Ingabe udokotela ukunike uhlobo lomuthi obizwa ngokuthi i-SNRI ngenxa yokucindezeleka kwakho noma ukukhathazeka okuqhubekayo? Mhlawumbe omunye wabangane bakho usebenzisa lo muthi. Kungenzeka ukuthi uzizwe wesaba kancane lapho uzwa leli gama. Mhlawumbe unemibuzo eminingi engqondweni yakho efana nokuthi, "Uyini lo muthi? Ingabe lokhu kuhle emzimbeni?" Ngakho-ke namuhla, ake sixoxe ngalolu hlobo lomuthi obizwa ngokuthi i-SNRI kalula, njengokungathi ukhuluma nomngane.
Kalula nje, ziyini lezi SNRI?
Incazelo ephelele ye-SNRI ithi i-Serotonin kanye ne-Norepinephrine Reuptake Inhibitors . Kulungile, leli gama lizwakala liyinkimbinkimbi kancane, akunjalo? Ake silichaze futhi siliqonde kalula.
Ngaphakathi kobuchopho bethu, kunezithunywa ezikhethekile zamakhemikhali ezilawula izinto eziningi, okuhlanganisa imizwa yethu, imicabango, ukulala, kanye nesifiso sokudla. Lokhu sikubiza ngokuthi "ama-Neurotransmitters." Njengomuntu othumela iposi, lezi zithunywa zithwala imiyalezo isuka kwenye ingxenye yobuchopho iye kwenye.
Ezimbili zalezi zithunywa yi -serotonin kanye ne-norepinephrine .
- I-Serotonin ibaluleke kakhulu ezintweni ezifana nesimo sethu sengqondo, ukulala, kanye nokugaya ukudla. Uma amazinga e-serotonin ephezulu, sizizwa sijabule futhi sikhululekile.
- I-Norepinephrine isisiza ukuthi sihlale sigxile, sinamandla futhi sisebenza.
Okuvame ukwenzeka ukuthi ngemva kokuba laba bathunywa bethule umyalezo wabo, amangqamuzana obuchopho ayawamunca futhi. Lokhu kubizwa ngokuthi "ukuphinda athathe." Njengoba nje umuntu othumela iposi ebuyela eposini ngemva kokuhambisa incwadi.
Kodwa-ke, kubantu abanezimo ezinjengokucindezeleka noma ukukhathazeka, umsebenzi walezi zithunywa ze-serotonin ne-norepinephrine ungase wehle kancane ebuchosheni.
Yilapho izidakamizwa ze-SNRI zingena khona. Lokho okwenziwa yilezi zidakamizwa ukuvimba okwesikhashana ukumuncwa kabusha kwalezo zithunywa. Kufana nokutshela umuntu othumelayo ukuthi "alinde isikhashana bese ehambisa eminye imiyalezo embalwa." Bese lezi zithunywa ezinhle (i-serotonin ne-norepinephrine) zihlala ebuchosheni isikhathi eside futhi zenze umsebenzi wazo omuhle. Lokhu kuqala ukuthuthukisa isimo sethu sengqondo, kunciphise ukukhathazeka, futhi kwandise amandla ethu.
Kalula nje, ama-SNRI awuhlobo lwemithi esisiza sizizwe singcono ngokulinganisela amazinga amakhemikhali emvelo ebuchosheni bethu alawula "injabulo namandla."
Yiziphi izimo ezisetshenziswa imithi ye-SNRI?
Nakuba le mithi inqunyelwe kakhulu izinkinga zempilo yengqondo, odokotela bayinqunyelwe nezinye izimo eziningana zomzimba. Ake sibheke ukuthi iyini.
| Ukugula | Incazelo elula |
|---|---|
| Imicimbi enconywe kakhulu | |
| Isifo Sokucindezeleka Esiyinhloko | Ukuqeda izimpawu ezinjengokudabuka isikhathi eside, ukulahlekelwa yisithakazelo kunoma yini, kanye nokudinwa yimpilo. |
| Isifo Sokukhathazeka Esijwayelekile | Ukulawula ukwesaba, ukukhathazeka, kanye nokungahlaliseki okuhlala kubuya engqondweni ngaphandle kwesizathu esithile. |
| Isifo Sokukhathazeka Komphakathi | Ukunciphisa ukwesaba ngokweqile kanye namahloni okukhuluma nokwenza phambi kwabanye. |
| Isifo Sokwethuka | Ukuvimbela ukuhlaselwa uvalo okungazelelwe nokungalawuleki. |
| Ubuhlungu Obungapheli | Ukuqeda ubuhlungu obungapheli obubangelwa yizimo ezifana ne-neuropathy ehlobene nesifo sikashukela kanye ne-fibromyalgia. |
| Amanye amacala (Ukusetshenziswa ngaphandle kwelebula) | |
| Isifo Sokucindezeleka Okungapheli (OCD) | Ukulawula ukwenzeka njalo kwemicabango engafuneki kanye nokuphindaphinda kwezinto ezithile ngenxa yazo. |
| Izimpawu Zokunqamuka Kwesikhathi | Ukulawula izimpawu ezifana nokushisa okwenzeka ngesikhathi sokunqamuka kokuya esikhathini. |
| I-Migraines | Njengokwelashwa kokuvimbela i-migraines. |
Ungase uzibuze ukuthi kusho ukuthini "ukusetshenziswa ngaphandle kwelebula". Kusho ukuthi udokotela, ngokusekelwe olwazini lwakhe lwezokwelapha kanye nokuhlangenwe nakho, utusa umuthi wesinye isimo, ngaphezu kwesimo esiyinhloko esivunyelwe sona. Lokhu kuyinto evame ukwenziwa.
