Ingabe uzizwa ubuthakathaka? Ingabe izitho zakho zomzimba ziyathuthumela? Ake sifunde nge-CIDP (Chronic Inflammatory Demyelinating Polyneuropathy)!

Ingabe ngezinye izikhathi uzizwa ukhathele kakhulu, izingalo nemilenze yakho kubuhlungu, noma unomuzwa wokucasuka? Ngezinye izikhathi ungase ungazinaki kakhulu lezi zinto. Kodwa-ke, ezimweni ezingavamile, lezi zimpawu zingaba uphawu lokuthile okungathi sína kakhulu. Esinye isimo esingavamile kodwa esibalulekile okufanele usiqaphele sibizwa ngokuthi i-CIDP (Chronic Inflammatory Demyelinating Polyneuropathy) . Nakuba igama lingase libonakale lide kancane, masiligcine lilula.

Kuyini i-CIDP (Chronic Inflammatory Demyelinating Polyneuropathy)?

Nakuba leli gama lingase libonakale liyinkimbinkimbi kancane, uma sichaza incazelo yalo, singathola umbono ongcono ngalesi sifo.

• Okungalapheki: Lokhu kusho "isikhathi eside." Lokhu kusho ukuthi i-CIDP ayiveli ngokuzumayo futhi ilulame ngokushesha. Ikhula kancane, esikhathini esingamaviki ayisishiyagalombili okungenani. Ngezinye izikhathi izimpawu ziyaphela bese ziphinde zivele ezinyangeni noma ngisho neminyaka kamuva. Kufana nenkinga ephindaphindayo.

• Ukuvuvukala: Lokhu kusho "ukuvuvukala" . Uma sithola ukulimala endaweni ethile emzimbeni wethu, kuyavuvukala bese kuba bomvu, akunjalo? Yilokho okuyikho. Kodwa ku-CIDP, lokhu kuvuvukala kwenzeka ngenxa yenkinga ethile ohlelweni lokuzivikela lomzimba wethu. Kalula nje, amasosha okufanele avikele umzimba wethu aqala ukuhlasela imizwa yethu ngephutha. Lokhu kubizwa ngokuthi "Ukuhlasela Okuzenzakalelayo" . Ukuvuvukala okweqile okubangelwa yilokhu kulimaza imizwa yethu yangaphandle . Le mizwa yangaphandle iyimizwa esukela ebuchosheni nasemgogodleni.

• Ukususa imyeloni: Leli igama elijulile kancane. Ama-neurons ethu anesembozo esivikelayo esiwazungezile. Kufana nesigxobo sepulasitiki esizungeze intambo kagesi. Lesi sembozo sibizwa ngokuthi `(Myelin Sheath)` . Lesi sembozo se-myelin yisona esivumela imiyalezo yezinzwa ukuthi ihambe ngokushesha nangokunembile. `(Ukususa imyeloni)` kusho ukuthi isigxobo se-myelin siyabhujiswa noma sonakele. Khona-ke, njengalapho ipulasitiki esentambo isuswa, ukuvuza kwamanje, kanye nemiyalezo yezinzwa akuhambi kahle.

• I-Polyneuropathy: Igama elithi "Poly" lisho "okuningi." Igama elithi "Neuropathic" lisho ukulimala kwemizwa. I-Polyneuropathy lisho ukulimala kwemizwa eminingi engaphandle komzimba ngesikhathi esisodwa. Lokhu kungabangela izinkinga ezahlukahlukene njengobuthakathaka bemisipha, ukungazweli, kanye ne-paresthesia.

Ngakho-ke, kafushane nje, i-CIDP yisimo sesikhathi eside lapho i-myelin sheath ezungeze izinzwa ezingaphandle yonakala khona ngenxa yokungasebenzi kahle kwesimiso sethu somzimba sokuzivikela, okuholela ekungasebenzi kahle kwezinzwa eziningi. Uyaqonda?

