Dzimwe nguva, mushure mekudya chikafu chine munyu, unonzwa kupisa muchipfuva, handiti? Kana kuti unonzwa kusagadzikana sekunge acid yemudumbu yako yawedzera uye iri kuuya muhuro mako here? H2 blockers rudzi rwemushonga unoshandiswa nevanhu vazhinji panguva dzakadai. Saka nhasi, ngatitaurei nezvemaH2 blockers aya, mashandiro awo mumiviri yedu, uye zvinhu zvakakosha zvatinofanira kuziva patinenge tichiashandisa.
Ndezvipi izvi H2 Blockers?
Zvichitaurwa zviri nyore, mishonga inovhara H2 (inonziwo H2 antagonists) imhando yemishonga inodzora kana kuderedza kugadzirwa kweasidhi mudumbu.
Asidhi yemudumbu inokosha pakugaya chikafu chatinodya. Asi kana acid iyi yakawandisa, inogona kukuvadza jira remudumbu mako. Izvi zvinogona kukonzera zviratidzo zvakaita sekurwadziwa mudumbu uye chirungurira. Zvinogona kusagadzikana sekunge wakazvidemba nezvekudya kwawakadya kekupedzisira.
Kana uri kunzwa kusagadzikana nekuda kwekuwedzera kweacid mudumbu, ungangoda kufunga nezvekushandisa H2 blocker.
MaH2 blockers anoshandiswa mumamiriro api ezvinhu?
Mishonga yeH2 blockers inonyanya kushandiswa kurapa zvirwere zvine chekuita nekuwanda kweacid mudumbu. Zvisinei, zvakakosha kuyeuka kuti mishonga iyi inogona kurasikirwa nekushanda kwayo zvishoma nezvishoma kana ikashandiswa nguva dzose kwenguva yakareba.
Kana uine chirwere chisingaperi, chiremba wako anogona kukurudzira rudzi rwemushonga unonzi Proton Pump Inhibitor (PPI) panzvimbo peH2 blockers. Kunyange hazvo maPPI achitora nguva yakareba kuti ashande, anogona kudzora kugadzirwa kweasidhi zvinobudirira kupfuura maH2 blockers. Anogonawo kushandiswa kwenguva refu.
Zvimwe zvezvirwere zvikuru zvinorapwa neH2 blockers zvakanyorwa pazasi.
| Dambudziko rehutano | Tsananguro iri nyore |
|---|---|
| Maronda emudumbu | Asidhi yakawandisa inogadzirwa inogona kukuvadza dumbu uye kukonzera maronda. Kuderedza asidhi neH2 blockers kunopa maronda iwayo nguva nenzvimbo yaanoda kuti apore. |
| Maronda emudumbu | Asidhi yemudumbu inogona kufamba ichipinda muchikamu chekutanga cheura hudiki (duodenum) yokonzera maronda ipapo. Dambudziko iri rinogonawo kurapwa neH2 blockers, kunyange hazvo maPPI ari kushanda zviri nani. |
| Kudzoka kweasidhi mumuviri | Asidhi yemudumbu inodzokera kumusoro mugurokuro nepahuro, zvichikonzera chirungurira. Izvi zvinogonawo kukonzera esophagitis. H2 blocker inzira yakanaka yekurapa chirwere ichi nguva nenguva. Asi kana izvi zvikaitika kakawanda (GERD), PPI ndiyo yakakodzera. |
| Chirwere cheZollinger-Ellison | Ichi chirwere chisingawanzoitiki. Mamwe mabundu anoumbwa muchirwere ichi anoita kuti mudumbu mubudise acid yakawandisa. Kunyange hazvo mishonga inovhara H2 ichigona kubatsira kudzora chirwere ichi, vanachiremba vanowanzo kurudzira maPPI. |
H2 blockers inobatsira kuderedza zviratidzo zvinotevera zvine chekuita nemamiriro aya:
- Kusagadzikana kwekugaya chikafu
- Kurwadziwa kwedumbu
- Kurwadziwa pachipfuva uye pahuro panorwadza
- Kusvotwa nekurutsa
- Dumbu rinovava
Mushonga uyu unoshanda sei mumuviri?
