Xa wena okanye umntu omthandayo enikwa iyeza elitsha lokunyanga umhlaza, kuyinto eqhelekileyo ukuba novalo kwaye ube nomdla. Ingakumbi xa usiva igama elifana ne-Acalabrutinib, usenokuba uzibuza, "Luhlobo luni lweyeza eli? Kwenzeka ntoni kulo ?" Ungakhathazeki. Yiloo nto kanye esithetha ngayo kweli nqaku. Siza kuthetha ngale chiza ngendlela elula onokuyiqonda.
Luhlobo luni lonyango i-Acalabrutinib?
Ngamafutshane, i-Acalabrutinib liyeza elisetyenziselwa ukunyanga iintlobo ezithile zomhlaza, ingakumbi i-leukemia kunye ne-lymphoma. Kwilizwe lethu, eli yeza lifumaneka phantsi kwegama le-CALQUENCE.
Oku akufani namayeza omhlaza emveli. Oku kusebenza "njengonyango olujoliswe kulo." Oko kukuthi, eli yeza lijolise ngqo kwiproteni ethile enceda iiseli zomhlaza zikhule kwaye zisasazeke. Xa le proteni iyeka ukusebenza, amandla okukhula kweeseli zomhlaza ayancitshiswa, okanye zife ngokupheleleyo. Ngale ndlela, eli yeza linceda ukulawula umhlaza.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale amayeza
Ngaphambi kokuba uqale i-acalabrutinib, kubaluleke kakhulu ukunika ugqirha wakho inkcazo epheleleyo ngempilo yakho. Qiniseka ukuba uxelele ugqirha wakho ukuba unenye yezi meko zilandelayo:
- Ukuba unesifo sokopha (umz., iingxaki zokujiya kwegazi).
- Ukuba usandul’ utyando okanye uceba ukulutyanda kwixesha elizayo.
- Ukuba unesifo sentliziyo , uxinzelelo lwegazi oluphezulu , okanye ukubetha kwentliziyo okungaqhelekanga.
- Ukuba kukho usulelo olukhoyo.
- Ukuba unesifo sesibindi .
- Ukuba uthatha amayeza okunciphisa igazi ukuthintela okanye ukunyanga amahlwili egazi.
- Ukuba une -allergies kwi-acalabrutinib okanye naliphi na elinye iyeza, ukutya, okanye idayi.
- Ukuba ukhulelwe , uzama ukukhulelwa , okanye uncancisa .
Ngokunika ugqirha wakho olu lwazi ngokuchanekileyo, uya kukwazi ukukunyanga ngokukhuselekileyo nangendlela efanelekileyo.
Ndingayisebenzisa njani le yeza?
Kubaluleke kakhulu ukulandela imiyalelo echanekileyo yokusebenzisa eli yeza.
- Ginya le kapsule yonke ngeglasi yamanzi .
- Ungaze uyiqhekeze, uyityumze, okanye uyihlafune le kapsuli. Yiginye yonke.
- Ukuba ufumana iziphumo ebezingalindelekanga, ugqirha wakho angakucela ukuba utshintshe idosi yamayeza okanye uyeke ukuwasebenzisa okwethutyana. Musa ukuyeka ukuwasebenzisa amayeza okanye ukutshintsha idosi nangasiphi na isizathu ngaphandle kwengcebiso kagqirha wakho.
- Musa ukuthatha eli yeza kunye nejusi yegrapefruit.
- Ukuba usela amayeza esisu (i-antacids okanye i-H2-blockers), yisele iiyure ezi-2 ngaphambi okanye emva kokuthatha i-Acalabrutinib.
Kuthekani ukuba ngempazamo ndithathe amayeza amaninzi kakhulu?
Ukuba ucinga ukuba uthathe amayeza amaninzi kunokuba ucinga, ungoyiki kwaye ngoko nangoko fowunela iZiko loLwazi lweeTyhefu leSizwe kwiSibhedlele sikaZwelonke saseColombo . Okanye, yiya kwiYunithi yoNyango oluNgxamisekileyo (i-ETU) yesibhedlele esikufutshane.
