Masifumanise ngenqanaba lakho le-CK. Yintoni le Creatine Kinase (CK)?

Ngamanye amaxesha xa usiya kugqirha, ukucela ukuba wenze uvavanyo lwegazi, akunjalo? Olunye lwazo lolu vavanyo lubizwa ngokuba yi-CK. Ngoko ke, xa abantu abaninzi besiva oku, umbuzo omncinci ufika engqondweni, "Yintoni le CK?" "Kutheni le ihlolwa?" Ungakhathazeki, namhlanje siza kuthetha ngale CK, emele iCreatine Kinase, ngendlela elula onokuyiqonda.

Yintoni i-creatine kinase (CK)?

Ngamafutshane, i-CK yi -enzyme . I-enzyme luhlobo lweproteni ekhawulezisayo kwaye inceda kwiimpendulo ezahlukeneyo zamakhemikhali emizimbeni yethu. Le enzyme ye-CK ifumaneka ikakhulu kwimisipha yentliziyo yakho (oko kukuthi, imisipha esentliziyweni yakho), imisipha enamathele emathanjeni akho (esiyibiza ngokuba yi-'skeletal muscles', oko kukuthi, imisipha ekuncedayo ukuhambisa amalungu akho nokuhamba), kwaye inani elincinci kakhulu lisebuchotsheni .

Ngoko ke, ukuba kukho nawuphi na umonakalo kwezi seli zemisipha, oko kukuthi, izihlunu zentliziyo, izihlunu zamathambo, okanye iiseli zobuchopho, ezo seli ziyaqhekeka kwaye umxholo uphuma. Kulapho ke le enzyme ye-CK ikhutshwa khona egazini. Ngokwesiqhelo, inani elincinci kakhulu le-CK egazini lethu livela kwezo zihlunu zamathambo.

Khawuthelekelele ukuba ubuzilolonge kakhulu. Emva koko izihlunu zakho zinokonakala kancinci. Ngamaxesha anjalo, amanqanaba e-CK anokunyuka egazini. Kwakhona, ukuba kukho izifo zemisipha (`Myopathies`), umzekelo, abantu abanezifo ezifana ne-`Muscular Dystrophy` nabo banamanqanaba aphezulu e-CK.

Ngaba kukho iintlobo zee-enzymes ze-CK?

Ewe, kukho iintlobo ezintathu eziphambili zale enzyme ye-CK. Njengabantwana bosapho olunye, uhlobo ngalunye lufumaneka kwiindawo ezahlukeneyo zomzimba wethu:

• CK-MM: Olu hlobo lufumaneka kakhulu kwimisipha yakho yamathambo .
• I-CK-MB: Oku kufumaneka kakhulu kwimisipha yentliziyo yakho.
• CK-BB: Olu hlobo lufumaneka kakhulu kwizicubu zobuchopho .

Kubalulekile ukwazi ezi ntlobo, kuba xa amanqanaba e-CK enyuka, ngokujonga ukuba loluphi uhlobo lwe-CK olunyukileyo, ungafumana umbono ocacileyo wokuba umonakalo wenzeke phi emzimbeni.

Ngoko ke, yintoni uvavanyo lwe-creatine kinase (CK)?

Uvavanyo lwe-creatine kinase (CK) lulinganisa ubungakanani be-CK egazini lakho . Olu vavanyo lunokubonisa ukuba inqanaba le-CK yakho liphezulu kunesiqhelo. Ukuba kunjalo, lunokubonisa ukuba kukho umonakalo okanye ingxaki ethile kwimisipha yakho yamathambo, intliziyo, okanye ingqondo. Lo monakalo unokuba ngowexesha elifutshane (obukhali) okanye owexesha elide (ongapheliyo).

Olu vavanyo lwe-CK lukwabizwa ngokuba:

• Ixabiso lilonke le-CK
• I-CK creatine
• I-Phosphokinase CPK

Yintoni umsebenzi we-enzyme ye-creatine kinase (CK)?

