Pane mumwe munhu mumhuri mako, pamwe baba vako, amai vako, kana mumwe munhu waunoziva, ane chirwere cheParkinson's Disease here? Unofanira kunge wakasuruvara zvikuru kuona maoko avo achidedera, kuoma kwavo kufamba, muviri wavo uchioma, uye chiso chavo chichirasikirwa nemanzwiro ese. Hazvisi nyore kurarama nechirwere ichi. Asi chinhu chakanakisa ndechekuti nesainzi yekurapa yanhasi, nemishonga chaiyo, unogona kudzora zviratidzo izvi zvakanyanya uye kurarama hupenyu hwakanaka. Saka nhasi, ngatitaurei zviri nyore uye zvine mutsa nezvemishonga inopiwa yeParkinson's disease.
Kutanga, ngationei, chii chaizvo chinonzi chirwere cheParkinson?
Ngatinzwisisei izvi zviri nyore. Parkinson's chirwere chine chekuita netsinga dzedu. Kunyanya, uropi hwedu. Idambudziko rinoenderera mberi rinokura zvishoma nezvishoma nekufamba kwenguva . Kune nzvimbo yeuropi hwedu inonzi `substantia nigra' inodzora kufamba. Masero etsinga munzvimbo iyi anokuvadzwa uye anofa zvishoma nezvishoma.
Masero aya etsinga anogadzira chinhu chakakosha zvikuru chinotuma makemikari, `neurotransmitter`, yemuviri wedu. Zita rayo rinonzi dopamine . Dopamine iyi inokosha kuti mafambiro emuviri wedu ave akatsetseka uye akadzorwa. Saka kana masero iwayo etsinga aparadzwa, huwandu hwedopamine muuropi hunoderera. Ndosaka zviratidzo zvakaita sekubvunda, kuoma kufamba, uye kuomarara zvichiitika muchirwere cheParkinson.
Chinhu chakakosha ndechekuti mishonga inopihwa yechirwere cheParkinson inodzora zviratidzo izvi. Parizvino, hapana mushonga wechirwere ichi. Zvisinei, mishonga iyi inobatsira zvikuru mukuderedza zviratidzo uye kuvandudza hupenyu.
Mishonga mikuru yechirwere cheParkinson
Pakurapa chirwere cheParkinson, vanachiremba vanowanzo shandisa musanganiswa wemishonga yakasiyana-siyana, pane mushonga mumwe chete. Izvi zvinosiyana zvichienderana nezviratidzo zvemunhu, zera, uye danho rechirwere. Ngatitarisei mhando huru dzemishonga.
1. Levodopa neCarbidopa
Uyu ndiwo mushonga mukuru uye unoshanda zvikuru wechirwere cheParkinson. Unonziwo muyero wegoridhe.
- Levodopa: Kana mushonga uyu ukapinda mumuviri wedu, unopinda muuropi woshanduka kuita dopamine. Kureva kuti, mushonga uyu unodzorera huwandu hwedopamine hwakanga hwapera muuropi.
- Carbidopa: Asi pane dambudziko. Kana tikatora levodopa chete, yakawanda yacho inoparadzwa nema enzymes mumuviri wedu isati yasvika kuuropi. Kuti izvi zvisaitike, mushonga unonzi carbidopa unopihwa pamwe chete nelevodopa. Carbidopa inobvumira kuti levodopa yakawanda isvike kuuropi zvakachengeteka. Zvakare, carbidopa inobatsira kuderedza migumisiro yekutora levodopa chete, senge kuda kurutsa nekurutsa.
Musanganiswa uyu wemishonga unowanzo shanda zvakanaka pakurapa zviratidzo zvebradykinesia, kuomarara, uye kudedera.
| Rudzi rwemushonga | Mazita Emhando Dzinozivikanwa muSri Lanka |
|---|---|
| Musanganiswa weLevodopa-Carbidopa | Sinemet®, Rytary®, Parcopa®, Dhivy® |
2. Vadyi veDopamine Agonists
Rudzi urwu rwemushonga rwakafanana nerwemutambi. Kureva kuti, haisi dopamine chaiyo. Asi inoenda kuuropi uye inoshanda sedopamine. Inokurudzira dopamine receptors muuropi, zvichiita kuti uropi hunzwe sekuti dopamine iripo.
