Ngamanye amaxesha, emva kokutya isidlo esinongwe ngespice, ufumana imvakalelo yokutsha esifubeni sakho, akunjalo? Okanye uzive ungakhululekanga ngokungathi i-asidi yesisu sakho inyukile kwaye ingena emqaleni wakho? Ii-H2 blockers luhlobo lwamayeza abantu abaninzi abawasebenzisayo ngamaxesha anje. Ngoko ke namhlanje, masithethe ngezinto ezi zi-H2 blockers, indlela ezisebenza ngayo emizimbeni yethu, kunye nezinto ezibalulekileyo ekufuneka sizazi xa sizisebenzisa.
Zithini ezi H2 Blockers?
Ngamafutshane, ii-H2 blockers (ezikwabizwa ngokuba zii-H2 antagonists) luhlobo lwamayeza alawula okanye anciphisa ukuveliswa kwe-asidi esiswini sakho.
I-asidi yesisu ibalulekile ekugayeni ukutya esikutyayo. Kodwa ukuba le asidi ininzi kakhulu, inokonakalisa ulwelo lwendlela yakho yokugaya ukutya. Oku kunokukhokelela kwiimpawu ezifana nentlungu yesisu kunye nesitshiso sentliziyo. Kunokuba nzima njengokuzisola ngesidlo sokugqibela osityileyo.
Ukuba ufumana ukungakhululeki ngenxa yokwanda kwe-asidi yesisu, ungacinga ngokusebenzisa i-H2 blocker.
Zeziphi iimeko ezisetyenziselwa ii-H2 blockers?
Ii-H2 blockers zisetyenziswa kakhulu ukunyanga iimeko ezinxulumene nokuveliswa kwe-asidi egqithisileyo esiswini. Nangona kunjalo, kubalulekile ukukhumbula ukuba la mayeza anokulahlekelwa kancinci kancinci kukusebenza kwawo xa esetyenziswa rhoqo ixesha elide.
Ukuba unesifo esinganyangekiyo, ugqirha wakho unokucebisa uhlobo oluthile lonyango olubizwa ngokuba yiProton Pump Inhibitor (PPI) endaweni yee-H2 blockers. Nangona ii-PPI zithatha ixesha elide ukusebenza, zinokulawula ukuveliswa kwe-asidi ngempumelelo kunee-H2 blockers. Zingasetyenziswa nexesha elide.
Ezinye zeemeko eziphambili ezinyangwa nge-H2 blockers zidweliswe ngezantsi.
| Imeko yezonyango | Ingcaciso elula |
|---|---|
| Izilonda zesisu | I-asidi egqithisileyo eveliswayo inokonakalisa ulwelo lwesisu kwaye ibangele izilonda. Ukunciphisa i-asidi ngee-H2 blockers kunika ezo zilonda ixesha kunye nendawo eziyifunayo ukuze ziphiliswe. |
| Izilonda zeDuodenal | I-asidi yesisu inokunyuka iye kwinxalenye yokuqala yamathumbu amancinci (i-duodenum) ize ibangele izilonda apho. Le meko inokunyangeka ngee-H2 blockers, nangona ii-PPI zisebenza ngakumbi. |
| I-asidi reflux | I-asidi yesisu ibuyela phezulu iye kwi-esophagus nasemqaleni, nto leyo ebangela isitshiso sentliziyo. Oku kunokubangela ne-esophagitis. I-H2 blocker sisisombululo esilungileyo kwesi sifo singaqhelekanga. Kodwa ukuba oku kwenzeka rhoqo (GERD), i-PPI ifanelekile ngakumbi. |
| Isifo sikaZollinger-Ellison | Le yimeko engaqhelekanga kakhulu. Ezinye iithumba ezenzeka kule meko zibangela ukuba isisu sivelise iasidi eninzi kakhulu. Nangona ii-H2 blockers zinokunceda ekulawuleni le meko, oogqirha badla ngokucebisa ii-PPI. |
Ii-H2 blockers zinceda ekunciphiseni iimpawu ezilandelayo ezinxulumene nezi meko:
- Ukungagayi kakuhle kokutya
- Intlungu yesisu
- Intlungu yesifuba kunye nomphimbo obuhlungu
- Isicaphucaphu nokuhlanza
- Isisu esimuncu
Eli yeza lisebenza njani emzimbeni?