Nantsi into ebalulekileyo. Akukho nxibelelwano lungako phakathi komsebenzi oqhelekileyo we-enzyme ye-CK kunye noko ikutshoyo xa inqanaba le-CK liphezulu egazini. Umsebenzi wokwenyani we-enzyme ye-CK kukongeza iqela le-phosphate kwi-substance ebizwa ngokuba yi-creatine ngaphakathi kweeseli zethu zemisipha. I-Creatine yinto enceda izihlunu zivelise amandla. Ngoko ke, xa i-enzyme ye-CK yongeza i-phosphate kule creatine, iba yimolekyuli enamandla aphezulu ebizwa ngokuba yi-phosphocreatine . Imizimba yethu isebenzisa le phosphocreatine ukuvelisa amandla.

Ngoko ke, ukuba izihlunu zakho, intliziyo, okanye ubuchopho bakho zonakele, ezo seli ziyaqhekeka. Emva koko i-enzyme ye-CK engaphakathi kwezo seli, kunye nezinye izinto, ikhutshwa egazini. Yiyo loo ndlela inqanaba le-CK egazini liyanda ngayo. Oko kuthetha ukuba inqanaba le-CK liyakhula, kungengenxa yokusebenza kwayo okuqhelekileyo, kodwa ngenxa yokuba iiseli zonakele kwaye i-CK ivuza egazini.

Zisetyenziselwa ntoni iimvavanyo ze-CK?

Oogqirha badla ngokusebenzisa uvavanyo lwe-CK ukuxilonga nokujonga iingxaki zemisipha . Oko kuthetha ukuba:

• Izifo zemisipha (`Izifo zemisipha` / `Ii-Myopathies`): Imizekelo yezi zinto zezi:
• I-Duchenne muscular dystrophy (DMD): Esi sisifo esingaqhelekanga, esizuzwe njengelifa esibangela ukuba izihlunu zamathambo zibe buthathaka, ziqhekeke, kwaye zingasebenzi kakuhle. Sidla ngokuchaphazela abafana.
• I-Rhabdomyolysis: Le yimeko apho izihlunu zemisipha ziqhekeka ngokukhawuleza. Oku kunokubangelwa kukwenzakala okukhulu, isifo semisipha, okanye enye imeko.
• Ukulimala kwemisipha: Oku kungaba:
• Ukuxinezeleka kwemisipha, ukuxinezeleka, ukukrazuka, okanye ukutsalwa ngenxa yengozi okanye umthambo ogqithisileyo.
• Ukutsha kwenqanaba lesithathu.
• Umothuko wombane.
• Ukudumba kwemisipha (Myositis): Imizekelo yoku ibandakanya:
• I-Polymyositis: Esi sisifo sokudumba esibuthathaka izihlunu. Sidla ngokuchaphazela izihlunu ezikufutshane nomzimba.
• I-Dermatyositis: Le yimeko engaqhelekanga ebangela ubuthathaka bemisipha kunye nokonakala kolusu.
• I-Pyomyositis: Olu lusulelo olungaqhelekanga lwezihlunu olubangelwa yintsholongwane. Ngokuqhelekileyo kuvela ithumba.

Ngenxa yokuba iimpawu zemisipha ngamanye amaxesha zinokuba ziimpawu zezinye iimeko ezininzi, ugqirha wakho unokuyalela ezinye iimvavanyo ezininzi kunye novavanyo lwe-CK. Umzekelo:

• Ii-electrolyte
• I-BUN (i-nitrogen ye-urea egazini)
• I-Creatinine
• I-Myoglobin kumchamo

Uvavanyo lwe-CK kunye nokusilela kwentliziyo

Ngaphambili, uvavanyo lwe-CK lwalusetyenziselwa ukuxilonga isifo sentliziyo. Kodwa ngoku alwenziwa rhoqo. Kuba ngoku kusetyenziswa iTroponin.Kukho olunye uvavanyo olubizwa ngokuba yi-troponin, olungcono kune-CK ekufumaneni umonakalo wentliziyo. Yiyo loo nto ngoku, uninzi lwexesha, ukuba kurhanelwa ukuba kukho isifo sentliziyo, i-troponin luvavanyo olujongwayo.

Kutheni ndifuna uvavanyo lwe-CK?

Ukuba uneempawu zokuphazamiseka kwemisipha, ugqirha wakho unokuyalela uvavanyo lwe-CK. Ezi mpawu ziquka:

• Intlungu yemisipha kunye/okanye ukuqina kwayo.
• Ubuthathaka bemisipha.
• Iingxaki ngokulinganisela komzimba.
• Ukungaziva mnandi okanye ukurhawuzelelwa.
• Umchamo onombala omnyama (njengomthubi).

