Ngaba wakha wazibuza ukuba amanqanaba ethu eswekile egazini alawulwa njani? Kukho into ekhethekileyo enceda kule nto ibizwa ngokuba yiGlucagon. Njengeqhawe elincinci emzimbeni wethu, iGlucagon igcina amanqanaba ethu eswekile egazini engaphantsi kakhulu. Namhlanje, siza kuthetha ngale Glucagon ngokweenkcukacha nangokulula.
Yintoni iGlucagon?
Ngamafutshane, i-glucagon yi-hormone yendalo eveliswa yimizimba yethu . Uyazi, iveliswa zii-alpha cells kwi-pancreas yethu. Xa amanqanaba eglucose egazini lethu ehla, xa singatyi ixesha elide (ukuzila ukutya ixesha elide), xa sizilolonga nzima, okanye xa sitya isidlo esineeproteni ezininzi, le glucagon iyakhutshwa.
Cinga ngayo, i-glucose lolona hlobo luphambili lweswekile egazini lethu. Sifumana le glucose kwiicarbohydrates kwizinto esizityayo nesiziselayo. Le swekile yiyo enika amandla kumalungu omzimba wethu, kwimisipha nakwinkqubo yemithambo-luvo. Ifana nepetroli yemoto. Ngoko ke, umzimba wethu uhlala ugcina le swekile yegazi ikwinqanaba elifanelekileyo ngendlela entsonkothileyo. Nokuba oku kuphezulu kakhulu okanye kuphantsi kakhulu, izifo ezahlukeneyo kunye nokungonwabi kunokwenzeka.
Iinaliti zeGlucagon kunye nezitshizi zeempumlo
Ukongeza kwi-glucagon yendalo, kukwakho nee-glucagon ezenziweyo. Ezi zinokunikwa njengenaliti okanye njenge-spray eyomileyo yempumlo. Usenokuba ukubonile oku kusetyenziswa kwiimeko ezingxamisekileyo, ngakumbi kubantu abanesifo seswekile sohlobo 1 , xa iswekile yabo yegazi yehla ngequbuliso kakhulu (i-hypoglycemia). I-glucagon enikwa ngeli xesha ikhupha i-glucose egcinwe kwisibindi sethu kwaye inyusa ngokukhawuleza amanqanaba eswekile yegazi lethu. Kufana nokusinika 'ukhuthazo' oluncinci.
Yintoni eyenziwa yi-glucagon emizimbeni yethu?
Ukuba i-pancreas yakho isebenza kakuhle, umzimba wakho uya kulawula ngononophelo amanqanaba eswekile egazini lakho. Oku kwenziwa ikakhulu ziihomoni ezimbini ezibizwa ngokuba yi-glucagon kunye ne-insulin . Umzekelo, xa amanqanaba eswekile egazini lakho ehla kakhulu (i-hypoglycemia), i-pancreas yakho ikhupha i-glucagon engakumbi. Le glucagon inceda ukuphakamisa amanqanaba eswekile egazini lakho ngeendlela ezahlukeneyo:
- Okokuqala, i-glucagon iya esibindini sethu ize iguqule i-glucose egcinwe apho - esiyibiza ngokuba yi-glycogen - ibe yinto esinokuyisebenzisa. Isibindi emva koko siyikhuphela egazini.
- Okwesibini, i-glucagon inokuthintela isibindi ekuthatheni nasekugcineni i-glucose, nto leyo eshiya i-glucose engaphezulu egazini.
- Okwesithathu, ii-amino acidsI-Glucagon ikwanceda umzimba ukuba wenze i-glucose kwezinye izinto, ezinje:
Khumbula, kufana ne-seesaw. Xa amanqanaba eswekile egazini ehla, i-glucagon iyasebenza, kwaye xa amanqanaba eswekile egazini enyuka, i-insulin iyasebenza!
Ziziphi izifo ezinokunxulunyaniswa neengxaki zokusebenza kweglucagon?
Ngoku makhe sibone ukuba zeziphi iingxaki ezinokuvela ukuba i-glucagon ayisebenzi kakuhle.
Ukuba unesifo seswekile, umzimba wakho usenokungakwazi ukukhupha i-glucagon eyaneleyo xa iswekile yakho yegazi iphantsi. Oku kunokukwenza ube namathuba amaninzi okuba neswekile ephantsi yegazi rhoqo, okanye iswekile ephantsi kakhulu egazini . Lo mngcipheko uphezulu ngakumbi ukuba uthatha amayeza okunciphisa iswekile egazini afana ne-insulin okanye i-sulfonylureas.
Kwabanye abantu abanesifo seswekile sohlobo lwesibini, amanqanaba eglucagon anokuba phezulu kunesiqhelo, xa kuthelekiswa namanqanaba eswekile egazini. Esi sisizathu sokuba amanqanaba eswekile egazini abe phezulu.