Yiziphi izinhlobo ezivame kakhulu ze-SNRI eSri Lanka?
Kunezinhlobo eziningana zemithi ye-SNRI. Udokotela wakho uzokhetha imithi ekufanele kakhulu kuye ngesimo sakho, ubudala, kanye nezinye izimo zempilo.
- I-Venlafaxine (njengegama lomkhiqizo i-Effexor®)
- I-Duloxetine (njengegama lomkhiqizo i-Cymbalta®)
- I-Desvenlafaxine (igama lomkhiqizo i-Pristiq®)
- I-Milnacipran (igama lomkhiqizo i-Savella®)
- I-Levomilnacipran (njengegama lomkhiqizo i-Fetzima®)
Umuthi owutholile ungase ube nomunye walokhu okungenhla.
Yimiphi imiphumela emibi engaba khona yokusebenzisa lo muthi?
Njengayo yonke imithi, lena ingaba nemiphumela emibi emincane. Kodwa kubantu abaningi, lokhu akukubi kangako. Ngokuvamile kwenzeka emavikini ambalwa okuqala okuthatha imithi bese kunyamalala njengoba umzimba wakho ujwayela imithi.
| Umphumela ongemuhle | Incazelo |
|---|---|
| Izinkinga zesistimu yokugaya ukudla | Isicanucanu, ukuhlanza, izinhlungu zesisu, ukuqunjelwa, noma uhudo. |
| Isiyezi (i-vertigo) | Ukuzungeza, ikakhulukazi uma umi noma ushintsha izikhundla. |
| Umlomo owomile | Umuzwa wokunamathelana kwamathe emlonyeni. Lokhu kungalawulwa ngokuphuza amanzi amaningi. |
| Ukujuluka ngokweqile | Ukujuluka kunganda, ikakhulukazi ebusuku. |
| Izinkinga zokulala | Abanye abantu bangase bazizwe belele kakhulu. Abanye bangase bazizwe belele kakhulu. |
| Izinkinga zocansi | Izinto ezinjengokuncipha kwesifiso socansi kanye nobunzima bokukhipha isidoda zingase zenzeke. Ungabi namahloni okukhuluma nodokotela wakho ngalokhu. |
Into ebaluleke kakhulu ukuthi, uma uhlangabezana nemiphumela emibi efana nale, futhi kunzima ukuyibekezelela, ungalokothi uyeke ukuthatha umuthi wedwa. Qiniseka ukuthi ukhuluma nodokotela wakho ukuze akunike iseluleko.
Izimo ezikhethekile zengozi okufanele uzinake
Nakuba ama-SNRI ngokuvamile ewumuthi ophephile, kuhle ukuqaphela izingozi ezinkulu, yize zingavela kaningi.
1. Isifo se-Serotonin
Lena yinto ebaluleke kakhulu okufanele uyiqaphele. Uma ama-SNRI neminye imithi ethinta amazinga e-serotonin ithathwa ndawonye, amazinga e-serotonin ebuchosheni angaba phezulu ngokungadingekile. Lesi yisimo esiphuthumayo sezokwelapha esingathi sína .
- Izimpawu: Ukudideka okungachazeki, ukushaya kwenhliziyo okusheshayo, umkhuhlane omkhulu, imisipha eqinile noma eshaya ngamandla, kanye nokujuluka ngokweqile.
- Okufanele ukwenze: Uma wena noma othile omaziyo eba nalezi zimpawu ngokuzumayo, bona udokotela ngokushesha noma uye eMnyangweni Wezimo Eziphuthumayo (ETU) wesibhedlela esiseduze.
2. Izimpawu ezenzeka lapho uyeka umuthi (i-Antidepressant Discontinuation Syndrome)
Uma uthatha lo muthi isikhathi eside bese uyeka ngokuzumayo, umzimba wakho ungase uzizwe ungakhululekile ngenxa yawo.
- Izici:Isiyezi, ikhanda elibuhlungu, isicanucanu, izinhlungu zomzimba (njengalapho unomkhuhlane), kanye nokukhathazeka okukhulu.
- Ukuvimbela: Ungalokothi uyeke ukuthatha imithi ngaphandle kokubonisana nodokotela wakho. Uma udinga ukuyeka, udokotela wakho uzonciphisa kancane kancane umthamo esikhathini esingangenyanga noma ezimbili, avumele umzimba wakho ulungise, bese ekutshengisa ukuthi ungayiyeka kanjani ngokuphephile.