Kwakhona, ukuba ukhe wenzakala kwimisipha okanye wahlaselwa sistroke, unokufuna ukuba olu vavanyo lwenziwe ngelo xesha. Kwezinye iingozi, kungathatha ukuya kuthi ga kwiintsuku ezimbini ukuba amanqanaba e-CK afikelele kwinqanaba eliphezulu. Ngoko ke unokufuna ukuba olu vavanyo lwenziwe izihlandlo ezingaphezu kwesinye.

Ngubani owenza uvavanyo lwe-CK?

Ngokwesiqhelo, isampuli yegazi, oko kukuthi, isampuli yegazi yovavanyo lwe-CK, ithathwa ngumsebenzi wezempilo obizwa ngokuba yi-phlebotomist . Nangona kunjalo, nawuphi na umsebenzi wezempilo oqeqeshwe ukuthatha igazi angakwenza oku. Isampuli yegazi emva koko ithunyelwa kwilabhoratri. Apho, isazinzulu selabhoratri yezonyango silungiselela isampuli kwaye siyivavanye ngee -analyzers .

Ndilungiselela njani uvavanyo lwe-CK?

Kwiimeko ezininzi, akukho nto kufuneka uyenze ukuze ulungiselele ngokukodwa uvavanyo lwegazi lwe-CK.

Nangona kunjalo, ukuba ugqirha wakho uyalela olu vavanyo lwe-CK ukuze ajonge naziphi na iingxaki zemisipha, kufuneka unciphise umthambo wakho onzima kwiintsuku ezikhokelela kuvavanyo. Oku kungenxa yokuba umthambo unokubangela uxinzelelo lwemisipha okwethutyana, olunokunyusa amanqanaba e-CK egazini. Ngoko ke, yenza nje imisebenzi yakho eqhelekileyo.

Yintoni omawuyilindele xa usenza uvavanyo lwegazi lwe-CK?

Nantsi into eyenzekayo xa unikela ngegazi:

1. Uza kuhlala esitulweni. Umsebenzi wezempilo uza kufumana umthambo olula engalweni yakho ukuze atsale igazi kuwo. Amaxesha amaninzi, kukhethwa umthambo ngaphakathi engalweni yakho, kwicala elichasene nengqiniba yakho.

2. Nje ukuba umthambo ufunyenwe, indawo iyacocwa kwaye kufakwe isibulali-ntsholongwane.

3. Emva koko, kufakwa inaliti encinci kuloo mthambo kwaye kuthathwa isampuli yegazi. Ngeli xesha, ungaziva ngathi ulunywe yimbovane encinci.

4. Emva kokufaka inaliti, igazi elincinci liya kuqokelelwa kwityhubhu yovavanyo.

5. Emva kokuba isampuli yegazi ithathiwe, inaliti iyasuswa kwaye isiqwenga sekotoni okanye i-gauze sibekwe kwindawo leyo kwaye sifakwe uxinzelelo ukuze kumiswe ukopha.

6. Emva koko kufakwa iplasta kuloo ndawo. Yiyo leyo.

Lonke eli xesha lithatha ngaphantsi kwemizuzu emihlanu.

Kwenzeka ntoni emva kovavanyo lwe-CK?

Emva kokuba isampuli yegazi lakho ithathiwe, lithunyelwa kwilebhu. Nje ukuba iziphumo zovavanyo zifike, ugqirha wakho uza kukwazisa iziphumo.

Ngaba kukho naziphi na iingozi zovavanyo lwegazi lwe-CK?

Uvavanyo lwegazi luvavanyo oluqhelekileyo noluyimfuneko kwezonyango. Akukho mingcipheko mikhulu yokunikela ngegazi. Usenokuziva uqaqanjelwa okanye utyumkile kancinci apho igazi litsalwe khona. Kodwa oko kuya kukhawuleza kulunge.

Ndiza kuzazi nini iziphumo zovavanyo lwe-CK?

Uninzi lwexesha, kufuneka ufumane iziphumo zovavanyo lwakho lwe-CK kungekapheli usuku okanye ezimbini , kodwa ngamanye amaxesha kungathatha ixesha elide.

Zisixelela ntoni iziphumo zovavanyo lwe-CK?

