Pane dambudziko here nemasero elymph mumuviri wako? Ngatikurukurei nezveLymphoproliferative Disorders (LPDs)!

Wakambonzwa here kuti kune masoja madiki mumiviri yedu anotidzivirira kubva kuzvirwere? Masoja iwayo anonzi masero machena eropa. Pakati pemasero machena aya, pane rudzi rwakakosha runonzi lymphocytes . Basa ravo guru nderekuchengetedza immune system yedu yakasimba nekurwisa vavengi vakaita semavhairasi nemabhakitiriya anopinda mumuviri wedu, uye kutoparadza masero ekenza. Zvisinei, dzimwe nguva ma lymphocytes aya anomira kushanda zvakanaka, kana kuti anotanga kuwanda zvakanyanya. Ndipo patinodaidza boka rezvirwere kuti Lymphoproliferative Disorders (LPDs) . Ichi chirwere chisingawanzoitiki. Ngatitaurei nezveizvi zvakadzama, handiti?

Chii chinonzi Lymphoproliferative Disorders (LPDs)? Pane mhando dzezvirwere here?

Zvichitaurwa zviri nyore, maLPD iboka rezvirwere zvinoitika kana masero edu elymph, anonzi malymphocytes, asingashande zvakanaka kana kukura zvisingadzoreki. Izvi zvinogona kukamurwa kuita mapoka maviri makuru.

1. LPDs (Matambudziko eImmunologic) ane chekuita nesystem yekudzivirira muviri

Mhando idzi dzeLPD dzinokanganisa maitiro anoita masoja edu emuviri kune vanopinda muzvirwere zvekunze. Vanhu vane zvirwere izvi vari panjodzi yakakura yekubatwa nekenza dzakadai se lymphoma .

• Chirwere cheX-linked lymphoproliferative (XLP): Kana munhu ane chirwere ichi akatapukirwa nehutachiona hweEpstein-Barr , chinogona kukura kuita lymphoma.
• Autoimmune lymphoproliferative syndrome (ALPS): Apa ndipo apo huwandu hwakawanda hwemalymphocytes hunoungana munzvimbo dzakadai semalymph nodes edu, spleen, nechiropa, zvichiita kuti nhengo idzodzo dzizvimbe. Zvinoita sekuti masero edu ari kungoungana munzvimbo dzisingadzoreki.
• Matambudziko emuviri mushure mekuisirwa lymphoproliferative (PTLD): Ichi chirwere chisingawanzoitiki asi chakakomba. Chinogona kuitika mushure mekuisirwa nhengo (semuenzaniso, itsvo, chiropa) kana kuisirwa masero emuviri akabatana . Izvi zvinonyanya kuitika kana iwe kana munhu akapa nhengo kana masero emuviri akatapukirwa nehutachiona hweEpstein-Barr, hunokanganisa masero eB.

2. Kenza dzeropa dzeLymphoid

Izvi ndizvo zvirwere zvakakomba zvatinowanzonzwa nezvazvo, zvakaita seLeukemia neLymphoma . Chinoitika pano ndechekuti masero machena eropa ari mumongo wedu wemapfupa neropa, kureva masero eB, masero eT nemasero eNatural killer (NK cells), anokuvadzwa.Kuchinja-chinja kwemasero, masero asina kujairika anowanda zvisingadzoreki. Masero aya asina kujairika anovhara masero eropa ane hutano. Kunyangwe aya achigona kurapwa dzimwe nguva, zvirwere zvakakomba zvinogona kutyisidzira hupenyu.

