Ngatidzidzei chaizvo nezvezvirwere zvisinganzwisisike zvinosangana nekenza (Paraneoplastic Syndromes)!

Wakambonzwa here nezvemunhu ane kenza achiona zviratidzo zvisingakonzerwi nekenza pachayo, asi zvinokonzerwa nezvimwe zvirwere? Zvakaita sekuti kenza iri mune imwe nhengo yemuviri, asi mhedzisiro yayo iri kupararira kune dzimwe nhengo. Ndizvo zvatinodaidza kuti (Paraneoplastic Syndromes) . Izvi zvinganzwika zvakaoma, asi ngatitaurei nezvezviri kuitika. Musatya, zvakakosha kuziva izvi.

Chii chinonzi paraneoplastic syndrome?

Zvichitaurwa zviri nyore, kana uine kenza, tinoidaidza kuti Paraneoplastic Syndrome , iyo inoitika apo zvimwe zviratidzo zvinoonekwa mumuviri zvisingakonzerwi zvakananga nemasero ekenza. Fungidzira, kune kenza mumuviri, asi mamwe mahormone kana mapuroteni anoburitswa nayo anokonzera kuti imwe system mumuviri itange kushanda zvakasiyana. Kana, dzimwe nguva immune system yedu, ichiedza kuparadza masero ekenza, inorwisawo masero akanaka zvisirizvo. Tinodaidza izvi kuti autoimmune response . Zviratidzo izvi zvinogonawo kuitika mune zvakadaro.

Paraneoplastic syndromes inogona kukanganisa masisitimu akasiyana-siyana mumuviri. Semuenzaniso, sisitimu yako yetsinga , sisitimu yeendocrine (sisitimu inogadzira mahormone), itsvo , mapfupa , majoini , ganda, neropa zvese zvinogona kukanganiswa.

Kazhinji, zviratidzo zvechimwe chezviratidzo izvi (Paraneoplastic Syndromes) ndizvo zviratidzo zvekutanga zvegomarara. Saka, zvakakosha kuziva izvi.

Ndiani angangonyanya kubatwa nechirwere ichi? (Ndiani akabatwa neparaneoplastic syndromes?)

MaParaneoplastic syndromes anowanzoonekwa muvanhu vane makore epakati nepakati nevakuru, kunyanya avo vane zvirwere zvakaita sekenza yemapapu , kenza yelymphatic , kenza ye ovarian , kana kenza yemazamu . Zvinhu zvakafanana zvinokonzera kenza zvinogonawo kukonzera zvirwere izvi.

Izvi zvakajairika sei? (Marwadzo eparaneoplastic syndromes akajairika sei?)

Paraneoplastic Syndromes inowanikwa pakati pe8% ne20% yevanhu vane kenza. Izvi zvinoreva kuti havasi varwere vese vane kenza vanoibata, asi inogona kukanganisa vanhu vakawanda.

Ndezvipi zvirwere zvegomarara zvinobatanidzwa neparaneoplastic syndromes?

Munhu wese ane bundu rekenza (Paraneoplastic Syndrome)Kunyangwe chero chimwe chinogona kuitika, kune mhando dzakasiyana dzekenza dzinowanzobatanidzwa nezvirwere izvi:

• Kenza yemazamu
• Kenza yemudumbu
• Leukemia
• Lymphoma
• Kenza yemapapu (kunyanya kenza yemapapu yemasero madiki)
• Kenza yemudumbu
• Kenza yepancreatic
• Kenza yeprostate
• Kenza yeitsvo
• Kenza yemazamu

Chii chinokonzera paraneoplastic syndromes?

Tatokurukura kuti pane zvikonzero zviviri zvikuru zveizvi.

1. Zvinhu zvinoburitswa nemasero egomarara: Mamwe magomarara anoburitsa mahormone nemapuroteni . Izvi zvinokonzera kuti dzimwe nhengo dzemuviri dzishande zvisina kunaka. Kana zvikasarapwa, izvi zvinogona kutokonzera kukuvara zvachose.

2. Kusashanda zvakanaka kwemasoja emuviri: Masoja emuviri wedu aripo kuti atidzivirire kubva kuzvirwere. Sisitimu iyi inogadzira zvinhu zvinonzi ma antibodies . Ma antibodies aya anoziva uye anoparadza masero asina kujairika, akadai semasero ekenza. Asi dzimwe nguva, zviratidzo izvi zvinosanganiswa uye ma antibodies anotanga kurwisa masero ane hutano futi. Ndipo panoonekwa zviratidzo zve (Paraneoplastic Syndrome) .