Ingxelo yovavanyo lwegazi, oko kukuthi, ingxelo yovavanyo lwe-CK, idla ngokuba nolwazi olulandelayo:

• Igama lovavanyo lwegazi, okanye oko kwalinganiswa egazini lakho.
• Inani okanye umlinganiselo weziphumo zovavanyo lwakho lwegazi.
• Uluhlu oluqhelekileyo lokulinganisa olo vavanyo.
• Ulwazi olufana nokuba iziphumo zakho ziqhelekile, aziqhelekanga, ziphezulu, ziphantsi, zilungile, okanye zimbi.

Zithini ii-creatine kinase (CK) eziqhelekileyo?

Inqanaba eliqhelekileyo le-CK kumntu omdala osempilweni linokwahluka ngokuxhomekeke kwizinto ezininzi:

• Isini sakho.
• Uhlanga lwakho.
• Inqanaba lomsebenzi wakho (oko kukuthi, ubungakanani bomthambo kunye nokuzivocavoca umzimba okwenzayo).

Kwakhona, la manqanaba aqhelekileyo anokwahluka ngokuxhomekeke kwiindlela zovavanyo ezisetyenziswa yilabhoratri nganye. Ngoko ke, soloko ujonga uluhlu lwesalathiso olunikiweyo kwingxelo yakho yelabhoratri. Ngokomndilili, amadoda anamanqanaba e-CK aphezulu kancinci kunabafazi.

Abantu abanezihlunu eziphezulu (oko kukuthi, abo banamafutha amaninzi emzimbeni) banokuba namanqanaba aphezulu e-CK kunabanye.

Kuthetha ukuthini ukuba ne-creatine kinase ephezulu (CK) level?

Ukuba inqanaba lakho le-CK liphezulu, okanye ukuba inqanaba lakho le-CK lihlala liphezulu kwiimvavanyo ze-CK eziphindaphindwayo, oko kuthetha ukuba kutshanje ukhe wahlangabezana nomonakalo othile kwimisipha. Nangona kunjalo, uvavanyo lwe-CK lodwa alunakuxelela ngqo ukuba loluphi uhlobo lwemisipha eyonakeleyo, okanye yintoni ebangele umonakalo.

Kubalulekile: Musa ukoyika ukuba inqanaba lakho le-CK liphezulu. Ugqirha wakho unokufuna ukwenza uvavanyo oluthe kratya ukuze afumane unobangela.

Oogqirha badla ngokwenza uthotho lweemvavanyo ze-CK ukuze babone ukuba amanqanaba e-CK yakho atshintsha njani. Ukuba amanqanaba e-CK yakho aphezulu aze anciphe kancinci kancinci, oko kuthetha ukuba umonakalo wemisipha yakho uyehla. Kodwa ukuba amanqanaba e-CK yakho ayaqhubeka nokunyuka, okanye ahlale ephezulu, oko kunokubonisa ukuba ufumana umonakalo wemisipha oqhubekayo okanye ukuwohloka kwemisipha.

Ukuba iziphumo zakho zibonisa ukuba amanqanaba akho e-CK aphezulu kunesiqhelo, ugqirha wakho unokuyalela uvavanyo lweentlobo zee-enzymes ze-CK endizikhankanyileyo ngaphambili (CK-MM, CK-MB, CK-BB) ukunceda ekufumaneni uhlobo lwemisipha eyonakeleyo:

• Ii-enzymes ze-CK-MM: Ukuba la manqanaba aphezulu, oko kunokubonisa ukwenzakala kwemisipha okanye isifo semisipha, umzekelo, imeko efana ne-muscular dystrophy okanye i-rhabdomyolysis.
• I-enzyme ye-CK-MB:Ukuba la manqanaba aphezulu, oko kungabonisa ukuba une-inflammation kwimisipha yentliziyo yakho, okanye ukuba unesifo sentliziyo okanye kutshanje ukhe waba naso.
• Ii-enzymes ze-CK-BB: Ukuba la manqanaba aphezulu, oko kunokubonisa ukuba ukhe wahlaselwa sistroke okanye wenzakala engqondweni.