Zviri nyore kwazvo. Rimwe zita rema H2 blockers ihistamine-2 (H2) antagonists. Takadzidza kuchikoro kuti 'antagonist' munyaya chinhu chinopindirana nechimwe chinhu? Zvinoitwa nema H2 antagonists aya kupindirana nemaitiro ekugadzira acid mudumbu.
Funga nezvazvo nenzira iyi. Mushure mekudya, miviri yedu inoburitsa kemikari inonzi H2. H2 iyi inoenda yonamatira kumaH2 receptors ari pamadziro edumbu. Yakaita sekiyi inoiswa mukiyi. Iyi link ndiyo inoudza dumbu kuti, "Zvakanaka, gadzira acid."
Kana ukatora H2 blocker, mushonga unoenda wonosunga kumaH2 receptors (malocks) uye "woavhara". Nenzira iyi, H2 (makiyi) haawani mukana wekuuya kuzosunga kumareceptors. Kana chiratidzo chekuti acid imire, dumbu rinoburitsa acid shoma.
Izvi hazvikanganisi kugaya kwako chikafu. Zvinongodzora huwandu hweasidhi inogadzirwa inokonzera marwadzo uye kusagadzikana.
Ndeipi mishonga yeH2 blocker iripo?
Kune mhando dzakasiyana dzemishonga inovhara H2. Dzimwe dzinogona kutengwa pasina muripo wekutenga (OTC), nepo dzimwe dzichida mushonga wechiremba.
| Zita remushonga uyu | Chiratidzo chinowanzoonekwa | Maitiro ekuiwana |
|---|---|---|
| Cimetidine | Tagamet® | Mishonga inotengeswa nechiremba uye inonyorerwa nechiremba (OTC & Rx) |
| Famotidine | Pepcid® | Mishonga inotengeswa nechiremba uye inonyorerwa nechiremba (OTC & Rx) |
| Nizatidine | Axid® | Kungopihwa nachiremba chete (Rx chete) |
Chinyorwa Chakakosha: Ungayeuka mushonga weH2 blocker Ranitidine (Zantac®) waimbove wakakurumbira zvikuru. Asi muna Kubvumbi 2020, masangano akaita seFDA (US Food and Drug Administration) akaudza vagadziri kuti vabvise mushonga uyu pamusika. Chikonzero chaive chekuti bvunzo dzakaratidza kuti nekufamba kwenguva uye padzakachengetwa pakupisa kwakanyanya, huwandu hwekemikari inonzi nitrosodimethylamine, kana NDMA, iyo inogona kukonzera kenza, yakawedzera kusvika padanho risina kuchengetedzeka.
Mushonga uyu unofanira kushandiswa sei uye rini?
Mishonga inovhara H2 inogona kunwiwa nemuromo semapiritsi kana makapisi. Kunewo hupfu hunogona kunyungudutswa mumvura kuvanhu vanonetseka kumedza mapiritsi. Hunogonawo kupiwa netsinga (IV) kuvarwere vari muchipatara uye vasingakwanise kutora mishonga inonwiwa.
Nguva yakanakisisa yekutora mushonga
- Kune dzimwe nguva kusagadzikana:Kana uchiziva kuti kudya chikafu chine mhiripiri kana chine mafuta kunogona kukonzera matambudziko, tora mushonga weH2 blocker kwemaminitsi makumi matatu kusvika makumi matanhatu usati wadya chikafu ichocho. Izvi zvinopa nguva yekushanda. Hazvina kuipa kuitora mushure mekunge dambudziko ratanga, asi zvinogona kutora kusvika awa kuti zviratidzo zviderere.
- Kana paine chirwere chakadai sekupora kwemaronda: Chiremba wako anogona kukurudzira kuti utore kamwe chete pazuva usati warara, kana kamwe chete mangwanani uye kamwe chete husiku, zvichienderana nemirairo yachiremba wako.
Chinhu chinonyanya kukosha ndechekuti kana uchida kushandisa mishonga iyi kweanopfuura mavhiki maviri panguva imwe chete, unofanira kuona chiremba wako. Hazvikurudzirwi kuramba uchishandisa mishonga iyi usina kuziva chikonzero chaicho chezviratidzo zvako.