Ndezvipi zviratidzo zveparaneoplastic syndromes?

Zviratidzo zvinoonekwa mune izvi zvinogona kusiyana kubva pamunhu kusvika pamunhu. Zvinoenderana nekuti muviri wako wabatwa nechirwere chipi. Zvinoshamisa kuti mune zvinopfuura 60% zvezviitiko, zviratidzo zvechirwere ichi zvinoonekwa kenza isati yatomboonekwa. Saka, kana zviratidzo izvi zvikaonekwa nekukurumidza, kenza inogona kuonekwa uye kurapwa padanho rekutanga. Ipapo mikana yekubudirira kwekurapa inenge yakakwira.

Zviratidzo zvakajairika

Izvi ndizvo zvimwe zvezviratidzo zvinonyanya kuzivikanwa:

• Kupindwa nechando
• Kurasikirwa nechido chekudya uye kudzikira kwehuremu
• Kudikitira husiku

Kana sisitimu yetsinga ikakanganiswa

Kana sisitimu yako yetsinga (ndiko kuti, uropi hwako nemuzongoza) uye sisitimu yetsinga yeropa (tsinga dzinobuda muuropi nemuzongoza) zvikakanganiswa, unogona kuona zviratidzo zvakaita seizvi:

• Dzungu
• Kuona kaviri
• Kuoma kwekutaura
• Kurasikirwa nendangariro
• Zvirwere zvepfari ( pfari )
• Kushaya simba kwetsandanyama
• Kuderedza mafungiro, kunzwa kana kubatana
• Kurasikirwa nekunzwa mumaoko ako nemakumbo

Fungidzira, mumwe munhu ane kenza yemapapu, asi anongoerekana atanga kurasikirwa nendangariro dzake, kutaura zvisina kunaka paanotaura, uye zvinomuomera kuramba akadzikama paanofamba. Ndipo vanachiremba pavanofungidzira kuti iyi i (Paraneoplastic Syndrome) .

Kana endocrine system ikakanganiswa

Kana hormone system yako ikakanganiswa, unogona kuona zviratidzo zvakaita se:

• Kuneta kwakanyanya
• Kukwira kweropa
• Kushaya simba kwetsandanyama
• Kusvotwa nekurutsa
• Kuwedzera uremu kamwe kamwe pasina chikonzero

Kana majoini, mapfupa netsandanyama zvakanganiswa (Majoini, mapfupa netsandanyama - rheumatologic)

Kana masisitimu aya akakanganiswa:

• Mamiriro ezvinhu akadai searthritis
• Kurwadziwa kwemajoini, kuzvimba kana kuomarara

Kana zvichikanganisa ganda (Ganda)

Dzimwe nguva ganda rinogonawo kukanganiswa:

• Kukwenya
• Kushambadza
• Ganda rakakora
• Kukura kweganda kusina njodzi (kusina kenza)

Ndeapi marudzi eparaneoplastic syndromes?

Kune mhando dzakasiyana dzeParaneoplastic Syndromes . Dzinorongwa zvichienderana nekuti dzinokanganisa sei system yega yega.

Zvirwere zveparaneoplastic system yetsinga

Mimwe mienzaniso:

• `(Kuora kwetsinga dzemuuropi)`: Uku kukuvara kwetsinga dzemuuropi, zvichikanganisa zvinhu zvakaita sekuzvibata zvakanaka uye kufamba.
• Dysautonomia: Inokanganisa mashandiro ehurongwa hwetsinga hwe autonomic.
• Encephalitis: Kuzvimba kweuropi.
• Encephalomyelitis: Kuzvimba kweuropi nemusana.
• Lambert-Eaton myasthenic syndrome (LEMS): Inokonzera kushaya simba kwetsandanyama.
• Myasthenia gravis (MG): Ichi chimwe chirwere chinokonzera kushaya simba kwetsandanyama.
• Myelopathy: Zvirwere zvinokanganisa musana.
• Neuromyotonia: Kugara uchibata tsandanyama.
• `(Opsoclonus-myoclonus syndrome)`: Kufamba kusina kujairika kwemaziso netsandanyama.
• `(Neuropathy (peripheral neuropathy))`: Kukuvadzwa kwetsinga dzemumativi.
• `(Stiff-person syndrome)`: Kuoma kwetsandanyama uye kurwadziwa kwekusunga.