Uyini umehluko phakathi kwe-Guillain-Barré Syndrome (GBS) kanye ne-CIDP?

Cishe wenaKungenzeka ukuthi uke wezwa nge -` (Guillain-Barré Syndrome)` noma ` (GBS) .` Isifo i-CIDP sifana kakhulu ne-GBS. Odokotela babheka i-CIDP njengohlobo lwe-GBS oluhlala isikhathi eside. I-GBS futhi iyisifo esingavamile lapho amasosha ethu omzimba ehlasela khona izinzwa zangaphandle.

Kodwa umehluko omkhulu isikhathi. Okubi kakhulu kwe-GBS kuvame ukufika emavikini amabili kuya kwamathathu ngemva kokuqala kwezimpawu. Kodwa abantu abaningi baba ngcono kancane kancane ngemva kwalokho. Kodwa i-CIDP ihlala isikhathi eside. Izimpawu ziya ziba zimbi kancane kancane emavikini okungenani ayisishiyagalombili .

Ivame kangakanani i-CIDP?

I-CIDP empeleni iyisimo esingavamile kakhulu . Ngokusho kwabacwaningi, inani lamacala amasha e-CIDP e-United States liphakathi kuka-0.8 no-8.9 kubantu abayi-100,000 ngonyaka. Lolu hlu lukhulu kancane, ngoba i-CIDP ingathinta abantu abahlukene ngezindlela ezahlukene, futhi ngoba kunzima ukuxilonga lesi sifo.

I-CIDP ingakhula kunoma yimuphi ubudala.

Ziyini izimpawu ze-CIDP?

Izimpawu ze-CIDP zingahluka kuye ngohlobo. Kodwa-ke, uphawu oluvame kakhulu ubuthakathaka bemisipha obuqhubeka buhlala okungenani amasonto ayisishiyagalombili. Lokhu kuvame ukuthinta izinhlangothi zombili zomzimba ngokulinganayo. Ngokuqondile:

• Imisipha yendawo yesinqe nethanga
• Imisipha yehlombe kanye nendawo engaphezulu yengalo
• Intende yesandla neminwe
• Izinyawo nezinzwane

Cabanga nje, ngokuzumayo uthola kunzima ukuvuka esihlalweni, uzizwe sengathi awukwazi ukukhuphuka izitebhisi, noma ukuthola kunzima ukukama izinwele zakho noma ukubamba inkomishi. Izinto ezinjengalezi zingenzeka.

Ezinye izimpawu ezingase zibonakale zifaka:

• Ukuqina kwemisipha ethintekile
• Ukuba ndikindiki, ukuqaqamba, noma ukulahlekelwa umuzwa eminweni nasezinzwaneni (i-Paresthesia)
• Ubunzima bokugcina ibhalansi yomzimba kanye nokungasebenzi kahle kokuxhumana (njengokukhubeka)
• Ubunzima bokuhamba noma ukulahlekelwa ukuhamba ngokuphelele
• Ukulahlekelwa noma ubuthakathaka be-deep tendon reflexes (yilokhu udokotela azokuhlola ngokushaya idolo ngesando esincane)
• Ubuhlungu be-Neuropathic. Lobu ubuhlungu obuzwakala sengathi busha noma bushaqiswe ngogesi.

Akuvamile kakhulu, ungase ubone nezimpawu ezifana nalezi:

• Ubunzima bokugwinya (i-Dysphagia) kanye nobuthakathaka bentamo engenhla
• Umbono Ophindwe Kabili

Lezi zimpawu zingashintsha ngokuhamba kwesikhathi. Zingaqala kancane kancane, noma zingase zithuthuke ngokushesha. Ngezinye izikhathi zingase zifike zidlule, ziphele ngemva kwezinsuku ezimbalwa, bese zibuya. Uma unalezi zimpawu, kubalulekile ukubona udokotela ngokushesha okukhulu.Ukuxilongwa kusenesikhathi kanye nokwelashwa kusiza kakhulu ekululameni.

