Uke wezwa ngesifo sikashukela sohlobo 1? Lesi yisimo lapho amasosha omzimba wethu eqala ukuhlasela amangqamuzana akhiqiza i-insulin kuma-pancreas. Lokhu kuyesabeka kancane. Kodwa ngokuthuthuka kwesayensi yezokwelapha, kuvela izindlela ezintsha zokuphatha lezi zimo. Elinye ithemba elisha umuthi obizwa ngokuthi i-Teplizumab. Yilokhu okwenzayo, kubambezela ukuqala kwesifo sikashukela sohlobo 1. Ngakho ake sixoxe ngalokhu namuhla ngendlela elula ongayiqonda.
Uhlobo luni lomuthi iTeplizumab?
Kalula nje, i-Teplizumab iwumuthi ovumela abantu abasengozini yokuthola isifo sikashukela sohlobo 1 ukuba babambezele ukuqala kwalesi sifo ngeminyaka embalwa. Akuyona ikhambi lesifo sikashukela, kodwa iyabambezela ukuqala kwalesi sifo. Yindaba enkulu leyo, akunjalo?
Lo muthi ungoweqembu elibizwa ngokuthi i-Monoclonal Antibody . Ungakhathazeki uma uzwa lelo gama. Cabanga ukuthi amasosha (ama-antibodies) ohlelweni lokuzivikela komzimba wethu ayaphambuka aqale ukuhlasela amangqamuzana ethu amahle. Ngaleso sikhathi, ukulawula la masosha enza amaphutha, olunye uhlobo lweprotheyini olwenziwe ngokukhethekile elabhorethri lubizwa ngokuthi i-Monoclonal Antibody. Lokho okwenziwa yi-Teplizumab ukucindezela kancane isenzo sohlelo lokuzivikela komzimba oluhlasela ngephutha amangqamuzana enza i-insulin. Ngakho-ke, ukuthuthukiswa kwesifo sikashukela kuyabambezeleka.
Lo muthi uvame ukutholakala emakethe ngaphansi kwegama lomkhiqizo i-Tzield .
Izinto okudingeka uzitshele udokotela wakho ngaphambi kokuqala lokhu kwelashwa
Lokhu kubaluleke kakhulu. Ngaphambi kokuthi uqale ukwelashwa nge-Teplizumab, kubalulekile ukutshela udokotela wakho ulwazi olulandelayo. Lezi zinto zithinta ngqo impumelelo yokwelashwa kanye nokuphepha kwakho.
| Isimo okudingeka usibike | Kungani lokho kubalulekile? |
|---|---|
| Isimo samanje esithathelwanayo (isb. umkhuhlane, umkhuhlane, ukukhwehlela) | Ngenxa yokuthi lo muthi unciphisa ukusebenza kwesimiso somzimba sokuzivikela, ukutheleleka okukhona kungase kube kubi kakhulu. |
| Isifo sesibindi | Njengoba isibindi sibalulekile enqubweni yokukhipha izidakamizwa emzimbeni, kufanele wazise udokotela wakho uma unezinkinga zesibindi. |
| Ukwehla kwezingxenye zegazi (amangqamuzana abomvu egazi, amangqamuzana amhlophe egazi, ama-platelet) | Lo muthi ungabangela ukuthi izingxenye zegazi zehle kakhulu, ngakho-ke kuyingozi uma amazinga esephansi kakade. |
| Umuthi wokugomela wakamuva noma ozayo | Imithi yokugomela igciwane eliphilayo ikakhulukazi ingasebenzisana nalo muthi. Ngakho-ke, sicela unikeze incazelo ephelele yomuthi wokugomela. |
| Ukungezwani neminye imithi, ukudla, noma izinto ezithile | Lokhu kubalulekile ukwazi ukuthi une-allergy ku-Teplizumab noma kunoma yiziphi izithako zayo. |
| Uma uzama ukukhulelwa noma ukhulelwe | Akukho datha ephelele ngokuphepha kwalomuthi ngesikhathi sokukhulelwa, ngakho-ke kufanele ukhulume nodokotela wakho ngalokhu. |
| Uma ungumama oncelisayo | Lolu lwazi lubalulekile ukuze kutholakale ukuthi umuthi udlulela enganeni ngobisi lwebele. |
Lo muthi unikezwa kanjani emzimbeni?
I-Teplizumab akuyona imithi ongayithatha ekhaya bese uyisebenzisa.
- Lokhu kunikezwa njengokufakwa kwe-intravenous (IV) .
- Kwenziwa esibhedlela noma emtholampilo ngaphansi kokuqondisa kwethimba lezokwelapha.
- Lokhu kwelashwa kuvame ukunikezwa nsuku zonke izinsuku ezingu-14.
- Ngaphambi kokuba uqale ukwelashwa, uzonikezwa incwajana ekhethekile (i-MedGuide) enemininingwane ngalo muthi. Yifunde ngokucophelela njalo.
- Lo muthi unganikezwa nezingane ezingaphezu kweminyaka engu-8 ngaphansi kwezimo ezithile. Kodwa-ke, kunezinye izinto ezikhethekile okufanele uziqaphele. Khuluma nodokotela wakho ngalokhu.
