Wakambozvibvunza here kuti pfungwa dzedu dzakabatikana zvakadii? Zvakafanana neColombo Town, nezvinhu zvakawanda zviri kuitika panguva imwe chete. Mashoko ari kuenderera mberi, zvisarudzo zviri kuitwa, manzwiro ari kudzorwa... zvese izvi zvinoitika kuburikidza ne network yevatumwa vadiki vemakemikari. Saka, chii chinoitika kana zvese zvikamhanya munzvimbo yakabatikana kudaro? Zvese zvinova nyonganyonga, handiti? Pane mumwe munhu muuropi hwedu anomisa nyonganyonga iyoyo, anodzikamisa zvese, uye anoidzora. Nhasi tichataura nezvemutumwa anokosha iyeye, kureva 'kubhureka' kwechisikigo muuropi hwedu. Ndiyo GABA.
Chii chaizvo chinonzi GABA?
Zvichitaurwa zviri nyore, GABA , iyo iri muchidimbu gamma-aminobutyric acid, inhengo yemakemikari muuropi hwedu. Mukurapa, tinodana ma neurotransmitters aya. Kufanana ne postmen, anotakura mameseji kubva kune imwe tsinga muuropi kuenda kune imwe.
Asi shoko riri kutaurwa naGABA rinokosha zvishoma. Harisi shoko rinoti "Kurumidza, mhanya." Ishoko rinoti "Zvakanaka, zvakanaka, zvakwana izvozvi. Chimbomira zvishoma, dzikama." Kureva kuti, GABA inodzora zvishoma mashandiro etsinga dzedu dzemukati - ndiko kuti, uropi nemuzongoza. Inomisa masero etsinga kuti asakurumidzirwe zvisina kufanira.
Ndosaka tichitenda kuti GABA inobatsira zvikuru mukudzikamisa pfungwa dzedu uye kudzora zvinhu zvakaita sekushushikana, kutya, uye kuzvidya mwoyo. Zvakafanana nemushonga wepfungwa dzedu wepanyama.
Ngatinyatsoongorora mashandiro anoita GABA.
Kuti unzwisise izvi, fungidzira kuti masero etsinga ari muuropi hwako ari kutaurirana. Asi haana kubatana. Pane mukaha mudiki pakati pesero rimwe nerimwe. Tinoridaidza kuti synapse. Kana meseji ichida kutumirwa, neurotransmitter inoburitswa kubva musero rimwe, yoyambuka mukaha iwoyo, yobatana nechinhu chakakosha chinogamuchira masero pasero rinotevera.
Zvakafanana nekiyi nekiyi. Haasi makiyi ese anogona kuvhura kiyi yega yega. Zvakare, haasi ma "Neurotransmitter" ese anogona kubatana ne "Receptor" yega yega. "Kiyi" inonzi GABA inongogona kuvhura ma "locks" anonzi maGABA receptors chete.
Kana GABA yaenda yobatana ne'receptor' yayo, meseji inogamuchirwa nesero rinotevera retsinga ndeye "kuderedza mashandiro ako." Kureva kuti, kugona kwesero iroro kugamuchira mameseji kubva kune mamwe masero, kugadzira mameseji matsva, kana kutumira mameseji kune mamwe masero kunodzikira. Nenzira iyi, mashandiro ese europi anodzikamiswa. Kungofanana nepanoita mwenje wemotokari wakatsvuka mumugwagwa une vanhu vakawanda, mota dzinomira uye traffic inodzorwa zvishoma.
GABA neGlutamate - mashandisirwo maviri e'On' ne'Off' muuropi
Kuti uropi hwedu hushande zvakanaka, kuenzana kwakakosha zvikuru. Patinotaura nezveGABA, tinofanirawo kutaura nezvezvakasiyana nayo, iyo inonzi Glutamate .
GABA ne glutamate zvinoshanda sema switch maviri ekuti 'On' ne 'Off'.
- GABA ndiyo nzira huru yekubvisa pfungwa. Kureva kuti, neurotransmitter huru inomisa kushanda uye inokudzikamisa.
