Wakambonzwa nezvechirwere ichi here paunoshanduka kuita bhuruu kana uchitonhora wonzwa kuneta zvakanyanya? (Cold Agglutinin Disease)

Dzimwe nguva unonzwa bhuruu muminwe yako nezvigunwe zvako kana uchitonhora chaizvo here? Kana kuti unonzwa kuneta zvisina kujairika uye usina simba pasina chikonzero here? Pamwe ganda rako rachinja ruvara. Kana uine zviratidzo izvi, chikonzero chingave chirwere chisingawanzoitiki, asi chinhu chatinofanira kuziva tese. Nhasi, tichataura nezvechirwere ichi chinonzi `Cold Agglutinin Disease (CAD),' zvinoreva "chirwere chekuunganidza masero eropa anotonhora" muchiSinhala.

Chii chinonzi `Cold Agglutinin Disease (CAD)`? Ngatizvinzwisise zviri nyore.

Zvichitaurwa zviri nyore, `Cold Agglutinin Disease (CAD)` chirwere cheropa chisingawanzoitiki umo masoja emuviri wedu ekudzivirira zvirwere - masoja anotidzivirira kubva kuzvirwere semasoja ari mumiviri yedu - anorwisa masero edu matsvuku eropa ane hutano zvisizvo .

Fungidzira, masoja edu ekudzivirira muviri anowanzo gadzira rudzi rwakakosha rweprotein inonzi `antibodies' yekuparadza utachiona hunokuvadza hunopinda mumuviri. Asi munyaya iyi yeCAD, masoja edu ekudzivirira muviri anogadzira rudzi rwakakosha rwe`antibody' inonzi `autoantibody', inozivikanwawo se `cold agglutinin'. Chinhu chakakosha pane izvi ndechekuti inorwisa nekuparadza masero matsvuku eropa ane hutano mumuviri wedu.

Sezvamunoziva, masero matsvuku eropa rudzi rwakakosha kwazvo rwemasero anotakura okisijeni mumuviri wedu wese. Okisijeni iyi inobatsira masero edu kugadzira simba raanoda. Saka, kana huwandu hwemasero matsvuku eropa hukadzikira, ndiko kuti, kana paine anemia , muviri wedu unonzwa kusagadzikana kwakasiyana-siyana.

`Chirwere cheCold Agglutinin` ndecheboka reanemias rinonzi `hemolytic anemia`. `Hemolytic anemia` inguva iyo mupfupa wedu unopwanya masero matsvuku eropa nekukurumidza kupfuura paanogona kugadzira matsva. Zvakafanana nebhaketi rine buri mariri rotanga kudonhedza mvura.

Chirwere ichi chinonzi `Cold Agglutinin Disease` chakajairika zvakadii?

Ichi chirwere chisingawanzoitiki . Munhu mumwe chete pavanhu 100,000 ndiye anotanga kuonekwa aine chirwere ichi gore rega rega. Chinonyanya kuitika kuvakadzi vari pakati pemakore 40 ne80. Zvisinei, huwandu hwakawanda hwevanoonekwa vaine chirwere ichi hunowanikwa kuvanhu vari pakati pemakore 60.

`Chirwere cheCold Agglutinin` chinokanganisa sei muviri wangu?

Chirwere ichi chinogona kukonzera kuti uve nezviratidzo zvekushaya ropa. Kushaya ropa mumuviri kunoitika kana muviri usina masero matsvuku eropa akakwana. Zvichienderana nechikonzero, chirwere ichi chinogona kuva chenguva refu kana chenguva pfupi . Uyewo, migumisiro yacho inogona kusiyana kubva padiki kusvika pakanyanya .

Semuenzaniso, kana chirwere cheCAD chisina kunyanya kuipa, zviratidzo zvinogona kuoneka zvishoma nezvishoma. Zvinogona kutora makore kuti chirwere ichi chiongororwe. Zvisinei, muzviitiko zvakakomba, chirwere cheCAD chinogona kutungamira kumatambudziko emwoyo akakomba, anotouraya.Zvinogoneka kuti zvichaitika.

Zita rechirwere ichi rine izwi rekuti "cold". Saka, zviratidzo izvi zvinonyanya kunzwika munzvimbo dzine mamiriro ekunze anotonhora kana mumazuva anotonhora.