Ingabe kunezinhlobo ezahlukene ze-CIDP?

Yebo, kunezinhlobo ezahlukene ze-CIDP, futhi izimpawu zazo zihlukile kancane.

Uhlobo oluvame kakhulu yi-CIDP ejwayelekile , ebangela ubuthakathaka bemisipha kanye nezimpawu zokuzwa (njengokungazweli) kuzo zombili izinhlangothi zomzimba.

Ezinye izinhlobo ezingavamile yilezi:

• ` (I-Multifocal Motor Neuropathy)`: Lokhu kuhilela ubuthakathaka bemisipha kuphela. Lobu buthakathaka abulingani, okusho ukuthi bungathinta indawo eyodwa kuphela ohlangothini olulodwa lomzimba, noma izindawo eziningana ngezindlela ezahlukene.
• (I-Lewis-Sumner Syndrome): Lokhu kuhilela kokubili ubuthakathaka bemisipha obungalingani kanye nezimpawu zokuzwa.
• ` (I-Pure Sensory CIDP)`: Lokhu kungabangela ukungazweli, ubuhlungu, izinkinga zokulinganisela, kanye nokuhamba okungajwayelekile. Kodwa akukho ubuthakathaka bemisipha.
• `(Pure Motor CIDP):`: Kulokhu, ubuthakathaka bemisipha kanye nokulahlekelwa yizinzwa ezithinta izinhlangothi zombili zomzimba kungabonakala, kodwa azikho izimpawu zokuzwa.

Abacwaningi basafunda ezinye izinhlobo ze-CIDP.

Yini ebangela i-CIDP?

Njengoba sesixoxile ngaphambili, abacwaningi bakholelwa ukuthi i-CIDP ibangelwa ukungasebenzi kahle kwesimiso sethu somzimba . Nakuba imbangela eqondile ingakaziwa okwamanje, isimiso sethu somzimba sibona i-myelin sheath njengesitha bese siqala ukuyihlasela (ukusabela okuzenzakalelayo).

I-myelin sheath iyingqimba evikelayo ezungeze amangqamuzana ethu ezinzwa. Izungeza ingxenye ende ye-nerve fiber (i-axon). I-Myelin yiyona evumela ama-electrical impulses ukuthi ahambe kahle emthanjeni. Uma i-myelin yonakele, la ma-electrical impulses ahamba kancane kakhulu, noma alahleke ngokuphelele. Khona-ke "imiyalezo" ayifiki lapho kufanele iye khona. Yilokho okubangela izimpawu ze-CIDP.

Cabanga ngentambo kagesi efakwe kahle. Ihambisa ugesi kahle. Kodwa kwenzekani uma igobolondo lepulasitiki kuleyo ntambo liphuma ezindaweni ezithile? Ugesi uyavuza, noma awugelezi kahle, akunjalo? Yilokho okwenzekayo lapho igobolondo le-myelin lonakele.

I-CIDP ihlolwa kanjani?

Ukuxilonga i-CIDP kungaba nzima ngoba izinhlobo ezahlukene zinezimpawu ezahlukene. Ukuze axilonge i-CIDP, udokotela wakho uzokwenza okulandelayo:

• Bazolalela ngokucophelela izimpawu zakho futhi babuze ngomlando wakho wezokwelapha .
• Kuhlolwa umzimba kanye nokuhlolwa kwezinzwa .
• Kungase kudingeke ukuhlolwa okukhethekile okuningana ukuqinisekisa ukuxilongwa noma ukuqeda ezinye izimo.

Yiziphi izivivinyo ezisetshenziswa ukuxilonga i-CIDP?