- Glutamate ndiyo inonyanya kushandiswa muuropi kuti 'On' . Kureva kuti, i'neurotransmitter' inosimudzira masero etsinga uye inowedzera kushanda kwawo.
Funga nezvazvo semuchina wekumhanyisa mota nebhureki mumotokari. Kana uchida kutyaira mota zvakanaka, unofanira kushandisa zvese zvakanaka uye panguva yakakodzera. Kuva neimwe chete hazvibatsiri. Kana uine muchina wekumhanyisa mota chete, unodonha kwese kwese. Kana uine bhureki chete, haugone kufambira mberi. Saizvozvowo, kuti uropi hwedu hushande zvakanaka uye zvine hutano, panofanirwa kuve nekuenzana kwakanaka pakati pemhedzisiro yekudzikamisa yeGABA nemhedzisiro yekukurudzira yeglutamate.
Zvinoshamisa kuti, chinhu ichi chinonyaradza chinonzi GABA chinogadzirwa kubva kune chimwe chinhu chinokurudzira, glutamate. Glutamate inoshandurwa kuita GABA nekushanda kwe enzyme yakakosha.
Chii chinoitika kana mazinga eGABA asina kuenzana?
Kana kuenzana kwatataura nezvako kukarasikirwa, kunyanya kana kushanda kweGABA kukadzikira, 'mabhureki' europi haazoshande nemazvo. Ipapo kushanda kweuropi kuchawedzera zvisina kufanira, uye dambudziko rimwe nerimwe rinogona kumuka. Ngatitarisei mamwe ematambudziko ehutano anofungidzirwa kuti ane chekuita nekuderera kwebasa reGABA pazasi.
| Dambudziko rehutano | Tsananguro iri nyore |
|---|---|
| Kuzvidya Mwoyo uye Matambudziko Emanzwiro | Kana pasina GABA yakakwana yekudzikamisa pfungwa, kutya kusingakoshi, pfungwa dzinovhiringidza, uye kusagadzikana zvinogona kuitika. |
| Schizophrenia | Chirwere chepfungwa chakaoma chinokanganisa pfungwa, manzwiro, uye maitiro. Pane humbowo hwekuti kusarongeka kweGABA kunogona kukonzera izvi. |
| Dambudziko reAutism Spectrum | Dambudziko rekukura rinokanganisa hukama hwevanhu nekutaurirana. Rinogona kuonekwa mukuchinja kuri kuita GABA system. |
| Kuora mwoyo | Kusuruvara kwenguva refu uye kurasikirwa nehanya nezvinhu. Izvi zvinogona kunge zvine chekuita nemazinga akaderera eGABA. |
| Pfari / Kubatwa nepfari | Kuwedzera kamwe kamwe kwekushanda kwemagetsi muuropi kusingadzoreki. Chikonzero chikuru cheizvi kuderera kwemaitiro e'brake' eGABA. |
| Chirwere cheHuntington | Chirwere chinogara nhaka chinoparadza masero europi zvishoma nezvishoma. |
| Kutya kusuruvara zvakanyanya | Kurara zvakanyanya masikati kana kurara kwenguva refu kunogona kukonzerwa nekunyanya kushanda kweGABA system. |
Pane mishonga here inotarisa GABA?
Ehe. Nekuti GABA ine basa rakakosha muuropi hwedu, vagadziri vemishonga vakagadzira mishonga yakawanda inotarisa sisitimu yeGABA. Mishonga iyi inoshanda nekuwedzera mhedzisiro yechisikigo yeGABA yekudzikamisa kana nekuita seGABA.
Zvakakosha: Mishonga inotevera inongova mienzaniso chete. Usashandise kana kurega kuishandisa chero chikonzero chipi zvacho usina kupiwa zano uye kurudziro kubva kuna chiremba. Mimwe yeiyi inogona kukanganisa muviri uye inogona kukonzera migumisiro yakaipa.
