Uri kunzwa kuderera kwehuwandu hwemasero machena eropa here? Ngatidzidzei nezve Autoimmune Neutropenia (AIN)!

Wakambozvibvunza here kuti sei masoja edu emuviri, pachinzvimbo chekutidzivirira, dzimwe nguva achigona kutanga kurwisa masero edu? Ichocho chirwere chakaoma asi chinonzwisisika chinonzi Autoimmune Neutropenia (AIN) . Chinoitika ndechekuti masoja edu emuviri anorwisa rudzi rwakakosha rwemasero machena eropa mumuviri wedu, anonzi `neutrophils.` Saka ngatitaurei nezvazvo zviri nyore, nenzira yaunogona kunzwisisa.

Saka, chii chinonzi Autoimmune Neutropenia (AIN)?

Zvichitaurwa zviri nyore, `Autoimmune Neutropenia` (AIN) chirwere chinokonzerwa neropa. Chinoitika pano ndechekuti masoja edu emuviri, ayo anofanirwa kutidzivirira, anorwisa masero edu machena eropa anonzi `neutrophils' zvisirizvo. Fungidzira izvi, semauto ari kuchengetedza nyika yedu achirwisa vanhu vedu zvisirizvo.

Chii chinonzi 'Neutrophils'?

MaNeutrophils zvikamu zvakakosha zvikuru zvemuviri wedu wekudzivirira muviri. Akafanana nemasoja madiki mumiviri yedu. Basa rawo guru nderekutsvaga nekuparadza zvinhu zvinokuvadza zvinopinda mumuviri, zvakaita semabhakitiriya nefungus zvinokonzera zvirwere. Saka, kana iri `Autoimmune Neutropenia`, muviri wedu wekudzivirira muviri unoparadza masero aya anokosha e`neutrophils`, saka huwandu hwe`neutrophils` muropa hunoderera pasi pemazinga akajairwa.

Kune mhando mbiri huru dzeAIN:

1. Primary Autoimmune Neutropenia (AIN): Izvi zvinonyanya kuonekwa muvacheche nevana vadiki . Chinoitika pano ndechekuti huwandu hwe `neutrophils' hunoderera pasina chimwe chikonzero. Asi mashoko akanaka ndeekuti chirwere ichi chinowanzo pera mukati memakore mashoma.

2. Secondary Autoimmune Neutropenia (AIN): Izvi zvinowanzoitika kuvana vakuru nevakuru . Pano, huwandu hushoma hwema neutrophil hunokonzerwa nechimwe chirwere. Semuenzaniso, zvinogona kukonzerwa nehutachiona, chimwe chirwere cheropa, kana chimwe chirwere che autoimmune (chirwere umo masoja emuviri anorwisa muviri wawo). Chirwere ichi chesecondary AIN chinowanzova chenguva refu .

Nhamba yema neutrophils inonzi neutropenia yakaderera sei?

Kuzvidzivirira kwemuviri (Autoimmune Neutropenia) imhando imwe chete yechirwere chakakura chinonzi Neutropenia. Neutropenia inorongwa seyakapfava, iri pakati nepakati, kana kuti yakanyanya, zvichienderana nehuwandu hwema neutrophils pa microliter (microL) yeropa.

• Kushaya simba kwemasero machena: 1,000 - 1,500 neutrophils pa microL.
• Neutropenia iri pakati nepakati: 500 - 1,000 neutrophils pa microL.
• Neutropenia Yakanyanya: MaNeutrophils ari pasi pe500 pa microL.

Chinhu chinonyanya kukosha ndechekuti tsika idzi dzinofanira kusimbiswa nachiremba. Kana usina chokwadi nezveizvi, zvakakosha kutsvaga mazano echiremba.

AIN inokanganisa sei muviri wangu?

Maitiro aAIN aunoita anogona kusiyana kubva pamunhu kusvika pamunhu. Zvinoenderana nezvinhu zvakawanda, saka zvakanaka kutaura nachiremba wako nezveizvi. Kana huwandu hwema neutrophil ako hukadzikira zvakanyanya, une mukana wekutapukirwa nehutachiona . Dzimwe nguva hutachiona uhwu hunogona kutyisidzira hupenyu hwako, kunyanya kana usingawani rubatsiro rwechiremba nekukurumidza.

Zvisinei, mune dzimwe nguva, autoimmune neutropenia inogona kungokonzera hutachiona husina kunyanya kuoma. Kana kuti inogona kunge isina zviratidzo. Ndosaka zvichikosha kushanda nachiremba kuti muzive chiri kukonzera neutropenia yenyu. Zvichienderana nechikonzero chacho, chiremba wenyu anogona kutarisa mamiriro enyu uye kukubatsirai kudzora hutachiona.

