Ngaba uyazi ngeepilisi zeBosutinib? Ezi zinto zibaluleke kakhulu kunyango lomhlaza!

Ngaba wena okanye umntu osondeleyo kuwe unikwe iyeza elithi `Bosutinib` ngugqirha wakho? Okanye unomdla wokufunda okungakumbi ngeli yeza? Ngoko ke namhlanje, masithethe ngeli yeza elithi `Bosutinib` ngokweenkcukacha nangendlela elula kakhulu. Ukuba nokuqonda ngokuchanekileyo ngala mayeza kunceda kakhulu ekwenzeni unyango luphumelele.

Yintoni le yeza? Yintoni iBosutinib?

Ngamafutshane, iBosutinib liyeza elijolise kwiiproteni ezithile kwiiseli zomhlaza kwaye lizithintele ekukhuleni kwazo . Ngokukodwa, lisetyenziswa kakhulu ukunyanga uhlobo lomhlaza wegazi olubizwa ngokuba yiChronic Myelogenous Leukemia (CML). Likwiqela lamayeza abizwa ngokuba yiTargeted Therapy. Oku kuthetha ukuba eli yeza alichaphazeli iiseli ngokubanzi kuphela, kodwa lichaphazela ngokukodwa iiseli zomhlaza.

Usenokukwazi ukufumana ugqirha ukuba akunike eli yeza phantsi kwegama lophawu elithi ``BOSULIF.'' Elo ligama lophawu oludumileyo lwale yeza.

Kodwa khumbula, ngamanye amaxesha oogqirha banokulisebenzisa eli yeza nakwezinye iimeko. Ngoko ke kungcono ukubuza ugqirha wakho okanye ingcali yezemithi ukuba kutheni unikwe eli yeza.

Yintoni omele uyixelele ugqirha wakho ngaphambi kokuba uqale eli yeza?

Oku kubaluleke kakhulu. Ngaphambi kokuba uqale iBosutinib, kubalulekile ukwazisa ugqirha wakho ngazo naziphi na iimeko zempilo onokuba nazo. Oku kuya kumnceda ukuba agqibe ukuba eli yeza likulungele na kwaye zeziphi izilumkiso ekufuneka uzithathe.

Nazi ezinye izinto onokuzithetha ngokuqinisekileyo:

• Ukuba unesifo seswekile ( amanqanaba aphezulu eswekile egazini).
• Ukuba unesifo sentliziyo .
• Ukuba une -`High Blood Pressure` .
• Ukuba unesifo sezintso .
• Ukuba unesifo sesibindi .
• Ukuba ukhe waba ne -allergy engaqhelekanga kwi-Bosutinib, amanye amayeza, ukutya, iidayi, okanye izithinteli.
• Ukuba ukhulelwe okanye uzama ukukhulelwa , oku kubaluleke kakhulu!
• Ukuba ungumama oncancisayo .

Kubaluleke kakhulu kukhuseleko lwakho ukuxelela ugqirha ngaphandle kokufihla olu lwazi, kulungile?

Ndingayisebenzisa njani le yeza?

Kulungile, ngoku makhe sibone indlela yokusebenzisa ezi pilisi ze-`Bosutinib` ngqo. Eyona nto ibalulekileyo kukuthatha amayeza kanye njengoko ugqirha ekuxelela.

• Le pilisi kufuneka ithathwe ngomlomo neglasi yamanzi .
• Landela imiyalelo ekwileyibhile kagqirha ngokuchanekileyo.
• Eli yeza lifanele lithathwe kunye nokutya. Musa ukulithatha ungenanto esiswini. Ukulithatha kunye nokutya kunceda ukuba iyeza lifunxwe ngcono kwaye kunokunciphisa ezinye zeziphumo ebezingalindelekanga.
• Musa ukuyisika, ukuyityumza, okanye ukuyihlafuna. Ginya ipilisi yonke.
• Musa ukulisebenzisa eli yeza kunye nejusi yegrapefruit. Igrapefruit sisiqhamo esifana neorenji enkulu. Ijusi eyenziwe ngesi siqhamo inokusabelana neli yeza kwaye ichaphazele indlela elisebenza ngayo. Ngoko ke lumka kakhulu ngale nto.
• Ukuba uthatha ii-H2 blockers (umz., i-cimetidine, i-famotidine, i-ranitidine) okanye ii-antacids (umz., i-Digene, i-Gelusil) xa une-heartburn okanye i-gastritis , kufuneka uzithathe iiyure ezi-2 ngaphambi okanye iiyure ezi-2 emva kwe-bosutinib. Oku kuthetha ukuba kufuneka kubekho ubuncinane isithuba seeyure ezi-2 phakathi kokuthatha la mayeza mabini. Buza ugqirha wakho okanye i-pharmacist ukuze ufumane ulwazi oluthe kratya.
• Sela amayeza akho rhoqo nangexesha elifanelekileyo. Musa ukuthatha ngaphezu komlinganiselo omiselwe ngugqirha wakho, okanye uwathathe rhoqo.
• Musa ukuyeka ukuthatha eli yeza ngequbuliso ngaphandle kwengcebiso kagqirha wakho.