Gomarara rinokonzerwa nemasero eB

Mamwe marudzi emhando dzisiri dzeHodgkin lymphomas anowira muchikamu ichi ndeaya:

• Kupararira kweB-cell lymphoma yakakura
• Follicular lymphoma
• Lymphoma yemasero eMantle

Kunewo marudzi eB-cell leukemia:

• Chronic lymphocytic leukemia (CLL): Pano, masero eB-akajairika mumongo wemapfupa anowanda zvakanyanya, achivhara masero eropa ane hutano nemaplatelet.
• B-cell prolymphocytic leukemia: Pano zvakare, B-cells dzisina kujairika dzinoumbwa mumongo wemapfupa, dzichivhara masero ane hutano.
• Leukemia yemasero ane bvudzi: Sezvinoratidzwa nezita racho, masero machena aya asina kujairika anopiwa mazita nekuti anoita sebvudzi kana akatariswa nemaikorosikopu. Anoumbwawo mumwongo wemapfupa uye anowanda zvakanyanya.

Gomarara rinokonzerwa nemasero eT

Matambudziko ane chekuita nemasero eT anonyanya kupatsanurwa muzvikamu zviviri:

• Systemic T-cell lymphomas: Izvi zvinogona kukanganisa ma lymph nodes ako, spleen, bone marrow, ropa, nedzimwe nhengo dzemuviri.
• Malymphoma eT-cell eganda: Aya anonyanya kukanganisa ganda, asi dzimwe nguva anogona kukanganisa ma lymph nodes, ropa, mupfupa, uye nhengo dzemukati.

Kune mhando dzakasiyana dzemasero eT-cell lymphomas. Dzimwe dzemhando dzakajairika ndedzinotevera:

• Peripheral T-cell lymphoma haina kutaurwa neimwe nzira (PTCL NOS)
• Angioimmunoblastic T-cell lymphoma (AITL)
• Anaplastic large cell lymphoma

Kunewo mhando dzisingawanzoonekwi:

• Hepatosplenic T-cell lymphoma (HSTCL)
• T-cell lymphoma (EATL) inobatanidzwa neEnteropathy

Mamwe ma lymphoma eT-cell anonziwo chronic T-cell leukemias . Mienzaniso:

• T-cell prolymphocytic leukemia (T-PLL)
• T-cell large granular lymphocytic leukemia (T-LGL)

Mhando mbiri huru dzeT-cell lymphoma dzinonzi cutaneous T-cell lymphoma:

• Mycosis fungoides
• Chirwere cheSézary

Matambudziko ane chekuita neNK-cell

Izvi hazviwanzoitiki uye zvinokanganisa masero eNK.

• Extranodal NK T-cell lymphoma mhando yemhino
• Leukemia yeAggressive NK-cell (AKNL)
• NK-cell large granular lymphocytic leukemia (NK-LGL)

Iye zvino wava kuona kuti kune zvirwere zvakasiyana-siyana pasi peLPDs. Haufanire kuziva chimwe nechimwe zvakadzama, asi zvakakosha kuziva kuti chirwere ichi chiripo.

Ndezvipi zviratidzo zveLPD? Unozviziva sei?

Zviratidzo zveLPD idzi zvinogona kusiyana zvikuru, zvichienderana nerudzi rweLPD yaunayo. Asi pane zvimwe zviratidzo zvakajairika zvaunogona kuona. Ngatitarisei kuti ndezvipi:

• Kudikitira zvakanyanya husiku: Kwete kudikitira chete, asi kudikitira zvakanyanya zvekuti machira anonyorova.
• Ma lymph nodes, chiropa, kana chirebvu chakazvimba: Kana ukaona mapundu munzvimbo dzakadai semutsipa, muhapwa, kana mudumbu, kana kana uine kuzvimba kusingawanzoitiki mudumbu mako, unofanira kunetseka.
• Kubuda ropa zvisina kujairika kana kuti zvakanyanya: Kana uchibuda ropa rakawanda kunyangwe nekuda kwekukuvara kudiki, kana kuti uine mavanga ebhuruu panzvimbo dzakasiyana pamuviri wako.
• Kuneta nguva dzose: Kunzwa kuneta zvisinei nekuti unorara zvakadii.
• Kugara uchirwara nefivha: Kana uine fivha isingaperi pasina chikonzero.
• Kutapukirwa nehutachiona kakawanda: Nekuda kwekusasimba kwemasimba emuviri, unogona kugara uchirwara nezvirwere zvakaita sedzihwa nefuruu.
• Anorexia: Kunzwa kusada kudya.
• Kudzikira uremu kusingatsananguriki: Kana ukangoerekana wadzikira uremu usina kudya kana kurovedza muviri, chiratidzo chekuti unofanira kungwarira.