Ndiani anowana Autoimmune Neutropenia (AIN)?

• AIN Yekutanga: Izvi zvinonyanya kubata vacheche nevana vadiki . Inowanzoonekwa painenge yava nemwedzi misere yekuberekwa.
• AIN yechipiri: Izvi zvinowanzoitika kune chimwe chirwere che autoimmune, chakadai se lupus kana rheumatoid arthritis. Vana vane AIN yechipiri vanowanzoonekwa vaine chirwere ichi pazera remakore gumi. Vakuru vane AIN vanowanzoonekwa vane chirwere ichi vari pakati pemakore makumi mana nemakumi matanhatu.

Kuwanda kwe autoimmune neutropenia kwakajairika sei?

Chirwere chePrimary AIN chirwere chisingawanzoitiki . Chinongobata mwana mumwe chete pavana 100,000 vari pasi pemakore gumi. Saka unogona kuona kuti hachiwanzoitiki.

Ndezvipi zviratidzo zveAutoimmune Neutropenia?

Kuzvidzivirira kwemuviri (autoimmune neutropenia) hakusi nguva dzose kunokonzera zviratidzo zvikuru. Zvisinei, dzimwe nguva unogona kuona zviratidzo zvehutachiona. Semuenzaniso:

• Utachiona hwenzeve: Ichi chimwe chezviratidzo zvinonyanya kuzivikanwa. Fungidzira mwana wako achiramba achirwadziwa nenzeve, uye paunoenda kuna chiremba, vanokuudza kuti idambudziko renzeve.
• Zvirwere zvekufema: Dzihwa, kukosora, uye fivha.
• Matumbu emuromo: Zvinhu zvakaita semaronda emuromo uye gingivitis.
• Zvirwere zveganda.
• Chirwere chemabayo.
• Chirwere chemusana (Meningitis).
• Utachiona hwemunzira yeweti (UTIs).
• Sepsis: Utachiona hwakakomba zvikuru, hunogona kutyisidzira hupenyu.

Utachiona hunobatanidzwa neAIN yekutanga hunowanzova husina kusimba, asi hutachiona hwakakomba hwakadai sepneumonia, meningitis, uye sepsis hunowanzoonekwa muAIN yechipiri.

Chii chinokonzera autoimmune neutropenia?

AIN inorongwa seyekutanga kana yechipiri zvichienderana nechikonzero chemazinga akaderera e neutrophil.

Neutropenia Yekutanga Yekudzivirira Muviri (Primary AIN)

MuAIN yekutanga, ma antibodies anotarisa uye anoparadza ma neutrophils. Ma antibodies rudzi rweprotein mu immune system yedu. Basa rawo rakajairika nderekuparadza zvinhu zvinokuvadza, zvakaita semavhairasi nemabhakitiriya, zvinopinda mumuviri. Asi panguva ino, vaongorori havasati vaziva kuti sei ma antibodies edu achirwisa ma neutrophils aya.

Neutropenia Yechipiri Yekuzvidzivirira Mumuviri (Secondary AIN)

MuAIN yechipiri, huwandu hwema neutrophils hunodzikira nekuda kwechimwe chikonzero kana mamiriro ezvinhu. Izvi zvinoita kuti masoja emuviri aparadze ma neutrophils.

Zvimwe zvinhu zvinogona kukonzera izvi ndezvi:

• Zvimwe zvirwere zvinorwisa muviri: Mienzaniso inosanganisira rheumatoid arthritis, lupus, uye autoimmune hemolytic anemia.
• Kenza: Semuenzaniso, `large granular lymphocyte leukemia`.
• Utachiona: Utachiona hwakaita se 'HIV', 'Parvovirus', 'hepatitis B'.
• Mamota: Sezvakaita `Wilms bundu`, `Hodgkin's disease`.
• Zvirwere zvetsinga: Semuenzaniso, multiple sclerosis.
• Kuisirwa itsvo kana kuti mupfupa.
• Mimwe mishonga: Kunyanya mimwe mishonga yechemotherapy inopihwa yegomarara.

Chirwere cheAutoimmune Neutropenia chinoonekwa sei? (Kuongororwa)

Kana uine fivha kana hutachiona, chiremba wako anogona kuona kuti huwandu hwema neutrophil ako hwakaderera panguva yekuongorora ropa kuti aone chikonzero. Kuziva AIN kunogona kuoma zvishoma, sezvo paine zvikonzero zvakawanda zvinogona kuitika. Chiremba wako anogona kuona AIN mushure mekubvisa zvimwe zvirwere zvinogona kukonzera huwandu hwema neutrophil ako hwakaderera.