Ukuba unika abantwana eli yeza, kufuneka uthethe nogqirha wabantwana ngalo uze ulandele icebiso lakhe. Kunokufuneka unonophelo olukhethekileyo.

Ukuba ucinga ukuba uthathe eli yeza lininzi ngempazamo, fowunela iZiko loLawulo lweTyhefu okanye iGumbi loNgxamiseko elikufutshane ngoko nangoko.

Okubaluleke kakhulu: Eli yeza lelakho kuphela. Musa ukunika omnye umntu eli yeza nangasiphi na isizathu, nokuba loo mntu uneempawu ezifanayo nezakho.

Yintoni omawuyenze ukuba uphoswe yidosi yeyeza?

Ukungayifumani idosi yamayeza kunokwenzeka nakubani na. Ukuba oko kuyenzeka, ungakhathazeki.

• Thatha idosi oyiphosileyo ngokukhawuleza nje ukuba uyakhumbula.
• Nangona kunjalo, ukuba kungaphantsi kweeyure ezili-12 ngaphambi kokuba uthathe idosi elandelayo, musa ukuyithatha idosi ongayithathanga. Yitsibe uze uthathe idosi elandelayo ngexesha elicwangcisiweyo.
• Ungaze uthathe amayeza aphindwe kabini. Ukwenza njalo kwandisa umngcipheko weziphumo ebezingalindelekanga.

Ziziphi ezinye izinto ezinokusebenzisana nale mithi?

I-Bosutinib inokunxibelelana namanye amayeza, ukutya, kunye nezongezo zemifuno osenokuba uzithatha. Olu nxibelelwano lunokunciphisa ukusebenza kwe-Bosutinib okanye lonyuse umngcipheko weziphumo ebezingalindelekanga.

I-Bosutinib inokusebenzisana nezi zinto zilandelayo:

• Amanye amayeza okubulala iintsholongwane (umz. i-ciprofloxacin, i-clarithromycin, i-erythromycin)
• Ezinye izinto ezilwa nentsholongwane (umz. i-fluconazole, i-ketoconazole, i-itraconazole)
• Amanye amayeza okulwa nesifo sokuwa (umz. i-carbamazepine, i-phenobarbital, i-phenytoin)
• `Amanye amayeza eengxaki zesisu` (umz. `Ii-Proton Pump Inhibitors` kunye ne`H2 blockers` ezifana ne`cimetidine`, `famotidine`, `ranitidine`, `omeprazole`, `pantoprazole`)
• Amanye amayeza asetyenziswa ukunyanga usulelo lwe-HIV (umz. i-amprenavir, i-atazanavir, i-ritonavir)
• Ijusi yegrapefruit (ndikhe ndayitsho le nto ngaphambili, kodwa ndiza kuyiphinda!)
• Izongezo ezenziwe ngemifuno iSt. John's Wort (abanye abantu basebenzisela ezi zibonelelo kwimpilo yengqondo).
• Amanye amayeza amaninzi (umz., i-amiodarone, i-diltiazem, i-verapamil, i-rifampin).

Olu luhlu aluphelelanga. Kusenokubakho amanye amayeza. Ngoko ke, xelela ugqirha wakho ngawo onke amayeza owasebenzisayo (amayeza amiselweyo, athengiswa ngaphandle kwemvume kagqirha, awemifuno, iivithamini, okanye izongezo zokutya). Kwakhona, xelela ugqirha wakho ukuba uyatshaya, usela utywala, okanye usebenzisa ezinye iziyobisi. Usenokucwangcisa unyango lwakho ngokufanelekileyo.

Yintoni endifanele ndiyilumkele xa ndisebenzisa eli yeza?

Kubalulekile ukuqaphela naluphi na utshintsho emzimbeni wakho ngelixa uthatha iBosutinib.

