Sawubona! Namuhla sizokhuluma ngomuthi oyinkimbinkimbi kancane, kodwa obaluleke kakhulu. Uma wena noma othile emndenini wakho enesifo esibizwa ngokuthi i-Cystic Fibrosis, udokotela wakho kungenzeka ukuthi unikeze umuthi obizwa ngokuthi i-Trikafta. Uqukethe inhlanganisela yemithi emithathu ebizwa ngokuthi i-Elexacaftor, i-Tezacaftor, ne-Ivacaftor. Lokhu akufani nomuthi ojwayelekile, kodwa umuthi okhethekile oya emsukeni wesifo bese usithinta. Ngakho ake sibone ukuthi lo muthi usetshenziswa kanjani ngempela, yiziphi izinto okufanele uziqaphele, nokuthi yimiphi imiphumela emibi engabangela.
Kwenzekani ngempela ngalo muthi?
Kalula nje, i-Cystic Fibrosis yisifo esibangelwa izakhi zofuzo esibangela ukuthi uketshezi oluhlukahlukene lomzimba, ikakhulukazi amafinyila ezithweni ezifana namaphaphu kanye ne-pancreas, lube lujiyile futhi lunamathele kakhulu. Lokhu kungaholela ekuhluphekeni kokuphefumula, ekuthelelekeni kwamaphaphu, kanye nezinkinga zokugaya ukudla.
Lo muthi, i-Trikafta, usebenza ngokulungisa ingxenye yephrotheni engasebenzi kahle ezigulini ezine-genetic mutation ethile ebizwa ngokuthi i-F508del . Lokhu kusho ukuthi esikhundleni sokulawula izimpawu, kusiza ukunciphisa umthelela wephutha eliyisisekelo lezakhi zofuzo elibangela lesi sifo. Lokhu kuyimpumuzo enkulu ngempela kulaba ziguli.
Izinto okudingeka uzitshele udokotela wakho ngaphambi kokuqala imithi
Kubaluleke kakhulu ukuthi udokotela wakho azi umlando wakho wezempilo ophelele ngaphambi kokukunikeza lo muthi. Lo muthi awufanele wonke umuntu. Qiniseka ukuthi utshela udokotela wakho, ikakhulukazi uma unezinye zalezi zimo:
- Uma unesifo sezinso .
- Uma unesifo sesibindi (lokhu kubaluleke kakhulu).
- Uma une -allergies ku-Elexacaftor, Tezacaftor, Ivacaftor, noma yimuphi omunye umuthi, ukudla, noma idayi equkethwe kulo muthi.
- Uma ukhulelwe noma uhlela ukuba nomntwana maduze.
- Uma ungumama oncelisayo.
Ngokusekelwe kulolu lwazi, udokotela wakho uzonquma ukuthi lo muthi ukulungele yini noma ukuthi umthamo udinga ukushintshwa.
Ngiyisebenzisa kanjani ngempela le mithi?
Ukuze uthole okuningi kulo muthi, kubalulekile ukuwuthatha njengoba kuqondiswe.
Into ebaluleke kakhulu ukuthi uhlale uthatha lo muthi kanye nokudla okuqukethe uwoyela noma amafutha , ngoba imithi ekulo muthi imuncwa kangcono ngumzimba uma ihlanganiswa namafutha.
Isibonelo, ungawuthatha lo muthi:
- Namaqanda
- Nebhotela lamantongomane
- Nesidlo esinoshizi (isb. i-pizza yoshizi)
- No-avokhado
- Nge-yogurt (iyogathi enamafutha agcwele)
Ezinye izinto okufanele uzikhumbule:
- Gwinya amaphilisi wonke . Ungawaphuli noma uwachoboze, noma uwahlafune njengokuhlafuna ushungamu.
- Zama ukuphuza umuthi wakho ngesikhathi esifanayo nsuku zonke. Uma usukwenzile lokhu umkhuba, ngeke ukhohlwe.
- Ungalokothi uthathe lo muthi namagilebhisi noma ijusi likagrapefruit. Izithako zejusi likagrapefruit zingathinta kakhulu indlela lo muthi osebenza ngayo.
- Ungayeki ukuthatha imithi yakho kuze kube yilapho udokotela wakho ekuyala ukuthi uyeke.
- Lo muthi ngezinye izikhathi unikezwa izingane ezingaphezu kweminyaka engu-6, kodwa kuphela ngaphansi kokubhekwa okukhethekile kwezokwelapha.
Kuthiwani uma ngengozi ngithatha umuthi omningi kakhulu?
Uma ucabanga ukuthi usuthathe lo muthi omningi kakhulu, ungesabi. Shayela ngokushesha i-National Poisons Information Centre e-Colombo National Hospital . Noma uye e-Emergency Treatment Unit (ETU) yesibhedlela esiseduze. Kungcono uma ungathatha iphakethe lemithi nawe uma uya.