Ndezvipi zviratidzo zve `Cold Agglutinin Disease`?

Zviratidzo zveCAD zvinowanzoenderana nekushaya ropa mumuviri uye kusafamba zvakanaka kweropa mumuviri wese. Zviratidzo izvi zvinosanganisira:

• Kunzwa kuneta zvakanyanya (Kuneta) : Kwete kuneta chete, asi kunzwa sekuti hauna hupenyu.
• Kushaya simba : Muviri unopera simba zvekuti hauchakwanisi kuita chero chinhu.
• Dzungu : Kunzwa sekutenderera.
• Kudikitira : Kudikitira pasina.
• Kutadza kufema zvakanaka (dyspnea) : Kutadza kufema zvakanaka kunyangwe ukashanda nesimba zvishoma.
• Kurova kwemoyo kunowedzera (tachycardia) : Kurova kwemoyo kunowedzera.
• Kutsvuka : Ganda rinorasikirwa neropa robva ratsvuka.
• Zvigunwe, zvigunwe, nenzeve zvinoshanduka kuita bhuruu kana zvikaiswa muchando (chiitiko chaRaynaud) : Paunoenda kunzvimbo inotonhora seNuwara Eliya, kana paunobata mvura inotonhora, minwe yako, zvigunwe, nenzeve zvinoshanduka kuita bhuruu, dzimwe nguva zvichena. Izvi zvinogonawo kuperekedzwa nekusanzwa.

Unogonawo kuva nezviratidzo zvejaundice . Kana masero matsvuku eropa aparadzwa, anoburitsa chinhu cheyero chinonzi bilirubin. Kana bilirubin iyi yaungana mumuviri, jaundice inoitika. Zviratidzo zvejaundice zvinosanganisira:

• Weti yakasvibira.
• Pass, machena emaziso nemaziso emumaziso ari yero.

Ndezvipi zvikonzero zve 'Cold Agglutinin Disease'?

Chirwere cheCold Agglutinin chirwere che autoimmune hemolytic anemia. Izvi zvinoreva kuti masoja edu ekudzivirira muviri anorwisa masero edu. MuCAD, masoja edu ekudzivirira muviri anobatwa nemamiriro ekunze anotonhora uye anogadzira autoantibodies ino "nyora" masero matsvuku eropa kuti iaparadze. Masero matsvuku eropa ane tag anonamatirana pamwe chete uye anoungana pamwe chete (agglutinate). Masero akaungana anogona kubatwa nyore nyore uye kuparadzwa nechimwe chikamu chemasoja edu ekudzivirira muviri, chinonzi macrophages.

Maitiro aya anotanga kana tembiricha yadzikira pasi pe3-4 degrees Celsius (37-39 degrees Fahrenheit). Funga kuti tembiricha yemuviri wedu yakajairika inenge 37 degrees Celsius. Dambudziko iri rinotanga kana tikasangana netembiricha dzakaderera kupfuura idzodzo.

CAD inokanganisa purogiramu yenguva dzose yekuti miviri yedu igadzire masero matsvuku ane hutano. Kazhinji, masero matsvuku eropa anorarama kwemazuva angangoita 120. Munguva iyi, mupfupa wedu unogona kugadzira masero matsvuku matsva ekutsiva ayo anofa. Asi muCAD, kutenderera uku kunokanganiswa.

Vaongorori havasati vaziva kuti sei masoja edu emuviri achirwisa masero ane hutano.Dzimwe nguva CAD inogona kukonzerwa nechimwe chirwere chiripo. Izvi zvinonzi `secondary CAD`. Kana pasina hukama hwakadaro hunowanikwa, zvichireva kuti CAD inokura pasina chikonzero, inonzi `primary CAD` kana `idiopathic CAD`.

Ndezvipi zvimwe zvirwere zvinogona kusanganiswa ne `Cold Agglutinin Disease`?

CAD yechipiri inowanzobatanidzwa nehutachiona, zvirwere zve autoimmune, uye zvirwere zve lymphoproliferative. Semuenzaniso:

• `Infectious mononucleosis` (fivha yeglandular)
• Mycoplasma pneumonia
• `Cytomegalovirus`
• Lupus
• Arthritis ine rheumatoid
• `Non-Hodgkin lymphoma`
• Leukemia isingaperi yelymphocytic
• "Waldenstrom macroglobulinemia"

Mazita aya angaita seanokuvhiringidza zvishoma, asi aya mazita chaiwo anoshandiswa navanachiremba, saka zvakanaka kuti uvazive.