• Kuya kufuneka uhlolwe igazi rhoqo . Oku kuya kunceda ugqirha wakho abone indlela eli chiza elichaphazela ngayo umzimba wakho, ukuba amalungu akho anjengesibindi sakho kunye nezintso asebenza kakuhle na, nokuba kukho naluphi na utshintsho kwiinxalenye zegazi lakho.
• Eli yeza linokukwenza ube namathuba amaninzi okukrweleka okanye ukopha. Ukuba ubona nayiphi na imikrwelo engaqhelekanga, ukopha kweentsini, ukopha empumlweni, okanye ukopha, xelela ugqirha wakho ngoko nangoko.
• Ukuba unomkhuhlane, umkhuhlane, umphimbo obuhlungu , okanye iimpawu zosulelo ezifana nomkhuhlane okanye ukukhwehlela, musa ukuzenza unyango. Fowunela ugqirha wakho ngoko nangoko ukuze ufumane ingcebiso. Eli yeza linokunciphisa amandla omzimba wakho okulwa nokugula. Ke ngoko, zama ukuhlala kude nabantu abagulayo.
• Ingqwalasela ekhethekileyo malunga nokukhulelwa:
• Musa ukukhulelwa ngelixa usebenzisa eli yeza.
• Kuphephe ukukhulelwa ubuncinane iiveki ezimbini emva kokuyeka ukusebenzisa ipilisi.
• Abafazi abaceba ukukhulelwa okanye abacinga ukuba bakhulelwe kufuneka baxelele ugqirha wabo ngoko nangoko. Eli yeza linokubangela iziphumo ebezingalindelekanga ezibi kakhulu kusana olungekazalwa. Buza ugqirha wakho okanye ikhemisti ukuze ufumane ulwazi oluthe kratya.
• Ngokuphathelele ukuncancisa: Musa ukuncancisa umntwana wakho ngelixa usebenzisa eli yeza kwaye ubuncinane iiveki ezimbini emva kokuba uyekile ukusebenzisa eli yeza.
• Ukuzala: Eli yeza lisenokuchaphazela amandla akho okufumana abantwana. Ukuba ukhathazekile ngale nto, thetha nogqirha wakho.

Zithini iziphumo ebezingalindelekanga ezinokubakho zale yeza?

Njengalo naliphi na iyeza, iBosutinib inokubangela ezinye iziphumo ebezingalindelekanga. Nangona kunjalo, ayinguye wonke umntu ozifumanayo. Ezinye iziphumo ebezingalindelekanga ziyingozi kwaye kufuneka uxelele ugqirha wakho ngoko nangoko ukuba uzifumana. Ezinye azibi kakhulu kwaye zinokuphela emva kweentsuku ezimbalwa.

Iziphumo ebezingalindelekanga ekufuneka uzixele kugqirha wakho ngoko nangoko:

• Iimpendulo ze-allergy: Ukurhawuzelela kwesikhumba, ukurhawuzelela, amaqhuqhuva, ukudumba kobuso, imilebe, okanye ulwimi. Ukuba ezi mpawu ziyabonakala, funa uncedo lwezonyango ngokukhawuleza.
• Intlungu yomqolo ( inzima, engaqhelekanga).
• Indle ehlala ixesha elide enegazi okanye emnyama . Oku kungaba luphawu lokopha ngaphakathi emzimbeni.
• Urhudo oluqatha .
• Ukudinwa (okuqatha, okuxhaphakileyo).
• Intloko ebuhlungu (eqatha, enganyamezelekiyo).
• Iimpawu zokuhlaselwa yintliziyo: Ubunzima bokuphefumla, iintlungu okanye ukuqina esifubeni, entanyeni, emqolo, okanye ezingalweni.
• Iimpawu zokusilela kwentliziyo: Ukuphelelwa ngumphefumlo, ukubetha kwentliziyo okukhawulezayo okanye okungahambelaniyo, ukunyuka kobunzima ngequbuliso; ukudumba kwamaqatha, iinyawo, izandla.
• `Iimpawu zosulelo`: umkhuhlane, ukugodola, ukukhohlela, umphimbo obuhlungu, iintlungu okanye ubunzima bokuchama.
• Intlungu yamalungu ( inzima kakhulu).
• `Iimpawu zokulimala kwezintso`: Utshintsho kubungakanani bomchamo oveliswayo (owehla kakhulu okanye onyukileyo).
• `Isitulo esinombala okhanyayo` .
• Iimpawu zokulimala kwesibindi: Umchamo otyheli okanye omdaka omnyama, ukuziva ugula ngokubanzi okanye iimpawu ezifana nomkhuhlane, ukungabi namdla wokutya, iintlungu zesisu esingentla ngasekunene, ukutyheli kwamehlo okanye ulusu (i-jaundice).
• `Ukubalwa kweeseli ezibomvu zegazi ezisezantsi - I-Anemia`: Ubunzima bokuphefumla, ukuquleka, ukuziva unesizungu, uzive ngathi uza kuwa rhoqo, uzive udiniwe okanye ubuthathaka ngendlela engaqhelekanga.
• Isicaphucaphu (esinzima, esingapheliyo).
• `Umchamo obomvu okanye omdaka omnyama` .
• Intlungu yesisu ( eqatha).
• `Ukopha okanye ukukrweleka okungaqhelekanga`.
• `Ukudumba okungaqhelekanga` .
• Ukuhlanza (okuqatha, okungapheliyo).

