Iwe kana mumwe munhu mumhuri yako, kunyanya mwana, munowanzorwadziwa nemudumbu here? Makamboona ropa shoma mutsvina yenyu here? Kana kuti muri kunzwa kuneta uye kuneta here? Tinowanzo bvisa zviratidzo izvi sekurwadziwa kwemudumbu kana kusada kudya. Zvisinei, dzimwe nguva zviratidzo izvi zvinogona kukonzerwa nechirwere chatisati tanzwa zvakawanda nezvacho, asi tinofanira kuziva nezvazvo. Nhasi tichataura nezvechimwe chirwere chakadai, Juvenile Polyposis Syndrome (JPS).
Chii chaizvo chinonzi JPS?
Zvichitaurwa zviri nyore, Juvenile Polyposis Syndrome (JPS) chirwere chemajini umo kukura kusingawanzoitiki kunoumba pamadziro emukati medumbu redu (mudumbu - GI tract). Mukurapa, tinoti kukura uku mapolyps . Fungidzira bundu diki rakaita semazambiringa rakarembera kubva padzinde riri mukati medumbu redu. Ndiwo maumbirwo emapolyps aya.
Mapolyps aya anogona kuumbwa chero kupi zvako mudumbu redu.
- Dumbu
- Muura hudiki
- Muura hukuru (mudumbu)
- Muromo
Asi anowanzo kuwanikwa muura hukuru uye mu rectum. Munhu ane JPS anogona kunge aine ma polyps aya kubva pamazana kusvika mashoma.
Zvino ungafunga kuti nekuti rine izwi rekuti "juvenile" mukati maro, ichi chirwere chinongobata vana vadiki chete. Kwete chaizvo. Izwi rekuti "juvenile" pano harirevi zera iro chirwere chinokura. Rinoreva hunhu hwemasero anoonekwa kana polyp ikatorwa uye ikaongororwa pasi pemaikorosikopu. Zvisinei, kazhinji, zviratidzo zvechirwere ichi zvinotanga kuonekwa muhudiki kana kuyaruka , kazhinji vasati vasvitsa makore makumi maviri.
Kune mhando huru dzeJPS here?
Ehe, JPS inogona kukamurwa kuita mhando nhatu huru. Kupatsanurwa uku kwakavakirwa pahukuru hwema polyps anoumbwa uye nzvimbo yawo.
| Rudzi rweJPS | Tsananguro iri nyore |
|---|---|
| Juvenile polyposis yehucheche (JPI) | Iyi ndiyo mhando yeJPS yakanyanya kuipa uye yakakomba. Inowanikwa muvacheche nevana vadiki. Zviratidzo zvinogona kuoneka nekukurumidza. |
| Polyposis yevana vadiki yakajairika | Iyi ndiyo mhando yeJPS inonyanya kuwanikwa. Mapolyps anogona kukura chero kupi zvako mudumbu, kusanganisira mudumbu, muura hudiki, uye muura hukuru. |
| Polyposis coli yevana | Murudzi urwu, mapolyps anongoitika muura chete. Izvi zvishoma kana tichienzanisa nedzimwe mhando mbiri. |
Ndiani anowana chirwere ichi? Chinogarwa nhaka here?
JPS inokonzerwa nekuchinja kwemajini, saka chero ani zvake anogona kuiwana. Idambudziko risingawanzoitiki. Pasi rose, huwandu hwevanhu vanobatwa nechirwere ichi hunosvika munhu mumwe chete pavanhu zana vezviuru .
Ehe, chirwere ichi chinogona kugarwa nhaka . JPS ndiyo yatinodaidza kuti "autosomal dominant" mumamiriro ezvinhu. Izvi zvinongoreva kuti kunyangwe mwana akagara nhaka kopi imwe chete yejini rakachinjwa rechirwere ichi kubva kuna amai kana baba, zvakakwana kuti mwana awane chirwere ichi.
- Varwere vanosvika 75% veJPS vanogara nhaka chirwere ichi kubva kuvabereki vavo.
- Muzvikamu makumi maviri nemashanu kubva muzana (25%) zvezvirwere, chirwere ichi chinogona kuitika nekuda kwekushanduka kwemuviri wemwana, kunyangwe vabereki vasina kuchinja kwemajini uku.
Ndezvipi zviratidzo zveJPS?
