maviri ejini iri, rimwe kubva kuna amai vedu nerimwe kubva kuna baba vedu. Saka unogona kuva nemusanganiswa wemhando mbiri idzi (semuenzaniso e3/e3, e3/e4, e2/e4).
Ndeipi yemajini aya inobatanidzwa nechirwere cheAlzheimer?
Chekutanga, hapana jini rakawanikwa richikonzera chirwere cheAlzheimer . Zvisinei, tsvakurudzo yakawana kuti kuva nekopi imwe chete yeAPOE-e4 gene variant kunowedzera njodzi yekubatwa neAlzheimer's.
- APOE-e4: Vanhu vane kopi imwe kana mbiri dzerudzi urwu rwemajini vane mukana wakawedzerwa wekuva nechirwere cheAlzheimer chinotanga mushure memakore makumi matanhatu nemashanu.
- APOE-e2: Aya mashoko akanaka. Mhando iyi yemajini inogona kudzivirira chirwere cheAlzheimer. Kunyangwe kana munhu ane jini iri akarwara, kazhinji zvinoitika gare gare kupfuura munhu ane APOE-e4.
Chinhu chakakosha ndechekuti, nekuti une jini reAPOE-e4, haugone kutaura zvechokwadi kuti uchava neAlzheimer's. Uye, haugone kutaura kuti munhu asina jini iroro haazobatwe neAlzheimer's. Ichi chinongova chinhu chine njodzi.
Unoita sei bvunzo iyi? Ndiani anoiita?
Iyi haisi bvunzo yaunomanikidzwa kuita. Inyaya inongoitwa wega. Kana paine nhoroondo yechirwere cheAlzheimer mumhuri yako, ungangoda kuziva nezvazvo. Kana zvakadaro, unogona kutaura nachiremba wako wowana rumwe ruzivo nezveizvi.
Bvunzo iri nyore kwazvo:
1. Kutora DNA: Chiremba achatora DNA kubva kwamuri. Izvi zvinogona kuitwa nekutora ropa shoma kana nekukwesha mukati memuromo kana padama nekachira kadiki.
2. Kutumira kurabhoritari: Muenzaniso uyu unotumirwa kurabhoritari yakakosha kuti uongororwe.
3. Kuendesa mhedzisiro: Rabhoritari inoongorora DNA yako yotumira mhedzisiro yacho kuna chiremba wako.
4. Kukurukura nezvemhedzisiro: Zvadaro, chiremba wako kana mupi wezano wezvemajini achataura newe otsanangura zvinorehwa nemhedzisiro iyi.
Kune dzimwe nyika dziri kuwana bvunzo dzemajini kumba. Zvisinei, kunyangwe ukawana mhinduro kubva kune imwe, zvichiri kukosha kutaura nachiremba wemhuri yako kuti unzwisise zvese zviri kuitika.
Chii chatinodzidza kubva mumigumisiro yacho?
Mhedzisiro yebvunzo inokuudza kuti ndeapi marudzi (alleles) ejini reAPOE raunaro.
Zvinorevei kuti APOE4 positive?
"APOE4 positive" zvinoreva kuti une kopi imwe chete yejini reAPOE-e4 muDNA yako.
Ndeipi njodzi yekubatwa neAlzheimer's kana uine APOE4?
Pakati pe15% ne25% yevanhu pasi rose vane kopi imwe chete yejini reAPOE-e4. Pakati pe2% ne5% vane kopi dzese dziri mbiri. Kuva nekopi imwe chete kunogona kuwedzera njodzi yekubatwa neAlzheimer's.
Asi, ndinodzokorora, iyi haisi bvunzo inosimbisa kuvapo kwechirwere. Inongokuudza nezvengozi yacho.
| Mhedzisiro | Zvaungapiwa nachiremba |
|---|---|
| Une gene reAPOE-e4 (rine njodzi huru) | Chiremba wako achakukurudzira kuti urarame hupenyu hune hutano. |
| Hauna jini reAPOE-e4 (njodzi shoma) | Kunyangwe njodzi yacho iri shoma, zvichiri kukosha kuchengetedza mararamiro ane hutano. |
Kana mhedzisiro yacho ikaratidza kuti njodzi yacho yakakura, chiremba wako anogona kukuudza kuti uite zvinhu zvakaita se:
- Kurovedza muviri nguva dzose: Kuita maekisesaizi anokuita kuti udikitire kanenge mazuva mashoma pasvondo.
- Rara zvakanaka: Rara kwemaawa manomwe kusvika masere pazuva.
- Kuva neushamwari: kupedza nguva neshamwari nehama, kutora chikamu muzviitiko zvekushamwaridzana.
- Kunetsa uropi: Zvinhu zvakaita sekugadzirisa mapuzzle, kuverenga mabhuku, kudzidza mutauro mutsva kana chiridzwa chemimhanzi.
Kuziva mhedzisiro iyi kunogona kukanganisa pfungwa here?
Ehe, zvechokwadi. Patinodzidza mhedzisiro yekuongororwa kwemajini seizvi, zvinogona kutikanganisa munzira dzakawanda. Unganzwa kutya, kunetseka, kana hasha. Dzimwe nguva, mhedzisiro yacho ingasakupa mhinduro yakajeka yawaitarisira.
Usanetseka neruzivo urwu rwakaoma uri wega. Taura pachena nachiremba wako nezvenyaya iyi. Iye achakubatsira kunzwisisa mamiriro acho ezvinhu uye kuronga matanho ako anotevera.
Yeuka, zvisinei nekuti majini ako akaita sei, pane zvakawanda zvaunogona kuita kuti uderedze njodzi yako yechirwere cheAlzheimer. Zano rakanakisisa pane izvi nderekutaura nachiremba wako.
Mharidzo Yekuenda Nayo Kumba
- Kuongororwa kwemajini eAPOE kunongokuudza nezvengozi yako yekubatwa nechirwere cheAlzheimer, asi hakurevi kuti uchava nechirwere ichi.
- Kuva nejini reAPOE-e4 kunogona kuwedzera njodzi. Jini reAPOE-e2 rinogona kudzivirira.
- Kungoti une gene reAPOE-e4 hazvirevi kuti uchava nechirwere cheAlzheimer's. Uye hazvirevi kuti munhu asina gene racho haazombofi akachiwana.
- Zvakabuda muongororo zvinogona kukanganisa pfungwa, saka gara uchikurukura zvabuda nachiremba wako .
- Pasinei nekuti majini ako akaita sei, mararamiro ane hutano (kudya zvakanaka, kurovedza muviri, kuchengetedza pfungwa dzako dzichishanda) zvinogona kubatsira kuderedza njodzi yekurwara.
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