Dɛn ne Gastrin? So ɛka wo yafunu mu haw ahorow?

So woasusuw nneɛma dodow a ɛkɔ so wɔ yɛn nipadua mu, titiriw bere a yɛadi awie no ho pɛn? Yɛwɔ nnuru abɔfo nketewa kuw bi wɔ yɛn nipadua mu a wɔboa ma eyinom nyinaa ba. Yɛfrɛ saa hormone ahorow yi. Ɛnnɛ yɛrebɛka hormone soronko a ɛte saa biako ho asɛm. Ɛno ne gastrin. Saa gastrin yi ho hia yiye ma yɛn aduan mu nhyehyɛe no dwumadi.

Dɛn na Gastrin yɛ ankasa?

Okay, afei momma yɛnhwɛ nea saa adamfo yi a wɔfrɛ no Gastrin yɛ ma yɛn nipadua. Ɛwɔ dwumadi atitiriw pii.

• Yafunu mu acid a ɛba: Ade a ɛho hia sen biara ne sɛ wobɛka akyerɛ wo yafunu no sɛ ɛnnyi yafunu mu acid mfi mu. Saa yafunu mu acid yi ne nea yɛfrɛ no hydrochloric acid. Sɛ eyi nni hɔ a, ɛyɛ den yiye sɛ wobɛyam aduan.
• Yafunu mu ntini yɛ adwuma: Gastrin nso boa ma ntini a ɛwɔ wo yafunu mu no yɛ adwuma yiye, a ɛkyerɛ sɛ ɛma yafunu no tumi keka ne ho, na ɛboa ma aduan fra na ɛpaapae.
• Yɛ Yafunu Fasu no Foforo: Ɛsɛ sɛ yɛyɛ yɛn yafunu a ɛyɛ mmerɛw, mucosa, no foforo bere nyinaa. Gastrin boa wɔ eyi nso mu.
• Akisikuru ne dwensɔtwaa a ɛkanyan: Gastrin ne hormone foforo a wɔfrɛ no cholecystokinin boa ma wo akisikuru ne dwensɔtwaa no twetwe na ɛma aduan mu nsu fi mu.

Nsonsonoe bɛn na ɛda Gastrin ne Gastric acid ntam?

So eyi te sɛ nea ɛyɛ basaa kakra? Sɛ yɛbɛka no tiawa a, ɛte sɛ eyi. Gastrin yɛ hormone a ɛma nipadua no yɛ adwuma . Ɛte sɛ krataa. Saa krataa yi ka kyerɛ yafunu no sɛ, "Okay, afei gyae gastric acid." Afei saa yafunu mu acid yi ma aduan mu enzyme a wɔfrɛ no pepsin no yɛ adwuma. Saa abien yi bom yɛ yafunu mu nsu a ɛwɔ yɛn yafunu mu. So wote ase?

Ɛhe na wɔyɛ gastrin?

Akwaa ahorow a ɛwɔ yɛn aduan mu titiriw na ɛyɛ gastrin. Saa hormone yi fi nkwammoaa soronko bi a wɔfrɛ no G-cells mu. Nkyerɛwde "G" gyina hɔ ma "gastrin."

Gastrin dodow no ara fi wo yafunu mu , titiriw wo yafunu no ase (yɛfrɛ no antrum). Saa G-nkwaboaa yi wɔ yafunu mu ntini a ɛwɔ wo yafunu fasu mu no mu. Nea ɛka ho no, duodenum, wo dwensɔtwaa ketewa no fã a edi kan, ne dwensɔtwaa no na ɛyɛ gastrin bi.

Nneɛma bɛn na ɛka gastrin a ɛba no?

Ɛyɛ nwonwa sɛnea gastrin fi adi bere a wususuw adidi ho no! Wobɛyɛ dɛn ahu saa? Yɛn amemene ne yɛn aduan mu nhyehyɛe no nam ntini soronko bi a wɔfrɛ no vagal ntini so na ɛka bom bere nyinaa. Nsɛm fa ntini ahorow yi mu kɔ anim ne akyi.

Enti, sɛ wususuw aduan ho a, vagal nerves a ɛwɔ w'amemene mu no de nkra kɔ yafunu no mu, sɛ, "Okay, aduan reba, gyae gastrin na siesie wo ho ma aduan a wobɛyam." Afei, sɛ wufi ase didi a, ntini a ɛwɔ wo yafunu mu no hu sɛ aduan akɔ mu na ɛma gastrin pii fi mu.