Zvakakosha: Usavhunduke kana uine chimwe kana zviviri zvezviratidzo izvi. Zvinogonawo kukonzerwa nezvimwe zvikonzero zviri nyore. Zvisinei, kana zviratidzo izvi zvikaramba zviripo, zvakanaka kuti uone chiremba kuti akupe mazano.

Ndezvipi zvikonzero zveLPD?

Zvakaoma kuziva chikonzero chimwe chete chezvirwere zvakawanda zveLPD, asi zvinhu zvakasiyana-siyana zvinogona kukonzera izvi.

• Utachiona: Mamwe marudzi eLPD anogona kukonzerwa nehutachiona hwakadai sehutachiona hweEpstein-Barr kana hutachiona hweH. pylori . Fungidzira, mhando idzi dzetupukanana tunopinda mumiviri yedu dziri kukanganisa mashandiro emasero edu.
• Zvimwe zvirwere zve autoimmune: Rheumatoid arthritis, lupusVanhu vane zvimwe zvirwere vari panjodzi yekubatwa nemamwe marudzi eLPD (semuenzaniso marginal zone lymphomas). Apa ndipo apo masoja emuviri wedu anorwisa masero edu.
• Mishonga: Mimwe mishonga inodzvinyirira masoja emuviri (semuenzaniso, mishonga inopiwa kudzvinyirira masoja emuviri mushure mekuisirwa nhengo) inogona kukonzera zvirwere zvakaita se hepatosplenic T-cell lymphoma.
• Kuchinja kwemajini: Kashoma, unogona kugara nhaka kuchinja kwemajini kunokonzera rudzi urwu rweLPD. Semuenzaniso, vanhu vane X-linked lymphoproliferative disorder (XLP) vane kuchinja kwemajini maviri. Izvi zvinoita kuti vave nedambudziko guru rehutachiona hweEpstein-Barr uye vagadzire lymphoma. Kuchinja kwemajini kunokanganisa kukura kwemasero machena eropa kwakabatanawo nelymphoma neleukemia.

Vanachiremba vanoongorora sei LPDs? (Kuongororwa)

Nekuti kune mhando dzakawanda dzeLPDs, pavanenge vachiongorora chirwere, vanachiremba vanotanga vatarisa kuti vaone kuti nderudzii rweLPD ruri kukonzera zviratidzo zvako.

Kuti aite izvi, chiremba achaongorora zviratidzo zvako, zvakaita sema lymph nodes akazvimba, zviratidzo zvekuti chiropa chako kana chiremara chako chakakura kupfuura zvakajairika, uye achabvunza nezvenhoroondo yako yezvekurapa uye kana paine mumwe munhu mumhuri mako akambova nematambudziko akafanana.

Zvadaro zvinokwanisika kuita bvunzo dzakadai:

• Kuongororwa kwemapfupa: Kuongororwa kwemapfupa kunogona kuitwa kuti uone zviratidzo zvegomarara reropa zvakaita seleukemia kana lymphoma. Izvi zvinosanganisira kutora sampuli diki yemapfupa uye kuyedzwa. Dzimwe nguva chidimbu chidiki che lymph node yakazvimba chinogonawo kutorwa.
• Kuongororwa kweropa: Kuverengwa kweropa kwakazara (CBC) , Comprehensive metabolic panel (CMP) , Epstein-Barr antibody test, hepatitis test, HIV test, Lactate dehydrogenase (LDH) test, nezvimwewo. Izvi zvinogona kukuudza zvakawanda nezvekuchinja kwemasero eropa, hutachiona, uye mashandiro echiropa neitsvo.
• Miedzo yekufungidzira: Miedzo yakaita se computed tomography (CT) scans uye positron emission tomography (PET) scans inogona kuitwa. Izvi zvinogona kutarisa zvinhu zvakaita senhengo dziri mukati memuviri, mamiriro ema lymph nodes, uye kana masero ekenza akapararira. Zvakafanana nekutora mufananidzo wemukati memuviri.
• Miedzo yekurabhoritari: Miedzo yakasarudzika yakadai se flow cytometry inogona kubatsira kuona mhando chaiyo yeLPD.

