Kana chiremba wako akambotaura nezve BP yako, kana kutsanangura mishonga yaunotora yeBP yako, unogona kunge wakanzwa mazita akadai seACE inhibitors nemaARB. Nhasi tichataura nezve system iri shure kweizvi zvese, iyo inogara ichidzora BP yedu, sechikwata che super management chiri mumuviri wedu. Tinodaidza izvi kuti Renin-Angiotensin-Aldosterone System, kana kuti RAAS muchidimbu. Kunyangwe zita racho ringanzwika serakaoma, basa raro riri nyore uye rakakosha.
Zvichitaurwa zviri nyore, chii chinonzi RAAS?
Fungidzira kuti muviri wako une dziviriro inogara ichitarisa BP yako uye inokurumidza kupindura kana yaderera zvakanyanya. Ndizvo zvakaita RAAS. Iboka remahormone, maenzyme, nemapuroteni. Chinangwa chikuru chehurongwa uhwu ndechekuchengetedza BP yedu uye huwandu hweropa zvichidzorwa kwenguva refu.
Sisitimu iyi inobatsira kuwedzera kumanikidzwa kwedu munzira nhatu huru:
- Kuwedzera kutorwazve kwemunyu (sodium) neitsvo: Kana huwandu hwemunyu mumuviri hukawedzera, mvura inoramba iri mumuviri.
- Kuwedzera kwekunwa mvura zvakare (kuchengetwa kweropa): Izvi zvinowedzera huwandu hweropa mumuviri.
- Kusimba kwetsinga dzeropa: Kusimba kwetsinga dzeropa. Sekudzvanya pombi yemvura kunoita kuti mvura ifambe nekukurumidza, kana tsinga dzeropa dzichiita zvidimbu, kumanikidzwa kunowedzera.
Kune vatambi vatatu vakakosha muchikwata ichi chikuru. Ngativazivei.
| Chinhu chikuru chinoshandiswa | Basa riri kuitwa |
|---|---|
| Renin | Iyi ienzyme inogadzirwa neitsvo dzedu. Yakaita semuchengeti weropa. Ndiyo chiratidzo chekutanga chinoita kuti system iyi ishande kana ikaona kuti BP iri kudzikira. |
| Angiotensin II | Uyu ndiye mutungamiri weboka iri. Ihomoni ine simba guru. Inoita zvinhu zvakawanda zvakakosha, zvakaita sekumanikidza mitsipa yeropa uye kuudza muviri kuti uchengetedze munyu nemvura. |
| Aldosterone | Hormone iyi inobva kuma adrenal glands, ari pamusoro peitsvo dzedu. Basa rayo guru nderekuudza itsvo kuti dzichengetedze sodium (munyu) mumuviri uye dzibudise potassium muweti. |
Sisitimu iyi yeRAAS inoshanda sei?
Izvi zvakafanana nekufamba kwenguva. Kana chimwe chinhu chikaitika, chinobva chatanga chimwe chinhu. Ngatinzwisisei matanho aya senyaya iri nyore.
Fungidzira kuti nekuda kwechimwe chikonzero (semuenzaniso, warasikirwa nemvura yakawanda mumuviri wako - kupera mvura mumuviri, kana kuti warasikirwa neropa mutsaona diki) BP yako inoderera.
1. Chiratidzo chekutanga: Itsvo dzako dzakaita semasensa. Padzinonzwa kudzikira uku kwekumanikidzwa, dzinofara uye dzinoburitsa enzyme inonzi renin muropa.
2. Dudziro yekutanga: Sezvo renin iyi ichifamba nemuropa, inosangana nepuroteni inonzi angiotensinogen, inogadzirwa muchiropa chedu yoburitswa muropa. Renin inopwanya puroteni iyi yoishandisa kugadzira hormone inonzi angiotensin I. Asi angiotensin I iyi haishande, zvichireva kuti haigone kushanda zvakanyanya.