| Rudzi rwemishonga / zita | Inoshandiswa kuitei? (Muenzaniso) |
|---|---|
| Benzodiazepines - semuenzaniso Diazepam (Valium®), Alprazolam (Xanax®) | Kuderedza kuzvidya mwoyo, kudzora pfari, kudzora zviratidzo zvekurega doro, uye kuzorodza tsandanyama. |
| Mabhariturati | Iyi mishonga inonyaradzawo. Inoshandiswawo pakurapa pfari uye anesthesia. |
| Asidhi yeValproic | Inopihwa kudzora pfari uye zvakare senzira yekudzikamisa mafungiro. |
| Zolpidem (Zolpidem - Ambien®) | Piritsi rekurara rinoshandiswa kurapa kushaya hope. |
| Propofol | Mushonga une simba unoshandiswa pakurapa nekurwadziwa panguva yekuvhiyiwa. |
| Baclofen | Mushonga unopiwa kuderedza kuomarara kwetsandanyama kusingadiwe (spasticity). |
Chokwadi kana nhema nezve GABA supplements uye chikafu
Pamwe wakamboona "GABA Supplements" ichitengeswa muma pharmacy kana online. Vanoti vanokubatsira kuzorora, kurara, uye kuderedza kushushikana. Asi pane dambudziko.
Uropi hwedu inzvimbo yakachengeteka zvikuru. Hahubvumiri chero chinhu kuti chipinde. Kune sisitimu yakakosha yekuchengetedza yakakomberedza uropi inonzi Blood-Brain Barrier . Yakafanana negomba rakatenderedza nhare. Zvinhu zvakakosha kuuropi chete ndizvo zvinotenderwa kupfuura nepakati pesisitimu iyi yekuchengetedza.
Vaongorori vazhinji vanotenda kuti kugona kweGABA supplements dzatinotora kunze kuti tiyambuke chipingamupinyi cheropa-uropi kwakaderera zvikuru. Saka, kuti dzinokanganisa sei uropi hazvisati zvanyatsojeka. Vamwe vanhu vanoti vanonzwa vakadzikama pavanotora supplements idzi. Hakuchina kubvumirana kwesainzi pamusoro pekuti iyi GABA iri kusvika kuuropi here, kana kuti i placebo effect.
Saka, iva nechokwadi chekuti wataura nachiremba wako usati watora mushonga weGABA. Iye ndiye munhu akakodzera kusarudza kana wakakodzera chirwere chako kana kuti kwete.
Muchikafu mune GABA here?
Ehe, GABA inowanikwa mune zvimwe zvekudya, kunyanya zvekudya zvakaviriswa.
- Kimchi
- Miso
- Tempeh
Pamusoro pezvo, tii dzegirini, nhema, uye oolong dzinewo GABA. Zvakare, kune fungidziro yekuti zvekudya zvakaita semupunga webrown, soya, broccoli, sipinachi, matomatisi, uye cauliflower zvinobatsira kuwedzera kugadzirwa kweGABA mumuviri wedu.
Asi kufanana nezvinovaka muviri, hapasati pave neuchapupu hwakakwana hunoratidza kuti GABA inobva muzvikafu izvi inosvika kuuropi zvakadii. Asi kudya chikafu chakaringana uye chine hutano kwakanaka kumuviri munzira dzese.
Mharidzo Yekuenda Nayo Kumba
- GABA ndiyo chinhu chikuru chinonyaradza pfungwa dzedu. Inoshanda se "brake" iri muuropi hwedu.
- Kuenzana pakati pe glutamate, iyo inowedzera kushanda kweuropi, uye GABA, iyo inoderedza kushanda, kwakakosha kuti pfungwa dzive neutano hwakanaka.
- Mazinga eGABA akaderera anogona kusanganiswa nematambudziko akawanda ehutano, akadai sekuzvidya mwoyo, kuora mwoyo, uye pfari.
- Mishonga yakawanda inokosha inoshandiswa mukurapa inotarisa GABA system. Iyi inofanira kushandiswa chete pasi pekutarisirwa kwachiremba.
- Kuchine humbowo hwesainzi husina kukwana nezvekushanda kweGABA supplements pamusika, uye hazvina chokwadi kana dzichipinda muuropi zvechokwadi.
- Kana uine dambudziko rekuzvidya mwoyo, kushushikana, kana kushaya hope, zvakakosha kubvunza chiremba ane hunyanzvi uye kutsvaga mazano , pane kungovimba nezvinovaka muviri kana zvekudya chete.
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