MaLPD anorapwa sei?

Kurapwa kweLPD kunoenderana nerudzi rweLPD yaunayo. Havasi vese vane kurapwa kwakafanana. Semuenzaniso, kana uine leukemia kana lymphoma, unogona kurapwa seizvi:

• Chemotherapy: Mishonga inopihwa kuparadza masero ekenza.
• Kurapa nekudzivirira kenza: Kurapa kunosimudzira masoja emuviri wako kurwisa masero ekenza.
• Kurapa nemwaranzi: Kuparadza masero egomarara uchishandisa mwaranzi ine simba rakawanda.
• Kuisa masero emapfupa (stem morrow): Kuisa masero emapfupa ane hutano panzvimbo pemafupa akakuvara.
• Kurapa kwakanangana: Mishonga inorwisa mamorekuru chaiwo anobatsira masero ekenza kukura nekupona.

Yeuka kuti chiremba wako ndiye achasarudza mushonga wakanakira iwe. Iye ndiye anoziva mamiriro ako zvakanyanya.

Zvakaita sei kune munhu ane LPD? Zvinorapika here?

Mubvunzo uyu wakaoma kupindura nekuti kune mhando dzakawanda dzeLPD, uye zvinhu zvakawanda zvakaita sehutano hwako, zera, uye nhanho yechirwere zvinogona kukanganisa mhedzisiro yacho.

Mamwe marudzi eLPD anogona kurapwa zvachose. Semuenzaniso, chemo-immunotherapy inogona kurapa mamwe marudzi elymphoma, akadai se large B-cell lymphoma neBurkitt lymphoma. Munhu ane X-linked lymphoproliferative disorder (XLP) anogona kurapwa nekuisirwa stem cell.

Asi dzimwe nguva, kurapwa kunogona kuita kuti mamwe ma lymphomas aderere , zvichireva kuti zviratidzo zvinopera uye bvunzo hadzichakwanisi kuona chirwere chacho. Asi chirwere hachisati chapora zvachose. Mamwe maLPD anogona kudzoka mwedzi kana makore mushure mekunge kurapwa kwapera.

Kana uine LPD, ungangove uchinetseka kuti inogona kurapika here uye kuti unogona kurarama kwenguva yakareba sei. Nzvimbo yakanakisa yekuwana ruzivo nezveizvi kubva kuna chiremba wako. Iye anonyatsoziva iwe nemamiriro ako ezvinhu. Saka usatya kumubvunza chero mibvunzo yaunayo.

Ndinozvitarisira sei? (Kuzvitarisira)

LPDs zvirwere zvakakomba. Kunyange zvazvo kurapwa kuchigona kuderedza zviratidzo uye kutokonzera kurapwa, ungangosangana nematambudziko panguva yekurapwa. Heano mamwe mazano anogona kukubatsira:

• Bvunza nezvekuchengetedzwa kwevarwere vane marwadzo ekurwadziwa: Munhu ane LPD angangoda rubatsiro rwekutarisira zviratidzo nemigumisiro yekurapwa. Kutarisirwa kwevarwere vane marwadzo ekurwadziwa imhando yekurapa yakasarudzika inobatsira kuvandudza hupenyu hwemunhu uye kuderedza marwadzo nezvimwe kusagadzikana, pane kuedza kurapa chirwere chacho. Chikwata chako chekuchengetedzwa kwevarwere vane marwadzo ekurwadziwa chinogona kukupa mazano akanaka.
• Idya zvakanaka: Unogona kurasikirwa nechido chekudya kana uchirwara kana kuti uri kurapwa. Kana zvakadaro, bvunza nyanzvi yezvekudya . Iye achakupa mazano ezvekudya nezvinwiwa zvakakodzera kwauri.
• Ita maekisesaizi: Maekisesaizi akareruka anogona kubatsira kuderedza kushushikana kunokonzerwa nechirwere chakakomba. Asi iva nechokwadi chekutaura nachiremba usati watanga chirongwa chitsva cheekisesaizi.
• Zvidzivirire kubva kuzvirwere: Masoja emuviri wako anogona kushaiswa simba nekuda kwechirwere kana kurapwa. Saka bvunza chiremba wako nezvenzira dzekudzivirira hutachiona. Kudzivisa nzvimbo dzine vanhu vakawanda uye kugeza maoko ako nguva nenguva kwakakosha.

Ndinofanira kuona chiremba rini?

Kana uri kurapwa neLPD, bvunza chiremba wako kuti zviratidzo zvipi zvinoratidza kuti mamiriro ako ari kuipa (semuenzaniso, fivha inoramba iripo) kuitira kuti uzive nguva yekubata naye.

Kana chiremba achishandisa izwi rekurapa rekuti "lymphoproliferation" kana kuti "lymphoproliferative disorders (LPDs)," vanenge vachitaura nezveboka rezvirwere zvine chekuita nemasero machena eropa anogona kukanganisa masoja emuviri wako kana kuita kenza.

Kana uine chirwere chakadai, ungangoda kuziva zvakananga nezvechirwere chako kupfuura mazwi ekurapa. Asi kana uchirwara, ruzivo isimba. Panyaya iyi, kuziva zvinoreva zita racho kunogona kukubatsira kunzwisisa zviri kuitika mumuviri wako.

Semuenzaniso, LPD dzine zviratidzo nekurapwa kwakajairika. Asi hazvisi zvese zvakafanana. Zvakare, ruzivo rwako runogona kusiyana nerwevamwe vanhu. Kana chiremba wako achishandisa izwi rekuti "lymphoproliferative disorder (LPD), bvunza rumwe ruzivo nezvechirwere chako chaicho. Vachafara kupindura mibvunzo yako.

Pakupedzisira, meseji yekuenda nayo kumba:

Matambudziko eLymphoproliferative (LPDs) iboka rezvirwere zvakaoma, zvinogona kunge zvakakomba zvinokonzerwa nekusashanda zvakanaka kwemalymphocytes, masero ekudzivirira emuviri wedu.

• Ziva zviratidzo: Usave neusimbe kana uine fivha isingaperi, kuneta zvakanyanya, kudzikira uremu, kana kuzvimba kwema lymph nodes.
• Zvakakosha kutsvaga mazano echiremba: Kana usina chokwadi, enda kuna chiremba nekukurumidza kuti unoongororwa. Kana chirwere chikaonekwa nekukurumidza, mukana wekuti kurapwa kubudirire.
• Haasi ese maLPD akafanana: kune marudzi akasiyana, uye imwe neimwe ine marapirwo akasiyana. Chiremba wako ndiye achasarudza marapirwo akakunakira.
• Hausi wega: Paunenge uchitarisana nemamiriro ezvinhu akadai, rutsigiro rwemhuri, shamwari, nevashandi vekurapa runokosha zvikuru.

Chinhu chinonyanya kukosha kusatya, kuramba wakasimba, uye kutevedzera mazano evanachiremba. Nekurapwa kwakakodzera uye simba repfungwa rakanaka, unogona kukunda dambudziko iri.

Zvirwere zve lymphoproliferative, LPDs, lymphocytes, immune system, cancer, leukemia, lymphoma