Isifo seswekile siye saba sisifo esixhaphakileyo kubantu abaninzi kwilizwe lethu. Mhlawumbi omnye wamalungu osapho lwakho, umhlobo, okanye nawe ngokwakho uchatshazelwa yile meko. Isifo seswekile sohlobo lwesibini ngokukodwa yingxaki enkulu yempilo echaphazela abantu abangaphezu kwezigidi ezingama-400 kwihlabathi liphela. Ukuba asilawulwa kakuhle, sinokukhokelela kwiingxaki eziyingozi ezifana nokonakala kwezintso, ukulahleka kombono, isifo sentliziyo, kunye nokukhubazeka. Nangona kukho iintlobo ezingaphezu kwama-30 zamayeza okulawula esi sifo, akukho nanye kuzo enokusinyanga ngokupheleleyo. Kodwa... uphando olutsha lubonisa ukuba le meko inokutshintsha. Makhe sibone ukuba njani.
Oko besikucinga ngesifo seswekile ixesha elide
Kwiminyaka engamashumi amabini eyadlulayo, ukuba ububuza ingcali ngesifo seswekile, ibingathi eyona nto ibangela oku 'kukunganyangeki yi-insulin'. Ngamafutshane, i-insulin yi-hormone eveliswa yi-pancreas yethu. Umsebenzi wayo ophambili kukuthatha i-glucose (iswekile) evela ekutyeni esikutyayo size siyifake kwiiseli zomzimba wethu. Kulapho ke iiseli zifumana amandla.
Cinga nge-insulin njengesitshixo, neeseli njengomnyango. I-insulin sisitshixo esivula ucango ukuze i-glucose ingene kwiiseli.
Kodwa, iiseli zomntu onesifo se-insulin aziphenduli kakuhle kule insulin. Kufana nomngxuma wesitshixo emnyango onomhlwa. Emva koko, ngenxa yokuba ucango alunakuvulwa, ipancreas kufuneka yenze ezinye izitshixo ze-insulin. Ekuhambeni kwexesha, ipancreas iba buthathaka ngenxa yokusebenza nzima kangaka. Kulapho ke kuvela khona isifo seswekile sohlobo lwesibini. Eli libali esilaziyo ixesha elide.
Eyona nto intsha ibalulekileyo ifunyenweyo: Ibali leeseli ze-beta
Ngoku izazinzulu zifumanise ukuba ingxaki ayikokuxhathisa i-insulin kuphela. Esinye isiqingatha sengxaki sikumaseli ethu e-beta . La ngamaseli ahlala ngaphakathi kwi-pancreas kwaye afana neefektri ezincinci ezivelisa i-insulin.
Uninzi lwee-beta cells ezidingwa yimizimba yethu zenziwa kwiminyaka embalwa yokuqala yobomi bethu. Kodwa abanye abantu bazalwa benee-beta cells ezininzi kunezinye. Ngoko ke, nokuba bakhula benokumelana ne-insulin kamva ebomini, iifektri zabo zee-beta cells zinokwenza i-insulin eninzi ukuze zibuyisele umzimba.
Nangona kunjalo, xa umntu ozelwe enesifo sokungabikho kwee-beta cells efumana ukumelana ne-insulin, iiseli eziseleyo kufuneka zisebenze nzima kunokuba zikwazi ukumelana nazo. Ekugqibeleni, ezo seli ziyadinwa zize zife. Abo ngabantu abafumana isifo seswekile sohlobo lwesibini.
Ngoko ke, eyona njongo inkulu ngoku kukufumana iyeza elinokuphinda livelise ezi seli ze-beta ezifayo okanye lonyuse inani leeseli ezikhoyo. Ukuba oko kungenziwa, isifo seswekile sohlobo lwesibini sinokunyangwa, singalawulwa kuphela.
Amayeza amva nje azise ithemba
Njengoko izazinzulu zaziphanda oku, zifumene iyeza elinokunceda ekukhuliseni ezi seli ze-beta. Libizwa ngokuba yi -harmine . Liyi-compound efumaneka ngokwendalo kwizityalo ezahlukeneyo kwihlabathi liphela.