3. Imicabango yokuzibulala
Lesi yisihloko esibucayi kakhulu, kodwa kuyinto okudingeka kukhulunywe ngayo. Izifundo zithole ukuthi kunengozi encane kakhulu yokwanda kwemicabango yokuzibulala, ikakhulukazi entsheni engaphansi kweminyaka engama-25 , phakathi namasonto ambalwa okuqala okusebenzisa lo muthi.
- Okubalulekile: Uma unale micabango, sicela ungahlupheki wedwa. Lokhu akulona iphutha lakho, kungaba umphumela omubi womuthi. Tshela udokotela wakho ngokushesha. Tshela ilungu lomndeni noma umngane omethembayo. Ukucela usizo kuyakunika amandla.
Ezinye izinto okufanele uzicabangele lapho uthatha ama-SNRI
Ukuphuza utshwala
Kungcono ukugwema ukuphuza utshwala ngenkathi uthatha imithi yokucindezeleka njenge-SNRIs. Utshwala luphinde lube yisidambisi-ndlela sezinzwa esiyinhloko. Ngakho-ke, lungaphazamisa ukusebenza kahle kwemithi. Utshwala ngezinye izikhathi lungenza izimpawu zokucindezeleka zibe zimbi kakhulu.
Eminye imithi
Uma uthatha i-SNRI, tshela udokotela wakho ngayo yonke eminye imithi oyithathayo (iziqeda-zinhlungu, imithi yokukhwehlela, amavithamini, ngisho nemithi yamakhambi). Eminye imithi ingasebenzisana ne-SNRI.
- Izibulala-zinhlungu ezifana nama-NSAID (isib. i-Ibuprofen, i-Diclofenac)
- Imithi evimbela ukujiya kwegazi (isib. i-Aspirin, i-Clopidogrel)
- Ama-Triptan ayimithi yokwelapha i-migraine.
- Imikhiqizo yamakhambi njenge- St. John's Wort
Ukukhulelwa nokuncelisa
Uma uhlela ukukhulelwa, usuvele ukhulelwe, noma uncelisa, kufanele nakanjani ukhulume nodokotela wakho ngokusebenzisa lo muthi. Amanye ama-SNRI angathinta ingane esibelethweni. Futhi, ukuyeka umuthi ngokuzumayo kungaba yingozi kumama. Udokotela wakho angakusiza ukuthi unqume ukuthi iyiphi inketho ephephile kuwe nakumntwana wakho.
Kuthatha isikhathi esingakanani ukuthi umuthi usebenze?
Lona umbuzo abantu abaningi abawubuzayo. Ama-SNRI awawona umuthi osebenza ngokushesha njengePanadol. Kuthatha isikhathi esithile ukuthi izinqubo zamakhemikhali zobuchopho zilinganisele.
- Iningi labantu lizobona ukuthuthuka (intuthuko) kwezimpawu zingakapheli amasonto amane kuya kwayisithupha .
- Kungathatha phakathi kwamasonto angu-9 kuya kwangu-12 (izinyanga ezingu-2-3) ukuze abanye abantu bathole izinzuzo ezigcwele zomuthi.
Ngakho-ke, ungayeki ukuthatha umuthi ngoba nje ungezwa umehluko omkhulu emasontweni ambalwa okuqala.Yiba nesineke. Uma ungasazizwa umehluko ngemva kwaleso sikhathi, khuluma nodokotela wakho futhi. Angase akwazi ukulungisa umthamo noma akushintshele komunye umuthi.
Umlayezo Wokuya Nawe Ekhaya
- Ama-SNRI ayimithi ephumelelayo esiza ukulawula ukucindezeleka, ukukhathazeka, kanye nezinye izimo zobuhlungu ngokulinganisela ukusebenza kwezithunywa zamakhemikhali zemvelo ebuchosheni bakho.
- Lomuthi awusebenzi ngokushesha. Kufanele ubekezele futhi ulinde amasonto ambalwa ukuze ubone imiphumela.
- Njengayo yonke imithi, kungase kube nemiphumela emibi emincane. Ivame ukuphela ngokuhamba kwesikhathi. Uma unenkinga engabekezeleleki, tshela udokotela wakho.
- Ungalokothi, nganoma yisiphi isizathu, uyeke ukuthatha lo muthi ngokuzumayo ngaphandle kokubonisana nodokotela wakho. Ukwenza kanjalo kungabangela izimpawu ezingathandeki.
- Kubalulekile ukwazisa udokotela wakho ngayo yonke eminye imithi oyiphuzayo, uma uphuza utshwala, futhi uma ukhulelwe.
- Uma unemibuzo, ukukhathazeka, noma ukungabaza ngemithi yakho, xoxa ngakho ngokukhululekile nodokotela wakho. Ungumeluleki wakho ongcono kakhulu nomethembayo.
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