Mishonga iyi inowanzo nyorwa pakutanga kwechirwere, kunyanya kuvarwere vadiki. Dzimwe nguva inogona kubatsira kuwedzera kushanda kwe levodopa.
- Pramipexole (Mirapex®)
- Ropinirole (Requip®)
- Rotigotine (Neupro®)
3. Zvinodzivirira maEnzyme
Usatya kana ukanzwa zita iri. Zviri nyore kwazvo. Takambotaura kare kuti kune ma enzymes mumuviri wedu anoputsa dopamine. Zvinoitwa nemishonga iyi kumisa kushanda kwema enzymes iwayo. Ipapo dopamine iri muuropi haiparadzwe kwenguva yakareba.
Kune mhando mbiri huru dzeizvi:
- MAO-B Inhibitors: Izvi zvinovhara kushanda kwe `MAO-B`, enzyme huru inoputsa dopamine muuropi. Mienzaniso: `Selegiline`, `Rasagiline`.
- COMT Inhibitors: Izvi zvinodzivisa enzyme inonzi `COMT` inoputsa dopamine, iyo inoumbwa kubva mu levodopa. Nekuda kweizvi, simba re levodopa rinogara kwenguva refu. Mienzaniso: `Entacapone`, `Opicapone`.
4. Amantadine
Vamwe varwere vanotora mishonga yakaita selevodopa kwenguva yakareba vanogona kutanga kufambisa-famba vasingazvidi (dyskinesia). Amantadine inonyanya kushandiswa kurapa zvirwere izvi. Zvinoshamisa kuti pakutanga yakagadzirwa semushonga unorwisa mavhairasi. Asi yakazoonekwa kuti inobatsirawo nezviratidzo zveParkinson.
5. Mishonga yeAnticholinergic
Mushonga uyu unonyanya kubatsira pakubvunda uye kuomarara kweganda.Kudzora. Kana dopamine muuropi hwedu yadzikira, simba reimwe 'neurotransmitter' inonzi acetylcholine rinowedzera. Mishonga iyi inovhara simba reacetylcholine iyoyo. Mienzaniso: `Benztropine`, `Trihexyphenidyl`.
Mishonga yezvimwe zviratidzo zvisingabatanidzwi nekufamba
Chirwere cheParkinson hachingokanganisi kufamba chete. Chinogonawo kukonzera mamwe matambudziko, akadai sekuvimbiwa, matambudziko ekurara, kuora mwoyo, uye kusagadzikana pabonde. Chiremba wako achakupa mushonga wechimwe nechimwe cheizvi.
| Chiratidzo | Mhando dzemishonga inogona kunyorerwa |
|---|---|
| Kusashanda zvakanaka kwenhengo dzesikarudzi | Mishonga yakaita seSildenafil (Viagra®) |
| Kurara zvakanyanya masikati (Hypersomnia) | Modafinil (Provigil®) |
| Kuzvimba | Zvinonyorovesa tsvina, zvakaita se polyethylene glycol (MiraLax®) |
| Kuneta | Methylphenidate (Ritalin®) |
| Dementia | Zvinodzivisa Cholinesterase |
| Kuora Mwoyo/Kuzvidya Mwoyo | SSRIs (Selective Serotonin Reuptake Inhibitors) |
| Kufungidzira/Kufungidzira Zvisizvo | Mishonga yekurwisa pfungwa yakaita sepimavanserin |
Ngatidzidzeiwo nezvemigumisiro yemishonga iyi.
Kufanana nemishonga yese, mishonga yeParkinson inogona kuva nemigumisiro yakaipa. Zvakakosha kuziva izvi pachine nguva. Zvisinei, havasi vese vanowana migumisiro iyi yakaipa. Zvakare, mimwe yacho inonyangarika sezvo mushonga wacho uchiramba uchishandiswa.