Chiratidzo chikuru chechirwere ichi kuumbwa kwemapolyps, atakambotaura nezvawo, muura. Sezvo aya achiumbwa mukati memuviri, hatigoni kuaona kubva kunze. Kazhinji, mapolyps anogona kusaratidza zviratidzo kusvika akura zvishoma kana kuti huwandu hwawo huchiwedzera. Asi kana zviratidzo zvatanga kuoneka, zvinogona kutaridzika seizvi.
| Chiratidzo | Tsananguro |
|---|---|
| Kubuda ropa mutsvina | Ichi ndicho chiratidzo chinonyanya kuonekwa uye chekutanga. Unogona kuona ropa dzvuku rakatsvuka mutsvina yako. |
| Kurwadziwa kwemudumbu kana kurwadziwa | Unganzwa kurwadziwa kusinganzwisisike, kwakaita sekunge kurwadziwa mudumbu mako. |
| Manyoka | Manyoka anogona kuitika kwenguva refu. |
| Kuzvimba | Vamwe vanhu vanogonawo kuva nedambudziko rekuzvimba pachinzvimbo chemanyoka. |
| Kushaya ropa | Sezvo ropa richiramba richiyerera, huwandu hweropa mumuviri hunogona kudzikira, zvichikonzera anemia. Izvi zvinogona kuita kuti unzwe kuneta, kucheneruka, uye kushaya simba nguva dzese. |
| Kuderedza huremu | Kana ukaramba uchidzikira uremu pasina chikonzero, izvozvo zvinogonawo kuva chiratidzo. |
Zvimwe zvinhu zvinogona kuonekwa pakuzvarwa
Vanenge 15% yevarwere veJPS vane zvimwe zvirwere zvemuviri pakuzvarwa pamwe chete nezvirwere zvemudumbu.
- Muromo nemukanwa zvakachekwa
- Kuva neminwe kana zvigunwe zvekuwedzera (Polydactyly)
- Kusagadzikana kwekukura kweuropi, moyo, kana weti
- Kumonyoroka kweura (Malrotation)
Pane hukama here pakati peJPS nenjodzi yegomarara?
Ichi ndicho chinhu chakakosha kuziva nezvechirwere ichi. Mapolyps anokonzerwa neJPS pakutanga haasi ekenza (asina njodzi). Mabundu akajairwa. Zvisinei, nekufamba kwenguva, pane mukana mukuru wekuti mapolyps aya ashanduke kuita kenza.
Munhu ane JPS ane njodzi yehupenyu hwake hwese yekubatwa nekenza yemudumbu iri pakati pe30% ne50%.
Saka, munhu ane JPS ari panjodzi yakakura yekuwana mhando dzekenza dzinotevera:
- Kenza yemudumbu
- Kenza yemudumbu
- Kenza yemudumbu mudiki
- Kenza yepancreatic
Usatya izvi. Izvi hazvirevi kuti munhu wese achabatwa negomarara. Asi zvinoreva kuti njodzi yacho yakakura. Ndosaka zvichikosha zvikuru kuongorora chirwere panguva yakakodzera uye kuongororwa panguva dzakakodzera sezvakakurudzirwa nachiremba wako.
Chii chinonyanya kukonzera JPS?
Sezvatakambokurukura, ichi chirwere chemajini. JPS inonyanya kukonzerwa nekuchinja kwemajini maviri mumuviri wedu anonzi BMPR1A neSMAD4 .
Kuti tinzwisise izvi, ngatishandisei muenzaniso uri nyore. Fungidzira kuti masero ari mumuviri wedu akafanana nemota dziri mumugwagwa. Majini maviri anonzi BMPR1A neSMAD4 akafanana nemapurisa emumugwagwa. Anodzora kukura nekupatsanurwa kwemasero, achipa zviratidzo zvekuti "Zvakanaka, patsanura izvozvi" uye "Zvakanaka, mira izvozvi."
Kana majini maviri aya achichinja, sekuti kana mapurisa emumugwagwa apera, masero anorasikirwa nesimba. Anotanga kupatsanurana nenzira yaanoda, uye nekukurumidza. Ndiyo nzira iyo masero aya asingadzoreki anopatsanurana anoungana pamwe chete oumba mabundu aya anonzi mapolyps.
Kuwedzera kuJPS, vanhu vane shanduko mujini reSMAD4 vari panjodzi yekuve nechimwe chirwere chemajini chinonzi hereditary hemorrhagic telangiectasia (HHT).
Nzira yekuziva sei chirwere ichi?
Kana ukaudza chiremba wako nezvezviratidzo zvako, iye achakuongorora uye achakubvunza nezvenhoroondo yezveutano hwemhuri yako. Kuti uongorore JPS, unofanira kunge uine chimwe chezvinotevera:
- Kuva nemapolyps mashanu kana kupfuura muura hukuru uye/kana mu rectum.
- Kuvapo kwema polyps kune dzimwe nzvimbo mudumbu.
- Kuva nechirwere chepolyp chinenge chimwe chete uye nhoroondo yemhuri yechirwere cheJPS.
Kune miedzo mikuru miviri yekusimbisa chirwere ichi.
1. Kuongororwa kweEndoscopic / Colonoscopy: Izvi zvinosanganisira kuisa chubhu yakatetepa, inochinjika ine kamera uye chiedza chinopinda nemutsvina kuti uongorore mukati medumbu rese nedumbu. Izvi zvinogona kubatsira kuona kana paine mapolyps, kuti mangani aripo, uye kuti ari kupi. Panguva yekuongororwa, mapolyps madiki anogona kubviswa uye sampuli yenyama (biopsy) inogona kutorwa kuti iongororwe.