3. Kuzvarwa kweMutungamiriri: Zvino, sezvo iyi angiotensin I isina kurara ichifamba nemuropa, kunyanya kuburikidza nemapapu edu, kune enzyme yakakosha ipapo. Ndiyo Angiotensin-Converting Enzyme (ACE) . Chinoitwa neiyi enzyme yeACE kutora iyo angiotensin I isina kurara yoishandura kuita angiotensin II ine simba, inoshanda. Iye zvino mutungamiri chaiye anozvarwa.
4. Mirairo yemutungamiri: Iye zvino iyi angiotensin II ine simba iri kuita basa rakawanda panguva imwe chete:
- Inoenda zvakananga kumadziro etsinga diki dzeropa dziri mumiviri yedu yodzivhara , sekudzvanya pombi yemvura. Izvi zvinowedzera BP ipapo ipapo.
- Inoenda zvakananga kuma adrenal glands, ari pamusoro peitsvo, uye inovaudza kuti vagadzire hormone inonzi aldosterone .
- Zvinopawo chiratidzo kugland repituitary riri muuropi kuti rigadzire Antidiuretic Hormone (ADH).
5. Mugumisiro: Zvino sezvo aldosterone neADH zvichishanda pamwe chete kuudza itsvo kuti, " Musaburitsa sodium (munyu) nemvura mumuviri, zvichengetedzei mumuviri ." Panguva imwe chete, aldosterone inoburitsa potassium iyo muviri usingade muweti.
- Kana munyu ukachengetwa mumuviri, mvura inochengetwawo.
- Kana huwandu hwemvura mumuviri hukawedzera, huwandu hweropa riri mutsinga dzedu dzeropa (huwandu hweropa) hunowedzera.
- Kana huwandu hweropa hukawedzera uye tsinga dzeropa dzichiita shoma, BP inodzoka yoga padanho rakajairika.
Zvichitaurwa zviri nyore, sisitimu yeRAAS inzira inongoerekana yaita, iyo kana BP yadzikira, inowedzera BP nekuchengetedza munyu nemvura mumuviri, kudzvanya mitsipa yeropa, nezvimwewo.
Chii chiri hukama huripo pakati pehurongwa uhwu hweRAAS nekusashanda zvakanaka kwemoyo?
Iyi inyaya yakakosha zvikuru. Mumamiriro ezvinhu akajairwa, sisitimu yeRAAS inobatsira kuponesa hupenyu hwedu. Zvisinei, mumamiriro ezvinhu enguva refu akadai sekushaya simba kwemoyo, sisitimu iyi yakanaka inotanga kushanda kutirwisa.
Fungidzira kuti moyo wemunhu hauna simba uye haugone kupomba ropa rakakwana mumuviri. Izvi ndizvo zvatinodaidza kuti kukundikana kwemoyo.
- Kana simba remoyo rekupomba richiderera, huwandu hweropa rinosvika kunhengo dzakakosha dzakadai seitsvo hunoderera.
- Kana ropa rinoenda kuitsvo raderera, vanofunga kuti, "Ah, kumanikidzwa kwacho kwaderera, dambudziko guru!" Saka itsvo dzinokurumidza kumutsa RAAS system zvizere.
- Ipapo muviri unoburitsa angiotensin II nealdosterone zvakawandisa. Izvi zvinowedzera BP uye zvinoita kuti muviri urambe uine munyu nemvura.
- Asi dambudziko riripo pano nderekuti kuwedzera uku kwedzvinyiriro uye kuwedzera kwehuwandu hweropa zvinova mutoro mukuru pamoyo watove usina simba uye wava kupera simba. Zvakafanana nekuisa mumwe mutoro pamunhu asingakwanise kutakura mutoro unorema.
- Kana mwoyo ukamanikidzwa zvakanyanya nekufamba kwenguva, mwoyo unoshaya simba, tsandanyama dzemwoyo dzinokora, uye mwoyo unokura. Izvi zvinoita kuti kutadza kwemoyo kuwedzere.
Nekuda kwechikonzero ichi, mishonga yakawanda inopihwa navanachiremba kuvanhu vane chirwere chemwoyo neBP yakanyanya inonangwa zvakananga kudzora mashandiro eRAAS system iyi.