Nzira yekuongorora chirwere che'Cold Agglutinin'? (Kuongororwa)

Chiremba wako achakubvunza nezvezviratidzo zvako uye achaongorora nhoroondo yako yehutano. Zvadaro, vachakuraira kuongororwa kweropa kwakakosha kuti vaone kana uine hemolytic anemia uye kana uine autoantibodies ine chekuita neCAD.

Kuongororwa kweropa kunoshandiswa kuongorora hemolytic anemia ndeku:

• Kuverengwa kweropa kwakazara (CBC) : Izvi zvinopa ruzivo rwakadzama nezvemasero matsvuku eropa rako. Zvinogona kutarisa kuti une masero matsvuku mangani, kuti akakura sei, uye huwandu hwehemoglobin yako. Hemoglobin ipuroteni inokosha zvikuru inobatsira masero matsvuku eropa kutakura okisijeni.
• `Kuwanda kwemaReticulocyte` : Izvi zvinoyera kuti une masero matsvuku eropa (`reticulocytes`) mangani mumuviri wako. Kana masoja emuviri akaparadza masero matsvuku eropa akura, muviri unoedza kugadzira mamwe masero aya akura senzira yekutsiva.
• Kuongororwa kwemazinga eropa : Kuwanda kwemazinga e `lactate dehydrogenase (LDH)` uye `bilirubin` muropa, uye kudzikira kwemazinga e`haptoglobin` zviratidzo zve `hemolytic anemia`.

Zvadaro, kuti vaone kana CAD iriyo inokonzera hemolytic anemia yako, chiremba wako achaongorora kuvapo kweautoantibodies inorwisa masero matsvuku eropa. Miedzo inoitirwa izvi ndeiyi:

• Kuongororwa kweCoombs zvakananga (DAT) : Kuongororwa uku kunoongorora kuvapo kwemaautoantibodies ane chekuita neCAD. Mukuedzwa, masero matsvuku eropa rako anoparadzaniswa nemamwe ropa rako rose oiswa munzvimbo inodzorwa. Zvadaro mhinduro yakakosha inowedzerwa. Kana masero matsvuku eropa akabatana pamwe chete nemhinduro uye akabatana (agglutinate), bvunzo yacho inoratidza kuti iripo, zvichireva kuti autoantibody iripo.
• `Kuedzwa kweCold agglutinin titer`: Kuongororwa uku kunoyera huwandu, kana kuti huwandu, hwe `autoantibodies' idzi muropa rako. Kuwanda kwe `autoantibodies' idzi chiratidzo cheCAD.

Kana chirwere chako chasimbiswa, chiremba wako achaongororawo kana chirwere chako cheCAD chakabatana nechimwe chirwere (`secondary CAD`).

`Chirwere cheCold Agglutinin` chinorapwa sei?

Zvichienderana nekuoma kwezviratidzo zvako, kurapwa kunogona kusanganisira kuchinja mararamiro ako, mishonga, uye dzimwe nguva kuwedzerwa ropa mumamiriro ezvinhu epanguva yenjodzi .

• Mararamiro : Kana uine chirwere cheCAD, chiremba wako angangokurayira kuti usanyanya kutonhora . Ichi ndicho chinhu chakakosha. Unofanira kuita zvinhu zvakaita sekupfeka mbatya dzinodziya, kusageza nemvura inotonhora, uye kuderedza rwendo rwako kuenda kunzvimbo dzinotonhora.
• Mishonga : Mushonga unonyanya kushandiswa kurapa CAD ndi`Rituximab` . Izvi zvinoshanda nekumisa masoja emuviri wako kugadzira `autoantibodies` dzinorwisa masero matsvuku eropa. Mushonga mutsva unonzi `Sutimlimab` wabvumidzwawo munguva pfupi yapfuura. Izvi zvinoshanda nekumisa masoja emuviri zvakananga kurwisa masero matsvuku eropa.
• Kuwedzerwa ropa uye kuchinjana kweplasma : Kana chirwere chako cheCAD chikakura, chiremba wako angangoda kukupa ropa kana kuchinjana kweplasma kuti ugare zvakanaka. Kuchinjana kweplasma kunoshanda nekuderedza huwandu hwemaautoantibodies muropa rako.