Matambudziko eparaneoplastic system e endocrine

Mienzaniso:

• `(Cushing's syndrome): Chirwere chinokonzerwa nekuwedzera kwehomoni inonzi cortisol.
• Hypercalcemia: Kuwedzera kwecalcium muropa.
• `(Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH))`: Chirwere chinokonzera kuwedzera kwekuchengetedza mvura mumuviri.

Marwadzo eparaneoplastic syndromes erheumatic

(inokanganisa majoini, mapfupa, tsandanyama uye nyama dzinobatana)

Mienzaniso:

• `(Eosinophilic fasciitis)`
• `(Erythromelalgia)`
• `(Hypertrophic osteoarthropathy)`
• `(Palmar fasciitis)`
• `(Paraneoplastic polyarthritis)`

Zvirwere zveparaneoplastic muropa

Mienzaniso:

• `(Paraneoplastic erythrocytosis)`: Kuwedzera kwemasero matsvuku eropa.
• `(Paraneoplastic thrombocytosis)`: Kuwedzera kwemaplatelet eropa.

Zvirwere zveparaneoplastic paganda

Mienzaniso:

• Acanthosis nigricans: Mavara matema, akakora paganda.
• Dermatomyositis: Kuzvimba kweganda netsandanyama.
• Leukocytoclastic vasculitis: Kuzvimba kwetsinga diki dzeropa.
• `(Paraneoplastic pemphigus)`: Chirwere chinokonzera maronda paganda.
• `(Sweet syndrome)`: Fivha uye maronda eganda anorwadza.

Zvirwere zveparaneoplastic zveitsvo

Paraneoplastic glomerulonephritis chirwere chinokanganisa itsvo.

Paraneoplastic syndromes inoonekwa sei?

Chiremba wako achaongorora chirwere ichi nekukubvunza nezvenhoroondo yako yezveutano, kuita ongororo yemuviri, uye kuita mimwe miedzo yakati wandei.

• Kuongororwa kwetsinga: Nekuti chirwere ichi chinowanzo kanganisa tsinga, chiremba wako achakukumbira kuti uite zvimwe zvinhu kuti utarise mashandiro anoita uropi hwako netsandanyama. Vachatarisa shanduko musimba rako, ndangariro, uye kushanda pamwe chete.
• Miedzo yekufungidzira: Miedzo yakaita seCT scans , MRIs , uye ultrasound inogona kushandiswa kuona kana paine bundu riri kukonzera zviratidzo.
• Kuongororwa kweropa: Kuongororwa kweropa kunogona kuratidza zvinhu zvinogona kukonzera kufungira nezvegomarara. Vanogonawo kutarisa ma antibodies ane chekuita neparaneoplastic syndromes . Kuongororwa uku kunogonawo kuona kana zviratidzo zvichikonzerwa nezvimwe zvikonzero, zvakaita sehutachiona kana kusawirirana kwemahormone.
• Kuboorwa kwemusana/kupwanywa kwemusana: Mune zvimwe zviitiko, mvura yemusana (CSF) inoongororwa kuti ione kana paine ma antibodies anorwisa masero ane hutano. Izvi zvinosanganisira kuisa tsono diki kumusana wako wepazasi uye kutora sampuli yemvura yacho. Inobva yaongororwa.

Matambudziko aya anorapwa sei? (Marwadzo eparaneoplastic syndromes anorapwa sei?)

Chinhu chinonyanya kukosha kurapa kenza iri kukonzera zviratidzo zvako. Panguva imwe chete, unogadzirisawo zviratidzo zvako kuti uderedze kukuvara kwenhengo dzemuviri wako kana masisitimu.

