Isibindi singesinye sezitho ezibaluleke kakhulu emzimbeni wakho. Sifana nefektri enkulu. Senza umsebenzi omningi obalulekile, njengokususa ubuthi ekudleni esikudlayo, ukugcina amandla, nokwenza i-bile, okusisiza ukugaya ukudla. Ngakho-ke, ukugcina le fektri isebenza kahle kubaluleke kakhulu empilweni yomzimba wethu wonke. Kodwa ngezinye izikhathi kunezifo ezithinta isibindi buthule, izifo esingazizwa kakhulu ngazo. Namuhla sizokhuluma ngesifo esisodwa esinjalo. Leso yi-Primary Biliary Cholangitis, noma i-PBC njengoba siyibiza ngamafuphi.
Kalula nje, iyini i-PBC?
Kulungile, ake sikwenze lokhu kube lula. Njengoba ngishilo ekuqaleni, isibindi sikhiqiza uketshezi olubizwa ngokuthi i-bile . Yilokhu okusisiza ukugaya amafutha ekudleni esikudlayo, ukumunca amavithamini athile, nokususa i-cholesterol engafuneki kanye nobuthi emzimbeni.
Ake ucabange nje, ngaphakathi kwesibindi kukhona inethiwekhi yemigudu ye-bile, efana nohlelo lwepayipi elincane. I-bile eyenziwa yisibindi ihamba ngalezi payipi ezincane futhi igcinwe lapho, isiza ekugayeni ukudla uma kudingeka. Okwenzekayo ku-PBC ukuthi le migudu ye-bile yonakele.
Uma le migudu yonakele, i-bile ayikwazi ukugeleza kahle bese iqala ukunqwabelana ngaphakathi kwesibindi. Kufana nepayipi lamanzi eliphukile eligcwalisa indlu ngamanzi. I-bile enqwabelana ngale ndlela iqala ukulimaza amangqamuzana esibindi. Uma lokhu kulimala kwenzeka ngokuhamba kwesikhathi, izicubu zesilonda ziqala ukwakheka esikhundleni samangqamuzana esibindi anempilo. Lesi simo sibizwa ngokuthi i-cirrhosis . Lapho isibindi siba nesilonda ngale ndlela, ukusebenza kwaso okuvamile cishe kuyaphazamiseka ngokuphelele.
Izigaba ezine zesifo se-PBC
I-PBC ayibi yimbi ngasikhathi sinye. Ikhula kancane kancane, ngezigaba eziningana. Ngokuvamile kunezigaba ezine eziyinhloko.
| Isiteji | Kwenzakalani |
|---|---|
| Isigaba 1 (Isigaba se-Portal) | Lesi yisigaba sokuqala. Okwenzekayo lapha ukuvuvukala, okuwukuvuvukala, okuzungeze imisele ye-bile. Lolu shintsho luqala endaweni yokungena kwesibindi lapho imithambo yegazi kanye nemisele ye-bile ihlangana khona. |
| Isigaba 2 (Isigaba Esingaphandle) | Manje ukuvuvukala sekusabalele kancane futhi sekuqala ukuphuma eduze kwemisele yenyongo. Kukulesi sigaba lapho inani elincane lezicubu zesibazi (i-fibrosis) liqala ukwakheka khona. |
| Isigaba 3 (Isigaba sikaSepthemba) | Okwamanje, leso sikhumba sesisabalale kakhulu, sakha ukuxhumana phakathi kwezingxenye zesibindi. Kufana nenethiwekhi yezibazi ezifana nolwembu lwesicabucabu ezisakazeka kulo lonke isibindi. |
| Isigaba 4 (Isifo Sokusha Kwesibindi) | Lesi yisigaba esibi kakhulu nesokugcina salesi sifo. Ngalesi sikhathi, izicubu zesilonda sezisakazeke kulo lonke isibindi, zenza isibindi sibe lukhuni futhi sakhe amaqhubu. Lesi simo sibizwa ngokuthi i-cirrhosis. Kulesi sigaba, ukusebenza kwesibindi kuyaphazamiseka kakhulu. |
Yini ngempela ebangela i-PBC?
Lena inkinga abantu abaningi abanayo. Eqinisweni, odokotela abakayitholi imbangela eqondile ye-PBC. Kodwa-ke, umbono wamanje owamukelwayo uthi yisifo sokuzivikela komzimba esibangelwa ukuhlanganiswa kwezici zofuzo kanye nezemvelo .
Kulungile, siyini lesi sifo sokuzivikela komzimba?
Kalula nje, lokhu kuyiphutha ohlelweni lwethu lokuzivikela lomzimba. Ngokuvamile, amangqamuzana ethu amhlophe egazi (ikakhulukazi ama-T-cell) alwa namagciwane abangela izifo. Kodwa ku-PBC, lawa mangqamuzana omzimba ayaba namandla futhi aqale ukuhlasela amangqamuzana e-bile duct aphilile esibindini. Kufana nebutho lethu lihlasela abantu bakithi ngephutha.
Kulapho amangqamuzana ethu ehlasela njalo imigudu yenyongo ngale ndlela lapho umonakalo engikhulume ngawo ekuqaleni uqala khona ukwenzeka.