Lezi yizivivinyo ezingasiza ekuqinisekiseni i-CIDP nokukhipha ezinye izimbangela:

• Ukuhlolwa kwe-Electromyography (EMG) kanye nokuhlolwa kokuqhuba imizwa: Lokhu kuhlolwa kubheka impilo kanye nokusebenza kwemisipha yakho kanye nemizwa eyilawulayo. Lokhu kuhlolwa kuwusizo kakhulu ekubhekeni izinguquko ezisusa imyelin (ukudluliselwa kancane kwezimpawu zemizwa, ukuvinjelwa, njll.) njenge-CIDP. Lokhu kungasiza ukuhlukanisa i-CIDP kwezinye izinhlobo ezivamile ze-polyneuropathies.

• Ukubhoboza Umgogodla/Ukulimala Kwethambo: Kulolu vivinyo, udokotela ufaka inalithi encane emhlane wakho ongezansi bese ethatha isampula yoketshezi lwakho lwe-cerebrospinal (CSF) . Lesi sampula sithunyelwa elabhorethri ukuze sihlolwe. Kubantu abangu-85% kuya ku-90% abane-CIDP, inani lamaseli amhlophe egazi livamile, kodwa izinga lamaprotheni liphakeme. Okunye ukukhubazeka ku-CSF kungabonisa esinye isimo.

• Ukuskena kwe-Magnetic Resonance Imaging (MRI) komhlane ongezansi: Uma izimpande zemizwa emhlane wakho ongezansi zimunca idayi yokungafani ngesikhathi sokuskena kwe-MRI, kungasiza ekuxilongeni i-CIDP.

• Ukuhlolwa Kwegazi: Udokotela wakho angase akuyalele ukuhlolwa kwegazi ukuze akhiphe ezinye izimo ezingabangela i-neuropathy, njengesifo sikashukela, ukuntuleka kwamavithamini, isifo se-thyroid, isifo se-Lyme, i-HIV/AIDS, kanye ne-lymphoma. Bangase futhi bahlole ama-antibodies athile atholakale ehlotshaniswa ne-CIDP.

• I-Neural Biopsy: Akuvamile ukuthi udokotela ancome i-nerve biopsy, lapho kususwa khona ingxenye ye-nerve bese kuhlolwa ukuze kubonakale ukuthi i-myelin sheath yonakele yini.

Yiziphi izindlela zokwelapha i-CIDP?

Kunezindlela ezintathu eziyinhloko zokwelapha i-CIDP (zomugqa wokuqala):

• Ama-Corticosteroids: Imithi ye-steroid, njenge-prednisolone, isiza ekunciphiseni ukuvuvukala. Kwabaningi, lawa ma-steroid kuphela angasiza ekunciphiseni izimpawu. Kodwa-ke, ama-steroid angaba nemiphumela emibi kakhulu, ngakho-ke ukusetshenziswa kwesikhathi eside kwale mithi kunqunyelwe. Udokotela wakho angase futhi akunike eminye imithi (ama-immunosuppressants) kanye nama-steroids.

• Ukushintshaniswa Kwe-Plasma / I-Plasmapheresis: Kulokhu kwelashwa, umshini uhlukanisa i-plasma egazini lakho, uyelaphe, bese ubuyisela i-plasma negazi emzimbeni wakho. Kalula nje, uhlunga ama-antibodies ayingozi ku-plasma ahlasela imizwa yakho. Ukushintshaniswa kwe-plasma kuvame ukusebenza amasonto ambalwa kuphela. Kungase kudingeke ukuthi lokhu kwelashwa kuvuliwe futhi kuvaliwe izinyanga, noma ngisho neminyaka.

• Ukwelashwa Nge-Intravenous Immunoglobulin (IVIG): Kulokhu kwelashwa, amaprotheni abizwa ngokuthi ama-immunoglobulin (amaprotheni akhiqizwa yisimiso sethu somzimba ngokwemvelo ukuhlasela abahlaseli) anikezwa nge-intravenous (IV). Le immunoglobulin itholakala egazini lezinkulungwane zabantu abaphilile. I-IVIG inganciphisa umonakalo owenziwa yisimiso sakho somzimba ezinzwaneni zakho. I-IVIG inganikezwa ngemithamo ephezulu kakhulu ekuqaleni, futhi kungadingeka ukuthi uthole lokhu kwelashwa njalo izinyanga, noma ngisho neminyaka.