Kana uine `secondary CAD`, chiremba wako acharapawo dambudziko riripo.

Ko CAD inogona kudzivirirwa here?

Zvinosuwisa kuti chirwere cheCold Agglutinin hachisi chirwere chinogona kudzivirirwa. Zvisinei, unogona kudzora zviratidzo zvacho worarama hupenyu hwakanaka.

Unogona kurarama kwenguva yakareba sei nechirwere che'Cold Agglutinin'?

Vanhu vanoonekwa vaine chirwere cheCAD vanowanzorarama kwenguva yakareba seyevanhu vezera ravo vasina chirwere cheCAD. Sekureva kweongororo yakaitwa nguva pfupi yadarika, vanhu vanoonekwa vaine chirwere ichi pazera remakore makumi matanhatu nemasere vanogona kutarisira kurarama kusvika pamakore makumi masere. Izvi zvinoreva kuti kana ukarapwa zvakanaka uye uchitarisirwa, unogona kutarisira kurarama hupenyu hwakanaka.

Mibvunzo ipi yandinofanira kubvunza chiremba wangu?

Kana ukaonekwa uine CAD, zvakanaka kubvunza chiremba wako mibvunzo yakaita seiyi:

• Ko CAD yangu ine chekuita nechirwere chiripo here?
• Ndezvipi zviratidzo zvichandibatsira kuziva kana mamiriro angu ari kuvandudzika kana kuipa?
• Ndichafanira kuramba ndichitora mishonga yechirwere ichi here?
• Ndeipi mamiriro ekunze akanakira munhu ane CAD kugara mairi?
• Ndinofanira kudzivirira tembiricha dzipi kuti ndigone kudzora zviratidzo zvangu?

Zvakaitika kwauri nechirwere cheCold Agglutinin Disease (CAD) zvinoenderana nekuti ndechepakutanga here ('primary') kana kuti chechipiri ('secondary'). Kukosha kwezviratidzo zvako kuchakanganisawo kuti unoda kurapwa zvakanyanya sei. Nekurapa chirwere chiripo, chiremba wako anogona kukwanisa kurapa chirwere chako cheCAD. Kunyangwe uine chirwere cheCAD kwenguva refu, unogona kudzora zviratidzo zvako zvekushaya ropa uye kugara zvakanaka nekudzivisa dzihwa uye kutora mishonga yako sezvakarairwa.

Zvinhu zvakakosha zvekurangarira kubva pane zvatakurukura (Mharidzo Yekuenda Kumba)

• Chirwere cheCold Agglutinin (CAD) chirwere chisingawanzoitiki umo masoja edu emuviri anorwisa masero edu matsvuku eropa uye chinowedzerwa nechando.
• Zviratidzo zvinogona kusanganisira kurwadziwa kwemajoini, kuneta kwakanyanya, ganda rakachenuruka, minwe ichiita bhuruu muchando, uye dzimwe nguva jaundice .
• Izvi zvinogona kuva `primary` (zvisina chikonzero) kana `secondary` (zvinokonzerwa nechimwe chirwere).
• Kune bvunzo dzeropa dzinoongororwa kuti dzionekwe.
• Kurapwa kunogona kusanganisira kudzivirira dzihwa, mishonga, uye dzimwe nguva kuwedzerwa ropa.
• Kunyangwe izvi zvisingadzivisike, kana ukagara uchitarisirwa zvakanaka, unogona kurarama hupenyu hwakanaka.
• Kana uine zviratidzo izvi, usazeza kutsvaga rubatsiro rwechiremba. Kana ukangozviziva nekukurumidza, zvinova nyore kurapa.

Rangarirai kuti chinyorwa chino ndechekuzivisa vanhu chete. Kana muine zviratidzo, iva nechokwadi chekuona chiremba kuti akupei mazano.

Chirwere cheCold Agglutinin, CAD, anemia, masero matsvuku eropa, masoja emuviri, dzihwa, autoimmune, hemolytic anemia, chirwere cheropa