Ndeupi musiyano uripo pakati peH2 Blockers, Antacids uye PPIs?
Vanhu vazhinji vanovhiringidzika nezvemhando nhatu idzi dzemishonga inoshandiswa pakurapa chirungurira. Ngationei musiyano mukuru uripo pakati padzo.
| Rudzi rwemushonga | Nguva yakatorwa kuti ishande | Nguva yekushanda | Mukana wakakodzera zvikuru |
|---|---|---|---|
| Mishonga inorwisa asidhi (semuenzaniso Digene, Gelusil) | Kukurumidza zvikuru (maminitsi mashoma) | Ipfupi zvikuru (awa imwe kusvika maviri) | Kana rubatsiro rwekukurumidza ruchidiwa. |
| H2 Blockers | Inenge awa imwe chete | Maawa angangoita mana kusvika gumi | Kudzivirira chirungurira dzimwe nguva kana usati wadya. |
| MaPPI (Proton Pump Inhibitors) | Mazuva 1-4 kuti zvishande zvizere | Nguva refu (maawa makumi maviri nemana+) | Kune zvirwere zvakaita sechirwere chegastritis chisingaperi uye GERD. |
Pane mimwe migumisiro yakaipa here?
Mishonga inovhara H2 inowanzo kuve yakachengeteka uye ine migumisiro mishoma . Kunyangwe kana migumisiro yacho ikaitika, inowanzova midiki.
- Kurwadziwa kwedumbu
- Kurwadziwa kwetsandanyama
- Kuzvimba
- Manyoka
- Muromo wakaoma
- Kuneta
- Musoro
Kashoma, vanhu vari mumapoka ane njodzi huru (kunyanya avo vane makore anopfuura makumi mashanu, avo vane matambudziko eitsvo kana chiropa) vanogona kuona zviratidzo zvine chekuita netsinga, zvakaita sekutadza kuyeuka kana kuoma kutaura. Zvisinei, izvi hazviwanzoitiki . Zviratidzo izvi zvinowanzopera mukati memazuva mashoma mushure mekumira kushandisa mushonga.
Kudyidzana nemimwe mishonga
Mamwe maH2 blockers anogona kukanganisa mashandiro emimwe mishonga yauri kutora. Semuenzaniso, H2 blocker cimetidine inogona kuderedza kushanda kwemamwe maantidepressants (SSRIs) uye warfarin inobvisa ropa rakanyanya kuonda (`(warfarin)`).
Saka, usati watanga mushonga mutsva weH2 blocker, zvakakosha zvikuru kuzivisa chiremba wako nezvemimwe mishonga yese yauri kutotora.
Izvi zvakakodzera here kuna amai vane pamuviri uye vanoyamwisa?
Kuchiri kudiwa tsvakurudzo yakawanda pamusoro pekuchengetedzeka kwekushandisa H2 blockers panguva yekuzvitakura, asi zvinozivikanwa kuti mishonga iyi inopfuudzwa kumwana kuburikidza nemukaka wemuzamu.
Saka, kana uine pamuviri, uchironga kuva nepamuviri, kana kuti uri amai vanoyamwisa, iva nechokwadi chekutaura nachiremba wako usati watora chero ipi zvayo yemishonga iyi.
Mharidzo Yekuenda Nayo Kumba
- Mishonga yeH2 blockers imhando yemushonga unoderedza acid yemudumbu. Yakanakira kupa zororo renguva pfupi kubva pakurwadziwa kwechirungurira uye kurwadziwa kwechipfuva.
- Kunyangwe izvi zvichishanda nekukurumidza kupfuura maPPI, hazvina kukodzera kushandiswa kwenguva refu, zuva nezuva.
- Kana uchida kushandisa H2 blockers kweanopfuura mavhiki maviri panguva, zvinogona kureva kuti une rimwe dambudziko riripo. Ehe ona chiremba.
- Udza chiremba wako nezvemimwe mishonga yauri kutora (kunyangwe mavitamini).
- Kana uine pamuviri kana kuti uchiyamwisa, usashandise mishonga iyi usina kupiwa mazano nachiremba.
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