Iziphumo ebezingalindelekanga ezihlala zingadingi nyango (kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka okanye ziyakhathaza):

• `Ukuqhinwa` .
• `Ukudinwa` .

Khumbula, olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ubona into engaqhelekanga okanye eyahlukileyo, xelela ugqirha wakho ngayo.

Ndingawagcina njani amayeza am?

Kubaluleke kakhulu ukugcina amayeza akho ngokufanelekileyo.

• Gcina kude nabantwana kunye nezilwanyana zasekhaya.
• Gcina kubushushu begumbi. Oko kukuthi, phakathi kwama-20 ukuya kuma-25 degrees Celsius (ama-68 kunye nama-77 degrees Fahrenheit). Musa ukuyibeka kwindawo eshushu kakhulu, ebandayo, okanye efumileyo.
• Musa ukusebenzisa amayeza aphelelwe lixesha. Walahle.

Uzilahla njani amayeza angasetyenziswanga naphelelwe lixesha?

Akusoloko kufanelekile ukulahla amayeza aphelelwe lixesha, angasetyenziswanga enkunkuma okanye ukuwalahla endlwini yangasese. Anokuba yingozi kwindalo esingqongileyo.

• Eyona nto ingcono onokuyenza kukunikezela la mayeza "kwinkqubo yokubuyisela amayeza." Ungabuza ikhemesti yakho okanye abasemagunyeni bezempilo basekuhlaleni ukuba banazo na ezo nkqubo.
• Ukuba awukwazi ukufumana inkqubo enjalo, jonga iphakheji yamayeza okanye incwadana engaphakathi kuyo ukuze ubone ukuba inemiyalelo yokuba ungayilahla njani enkunkuma okanye kwindlu yangasese. Ukuba awuqinisekanga, buza ugqirha wakho okanye ikhemisti.
• Ukuba uqinisekile ukuba kukhuselekile ukuyifaka kwinkunkuma, susa iyeza kwibhotile okanye kwipakethi elifike kuyo, ulixube nento efana nekofu esetyenzisiweyo, inkunkuma yekati, okanye umhlaba, uze ulifake kwibhegi okanye kwisikhongozeli esivalwe kakuhle uze ulifake kwinkunkuma.

Eli phetshana lisisishwankathelo kuphela. Ukuba unemibuzo engaphezulu malunga neBosutinib, nceda uthethe nogqirha wakho, ikhemisti, okanye omnye umboneleli wezempilo.

Izinto ezibalulekileyo ekufuneka uzikhumbule (Umyalezo Wokuya Ekhaya)

Kulungile, masiphinde sikukhumbuze ngezinye zezinto esithethe ngazo ekufuneka uzikhumbule.

• I-Bosutinib liyeza elikhethekileyo elinikwa umhlaza ofana ne-chronic myelogenous leukemia (CML).
• Eli yeza lifanele lithathwe kunye nokutya . Akufanele lisikwe, lityunyuzwe, okanye lihlafunwe. Musa ukulisebenzisa kunye nejusi yegrapefruit.
• Ufanele uxelele ugqirha wakho malunga nazo zonke ezinye iindlela ozithathileyo, naziphi na ezinye izifo onazo, nokuba ukhulelwe okanye uncancisa.
• Musa ukukhulelwa ngelixa usela ipilisi. Lumka iiveki ezimbini emva kokuba uyekile.
• Ukuba ufumana ukopha okungaqhelekanga, umkhuhlane, amaqhakuva eluswini, ubunzima bokuphefumla, okanye iimpawu ze-jaundice, xelela ugqirha wakho ngoko nangoko.
• Fumana uvavanyo lwegazi ngexesha elifanelekileyo.
• Musa ukuyeka ukuthatha amayeza ngaphandle kwengcebiso kagqirha wakho.

Ndikunqwenelela ukuchacha ngokukhawuleza! Ndiyathemba ukuba olu lwazi luza kukunceda.

I- Bosutinib, i-Bosulif, i-CML, i-Chronic Myelogenous Leukemia, Unyango lomhlaza, amayeza omhlaza, iziphumo ebezingalindelekanga