Kunqabile kakhulu ukuba iingxaki zokuveliswa kweglucagon zivele ngaphandle kwesifo seswekile, kodwa kukho iimeko ezimbalwa apho zinokwenzeka khona:
- I-Pancreatitis: Ukuba unesifo seswekile ngenxa ye-pancreatitis kwaye uthatha i-insulin ngenxa yaso, usenokuba nokungabikho kwe-glucagon. Oku kwandisa umngcipheko wokuba neswekile ephantsi egazini.
- I-Glucagonoma: Le yi-tumor engaqhelekanga kwi-pancreas. Ikhupha i-glucagon eninzi kakhulu. Oku kubangela iimpawu ezifana neswekile ephezulu egazini, ukurhawuzelela kolusu, kunye nokwehla kobunzima.
- I-Multiple Endocrine Neoplasia (MEN): Le yimeko engaqhelekanga kakhulu yemfuza. Kule meko, iithumba zikhula kwiindlala ezingaphezu kwesinye kwinkqubo yakho ye-endocrine. Oku kuquka nepancreas.
- Iziphumo ebezingalindelekanga zePancreatectomy: Ukuba ngesizathu esithile inxalenye okanye yonke ipancreas yakho isusiwe, iiseli ezivelisa iglucagon kunye ne-insulin ziyalahleka.
Zithini iimpawu zeengxaki ezinxulumene neglucagon?
Njengoko besitshilo ngaphambili, ukungaqhelekanga kwamanqanaba e-glucagon kunokubangela iswekile ephantsi egazini (hypoglycemia) okanye iswekile ephezulu egazini (hyperglycemia). Makhe sijonge ukuba zeziphi ezo mpawu.
Iimpawu zeswekile ephantsi egazini (iHypoglycemia)
Khawuthelekelele umhlobo wakho, uNilanthi, esela amayeza esifo seswekile. Ngolunye usuku, ngequbuliso uqala ukungcangcazela, ukubila, nokuziva enesiyezi. Ubonakala ngathi uyawathetha amazwi amdaka xa ethetha. Ukuba ezi mpawu ziyenzeka, oko kuthetha ukuba iswekile yakhe yegazi iphantsi kakhulu.
Iimpawu eziqhelekileyo ziquka:
- Ukungcangcazela, ukungcangcazela
- Ukubila nokuziva ubanda
- Ukudinwa, ukuziva ukhaphukhaphu
- Ukubetha kwentliziyo
- Indlala
- Ubunzima bokugxila, ukudideka
Kubalulekile: Ukuba ufumana ezi mpawu, kubaluleke kakhulu ukutya into eneswekile, ukutya okutyebileyo kwiikhabhohayidreyithi okanye isiselo ngokukhawuleza . Oku kuya kunceda amanqanaba eswekile yakho egazini ukuba abuyele esiqhelweni. Ukuba ufumana ezi mpawu rhoqo, ngokuqinisekileyo kuya kufuneka ubone ugqirha wakho.
Iimpawu zeswekile ephezulu egazini (i-Hyperglycemia)
Iswekile ephezulu egazini (i-hyperglycemia) idla ngokubangelwa kukungabikho kwe-insulin, ayingongxaki nge-glucagon yodwa. Nangona kunjalo, iingxaki ezingaqhelekanga ze-glucagon zinokubangela iswekile ephezulu egazini. Iimpawu zokuqala zezi:
- Ukoma rhoqo kunye/okanye indlala
- Umbono ofipheleyo
- Ukuchama rhoqo ( ukuchama rhoqo)
- Intloko ebuhlungu
Ukuba unale mpawu, kubaluleke kakhulu ukubona ugqirha.
Zeziphi iimvavanyo ezenziwayo ukujonga amanqanaba eglucagon?
Ukuba uneempawu ezithile, ugqirha wakho unokuyalela uvavanyo lwegazi ukulinganisa amanqanaba akho e-glucagon. Kolu vavanyo, ugqirha okanye umongikazi uthatha isampuli yegazi emthanjeni wakho esebenzisa inaliti. Emva koko ithunyelwa kwilebhu ukuze ivavanywe.
Athini amanqanaba aqhelekileyo e-glucagon?
Ngokwesiqhelo, ubungakanani beglucagon esifanele sibe nayo egazini lethu buphakathi kwe-50 kunye ne-100 picograms nge-milliliter (pg/mL) . I-picogram yi-trillionth enye ye-gram! Inani elincinci kakhulu, akunjalo?
Kodwa khumbula, la maxabiso aqhelekileyo anokwahluka kancinci kwilabhoratri nganye. Anokwahluka ngokuxhomekeke ekubeni ubuzila ixesha elingakanani kwaye amanqanaba eswekile yakho egazini ebengakanani ngexesha lovavanyo. Ngoko ke, soloko uthelekisa iziphumo zakho namaxabiso akwingxelo yakho yovavanyo lwegazi . Ukuba unemibuzo, thetha nogqirha wakho.