| Rudzi rwemushonga | Migumisiro yakajairika |
|---|---|
| Levodopa | Kusvotwa, kurutsa, dzungu, musoro, hope masikati, kushaya simba mumuviri. Kuvhiringidzika kwepfungwa uye kuona zvinhu zvisipo zvinogona kuitika kune vakwegura. |
| Vadzvinyiriri veDopamine | Kuona zvinhu zvisipo, kuvhiringidzika mupfungwa, hope, kuda kurutsa, muromo wakaoma, dzungu. Izvi zvinogona kuitika kakawanda mumazuva mashoma ekutanga ekutora mushonga wozodzikira. |
| Zvinodzivirira Enzyme | (COMT inhibitors): manyoka, mafambiro asingadzoreki (dyskinesia). (MAO-B inhibitors): Marwadzo echipfuva, kuda kurutsa, muromo wakaoma, dzungu. |
| Amantadine | Kuomerwa nekuisa pfungwa pachinhu chimwe, kuvhiringidzika mupfungwa, kushaya hope, kurota hope dzakaipa, kuzvimba makumbo. |
| Mishonga yeAnticholinergics | Muromo wakaoma, kuona zvisipo, hope, kuzvimba, kuoma weti, matambudziko ekurangarira. |
Zvakakosha: Usarega kutora Levodopa kana kuderedza mushonga kamwe kamwe usina kurairwa nachiremba wako chero chikonzero chipi zvacho. Kuita izvi kunogona kukonzera chirwere chakakomba, chinotyisidzira hupenyu chinonzi `parkinsonism hyperpyrexia syndrome`.
Mishonga haina kukwana here? Chii chimwe chingaitwe?
Mishonga inongova chikamu chimwe chete chehondo yacho. Kana ukaita zvimwe zvinhu zvishoma pamwe chete nemishonga, unogona kudzora zviratidzo zvako zviri nani uye kuramba uchifara.
Kurapa Kwemuviri
Izvi zvechokwadi zvine chekuita nazvo. Kune mapurogiramu ekurapa muviri akagadzirirwa varwere vane Parkinson's. Izvi zvichakubatsira,
- Unogona kuvandudza kuenzana kwemuviri wako uye kufamba kwako.
- Zvinogona kuwedzera kugadzikana kwemuviri.
- Zvinobatsira zvikuru kuti munhu arambe achirarama hupenyu hune simba.
Kurovedza muviri
Kurovedza muviri ndiyo nzira yakanakisisa yekurapa chirwere cheParkinson. Kurovedza muviri ndicho chinhu chega chakaratidzwa nesainzi kuti chinononotsa kufambira mberi kwechirwere. Zvakanaka kuita kurovedza muviri kwemwoyo kwemaminitsi angangoita 150 pasvondo. Zvinhu zvakaita sekuchovha bhasikoro, bhokisi, uye kurovedza muviri mumimhanzi zvinobatsira zvikuru.
Kutarisira hutano hwepfungwa
Kana uchirarama nechirwere chenguva refu seParkinson's, zvakajairika kunzwa kuora mwoyo, kuzvidya mwoyo, uye kuzvidya mwoyo. Saka, kana uchinzwa seizvi, zvakakosha kuti usanyara nazvo uye kutsvaga rubatsiro kubva kune nyanzvi yehutano hwepfungwa, senge chiremba wepfungwa .
Unofanira kuona chiremba wako zvakare rini?
Kana uchishandisa mushonga weParkinson, zvakakosha kuti ugare uchiona chiremba wako kuti uone kana mushonga wacho uchishanda uye kana zviratidzo zvitsva zvatanga. Iva nechokwadi chekuona chiremba wako kunyanya muzviitiko izvi.
- Kana ukasangana nemigumisiro yausingakwanise kutsungirira .
- Kana zviratidzo zvako zvikasavandudzika kana kuti zvikasawedzera kuipa .
- Kana uchinzwa kuda kurega mushonga wako . (Usambofa wakasarudza izvi wega!)
Mharidzo Yekuenda Nayo Kumba
- Mishonga yechirwere cheParkinson's haigone kurapa chirwere chose, asi inogona kudzora zviratidzo uye kuvandudza hupenyu.
- Levodopa ndiyo mushonga mukuru uye unoshanda zvakanyanya pakurapa izvi.
- Kufanana nemishonga yese, migumisiro inogona kuitika. Taura pachena nachiremba wako nezvazvo.
- Usarega kutora mishonga kana kuchinja mushonga usina kurairwa nachiremba wako chero chikonzero chipi zvacho. Zvinogona kuva nengozi.
- Kuwedzera pakushandisa mishonga, kurovedza muviri uye kurovedza muviri nguva dzose zvakakosha zvikuru mukudzivirira chirwere ichi.
- Chengetedza hutano hwepfungwa dzako panguva iyi. Tsvaga rubatsiro rwenyanzvi kana zvichidikanwa.
💬 Comments (0)
Hapana zvakataurwa parizvino. Isa mhinduro yako pano kekutanga.
Wedzera zvaunofunga