Mamwe emishonga inoshandiswa kurapa Paraneoplastic Syndromes :

• Corticosteroids:Mishonga yakaita se `(Cortisone)` kana `(prednisone)`. Iyi inoshanda nekuderedza kuzvimba mumuviri.
• Kuderedza Dziviriro Yemuviri: Mishonga inoderedza kupindura kwemasoja emuviri wako. Chiremba wako achakupa mishonga zvichienderana nerudzi rweparaneoplastic syndrome yaunayo.
• Mutsinga wemushonga unopinzwa mumuviri (IVIG): Kurapa uku kunoshanda nekuparadza masoja anokuvadza. Mukuita izvi, masoja ane hutano anopihwa sejekiseni, iro rinoparadza masoja anokuvadza.
• Plasmapheresis: Izvi zvinosanganisira kubvisa plasma (chikamu cheropa chinoyerera) kubva muropa kuderedza huwandu hwemasoja ekudzivirira chirwere, ari muplasma iyi uye anogona kukuvadza tishu dzine hutano.
• Kurapa kwemuviri nekutaura: Izvi zvinosanganisira kurovedza tsandanyama kuti zvivandudze mabasa akadai sekutaura nekufamba. Ungangoda kurapwa uku kana uine paraneoplastic syndrome ine chekuita nehurongwa hwetsinga.

Chii chandingatarisira kana ndine paraneoplastic syndrome?

Kufanotaura kwako nezvechirwere ichi kunoenderana zvikuru nedanho regomarara rako. Mune zvimwe zviitiko, zviratidzo zvinokonzerwa nechirwere ichi zvinogona kunge zviri zvishoma uye zvenguva pfupi. Mune zvimwe zviitiko, zviratidzo zvinogona kunge zvakakomba uye zvinoda kurapwa kwenguva refu.

Taura nachiremba wako nezvekuti danho regomarara rako uye maitiro ako ekurapwa zvichakanganisa sei kupora kwako.

Ndezvipi zvinetso zvinobatanidzwa neparaneoplastic syndromes?

Izvi zvinogona kukonzera matambudziko akasiyana-siyana. Mamwe anogona kunge ari madiki, nepo mamwe anogona kunge akakomba uye achitoisa upenyu panjodzi kana akasarapwa. Chiremba wako achakutsanangurira matambudziko angangoitika uye nzira dzekurapa.

Ndirini pandinofanira kufonera chiremba nezve paraneoplastic syndromes?

Kana ukaona zviratidzo zveparaneoplastic syndrome pasina chikonzero chakajeka, enda kuna chiremba. Kunyanya kana wakamborapwa kenza mumakore mashanu apfuura uye uri kuona zviratidzo izvi, zvakanaka kuti uongororwe zvakare. Izvi zvichabatsirawo chiremba wako kuona kana kenza yadzoka.

Mibvunzo ipi yandinofanira kubvunza chiremba wangu?

Mimwe mibvunzo yaunogona kubvunza chiremba wako:

• Chii chinokonzera zviratidzo zvangu?
• Ko chirwere changu cheParaneoplastic Syndrome (Paraneoplastic Syndrome) chinokanganisa sei hurongwa hwangu hwekurapa kenza?
• Ndedzipi nzira dzekurapa dzandinadzo?
• ZvanguParaneoplastic Syndrome inokanganisa sei kupora kwangu?
• Zviratidzo zvangu zvichava nani here mushure mekurapwa kenza?
• Nzira yekubata nayo zviratidzo munguva pfupi? Nzira yekubata nayo zviratidzo kwenguva refu?

Pakupedzisira, meseji yekudzokera nayo kumba

Mabundu egomarara anogona kukonzera shanduko dzisingatarisirwi mumuviri. Dzimwe nguva, anogonawo kusanganisira zviratidzo zveparaneoplastic syndrome . Nekuti kune marudzi akati wandei ezvirwere izvi uye zviratidzo zvakasiyana-siyana, zvinogona kutora nguva kuti chiremba wako azive kuti zviratidzo zvako zvine chekuita negomarara. Zvisinei, kana chirwere chacho chasimbiswa, anogona kurapa zviratidzo uye, chinonyanya kukosha, kurapa gomarara riripo .

Nzira yakanakisisa yekurapa Paraneoplastic Syndrome ndeyekuwana mushonga unoshanda kwazvo wegomarara. Saka, usaregeredza zviratidzo chero zvipi zvazvo. Kana usina chokwadi, enda kuna chiremba nekukurumidza. Ndipo chete patinogona kuramba tiine hutano hwakanaka.

Paraneoplastic syndromes, kenza, zviratidzo, tsinga, endocrine system , immune system, kurapwa kwekenza