Ndifanele ndimbone nini ugqirha malunga namanqanaba am e-glucagon?
Ukuba unesifo seswekile kwaye uneziqendu ezihlala zikho zeswekile ephantsi okanye ephezulu egazini, kubalulekile ukubona ugqirha. Amanqanaba eGlucagon awasoloko elinganiswa kubantu abanesifo seswekile. Nangona kunjalo, kunokufuneka utshintshe indlela olawula ngayo isifo seswekile ukuze unciphise ezi ziqendu.
Nangona ezinye iingxaki ezinxulumene neglucagon zinqabile, ukuba uneempawu, kubalulekile ukufumana unobangela. Ngoko ke, qiniseka ukuba ubona ugqirha wakho.
Yintoni umahluko phakathi kweGlucagon kunye neGlycogen?
Azifani ezi zimbini? I-Glycogen luhlobo lwe-glucose (iswekile) egcinwa esibindini.Imizimba yethu igcina i-glycogen ikakhulu kwisibindi nakwimisipha.
I-Glucagon yi-hormone enika isibindi imiqondiso yokuba siguqule i-glycogen ibe yi-glucose. Loo glucose ingena egazini ize isetyenziswe njengamandla emizimbeni yethu.
Kwenzeka ntoni kwi-glucagon ngexesha lokuzila ukutya?
Xa sizila ukutya, i-glucagon ibaluleke kakhulu ekugcineni amanqanaba eswekile egazini lethu engaphantsi kakhulu. Oku kungenxa yokuba imizimba yethu ayifumani iswekile ekutyeni ngelo xesha.
Xa sizila ukutya ixesha elide, i-glucagon ibangela ukuba umzimba wenze i-glucose kwizinto ezingezizo ii-carbohydrate – ezinje ngee-lipids, ii-amino acids, kunye neeproteni. Le nkqubo ibizwa ngokuba yi -gluconeogenesis .
Okokugqibela, kufuneka ndithi... (Umyalezo Wokuya Ekhaya)
Ngoko ke, mhlawumbi uyaqonda ukuba i-glucagon yi-hormone ebaluleke kakhulu enceda ukugcina amanqanaba ethu eswekile egazini esempilweni 'emva kweziganeko'. Akunakwenzeka ukuba unesifo seswekile okanye iingxaki ezinxulumene ne-glucagon.
Nangona kunjalo, ukuba ufumana iimpawu ezihlala zikho zeswekile ephantsi okanye iswekile ephezulu egazini, nceda ubone ugqirha wakho. Banokufumana unobangela baze bakunike unyango olufunayo. Ukunyamekela impilo yakho yeyona nto ibalulekileyo.
👩🏽⚕️ Imibuzo eyongezelelweyo (Ii-FAQ)
💬 Ngaba iGlucagon liyeza elihlisa iswekile egazini njenge-insulin?
Hayi! Le yi-hormone emzimbeni esebenza 'njengomzalwana ongendawo/icala elichaseneyo' le-insulin. I-insulin inyanzela amanqanaba eswekile emzimbeni ukuba ehle. Kodwa 'i-glucagon', xa amanqanaba eswekile emzimbeni ehla ngokuyingozi (i-Hypoglycemia), iyalela iswekile egcinwe esibindini (i-Glycogen) ukuba ingene egazini ngoko nangoko ize 'inyuse amanqanaba eswekile abuyele esiqhelweni'.
💬 Kutheni le nto le hormone yeGlucagon ifumaneka kwikhemesti njengonyango olungxamisekileyo?
Ukuba isigulane esinesifo seswekile sithatha amayeza amaninzi okanye i-insulin size sibe 'neswekile ephantsi egazini/siqhawuke ngequbuliso size silahlekelwe zingqondo' (Hypoglycemia), asinakuyitya iswekile ngelo xesha (sibambekile). Kuphela ngelo xesha, ukuba i-'Glucagon Pen' (inaliti engxamisekileyo) ifakwe ebhulukhweni okanye ethangeni lakhe, iswekile yegazi emzimbeni iyanda kwimizuzu embalwa kwaye isigulane sibuyela ezingqondweni.
💬 Ngaba kulula ukufaka le glucagon ekhaya?
Ewe! Oku kufana ne-EpiPen ye-allergies, kwaye kuza kwikhithi yongxamiseko enokutofwa ngokulula ekhaya ngamalungu osapho. (Kwamanye amazwe, ikwafumaneka njenge-nasal spray/Baqsimi.) Ukuba kukho umntu ekhaya othatha i-insulin yesifo seswekile, kubalulekile ukugcina le injection ye-glucagon efrijini okanye kwikhabhathi ukuze kuthintelwe ukufa ngequbuliso.
i- glucagon, iswekile yegazi, i-hypoglycemia, i-hyperglycemia, isifo seswekile, i-pancreas, i-hormone
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