Okubalulekile:Uma ucabanga ukuthi uphuze kakhulu lo muthi ngephutha, shayela ngokushesha i-National Poisons Information Centre e-Colombo National Hospital noma uye e-Emergency Treatment Unit (ETU) yesibhedlela esiseduze.
Kuthiwani uma ngiphuthelwa umthamo wemithi?
Kubaluleke kakhulu ukuthatha umthamo ngamunye walokhu kwelashwa ngesikhathi. Uma ungakwazi ukuya ekwelashweni okuhleliwe, shayela ithimba lakho lezempilo ngokushesha.
Izinto okufanele uzicabangele ngesikhathi sokwelashwa
Ithimba lakho lezokwelapha lizokuqapha ngokucophelela ngenkathi uthatha lo muthi.
- Ukuhlolwa kwegazi: Kuzodingeka ukuthi uhlolwe njalo. Lokhu kuzohlola amazinga ezinto ezifana namaseli amhlophe egazi, amaseli abomvu egazi, kanye nokusebenza kwesibindi egazini lakho.
- Ingozi yokutheleleka: Lo muthi unciphisa ukusebenza kwesimiso somzimba sokuzivikela, okwandisa ingozi yokuthola izifo. Uma uhlangabezana nezimpawu ezifana nomkhuhlane, ukubanda, umphimbo obuhlungu, noma ukukhwehlela, ungaziphilisi bese ushayela udokotela wakho ngokushesha. Kungumqondo omuhle futhi ukunciphisa ukuya ezindaweni lapho abantu begula khona phakathi nalesi sikhathi.
- Imithi Yokugoma: Lokhu kubaluleke kakhulu. Phakathi kwamasonto ayi-6 kuya kwangama-52 ngemva kokuthatha i-Teplizumab, umzimba wakho ungase ungasabeli kahle emithini yokugoma oyitholayo. Ngakho-ke uma udinga ukuthola umuthi wokugoma, tshela udokotela wakho ukuthi uwuthathile i-Teplizumab. Kungadingeka uthole imithamo yokuqinisa noma ushintshe ishejuli yakho yokugoma.
Imiphumela emibi engase ivele ngenxa yemithi
Njenganoma yimuphi umuthi, i-Teplizumab ingabangela imiphumela emibi. Eminye iyingozi kakhulu, kanti eminye ivamile.
| Imiphumela emibi okufanele ibikwe kudokotela ngokushesha | |
|---|---|
| Umphumela ongemuhle | Incazelo |
| Ukusabela Kokungezwani Nomzimba | Ukuqubuka kwesikhumba, ukulunywa, ukuvuvukala kobuso, izindebe, ulimi noma umphimbo. |
| I-Cytokine Release Syndrome (CRS) | Lesi yisimo esibi esibangelwa ukuhlaselwa okungazelelwe nokunzima kwesimiso somzimba sokuzivikela. Izimpawu zingase zihlanganise umkhuhlane, ukubanda, ubuthakathaka, ikhanda elibuhlungu, isiyezi, ubunzima bokuphefumula, kanye nokushaya kwenhliziyo okusheshayo . |
| Izimpawu zokutheleleka | Umkhuhlane, ukubanda, ukukhwehlela, umphimbo obuhlungu. |
| Imiphumela emibi evame ukungabi mibi kakhulu (kodwa okufanele ibikwe kudokotela uma iqhubeka) | |
| Uhudo | Ukuvuvukala kwesisu. |
| Ikhanda elibuhlungu | Ikhanda elibuhlungu. |
| Isicanucanu | Ukuzizwa sengathi uhlanza. |
| Ukuqhuma kwesikhumba | Amaqhubu amancane noma ukubomvu esikhumbeni. |
Lolu hlu alufaki yonke imiphumela emibi engaba khona. Uma uhlangabezana nanoma yini engavamile, sicela uxhumane nodokotela wakho ukuze uthole iseluleko sezokwelapha.
Umlayezo Wokuya Nawe Ekhaya
- I-Teplizumab ayilona ikhambi lesifo sikashukela sohlobo 1, kodwa iwumuthi ongalibazisa kakhulu ukuqala kwaso.
- Lokhu ukwelashwa okukhethekile okunikezwa umthambo esibhedlela, ngaphansi kokuqashwa kwezokwelapha.
- Ngaphambi kokuqala ukwelashwa, nikeza udokotela wakho incazelo ephelele yazo zonke izimo zakho zezokwelapha, imithi oyithathayo, futhi ikakhulukazi noma yimiphi imijovo oyitholile.
- Ngesikhathi sokwelashwaQaphela kakhulu izimpawu zokutheleleka njengomkhuhlane, ukukhwehlela, noma i-Cytokine Release Syndrome (CRS) . Uma kwenzeka noma yikuphi kwalokhu, yazisa udokotela wakho ngokushesha.
- Uma unemibuzo mayelana nalomuthi, umuntu ongcono kakhulu ongambuza udokotela wakho. Ungakhathazeki ngokubuza abanye abantu.
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