Eli yeza, elibizwa ngokuba yi-harmine, lisebenza ngokuthintela i-enzyme ebizwa ngokuba yi -DYRK1A ngaphakathi kwee-beta cells. Xa oku kuvaliwe, ii-beta cells ziqala ukwahlukana, ukwanda, nokwanda ngobukhulu. Kuvavanyo lweempuku, iimpuku ezineswekile ezinikwe eli yeza zinyuke kathathu ngobukhulu bee-beta cells! Kwangaxeshanye, amanqanaba azo eswekile egazini nawo abuyele kwisiqhelo.
Kodwa, ukuze oku kuphumelele ebantwini, izazinzulu zaqonda ukuba kukho enye into efunekayo. Ngoko ke, bavavanya ichiza le-harmine ngolunye uhlobo lwamayeza asele esetyenziswa kwisifo seswekile. Elo didi lamayeza libizwa ngokuba yi -GLP1R agonists . Ukuba ungumntu othatha amayeza eswekile, usenokuba ukhe weva ngala magama: `(exenatide)`, `(liraglutide)`, `(lixisenatide)` zezinye zeziyobisi ezikweli didi. Zisebenza ngokuvuselela iiseli ze-beta nokukhuthaza ukuveliswa kwe-insulin.
Ngoko ke, kwenzeka ntoni xa la mayeza mabini edityanisiwe? Iziphumo bezimangalisa!
| Unyango olusetyenzisiweyo | Ukukhula kweeseli zeBeta (kwiiyure ezingama-24) |
|---|---|
| I-Harmine kuphela | Ukukhula okumalunga ne- 2% |
| I-Harmine + GLP1R agonist drug | Ukukhula ukuya kuthi ga kwi -8% ! |
| Kwezinye iimeko, amanani eeseli ze-beta abonwe enyuka ngama- 40% kwiintsuku nje ezi-4. | |
Ezi ziphumo zinike ithemba elikhulu lokuba le ndlela yonyango iya kuphumelela nakubantu.
Umngeni ozayo kwaye kutheni oku kubalulekile?
Eyona ngxaki inkulu ngoku yindlela yokuhambisa lo mxube wamayeza ngqo kwiiseli ze-beta. Izazinzulu zithi, "Sinephakheji yokunyanga iiseli ze-beta, kodwa asazi idilesi echanekileyo yokuyithumela kuyo." Njengesisombululo, bacinga ngokusebenzisa into ebizwa ngokuba yi-monoclonal antibodies . Ezi zifana nenkonzo ye-courier ekrelekrele enokuhambisa iphakheji yethu yamayeza ngqo kwiiseli ze-beta.
Kutheni oku kubaluleke kangaka?
Khawucinge nje, amayeza esifo seswekile akhoyo ngoku alawula kuphela amanqanaba eswekile egazini. Ukuba uyeka ukuwasebenzisa la mayeza, isifo siya kuphinda sivele.
Eyona nto iphantse yafikelela kwisisombululo esihlala sihleli ukuza kuthi ga ngoku lutyando lwe-bariatric . Oko kukuthi, utyando lokunciphisa umzimba. Oku kudla ngokubeka isifo seswekile esichengeni. Kodwa kubantu abazizigidi ezingama-400 emhlabeni, utyando alusebenzi. Lubiza kakhulu, lunobungozi, kwaye luthatha ixesha elide ukuphiliswa.
Kodwa ukuba olu didi olutsha lwamayeza luyaphumelela, lunokutshintsha ubomi bezigidi zabantu kwihlabathi liphela. Alugcini nje ngokucinezela iimpawu, kodwa lubuyisela unobangela wesifo, oku kukulahleka kweeseli ze-beta.
Umyalezo Wokuya Ekhaya
- Isifo seswekile sohlobo lwesibini asibangelwa kuphela kukunganyangeki kwe-insulin. Ukuncipha kwenani lee-beta cells ezivelisa i-insulin nako kuyimbangela ephambili.
- Izazinzulu ngoku zizama ukufumana iyeza elinokukhulisa kwakhona ezi seli ze-beta ezilahlekileyo.
- Uphando lubonise ukuba ukudibanisa i-harmine kunye neyeza le-agonist elisele lisetyenzisiwe le-GLP1R kubangela ukuba iiseli ze-beta zikhule ngokukhawuleza.
- Nangona oku kusesekwinqanaba lophando, kunethemba elikhulu lonyango olunokunyanga ngokupheleleyo isifo seswekile kwixesha elizayo.
- Nangona konke oku kulithemba lekamva, kubalulekile ukulawula isifo sakho seswekile okwangoku. Landela icebiso likagqirha wakho.
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