Kuti uongorore kana kutarisa `Autoimmune Neutropenia`, chiremba wako anogona kuita bvunzo dzinotevera:

• Kuverengwa kweropa kwakazara (CBC): CBC inogona kutarisa huwandu hwema neutrophils muropa rako. Nekuti mazinga aya anogona kusiyana, chiremba wako anowanzoita CBC dzinopfuura imwe chete kuti asimbise neutropenia uye aongorore mazinga ako ema neutrophil. Kuongororwa kweCBC nguva dzose kunogonawo kubatsira kuona kana AIN yako iri chirwere chisingaperi.
• Kuongororwa kweropa rekunze: Sample yeropa inoongororwa nemaikorosikopu kuti ione chimiro uye hunhu hwema neutrophils. Izvi zvinobatsirawo pakuongorora chirwere.
• Kuongororwa kweVitamin B12, folate, uye copper: Kuongororwa uku kunogona kutarisa kushomeka kwezvinovaka muviri izvi. Muviri unoda izvi kuti ugadzire ma neutrophils.
• Kuongororwa kwebasa rechiropa: Izvi zvinogonawo kuongorora mashandiro echiropa uye kana paine hepatitis yehutachiona.
• HIV nedzimwe ongororo dzehutachiona: Utachiona hwehutachiona hwakaita seHIV hunogonawo kukonzera kudzikira kwemasero machena eropa.
• Flow cytometry: Iyi bvunzo yemurabhoritari inotarisa masero kuti aone zviratidzo zvechirwere. Inoshandiswa kuona kana neutropenia inokonzerwa nechirwere che autoimmune.
• Kufungidzira: Kana paine fungidziro yekuti AIN inokonzerwa negomarara rakadai se lymphoma, MRI kana CT scan inogona kuitwa.
• Kutsvaga mapfupa emupfupa uye biopsy: Pano, chiremba anotora sampuli diki yemapfupa emupfupa oiongorora kuti aone kana paine zviratidzo zvechirwere. Izvi zvinogona kubatsira kuona kana neutropenia inokonzerwa nekenza yeropa, yakadai seleukemia.

Chiremba wako anogonawo kuraira kuti uongorore ropa rako kuti uone kana paine ma antibodies ari muropa rako anorwisa ma neutrophils. Miedzo inowanzo shandiswa ndeye I-GIFT (Indirect granulocyte immunofluorescence test) uye GAT (Granulocyte agglutination test).

Zvinosuwisa kuti bvunzo idzi hadzisi dzechokwadi nguva dzose pakuona AIN. Zvichienderana nechikonzero che neutropenia yako nenguva yekuongororwa, bvunzo idzi dzingasaone masoja emuviri kana kuti dzingapa mhedzisiro yenhema. Mhedzisiro yenhema-yakanaka ndeye apo bvunzo inoratidza kuti masoja emuviri aripo asipo.

Kana chiremba achifungidzira kuti neutropenia inokonzerwa nechirwere chakati, anogona kuraira mimwe miedzo.

Chirwere cheAutoimmune Neutropenia chinorapwa sei?

Kurapwa kunoenderana nekuoma kwechirwere chako. Semuenzaniso, mwana ane neutropenia isina zviratidzo angangoda kupihwa CBCs nguva dzose uye neutrophils, asi angasade kurapwa nekukasika. Kana mwana wako aine hutachiona kakawanda, chiremba wako anogona kukupa mishonga inorwisa utachiona kudzivirira hutachiona. Mishonga inorwisa utachiona inowanzopihwa kurapa hutachiona, asi mishonga iyi inorwisa utachiona inopihwa kudzivirira hutachiona kuti husaitike.

Kune munhu ane secondary AIN, chiremba acharapa chirwere chiri kukonzera kuderera kwemazinga e neutrophil. Vanogonawo kunyora zvinotevera:

• Granulocyte colony-stimulating factor (G-CSF): Iyi ndiyo nzira huru yekurapa zvirwere zvakakomba zve neutropenia. Inobatsira muviri kugadzira ma neutrophils akawanda. G-CSF inogonawo kudzivirira hutachiona hunowanzobatanidzwa neAIN yekutanga.
• Corticosteroids: Corticosteroids, yakadai seprednisone, inoderedza kushanda kwemuviri wako, zvichideredza huwandu hwemasoja ekudzivirira muviri anorwisa ma neutrophils.
• Mamwe marapirwo: Mimwe mishonga yakaita seIVIG, rituximab, uye alemtuzumab yakashandiswawo muvarwere vanorwara zvakanyanya vane autoimmune neutropenia yakanyanya.