Izinto okungafanele zisetshenziswe ngalo muthi
I-Trikafta iyisidakamizwa esinamandla esingasebenzisana neminye imithi. Ngakho-ke, kufanele utshele udokotela wakho ngayo yonke imithi oyithathayo, hhayi nje leyo oyinikezwe udokotela wakho, kodwa nemithi ethengiswa ngaphandle kwemithi kadokotela, amavithamini, kanye nemikhiqizo yamakhambi.
| Izidakamizwa nokudla okungase kuhlangane ne-Trikafta | |
|---|---|
| Gwema ukuthatha i-Trikafta nalezi zinto | |
| Eminye imithi yokwelapha isithuthwane | I-Carbamazepine, i-Phenobarbital, i-Phenytoin |
| Ama-antibiotic | I-Rifampin, i-Rifabutin |
| Imikhiqizo yezitshalo | I-St. John's Wort |
| Ukudla | Ijusi le-Grapefruit kanye ne-grapefruit |
| Buza udokotela wakho ukuthi usebenzisa i-Trikafta yini ngalezi zidakamizwa. | |
| Amanye ama-antibiotic | I-Clarithromycin, i-Erythromycin |
| Imithi yokulwa nesikhunta | I-Fluconazole, i-Itraconazole, ne-Ketoconazole |
| Imithi yokuvimbela amasosha omzimba | I-Cyclosporine, i-Sirolimus, i-Tacrolimus |
| Okunye | I-Digoxin, i-Warfarin, eminye imithi yesifo sikashukela (isib. i-Glipizide, i-Glipizide) |
Yimiphi imiphumela emibi engaba khona yokuphuza umuthi?
Njenganoma yimuphi umuthi, i-Trikafta ingabangela imiphumela emibi. Eminye yale miphumela ingaba mibi kakhulu. Ngakho-ke kubaluleke kakhulu ukuqaphela lokhu.
| Umphumela ongemuhle | Incazelo nokuthi yini okufanele uyenze |
|---|---|
| Imiphumela emibi kakhulu okufanele ibikwe kudokotela wakho ngokushesha | |
| Izimpawu zokulimala kwesibindi | Umchamo ophuzi omnyama noma onsundu, ukuphuzi kwamehlo noma isikhumba, ubuhlungu engxenyeni engenhla kwesokudla yesisu, ukulahlekelwa yisifiso sokudla, isicanucanu, ukukhathala okungavamile. Uma uqaphela lokhu, tshela udokotela wakho ngokushesha. |
| Ukusabela okukhulu kokungezwani komzimba | Ukuqubuka kwesikhumba, ukulunywa, ukuvuvukala kobuso, izindebe noma ulimi, ubunzima bokuphefumula. Lesi yisimo esiphuthumayo. |
| Izinguquko ekuboneni | Bika noma yiziphi izinguquko kudokotela wakho , njengokufiphala kwamehlo akho amhlophe (izimbotshana) noma ukubona okufiphele. |
| Ushukela ophansi egazini (i-Hypoglycemia) | Ukungaphumuli, ukudideka, isiyezi, indlala enkulu, ukujuluka ngokweqile, ukuthuthumela, kanye nokushaya kwenhliziyo okusheshayo. |
| Imiphumela emibi evame ukungabi mibi kakhulu, kodwa okufanele ibikwe kudokotela uma iqhubeka | |
| Izinkinga zesistimu yokugaya ukudla | Ubuhlungu besisu, uhudo, igesi. |
| Izimpawu ezivamile | Ikhanda elibuhlungu, isiyezi, umkhuhlane, ukuminyana kwama-sinus. |
| Ikakhulukazi kwabesifazane | Ubuhlungu ngesikhathi sokuya esikhathini. |
Uma unezinye izimpawu ezingavamile ezingekho kulolu hlu, tshela udokotela wakho ngazo.
Umlayezo Wokuya Nawe Ekhaya
- I-Trikafta iwumuthi obaluleke kakhulu we-Cystic Fibrosis othinta imbangela yesifo.
- Lo muthi kufanele uthathwe kanye nokudla okunamafutha noma ukudla okunamafutha . Gwema ukuwuthatha esiswini esingenalutho.
- Ungalokothi uthathe lo muthi kanye nejusi likagrapefruit. Futhi, tshela udokotela wakho ngayo yonke eminye imithi oyithathayo.
- Funa usizo lwezokwelapha ngokushesha uma uba nezimpawu zokulimala kwesibindi (ukuphuzi kwamehlo, umchamo omnyama) noma ukusabela okukhulu kokungezwani komzimba.
- Hlangana nodokotela ngosuku oluhleliwe futhi ungaphuthelwa ukuhlolwa kwegazi namehlo akuyalayo.
- Lo muthi ungowakho wedwa. Ungalokothi wabelane ngawo nabanye.
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