Akunakushiwo ukuthi lesi sifo sidluliselwa kusuka esizukulwaneni kuya kwesinye ngokusebenzisa izakhi zofuzo. Okusho ukuthi, akukho mthetho wokuthi ngenxa yokuthi umama unaso, indodakazi yakhe nayo izosithola. Kodwa-ke, uma othile emndenini, ikakhulukazi isihlobo esiseduze (umama, udadewabo, noma umfowabo), ene-PBC, ingozi yokuba abanye bathole lesi sifo iphakeme kancane kunomuntu ojwayelekile. Ngakho-ke, kungacatshangwa ukuthi kukhona ukuxhumana kwezakhi zofuzo.
Ubani osengozini enkulu yokuthola i-PBC?
Nakuba noma ubani angaba ne-PBC, abanye abantu basengozini enkulu kancane. Ake sibheke ukuthi bangobani.
| Isici Sengozi | Imininingwane Engeziwe |
|---|---|
| Ubulili (Ubulili) | Lokhu kuyamangaza. I-PBC ivame kakhulu kwabesifazane. Abesifazane banamathuba aphindwe kayi-9 kuya kweyishumi okuthola lesi sifo kunabesilisa. |
| Ubudala | Iningi labantu abatholakale benalesi sifo baphakathi kweminyaka engama-30 nengama-60 , kodwa singaba khona nakubantu abancane noma abadala kunalokho. |
| Umlando Womndeni | Njengoba ngishilo ngaphambili, uma othile emndenini wakho (ikakhulukazi umama wakho noma udadewenu) ene-PBC, usengozini enkulu yokuthola lesi sifo kunabantu abaningi. |
| Isizinda Sofuzo | Emhlabeni jikelele, lesi sifo sivame ukubikwa kubantu abavela eNyakatho Yurophu (njengaseScotland nasemazweni aseScandinavia). Kodwa-ke, singavela kunoma yiliphi izwe kanye neqembu lobuhlanga emhlabeni. |
Ziyini izimpawu-ke?
Lokhu kuyinto ebaluleke kakhulu. Into eyesabekayo nge-PBC ukuthi abantu abaningi ababonisi zimpawu ezigabeni zokuqala. Ngezinye izikhathi kutholakala ngengozi lapho kwenziwa ukuhlolwa kwegazi kwesinye isimo.
Kodwa njengoba lesi sifo siqhubeka, izimpawu ezinjengalezi zingase zivele:
- Ukukhathala: Uphawu olukhulu ukuzizwa ukhathele kakhulu ngaphandle kwesizathu esibonakalayo, ngisho nalapho ulele.
- Isikhumba Esilumayo: Ungase ube nokulunywa okungabekezeleleki emzimbeni wakho wonke, ikakhulukazi ezintendeni zezandla zakho nasematheni.
- Amehlo nomlomo owomile: Ukwehla kokukhiqizwa kwezinyembezi emehlweni kanye namathe emlonyeni, okubangela umuzwa wokoma.
- Ubuhlungu bamalunga namathambo.
- Ubuhlungu obuncane noma ukungakhululeki ohlangothini oluphezulu kwesokudla lwesisu.
Njengoba lesi sifo siqhubeka (sifinyelela esigabeni se-cirrhosis), izimpawu ezifana nokuvuvukala kwemilenze, uketshezi esiswini, kanye nokuphuzi kwamehlo nesikhumba (i-jaundice) nazo zingase zivele.
Kufanele ubonane nini nodokotela?
Uma wena, ikakhulukazi uma ungowesifazane ophakathi kweminyaka engama-30 nengama-60, ubhekene nezimpawu ezifana nokukhathala okuqhubekayo kanye nesikhumba esilumayo ngaphandle kwesizathu esibonakalayo, ungamane nje ukuchithile njengokuthi "ukuguga nje" noma "umsebenzi omningi kakhulu." Bona udokotela wakho ngokushesha bese ukhuluma ngakho.
Udokotela uzokuxilonga futhi, uma kudingeka, acele ukuhlolwa kwegazi okuningana. Lesi sifo singatholakala kalula ngokuhlola ama-enzyme esibindi kanye nama-antibodies athile (AMA - Antimitochondrial Antibodies). Ngakho-ke ungazinaki izimpawu. Uma sitholakala ngokushesha, kulapho amathuba okuba selashwe futhi silawulwe khona.
Umlayezo Wokuya Nawe Ekhaya
- I-PBC yisifo esingamahlalakhona esilimaza imisele yenyongo emincane esibindini.
- Lesi akusona isifo esithathelwanayo. Sivame ukubangelwa iphutha ohlelweni lokuzivikela lomzimba wethu (i-autoimmune).
- Ezigabeni zokuqala, kungase kungabi nazimpawu nhlobo. Izimpawu zokuqala ezivame kakhulu ukukhathala kanye nokulunywa kwesikhumba.
- Lesi sifo sivame kakhulu kwabesifazane, ikakhulukazi labo abaneminyaka ephakathi kuka-30 no-60.
- Uma unemibuzo noma izimpawu ngalokhu, zihlole (Linda, lokho kuyisiThai. I-Typo enqubweni yami yokucabanga. Kumele uqaphele). Ungazibandakanyi ekuzihloleni, kodwa nakanjani bonana nodokotela ofanelekayo bese ucela iseluleko.
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