Kuthekani ukuba ndiphoswa lidosi leyeza?
Ukuba uphoswe yidosi, yithathe ngokukhawuleza xa ukhumbula. Nangona kunjalo, ukuba idlule iiyure ezingaphezu kwe-3 emva kwexesha , yitsibe idosi oyiphosileyo. Thatha idosi yakho elandelayo ngexesha elicwangcisiweyo. Musa ukuthatha iidosi ezimbini ngaxeshanye.
Ezinye izinto ezinokusebenzisana nale mithi (Intsebenziswano)
I-Acalabrutinib inokunxibelelana namanye amayeza, iivithamini, okanye iimveliso zezityalo osenokuba uzithatha. Ngoko ke xelela ugqirha wakho malunga nawo onke amayeza, iivithamini, kunye nezongezo ozithathayo. Nazi ezinye zezinto ezinokubangela iingxaki.
| Yintoni enokubangela iingxaki? | Inkcazo kunye nemizekelo |
|---|---|
| Amayeza okunciphisa i-asidi yesisu | Amayeza afana neCimetidine, iFamotidine, iOmeprazole, iLansoprazole. Iiantacids. |
| Amanye amayeza okubulala iintsholongwane | Amayeza afana neClarithromycin kunye neRifampin. |
| Izinto ezilwa nokungunda | Amachiza afana neKetoconazole, iItraconazole, iFluconazole. |
| Amayeza okunyanga isifo sokuwa | Iziyobisi ezifana neCarbamazepine kunye nePhenytoin. |
| Iimveliso zezityalo | Iimveliso ezifana neSt. John's Wort. |
| Ukutya neziselo | Ijusi yegrapefruit. |
Iziphumo ebezingalindelekanga ezinokubakho xa uthatha iyeza
Njengalo naliphi na iyeza, i-Acalabrutinib inokubangela iziphumo ebezingalindelekanga. Ezinye zincinci, ngelixa ezinye zifuna ingqalelo ekhawulezileyo.
| Imiphumela | Iimpawu |
|---|---|
| Izinto ekufuneka uzixelele ugqirha wakho ngoko nangoko | |
| Iimpendulo ze-allergy | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi okanye umqala. |
| Ukopha okungaqhelekanga | Indle emnyama okanye enegazi, ukuhlanza okufana nekofu egayiweyo, umchamo obomvu okanye omdaka, amabala amancinci abomvu okanye amfusa eluswini, kunye nokudumba okungaqhelekanga. |
| Utshintsho kwisantya sentliziyo | Ukuziva ngathi intliziyo yakho ibetha ngokukhawuleza okanye ngokungacwangciswanga, isiyezi, iintlungu zesifuba, ubunzima bokuphefumla. |
| Iintsholongwane | Umkhuhlane, ukubanda, ukukhohlela, umphimbo obuhlungu, amanxeba angapholiyo, iintlungu xa uchama. |
| I-anemia | Ukuziva udiniwe okanye ubuthathaka ngendlela engaqhelekanga, isiyezi, intloko ebuhlungu, ubunzima bokuphefumla. |
| Xelela ugqirha wakho ukuba iyaqhubeka okanye iyakukhathaza. | |
| Ezinye iingxaki eziqhelekileyo | Urhudo, intloko ebuhlungu, ukudinwa, iintlungu zemisipha, isicaphucaphu. |
Izinto ekufuneka ziqwalaselwe ngakumbi ngexesha lonyango
Impilo yamazinyo
Ngaphambi kokuba uqale ukusebenzisa eli yeza, kungcono ukubona ugqirha wamazinyo uze uhlole amazinyo akho. Ugqirha wakho unokukucebisa ukuba uphephe utyando olukhulu lwamazinyo ngexesha lonyango. Kwakhona, gcina amazinyo akho ecocekile.
Ukukhuselwa lilanga
Abanye abantu banokuba nomngcipheko okhulayo wokuba nezinye iintlobo zomhlaza (ingakumbi umhlaza wolusu) ngelixa besebenzisa eli yeza. Ngoko ke, nxiba impahla egquma kakuhle kwaye usebenzise isithambisi selanga xa uphuma elangeni.