2. Kuongororwa kweropa remajini: Sampuro yeropa inotorwa yoongororwa kuti ione kana paine shanduko dzeBMPR1A kana SMAD4 gene dzinokonzera JPS. Izvi zvinogona kusimbisa chirwere ichi 100%.
Ndeapi marapirwo eJPS?
Chinangwa chikuru chekurapa JPS kubvisa ma polyps.Izvi zvinogona kudzora zviratidzo uye kuderedza njodzi yekubatwa nekenza mune ramangwana. Chiremba wako ndiye achasarudza kurapwa kwakanakira iwe zvichienderana nezera rako, hutano hwako, huwandu hwemapolyps, uye nzvimbo yawo.
Kune nzira dzakasiyana-siyana dzekurapa:
- Kubvisa mapolyps panguva yekuongorora colonoscopy: Kana mapolyps ari mashoma uye madiki, anogona kuchekwa nekubviswa nechinhu chimwe chete chinoshandiswa pakuongorora.
- Kubviswa kwemapolyps pakuvhiyiwa: Kana mapolyps acho akakura kana kuti ari panzvimbo yakaoma kusvika ne colonoscope, kuvhiyiwa kunogona kudiwa.
- Kubviswa kwechikamu chemuura mukuru: Kana huwandu hwakawanda hwemapolyps hwakapararira munzvimbo imwe chete, vanachiremba vanogona kusarudza kubvisa chikamu chose chemuura mukuru nekuvhiyiwa.
Kana vana vadiki vaine polyp imwe chete, inowanzo bviswa panguva yekuongororwa kwecolonoscopy. Kuvhiyiwa hakuwanzoitwa pavana.
Nzira yekurapa chirwere mushure mekuongororwa?
JPS chirwere chinoda kurapwa kwenguva refu. Mushure mekurapwa nekubviswa kwemapolyps, tinofanira kugara tichiongororwa kuti tione kana achikura zvakare kana matsva abuda. Ndosaka tichiita bvunzo .
Chiremba wako achakuudza kuti uite bvunzo idzi panguva yakatarwa.
- Kuongororwa kweropa
- Colonoscopy
- Endoscopy yepamusoro
Bvunzo yekutanga inowanzoitwa kana zviratidzo zvangoonekwa kana usati wasvitsa makore gumi nemashanu. Kana mhinduro dzebvunzo dzakanaka, uchakumbirwa kudzokorora bvunzo yacho makore matatu ega ega. Zvisinei, kana uine mapolyps uye akabviswa, ungangoda kuongororwa gore rega rega . Kana mapolyps akasadzoka, nguva iri pakati pebvunzo inogona kuwedzerwa kusvika makore matatu.
Kutevedzera purogiramu iyi kwakakosha zvikuru pahutano hwako nehupenyu hwako. Zvinogona kukubatsira kuona nekudzivirira njodzi dzegomarara nekukurumidza.
Unofanira kuona chiremba rini?
Kana uine chimwe chezviratidzo zvatakurukura, kunyanya ropa riri mutsvina yako , usambozvifuratira. Chingave chirwere chehemorrhoid, kana kuti chingave chiratidzo chechirwere chakakomba seJPS. Saka, shanyira chiremba wako nekukasika.
Uyewo, kana mumwe munhu mumhuri mako akambova neJPS, kana kuti wakambova nekenza yemudumbu uchiri mudiki, kuchenjera kutaura nachiremba wako nezvazvo uye kuongororwa majini kana zvichidikanwa, kunyangwe usina zviratidzo.
Mharidzo Yekuenda Nayo Kumba
- Juvenile Polyposis Syndrome (JPS) chirwere chemajini chinokonzera kukura kusina kujairika (polyps) muura. 'Juvenile' zvinoreva hunhu hwepolyp, kwete zera.
- Usambofa wakafuratira zviratidzo zvakaita seropa riri mutsvina, kurwadziwa kwemudumbu kwenguva refu, kana kudzikira kwehuremu. Tsvaga rubatsiro rwechiremba nekukasika.
- JPS inowedzera njodzi yekubatwa negomarara mune ramangwana. Saka, zvakakosha kuti uongororwe nachiremba wako nenguva.
- Kunyangwe pasina mushonga wakakwana wechirwere ichi, chinogona kurapwa zvinobudirira uye hupenyu hune hutano hunogona kuraramwa nekubvisa mapolyps uye kuongororwa nguva nenguva.
- Kana muine nhoroondo yemhuri yechirwere cheJPS kana kenza yemudumbu, taurai nachiremba wenyu nezvazvo uye fungai nezvemajini ekubatsirana nekuongororwa.
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