Kulula kakhulu. Elinye igama le-H2 blockers yi-histamine-2 (H2) antagonists. Sifunde esikolweni ukuba 'umchasi' ebalini yinto ephazamisa into ethile? Kaloku, into eyenziwa ngaba bachasi be-H2 kukuphazamisa inkqubo yokuvelisa i-asidi esiswini.
Cinga ngale ndlela. Emva kokutya, imizimba yethu ikhupha ikhemikhali ebizwa ngokuba yi-H2. Le H2 iyahamba ize inamathele kwii-H2 receptors ezindongeni zesisu. Ifana nesitshixo esifakwa kwisitshixo. Le nto incamathiselayo yiyo exelela isisu ukuba, "Kulungile, yenza i-asidi ngoku."
Xa uthatha i-H2 blocker, iyeza liyabopha kwii-H2 receptors (ii-locks) kwaye "lizivale". Ngale ndlela, ii-H2 (ii-key) azifumani thuba lokuza zibopha kwii-receptors. Xa isibonakaliso sokwenza i-asidi siyeka, isisu sivelisa i-asidi encinci.
Oku akuphazamisi inkqubo yakho yokugaya ukutya. Kulawula nje ubungakanani be-asidi eyongezelelweyo eveliswayo ebangela iintlungu nokungonwabi.
Ngawaphi amayeza okuthintela i-H2 afumanekayo?
Kukho iintlobo ezahlukeneyo ze-H2 blockers. Ezinye zingathengwa ngaphandle kwekhawuntara (OTC), ngelixa ezinye zifuna uxwebhu oluvela kugqirha.
| Igama lesiyobisi | Uphawu oluqhelekileyo | Indlela yokuyifumana |
|---|---|---|
| I-Cimetidine | I-Tagamet® | Unyango oluthengiswa ngaphandle kwekhawuntara kunye nonyango olubhalwe ngugqirha (OTC & Rx) |
| I-Famotidine | I-Pepcid® | Unyango oluthengiswa ngaphandle kwekhawuntara kunye nonyango olubhalwe ngugqirha (OTC & Rx) |
| I-Nizatidine | I-Axid® | Kuphela ngomyalelo kagqirha (i-Rx kuphela) |
Inqaku Elikhethekileyo: Usenokukhumbula i-H2 blocker iRanitidine (Zantac®) eyayikade ithandwa kakhulu. Kodwa ngo-Epreli 2020, ii-arhente ezifana ne-FDA (US Food and Drug Administration) zaxelela abavelisi ukuba basuse eli yeza kwimarike. Isizathu yayikukuba iimvavanyo zibonise ukuba ngokuhamba kwexesha kwaye xa zigcinwe kumaqondo obushushu aphezulu, amanqanaba ekhemikhali ebizwa ngokuba yi-nitrosodimethylamine, okanye i-NDMA, enokuba yi-carcinogen, anda ukuya kumanqanaba angakhuselekanga.
Eli yeza lifanele lisetyenziswe njani kwaye nini?
Ii-H2 blockers zingathathwa ngomlomo njengeepilisi okanye iikhaphu. Kukwakho neempuphu ezinokunyibilikiswa kulwelo kubantu abanengxaki yokuginya iipilisi. Zinokunikwa ngemithambo yegazi (IV) kwizigulana ezilaliswe esibhedlele kwaye zingenako ukuthatha amayeza omlomo.
Ixesha elifanelekileyo lokuthatha iyeza
- Ngamaxesha athile ukungakhululeki:Ukuba uyazi ukuba ukutya ukutya okuneziqholo okanye okunamafutha kunokubangela ingxaki, thatha i-H2 blocker imizuzu engama-30 ukuya kwengama-60 ngaphambi kokuba utye loo mveliso. Oko kukunika ixesha lokusebenza. Kulungile ukuyithatha emva kokuba ingxaki iqalile, kodwa kungathatha ukuya kuthi ga kwiyure ukuba iimpawu ziphele.
- Kwimeko efana nokuphola kwenxeba: Ugqirha wakho unokucebisa ukuba uyithathe kanye ngosuku ngaphambi kokuba ulale, okanye kube kanye kusasa nakanye ebusuku, kuxhomekeke kwimiyalelo kagqirha wakho.
Eyona nto ibalulekileyo kukuba ukuba kufuneka usebenzise la mayeza kangangeeveki ezingaphezu kwezimbini ngexesha, ngokuqinisekileyo kuya kufuneka ubone ugqirha wakho. Akucetyiswa ukuba uqhubeke nokusebenzisa la mayeza ngaphandle kokufumanisa unobangela weempawu zakho.