Abacwaningi okwamanje bafunda ezinye izindlela zokwelapha ze-CIDP. Ungase futhi uthole ithuba lokubamba iqhaza ocwaningweni lwezokwelapha lwe-CIDP. Khuluma nodokotela wakho ngalokhu.

Impilo injani nge-CIDP? (Isibikezelo)

Umbono wesikhathi eside walesi sifo uncike ezintweni eziningana:

• Uneminyaka yakho lapho i-CIDP yaqala khona.
• Indlela lesi sifo esikhula ngayo kanye nohlobo lwesifo .
• Indlela lesi sifo esatholakala ngokushesha ngayo kanye nendlela yokwelashwa eyaqala ngayo .
• Indlela umzimba wakho osabela ngayo ekuqaleni ekwelashweni.

Cishe abantu abangu-90% abane-CIDP bangelapheka ngokwelashwa. Kodwa cishe abantu abangu-50% bayaphinda babuye. Ngokuvamile, ukubikezela kwesikhathi eside kwabantu abatholakale bene-CIDP besebancane kuhle. Uma ungatholi ukwelashwa kwe-CIDP, kungenzeka umonakalo wemizwa unomphela, okungaholela ekukhubazekeni okuthile.

Udokotela wakho uzokwazi ukukunikeza umbono omuhle wokuthi yini ongayilindela esikhathini esizayo ngokusekelwe esimweni sakho esithile.

Ingabe i-CIDP inciphisa isikhathi sokuphila?

I-CIDP ayisona isifo esibulalayo. Abantu abanalesi sifo bavame ukuba nesikhathi sokuphila esifana nesomuntu ongenaso lesi sifo. Ngakho-ke akukho okufanele ukhathazeke ngakho.

Ingabe i-CIDP ingavinjelwa?

Ngenxa yokuthi abacwaningi abakayitholi imbangela ethile ye-CIDP, okwamanje ayikho indlela eyaziwayo yokuvimbela lesi sifo ukuthi singabi khona.

Kufanele ngimbone nini udokotela? / Kufanele ngiye nini egumbini lezimo eziphuthumayo?

Uma utholakale une-CIDP, kufanele ubonane nodokotela wakho njalo ukuze aqaphe izimpawu zakho futhi athole ukwelashwa. Izimpawu ze-CIDP zingafika zidlule izinyanga noma ngisho neminyaka, ngakho-ke ukwelashwa okuqhubekayo kungadingeka.

Akuvamile kakhulu, i-CIDP ingathinta imisipha edingekayo ukuze uphefumule . Uma unenkinga yokuphefumula , shayela u-911 (noma inombolo yakho yezimo eziphuthumayo yendawo) ngokushesha, noma uye ekamelweni lezimo eziphuthumayo eliseduze. Lesi yisimo esiphuthumayo.

Okokugcina, izinto okufanele uzikhumbule

Kungaba yinto esabekayo ukuzizwa sengathi awukwazi ukulawula umzimba wakho. Kodwa izindaba ezinhle ukuthi izimpawu ze-CIDP (Chronic Inflammatory Demyelinating Polyneuropathy) zingelashwa, ikakhulukazi uma uqala ukwelashwa kusenesikhathi. Khumbula ukuthi ithimba lakho lezokwelapha linawe kuzo zonke izinyathelo zokubhekana nalesi simo. Ngakho-ke yiba nesibindi futhi ulandele iseluleko sikadokotela wakho.

` I-CIDP, I-Neuropathy, Ubuthakathaka Bemisipha, Ukuba ndikindiki, Isistimu Yokuzivikela Emzimbeni, I-Myelin, Isistimu Yezinzwa, Ukwelashwa kwe-CIDP, I-Chronic Inflammatory Demyelinating Polyneuropathy