Nneɛma afoforo a ɛkanyan gastrin ma ɛba:

• Yafunu no pH a ɛkɔ soro (kyerɛ sɛ, bere a acid no so tew).
• Wɔtwe yafunu no afasu bere a aduan hyɛn mu no.
• Nnuan bi , titiriw nea protein wom no, hyɛn yafunu no mu.

Gastrin ma yafunu mu acid fi mu ba, na ɛma pepsin yɛ adwuma. Eyinom bom paapae protein ahorow a ɛwɔ yafunu no mu na ɛyam. Gastrin nso ma ntini a ɛwɔ yafunu no mu no tu.

Wobɛyɛ dɛn agyae gastrin a ɛrepue no?

Bere a aduan fi wo yafunu mu na ɛkɔ dwensɔtwaa ketewaa no fã a edi kan, duodenum no, aduan a edi hɔ no fi ase. Ɛno ne bere a gastrin a ɛba no fi ase so tew. Bere a aduan fi yafunu no mu na yafunu mu acid dodow kɔ soro no, gastrin so tew.

Sɛ aduan kɔ duodenum no mu a, wo gallbladder ne pancreas no gyae wɔn aduan mu nsu no. Afei, yɛn aduan a yɛde di dwuma no ma hormone foforo a wɔfrɛ no somatostatin fi adi. Saa somatostatin yi dum nkwaadɔm afoforo (te sɛ gastrin). Ɛte sɛ nea woadum switch bi.

Ɔkwan bɛn so na wɔhwɛ sɛnea gastrin dodow te?

Mogya mu nhwehwɛmu titiriw bi wɔ hɔ a wɔde hwɛ sɛnea wo gastrin dodow te. Yɛfrɛ no gastrin sɔhwɛ. Akwahosan ho ɔyaresafo te sɛ oduruyɛfo anaa ɔyarehwɛfo gye mogya ketewaa bi fi ntini bi a ɛwɔ wo nsa mu mu na ɔde kɔ aduruyɛdan mu ma wɔkɔhwehwɛ mu.

Dɛn nti na me gastrin dodow ho hia?

Nnuruyɛfo hwɛ wo gastrin dodow mu hwɛ sɛ ɛdɔɔso dodo anaa . Gastrin dodow a ɛba fam ntaa mma, nanso gastrin dodow a ɛkɔ soro no betumi akyerɛ yafunu mu nyarewa ne tebea horow bi.

Dɛn na gastrin dodow a ɛkɔ soro (Hypergastrinemia) kyerɛ?

Sɛ gastrin dodow kɔ soro a, yɛfrɛ no hypergastrinemia. Ɛtɔ mmere bi a, hypergastrinemia betumi akyerɛ sɛ wowɔ akisikuru a ɛma gastrin wɔ wo nipadua mu, a wɔfrɛ no gastrinomas. Eyinom betumi aba wɔ wo dwensɔtwaa anaa wo dwensɔtwaa mu.

Mmere foforo nso, hypergastrinemia betumi akyerɛ sɛ biribi wɔ wo yafunu mu a ɛremma ɛnyɛ yafunu mu acid. Sɛ yafunu mu acid so tew a, gastrin pii fi nipadua no mu. Afei nso, nsɛnkyerɛnne a ɛtaa ma gastrin a wɔyɛ no gyae no sɛe.

Sɛ gastrin dodow kɔ soro a, dɛn na ɛba?

Sɛ wo gastrin dodow dɔɔso a, yafunu mu acid dodow a ɛwɔ wo yafunu ne wo yafunu mu no betumi ayɛ kɛse dodo. Acid pii betumi asɛe wo yafunu ne wo dwensɔtwaa a ɛbɔ wo ho ban a ɛyɛ mmerɛw no, na ɛde akuru a wɔsan frɛ no peptic ulcer disease aba.

Afei nso, sɛ obi nya acid pii wɔ yafunu mu a, ebetumi ama wanya tebea bi a wɔfrɛ no GERD (Gastroesophageal Reflux Disease), a ɛyɛ tebea a ɛtra hɔ kyɛ a acid ba menewam. Sɛ wowɔ peptic ulcer disease anaa GERD na sɛ wode nnuru di dwuma a, ɛnyɛ yiye a, ebia wo duruyɛfo bɛhwɛ wo gastrin dodow.