Ukukhulelwa kunye nokuncancisa
Oku kubaluleke kakhulu: Kuphephe ukukhulelwa ngelixa usela eli yeza kwaye ubuncinane iveki emva kokuyeka eli yeza. Eli yeza linokubangela ingozi enkulu kusana olungekazalwa. Kwakhona, kuphephe ukuncancisa xa usela eli yeza kwaye iveki ezimbini emva kokuyeka eli yeza.
Umyalezo Wokuya Ekhaya
- Soloko uginya i-acalabrutinib capsule yonke. Musa ukuyiqhekeza, ukuyityumza, okanye ukuyihlafuna.
- Xelela ugqirha wakho ngazo zonke ezinye iziyobisi, iivithamini, kunye nezongezo ozithathayo.
- Musa ukusela ijusi yegrapefruit kunye negrapefruit ngelixa usebenzisa eli yeza.
- Ukuba ubona ukopha okungaqhelekanga, ukukrweleka, okanye iimpawu zosulelo (umkhuhlane, ukubanda), xelela ugqirha wakho ngoko nangoko.
- Kuphephe ukusela eli yeza ngexesha lokukhulelwa okanye xa uncancisa. Thetha nogqirha wakho ngalo mba.
- Ungaze uyeke ukuthatha amayeza okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha wakho.
👩🏽⚕️ Imibuzo eyongezelelweyo (Ii-FAQ)
💬 Iikhaphu zeAcalabrutinib (Calquence) ziziyobisi ezibiza kakhulu ezisetyenziselwa ukunyanga isifo esinjani?
Le ayisiyo pilisi iqhelekileyo! Eli liyeza lomhlaza elisebenza kakuhle nelinamandla (iBruton Tyrosine Kinase - BTK Inhibitor) elifunyenwe kutshanje kwizigulane ezinomhlaza ezifana ne-'Mantle Cell Lymphoma (MCL)' kunye ne-'Chronic Lymphocytic Leukemia (CLL), ezizezona zinamandla nezinzima zomhlaza wegazi ezikhula kwiiseli ezimhlophe zegazi (iiseli ze-B), nakwabo bangakhange bafumane naluphi na olunye unyango!
💬 Xa iiseli zomhlaza wegazi zikhula ngendlela engalawulekiyo, ukuthatha ezi pilisi (iCalquence) kuwutshabalalisa njani umhlaza?
Ukuze iiseli zomhlaza wegazi zisasazeke kwaye ziphile, i-enzyme ekhethekileyo ebizwa ngokuba yi-'BTK' kufuneka ithumele umyalezo/umqondiso! Kwangoko nje eli yeza lingena emzimbeni, liya kumatshini we-'BTK' owondla/osasaza umhlaza kwaye uwuthintele ngokupheleleyo nangokusisigxina (Uyibopha ngokungenakuguquguquka) kwaye uwuvale. Kwangoko nje xa uphawu lulahlekile, zonke ezo seli zomhlaza ziyayeka ukusasazeka (Zithintela ukwanda kweeseli ze-B), umhlaza uyafa kwaye isigulane siyaphila.
💬 Zeziphi iingozi ezibulalayo kunye nemiphumo emibi ekufuneka abantu abasebenzisa eli yeza lomhlaza (i-Acalabrutinib) baziqaphele?
Eyona ngozi inkulu yale chiza kukuba iyonakalisa inkqubo yokujiya kwegazi, ngoko ke ngaphandle kwesizathu, isigulana sinokuba 'negazi elibulalayo' ebuchotsheni okanye emathunjini size sife ngequbuliso (yiyo loo nto amayeza okunciphisa igazi/iWarfarin engavumelekanga)! Enye ingozi enkulu kukuba iyenza buthathaka ngokupheleleyo inkqubo yomzimba yokuzikhusela, ngoko ke nosulelo oluncinci lwebhaktheriya lunokubangela ukuba isigulana sibe kwi-coma (Severe Infections). Inokubangela nesifo esibi apho intliziyo ibetha ngokungathi yi-crazy (Atrial Fibrillation).
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