Ko Autoimmune Neutropenia inogona kudzivirirwa here?

Hapana AIN yePrimary kana Secondary AIN inogona kudzivirirwa . Zvisinei, unogona kudzivirira matambudziko anokonzerwa ne `Autoimmune Neutropenia`, kureva kuti, kukura kwehutachiona. Kuti uite izvi, unofanirwa kutora matanho anodiwa kuti uzvidzivirire kubva kuhutachiona. Semuenzaniso, kudzivirira nzvimbo dzine vanhu vakawanda, kugeza maoko ako nguva dzose, uye kugara kure nevanhu vanorwara.

Munhu ane Autoimmune Neutropenia angatarisira remangwana rerudzii?

AIN yekutanga inowanzopera yega . Vana vanosvika 95% vane AIN vanodzoka padanho repamusoro pavanosvika makore maviri kusvika matatu. Vana vanenge vese vane AIN yekutanga vanopora zvizere pavanosvika makore gumi nerimwe. Izvi zvinonyaradza zvechokwadi, handiti?

Mune zvimwe zviitiko, zvinonzi secondary AIN, kupora kwako kunoenderana nezvinhu zvakati wandei, kunyanya chirwere chakakonzera neutropenia yako. Kurapa chirwere ichocho nekudzivirira hutachiona kunogona kubatsira kudzosa huwandu hwema neutrophil ako pahwakajairika.

Ndinofanira kutsvaga mazano ekurapa rini?

Kana uine chirwere che autoimmune neutropenia chakakomba uye ukaita fivha, enda kuna chiremba nekukasika . Dzimwe nguva, chiremba wako anogona kunge akakunyorera mishonga inorwisa mabhakitiriya pachine nguva kuti utore kana ukaita fivha. Kazhinji, uchafanira kurapwa muchipatara.

Kana uine chirwere che autoimmune neutropenia chakanyanya, kwenguva refu, chiremba wako achakutsanangurira zviratidzo zvaunofanira kuziva uye zvaunogona kuita kudzivirira matambudziko.

Yeuka: Kana iwe kana mwana wako akaonekwa kuti ane AIN, taura nachiremba wako nezvekuti inokubata sei. Kunyange zvazvo zviratidzo nezvikonzero zvichisiyana, mashoko akanaka ndeekuti kurapwa kwakadai seG-CSF kunoshanda zvikuru pakuwedzera huwandu hwe neutrophil.

Kana mwana wako aine AIN, ongororwa ropa nguva nenguva sezvakarairwa nachiremba wako. Tarisa zviratidzo zvehutachiona, uye tsvaga kurapwa nekukurumidza kana ukaona chimwe chinhu, kudzivirira matambudziko anogona kuitika.

Pfupiso (Mharidzo Yekuenda Nayo Kumba)

Zvakanaka, saka ndinovimba kuti ikozvino mava kunzwisisa zviri nani nezve `Autoimmune Neutropenia` (AIN) yatakataura nezvayo.

• AIN chirwere apo masoja edu emuviri anoparadza masero edu machena eropa anonzi `neutrophils'.
• Izvi zvinogona kuitika kuvana vadiki (Primary AIN) kana kuvanhu vakuru (Secondary AIN). Primary AIN muvana vadiki inowanzo pera yega.
• Njodzi huru ndeyekutapukirwa kakawanda.
• Kune bvunzo dzeropa nedzimwe bvunzo dzekuongorora chirwere.
• Kurapa kunosanganisira kutarisa, mishonga yekudzivirira hutachiona, G-CSF, uye corticosteroids.
• Chinhu chinonyanya kukosha ndechekuti musavhunduke kana kutya motsvaga mazano echiremba kana imi kana mwana wenyu muine zviratidzo izvi. Kana zvikaonekwa nekukurumidza uye zvikarapwa nemazvo, munogona kurarama hupenyu hwakanaka kunyangwe muine AIN.

Kana muine mimwe mibvunzo nezvenyaya iyi, iva nechokwadi chekutaura nachiremba wenyu. Ndivo vanogona kukupai mazano akanakisisa.

Neutropenia , Autoimmune Neutropenia, Masero Machena Eropa, Sisitimu Yekudzivirira Muviri, Utachiona, Zvirwere Zveropa, Vana