Yintoni umahluko phakathi kwe-H2 Blockers, ii-Antacids kunye nee-PPI?
Abantu abaninzi bayadideka malunga nezi ntlobo zintathu zamayeza asetyenziselwa isitshiso sentliziyo. Makhe sijonge umahluko omkhulu phakathi kwawo.
| Uhlobo lweziyobisi | Ixesha elithathiweyo ukusebenza | Ubude bexesha lesiphumo | Ithuba elifanelekileyo kakhulu |
|---|---|---|---|
| Iiantacids (umz. uDigene, uGelusil) | Ngokukhawuleza kakhulu (imizuzu embalwa) | Imfutshane kakhulu (iiyure ezi-1-2) | Xa kufuneka uncedo olukhawulezileyo. |
| Iibhloko ze-H2 | Malunga neyure | Malunga neeyure ezi-4-10 | Ukuthintela isitshiso sentliziyo ngamanye amaxesha okanye ngaphambi kokutya. |
| Ii-PPI (ii-Proton Pump Inhibitors) | Iintsuku ezi-1-4 ukuze isebenze ngokupheleleyo | Ixesha elide (iiyure ezingama-24 nangaphezulu) | Kwiimeko ezifana ne-gastritis engapheliyo kunye ne-GERD. |
Ngaba kukho naziphi na iziphumo ebezingalindelekanga?
Ii-H2 blockers zihlala zingamayeza akhuselekileyo kwaye azinazo iziphumo ebezingalindelekanga ezininzi . Nokuba iziphumo ebezingalindelekanga ziyenzeka, zihlala zincinci.
- Intlungu yesisu
- Intlungu yemisipha
- Ukuqhinwa
- Urhudo
- Umlomo owomileyo
- Ukudinwa
- Intloko ebuhlungu
Amaxesha amaninzi, abantu abakumaqela asengozini enkulu (ingakumbi abo baneminyaka engaphezu kwama-50 ubudala, abo baneengxaki zezintso okanye zesibindi) banokubona iimpawu ezinxulumene nenkqubo yemithambo-luvo, ezinje ngokulahlekelwa yinkumbulo okanye ubunzima bokuthetha. Nangona kunjalo, oku kunqabile kakhulu . Ezi mpawu zihlala ziphela kwiintsuku ezimbalwa emva kokuyeka amayeza.
Ukusebenzisana nezinye iziyobisi
Ezinye ii-H2 blockers zinokuchaphazela indlela amanye amayeza owasebenzisayo asebenza ngayo. Umzekelo, i-H2 blocker cimetidine inokunciphisa ukusebenza kwezinye ii-antidepressants (SSRIs) kunye ne-blood thinner warfarin (`(warfarin)`).
Ngoko ke, ngaphambi kokuba uqale i-H2 blocker entsha, kubaluleke kakhulu ukwazisa ugqirha wakho malunga nazo zonke ezinye iziyobisi osele uzisebenzisa.
Ingaba ezi zifanelekile koomama abakhulelweyo nabancancisayo?
Kusafuneka uphando oluthe kratya malunga nokhuseleko lokusebenzisa ii-H2 blockers ngexesha lokukhulelwa, kodwa kuyaziwa ukuba la mayeza adluliselwa ebantwaneni ngobisi lwebele.
Ngoko ke, ukuba ukhulelwe, uceba ukukhulelwa, okanye ungumama oncancisayo, qiniseka ukuba uthetha nogqirha wakho ngaphambi kokuba uthathe naliphi na kula mayeza.
Umyalezo Wokuya Ekhaya
- Ii-H2 blockers luhlobo lwamayeza anciphisa i-asidi yesisu. Ziluncedo kakhulu ekunikeni isiqabu sexesha elifutshane kwintlungu yesitshiso sentliziyo kunye nesifuba.
- Nangona ezi zisebenza ngokukhawuleza kunee-PPI, azifanelekanga ukusetyenziswa imihla ngemihla ixesha elide.
- Ukuba kufuneka usebenzise ii-H2 blockers ngaphezu kweeveki ezimbini ngexesha, oko kuthetha ukuba unenye ingxaki efihlakeleyo. Ngokuqinisekileyo bonana nogqirha.
- Xelela ugqirha wakho malunga neminye imithi oyithathayo (kwaneevithamini).
- Ukuba ukhulelwe okanye uncancisa, musa ukusebenzisa la mayeza ngaphandle kwengcebiso kagqirha.
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