Mwana wako anowanzova nefivha isingatsanangurike here? Izvi zvinogona kunge zvichikonzerwa neSAIDs (Systemic Autoinflammatory Diseases)!

Mwana wako mudiki anowanzova nefivha here? Dzimwe nguva vanowana fivha kamwe chete kana kaviri pamwedzi, asi vanachiremba vanoti hapana hutachiona, kureva kuti, hapana hutachiona kana mabhakitiriya mumuviri. Panguva dzakadai, saamai kana baba, une musoro kunzwa kutya uye kuzvidya mwoyo zvakanyanya. "Sei izvi zvichiitika kumwana wangu?" Pamwe wakafunga kakawanda. Pamwe chikonzero cheizvi chimwe chinhu chausati wambonzwa nezvacho. Nhasi, tichataura nezveSAIDs (Systemic Autoinflammatory Diseases), izvo zvakaoma kunzwisisa uye zvinogona kukonzera fivha kakawanda. Kare, izvi zvainzi `(Periodic Fever Syndromes)` kana `(Recurrent Fever Syndromes)`.

Ndezvipi izvi zvinonzi SAIDs (Systemic Autoinflammatory Diseases)?

Zvichitaurwa zviri nyore, SAIDs iboka rezvirwere zvinokonzerwa nekusashanda zvakanaka kana dambudziko rekudzora muviri wedu. Chinoitika ndechekuti, pasina chikonzero chekunze, kureva hutachiona kana mabhakitiriya, muviri unongogadzira kuzvimba. Ndosaka fivha iyi inowanzouya.

Zvino ungave uchifunga kuti, "Oh, ichi chimwe chezvirwere zveAutoimmune here?" Kwete, izvi zviviri zvakasiyana zvishoma. Semuenzaniso, muzvirwere zveAutoimmune, muzvirwere zvakaita seRheumatoid Arthritis kana Lupus, immune system yemuviri wedu inorwisa masero ayo ane hutano zvisirizvo. Asi muSAIDs, dambudziko riri paimmune system yatinozvarwa nayo.

MaSAID haawanzo kuwanikwa pane zvirwere zveAutoimmune. Kazhinji, izvi zvinoberekwa nenhaka , zvichireva kuti zvinokonzerwa nekuchinja kwemajini kana kuti shanduko yemajini.

MaSAID aya anowanzo (asi kwete nguva dzose) anotanga mwana wako ari mucheche kana mwana mudiki . Mwana achava nezviitiko kana kurwiswa kwechirwere pane dzimwe nguva. Munguva idzi, fivha nezvimwe zviratidzo zvinogona kuoneka. Zvisinei, pakati pe "kurwiswa" uku, mwana anogona kunge asina zviratidzo. Hapana mushonga weSAID, asi kazhinji pane mishonga inoshanda yekudzora zviratidzo.

Ndeapi marudzi makuru eSAIDs?

Vatsvagurudzi vakaona mhando dzeSAIDs dzinosvika makumi matanhatu, uye dzakawanda dziri kuwanikwa. Heano mamwe emhando dzakajairika:

• Fivha yeMediterranean yemhuri (FMF): Iyi ndiyo inonyanya kurwara nefivha inokonzerwa nemajini, uye inogona kukonzera kuzvimba kunorwadza mudumbu, chipfuva, uye majoini emwana.
• Fivha yenguva nenguva, aphthous-stomatitis, pharyngitis, adenitis (PFAPA): Izvi zvinowanzotanga muvana vadiki, kazhinji vasati vasvika makore mana. Zvisinei, mune vamwe vana, chirwere ichi chinogona kupera mushure memakore gumi.
• Chirwere cheTumor necrosis factor receptor-associated periodic fever (TRAPS): Izvi zvinogona kuitika kubva paudiki kusvika pakuyaruka, uye dzimwe nguva kusvika pakukura.
• Kushaikwa kweMevalonate kinase (MKD): Kare kwaizivikanwa seHyper-IgD syndrome, izvi zvinowanzotanga mwana asati asvitsa gore rimwe chete.
• Zvirwere zve autoimmune zvinokonzerwa neNLRP3: Izvi zvaimbonzi Cryopyrin-associated periodic syndromes (CAPS). Kune mamwe marudzi matatu ezvirwere izvi.
• Chirwere cheAdult-onset Still's (AOSD): Sezvinoratidzwa nezita racho, chirwere ichi chinotanga munhu mukuru. Ichirwere chevanhu vakuru chinonzi systemic juvenile idiopathic arthritis (JIA).
• Chirwere chegranulomatous chinokonzerwa neNOD-2 (Blau syndrome): Izvi zvinowanzotangawo mwana asati asvitsa makore mana. Chinonyanya kukanganisa ganda, maziso, uye majoini.