Ezinye izizathu zokuba amanqanaba e-creatine kinase (CK) anokunyuka

Ezinye iimeko zempilo kunye nokwenzakala okungahambelani ngqo nezihlunu zakho kunokubangela amanqanaba aphezulu e-CK. Nazi ezinye zezizathu:

• Izifo ze-endocrine, ezifana nesifo se-thyroid, isifo sika-Addison, okanye isifo sika-Cushing.
• Utyando lwexesha elide.
• Ukuxhuzula.
• Iintsholongwane (ezibangelwa yintsholongwane, iintsholongwane, imingxunya okanye iincukuthu).
• Izifo zezicubu ezidityanisiweyo, umzekelo, i-lupus kunye ne-rheumatoid arthritis.
• Isifo seCeliac.
• Ukungasebenzi kakuhle kwezintso.
• Umkhuhlane ophezulu kunye nokungcangcazela.
• Ihlwili legazi.
• Nasiphi na isiyobisi okanye ityhefu ephazamisa ukuveliswa kwamandla emisipha okanye eyonyusa iimfuno zamandla.
• Xa ufaka inaliti.

Ngaba kufuneka ndikhathazeke ukuba inqanaba lam le-creatine kinase (CK) liphezulu kunesiqhelo?

Nokuba iziphumo zovavanyo lwakho lwe-CK zibonisa ukuba inqanaba lakho le-CK liphezulu, akuthethi ukuba unesifo esithile. Inqanaba lakho le-CK linokunyuka okwethutyana ngenxa yezizathu ezininzi, ezinje ngokuzilolonga, ukuthatha amayeza athile, okanye ukufumana inaliti. Kusenokwenzeka ukuba kukho into engahambanga kakuhle ngexesha lovavanyo.

Xa esenza isigqibo malunga neziphumo zakho, ugqirha wakho uya kuqwalasela izinto ezininzi, ezifana namayeza owasebenzisayo ngoku, indlela ophila ngayo, kunye neempawu zakho. Uza kukuxelela ukuba ngaba udinga olunye uvavanyo.

Ukuba unemibuzo malunga neziphumo zakho, ungoyiki ukuthetha nogqirha wakho.

Ndifanele ndimbone nini ugqirha?

Iintlungu zemisipha kunye nobuthathaka zihlala zizinto zexeshana. Kodwa ukuba uneengxaki zemisipha eziqhubekayo , thetha nogqirha wakho malunga neempawu zakho. Uza kuyalela uvavanyo lwe-CK kunye nezinye iimvavanyo ukuze azame ukufumana unobangela weempawu zakho.

Kuqhelekile ukuba noloyiko xa ubona iziphumo zovavanyo ezingaqhelekanga. Kodwa khumbula, inqanaba eliphezulu le-CK akuthethi ukuba unesifo esinzima kwaye udinga unyango. Ugqirha wakho uza kukuxelela ukuba ufuna iimvavanyo ezingaphezulu ukuze kufunyanwe unobangela wenqanaba elingaqhelekanga. Ungoyiki ukubuza ugqirha wakho imibuzo. Bakho ukuze bakuncede.

Izinto ekufuneka uzikhumbule kweli nqaku (Umyalezo Wokuya Ekhaya)

Kulungile, ngoko ke sithethe kakhulu nge-CK namhlanje, akunjalo? Nazi izinto ezimbalwa ekufuneka uzikhumbule ngokufutshane:

• I-CK yi-enzyme eqokelelana egazini xa kukho umonakalo kwimisipha, intliziyo, okanye ingqondo.
• Uvavanyo lwe-CK lulinganisa inqanaba le-CK egazini. Ukuba liphezulu, lisenokubonisa umonakalo kwizihlunu.
• Zininzi izizathu zokuba i-CK ikhule. Ingabangelwa zizinto ezifana nokuzilolonga, amayeza athile, kunye nokwenzakala.
• Awunakuqiniseka ngesifo ngokujonga nje inqanaba lakho le-CK. Ugqirha wakho uza kwenza isigqibo ngokusekelwe kwezinye iimpawu zakho kunye nezinye iziphumo zovavanyo.
• Ukuba unemibuzo malunga nengxelo yakho ye-CK, ungoyiki ukubuza ugqirha wakho.

Ngoko ke, ndiyathemba ukuba olu lwazi luluncedo kuwe. Hlala usempilweni!

I- Creatine Kinase, Uvavanyo lwe-CK, Intlungu Yemisipha, Isifo Semisipha, Ii-Enzymes, Uvavanyo Lwegazi, Impilo