Mishonga inokanganisa hurongwa hweRAAS
Mishonga yakawanda mikuru yeBP yakakwira uye chirwere chemwoyo inovhara matanho akasiyana-siyana muRAAS system iyi.
| Rudzi rwemushonga | Mashandiro azvinoita |
|---|---|
| Zvinodzivirira ACE | Unoyeuka here enzyme yeACE inoshandura angiotensin I kuita angiotensin II ine simba? Zvinoitwa nemishonga iyi zvinovhara enzyme iyoyo. Ipapo kugadzirwa kwe "mutungamiri" iyeye kunoderera. |
| MaAngiotensin Receptor Blockers (ARBs) | Mishonga iyi haimisi kugadzirwa kwe angiotensin II. Asi inovhara "magedhi" (mareceptor) anobvumira angiotensin II iyoyo kuenda kunzvimbo dzakadai setsinga dzeropa uye kuita chimwe chinhu. Zvakafanana nemutungamiriri ari kupa mirairo, asi hapana anoteerera. |
| Mineralocorticoid Receptor Antagonists (MRA) | Izvi zvinodzivisa zvakananga kushanda kwehomoni inonzi aldosterone, iyo inoderedza kuchengetwa kwemunyu nemvura mumuviri. |
| Beta-blockers | Kunyangwe izvi zvisingakanganisi zvakananga system yeRAAS, zvinobatsira kuderedza kugadzirwa kwe renin neitsvo, zvinoreva kuti zvinodzora system yese kubva pakutanga. |
Ndeupi musiyano uripo pakati peRAAS neBaroreceptor Reflex?
Imwe nzira inodzora BP iBaroreceptor reflex . Ngatingonzwisisai musiyano uripo pakati pezviviri izvi.
- Baroreceptor Reflex: Iyi inzira inoshanda ipapo ipapo, mukati memasekonzi mashoma . Fungidzira kuti wakagara wobva wangoerekana wasimuka. Ipapo kumanikidzwa kunodzikira zvishoma. Panguva iyoyo, kuyerera kweropa kuenda mumusoro kunodzikira uye unganzwa dzungu. Asi izvozvo hazviitike, handiti? Chikonzero cheizvi iBaroreceptor reflex. Inowedzera kurova kwemoyo kwemasekonzi mashoma, inovhara mitsipa yeropa zvishoma, uye inogadzirisa kumanikidzwa. Yakafanana nezvinodzivirira kuvhunduka kwemotokari, zvichidzora shanduko dzinongoerekana dzaitika.
- Sisitimu yeRAAS: Iyi sisitimu inogara kwenguva refu , inononoka zvishoma. Zvinotora maawa, kunyange mazuva, kuti ishande. Inodzora BP kwenguva refu nekuchinja huwandu hwemvura nemunyu mumuviri. Zvakafanana nesisitimu yekutarisira injini mumotokari, ichitarisa mashandiro ayo kwenguva refu.
Masisitimu ese aya anoshanda pamwe chete kuti BP yedu irambe iri padanho rakanaka.
Mharidzo Yekuenda Nayo Kumba
- RAAS (Renin-Angiotensin-Aldosterone System) inzira inongoerekana yaita kuti ropa remuviri wedu rirambe riripo uye mvura inoramba ichiyerera mumuviri kwenguva refu.
- Kana BP yadzikira, nzira iyi inoshanda, ichichengetedza munyu nemvura mumuviri, ichivhara mitsipa yeropa, uye ichidzorera BP kune zvayakajairika.
- Mumamiriro ezvinhu akadai sekushaya simba kwemoyo uye BP, hurongwa uhwu hunogona kushanda zvakanyanya, zvichikanganisa moyo nemuviri.
- Mishonga yakawanda inoshandiswa kurapa BP yakakwira uye chirwere chemwoyo (senge ACE inhibitors nemaARB) inonangwa zvakananga kudzora mashandiro eRAAS system iyi.
- Kana uine BP yakakwira kana chirwere chemwoyo, zvakakosha kuti utore mushonga wako sezvawakarairwa nachiremba wako. Usamborega kutora mushonga wako kana kuchinja mwero usati watanga wabvunza chiremba wako.
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