Ndezvipi zviratidzo zveSAIDs?

Zviratidzo zveSAIDs zvinowanzotanga muhudiki. Chiratidzo chikuru uye chinowanzoonekwa ifivha yenguva nenguva kana kuti episodic fivha . Sezvambotaurwa, mwana anogona kunge ari mutano panguva iyo pasina fivha. Zvisinei, kune zvimwe zviratidzo zvakanangana nerudzi rumwe nerumwe rweSAID:

• MuFMF: Dumbu remwana, chipfuva, nemapfundo zvinogona kurwadza zvikuru uye kuzvimba. Dzimwe nguva, panogona kuva nemapundu pamakumbo epasi kana muzviziso.
• MuPFAPA: Huro inorwadza, maronda emuromo, kuzvimba kwemalymph nodes mumutsipa. Izvi ndizvo zviratidzo zvikuru.
• MuTRAPS: Muviri unogona kutonhora uye kupisa muviri. Mwana anogona kurwadziwa netsandanyama mudumbu nemumaoko. Mapundu matsvuku anorwadza anogona kuoneka, ayo anogona kupararira kubva mumaoko kuenda kumakumbo uye ozoenda kumuviri.
• MuMKD: Unogona kusangana nezviratidzo zvakaita sefuruwenza zvakaita sechando, musoro, kurwadziwa mudumbu, kushaya chido chekudya, nezvimwe zviratidzo.
• Muzvirwere zveNLRP3: mapundu eganda, musoro, kusagadzikana, kurwadziwa kwemajoini, uye kuzvimba kwemaziso (conjunctivitis) zvinogona kuitika.
• MuAOSD: mapundu eganda, kurwadziwa kwemajoini, kurwadziwa kwetsandanyama. Vamwe vanhu vanogonawo kunzwa kurwadziwa pahuro, kurwadziwa mudumbu, kuneta, uye kunzwa kushaya simba.
• Muchirwere cheBlau: Mwana anogona kuita maronda paganda pamaoko, makumbo, kana pakati pedumbu. Anogonawo kurwadziwa nemajoini uye kurwadziwa kwemaziso.

Fungidzira, mwanasikana mudiki waNalini anga achirwara nefivha yakanyanya kwemazuva matatu kusvika mana mwedzi wega wega kwemwedzi mishoma yapfuura. Pamwe chete neizvozvo, ari kuitawo maronda madiki mumuromo make nemapundu pamutsipa wake. Paakaratidza kuna chiremba, akati inogona kunge iri PFAPA.

Ndezvipi zvinokonzera SAIDs?

Mazhinji eSAIDs zvirwere zvemajini . Izvi zvinoreva kuti imwe neimwe yesyndromes idzi inokonzerwa nekusiyana kwemajini edu. Heano marudzi akajairika eSAIDs uye majini anokanganisa:

• FMF: Jini rinonzi `(MEFV)`. Jini iri rinorayira kugadzirwa kwepuroteni `(pyrin)`.
• PFAPA: Jini chairo rinokanganisa izvi harisati razivikanwa.
• MISUNGO: Jini rinonzi `(TNFRSF1A)`. Apa ndipo panobva mirairo yekugadzira puroteni `(tumor necrosis factor receptor - TNFR)`.
• MKD: Jini `(MVK)`. Izvi zvinorayira kugadzirwa kwepuroteni inonzi `(mevalonic kinase)`.
• Zvirwere zveNLRP3: Jini rinonzi `(NLRP3)`. Izvi zvinopa mirairo yekugadzira puroteni inonzi `(cryopyrin)`.
• AOSD: Chikonzero chaicho cheizvi hachisati chazivikanwa.
• Blau syndrome: Jini `(NOD2)`. Izvi zvinorayira kugadzirwa kwepuroteni `(NOD2)`.

Ruzivo rwemajini aya rungaita serwakaoma kwauri. Zvichitaurwa zviri nyore, majini aya anokanganisa kugadzirwa kwemapuroteni mamwe anodzora kuzvimba mumiviri yedu. Ndosaka muviri uchigadzira zvirwere zvekuzvimba pasina chikonzero.

Chii chingaitika kana SAIDs dzikasabatwa zvakanaka?

Zvakakosha zvikuru kuwana kurapwa kwakakodzera kweSAID idzi. Nekuti kana kuzvimba mumuviri kukaramba kuripo, chirwere chinonzi `(amyloidosis)` chinogona kuitika. Izvi zvinoreva kuti mhando yeprotein inochengetwa muitsvo dzedu, izvo zvinogona kukonzera kukuvara kweitsvo zvachose . Saka, kana paine zviratidzo, zvakakosha kutsvaga mazano echiremba usingazviregeredze.

Vanachiremba vanoongorora sei SAIDs?

Kuongororwa kweSAIDs kunogona kuoma nekuti zviratidzo zvinogona kufanana nezvezvimwe zvirwere zvakakomba, zvakaita se lupus kana lymphoma. Saka , zvakanaka kuona chiremba we rheumatologist, chiremba ane kudzidziswa kwakakosha muzvirwere zvinozvimba , kuti aongorore uye agadzirise mamiriro emwana wako nemazvo.

Chiremba wemapfupa emwana wenyu achaongorora zvinhu zvakati wandei kuti aongorore SAIDs. Achakubvunzai nezvezviratidzo zvemwana wenyu uye kana paine munhu mumhuri menyu ane nhoroondo yechirwere chedzihwa chinowanzoitika. Chiremba anogona kufungidzira dambudziko iri kana:

• Kana mwana achigara achirwara nefivha .
• Kana paine munhu mumhuri ane nhoroondo yefivha inowanzo itika .
• Kana mwana ari werudzi rwemumwe munhu, ndiye anogona kunyanya kusangana nefivha yakadaro.

Miedzo ipi inoshandiswa?

Kuti vasimbise chirwere ichi, chiremba wemapfupa emwana wenyu anogona kukurudzira bvunzo dzinoverengeka. Dzimwe dzacho dzinosanganisira:

• Kuongororwa kweropa murabhoritari: Kuongororwa kweropa kwakadai se `(C-reactive protein - CRP)` uye `(Complete blood count - CBC)` kunogona kutarisa kuzvimba mumuviri. Kuongororwa uku kunova `(positive)` kana uine fivha uye kunodzokera kune zvakajairika kana fivha yapera.
• Kuongororwa kweweti: Weti inoongororwa kuti ine mapuroteni akawanda here. Kana paine MKD, weti inoongororwawo kuti ine organic acid yakawanda inonzi ``mevalonic acid''.
• Kuongororwa kwemajini: Kuongororwa kwemajini kunogona kutarisa majini akasiyana ataurwa pamusoro apa. Zvisinei, vamwe vana vane SAIDs vanogona kunge vasina majini akasiyana akawanikwa, saka mhinduro dzebvunzo dzinogona kunge dzisina kunaka.

Ndeapi marapirwo eSAIDs?

Kurapwa kweSAIDs kunoenderana nerudzi uye kuoma kwechirwere . Hapana mushonga wezvirwere izvi, asi mishonga inogona kubatsira kudzora zviratidzo zvemwana wako . Kana mwana wako achingobatwa nechirwere kashoma pagore, unogona kugadzirisa zviratidzo nemishonga inoderedza marwadzo uye mishonga isingarwisi kuputika (NSAIDs). Zvisinei, kana chirwere chacho chakanyanya kuoma, chiremba wako anogona kukurudzira mamwe marapirwo:

• FMF: Izvi zvinogona kurapwa nemushonga unonzi `(Colchicine)` kuderedza kuzvimba. Kana `(Colchicine)` isingapihwe mwana, unogona kuedza mushonga we`(biologic)` unonzi `(Canakinumab)`.
• PFAPA: Mishonga inorwisa maronda yakaita seprednisone inogona kupfupisa nguva yekurwiswa kwePFAPA. Cimetidine, mushonga unopiwa vamwe vana wemaronda emudumbu, unogona kubatsirawo kuderedza zviratidzo.
• TRAPS: Mushonga wekuti `(Canakinumab)` unoshanda zvikuru paTRAPS. Zvakare, zviratidzo zvinogona kudzorwa nemishonga inorwisa kuzvimba yakaita se`(glucocorticoids)` yakanyorerwa nachiremba.
• MKD: `(Canakinumab)` mushonga unoshandawo weMKD. `(NSAIDs)` kana `(steroids)` zvinogona kubatsira panguva yekurwiswa.
• Zvirwere zveNLRP3: Mishonga inogadzirisa muviri yakaita seCanakinumab, Rilonacept, uye Anakinra yakashandiswa zvinobudirira kurapa zvirwere zvine chekuita neNLRP3.
• AOSD: Mishonga yakasiyana-siyana yekudzivirira kuzvimba yakaita semasteroid, mishonga inogadzirisa zvirwere inorwisa rheumatic (DMARDs), uye biologics inoshandiswa kurapa AOSD.
• Blau syndrome: Zvichienderana nezviratidzo zvemwana, mishonga inodzvinyirira immune, tumor necrosis factor (TNF) inhibitors, uye/kana mishonga yemaziso inogona kuyedzwa.

Kuverenga nezvemishonga iyi kunogona kuita kuti utye zvishoma. Asi yeuka kuti mishonga iyi yese inopihwa pasi pekutarisirwa kwakasimba kwachiremba, nenzira yakakodzera mwana. Saka, zvakakosha kutevedzera kurapwa sezvataurwa nachiremba.

Ko mamiriro eSAIDs ari kupera here?

Mamwe maSAID chirwere chehupenyu hwese . Mamwe anogona kugara kwemakore mashoma uye anopera nekukura . Mamwe matambudziko ndeehupenyu hwese, asi nekufamba kwenguva, kuwanda kwekurwiswa kunogona kudzikira uye zviratidzo zvinogona kudzikira. Chiremba wako achakutsanangurira zvakananga nezvechirwere chemwana wako.

Kuchengeta mwana ane SAID kunogona kuoma. Kana wakambozviitira SAID, unogona kushandisa ruzivo rwako kubatsira pakuchengeta mwana wako. Kunzwisisa kwako kwakakoshawo pakubatsira mwana wako kurarama nechirwere ichi chehupenyu hwese.

Chinhu chinonyanya kukosha ndechekutsvaga kurapwa kubva kuna vanachiremba vane ruzivo nezveSAIDs. Vanogona kubatsira kudzora zviratidzo zvemwana wako uye kumubatsira kuti ave nehudiki hwakanaka.

Zvinhu zvakakosha zvekurangarira (Mharidzo Yekuenda Kumba)

Zvakanaka, ngatidzokororei zvimwe zvezvinhu zvakakosha zvaunofanira kuyeuka kubva pane zvatataura nezvazvo:

• Kana mwana wako achigara achirwara nefivha, zvisingatsananguriki , zvinogona kuva chiratidzo cheSAID.
• MaSAID haakonzerwi nehutachiona , asi idambudziko rine masoja emuviri.
• Izvi zvirwere zvisingawanzoitiki zvinowanzokonzerwa nezvikonzero zvemajini .
• Zviratidzo zvinogona kusiyana zvichienderana nerudzi rweSAID, asi fivha yenguva dzose ndiyo chiratidzo chikuru .
• Zvakakosha kuona chiremba weRheumatologist kuti aonekwe uye arapwe nemazvo.
• Kunyange hazvo kurapwa kusingakwanise kurapa chirwere chose, zviratidzo zvacho zvinogona kudzorwa zvakanaka .
• Usafuratira zviratidzo, nekuti zvinogona kukonzera kukuvara kweitsvo kana zvikasarapwa.

Kana muine mimwe mibvunzo nezvenyaya iyi, musazeza kutaura nachiremba wemhuri yenyu kana chiremba wemapfupa. Vachakwanisa kukubatsirai zvakanyanya.

SAIDs , zvirwere zvefivha zvinogara zvichiitika, fivha inodzokororwa, zvirwere zvinozvimba, fivha, fivha muvana, zvirwere zvemajini