Ayaresa mu tebea horow bɛn na ebia ɛne gastrin dodow a ɛkɔ soro wɔ abusuabɔ?

Sɛ wowɔ gastrinomas a, ebia wo gastrin ne gastric acid nyinaa bɛkɔ soro. Gastrinomas yɛ dwensɔtwaa mu ntini mu akisikuru (PET) bi a ɛma gastrin fi nipadua no mu. Wobetumi ayɛ kokoram anaasɛ ɛnyɛ kokoram.

Tebea horow a ɛde gastrinomas ba:

• Zollinger-Ellison yare a ɛma obi nya ɔyare no.
• Endocrine neoplasia a ɛwɔ nipadua no mu pii type 1 (MEN1).

Tebea horow a gastrin ne yafunu mu acid kɔ soro a gastrinomas nka ho:

• Asaabo a entumi nyɛ adwuma yiye.
• Yafunu mu nsu a ɛkɔ mu a ɛsiw (GOO).

Sɛ wo yafunu mu acid a ɛba wo mu no sua a, ebia wo yafunu mu acid dɔɔso nanso wo yafunu mu acid sua. Ebia eyi fi atrophic gastritis, a ɛyɛ tebea a ɛma nkwammoaa a ɛma yafunu mu acid no sɛe no.

Nneɛma atitiriw a ɛde atrophic gastritis ba:

• H. pylori yare mmoawa.
• Nyarewa a nipadua no tumi ko tia nyarewa (e.g. autoimmune atrophic gastritis).

Nneɛma afoforo a ɛma yafunu mu acid a ɛba no so tew:

• Nnuru a esiw acid ano, te sɛ H2 blockers anaa proton pump inhibitors (PPIs).
• Vagotomy (oprehyɛn a wɔde yi vagal ntini no anaasɛ wotwa).

Sɛ mewɔ gastrin dodow a ɛkɔ soro ho sɛnkyerɛnne ahorow a, dɛn na ɛsɛ sɛ meyɛ?

Sɛ wowɔ yafunu mu sɛnkyerɛnne ahorow, titiriw sɛ ɛtaa ba anaasɛ ɛwɔ hɔ akyɛ a, ɛho hia sɛ wokɔ oduruyɛfo nkyɛn. Nsɛnkyerɛnne ahorow bi a ebia ɛne gastrin a ɛkɔ soro no wɔ abusuabɔ ni:

• Yafunu mu yaw anaasɛ akisikuru.
• Koko mu yaw a ɛkɔ so daa ne aduan a wontumi nnya.
• Acid reflux anaa aduan a ɛbɛkyere menewa mu.
• Menewa mu yaw a ɛkɔ so yɛ den na ɛyɛ dede.
• Atiridiinini a ɛkɔ so daa.
• Nnuan a wɔyam mu haw ahorow.

Saa sɛnkyerɛnne ahorow yi betumi akyerɛ sɛ wowɔ yafunu mu acid pii, anaasɛ wowɔ atrophic gastritis, peptic ulcer disease, anaa GERD. Ebia eyi ne gastrin wɔ abusuabɔ anaasɛ ɛnte saa. Nanso, ɛho hia sɛ wohu tebea horow yi na wɔsa no yiye.

Kae sɛ, sɛ wowɔ sɛnkyerɛnne te sɛ eyinom a, mmɔ mmɔden sɛ wobɛhwehwɛ wo ho denam nsɛm a wobɛhwehwɛ wɔ intanɛt so no so. Ɛyɛ papa sɛ wobɛkɔ oduruyɛfo nkyɛn na woanya afotu.

Nkrasɛm a Wɔde Kɔ Fie

Okay, enti momma yɛnhwɛ nneɛma a ɛnyɛ den bi a ɛsɛ sɛ yɛkae wɔ gastrin a yɛkaa ho asɛm no ho.

• Gastrin yɛ hormone a ɛho hia wɔ yɛn aduan mu .
• Ne dwumadi titiriw ne sɛ ɛbɛka akyerɛ yafunu no ma ayi yafunu mu acid afi mu .
• Sɛ wo yafunu mu acid dɔɔso dodo anaasɛ ɛba fam dodo a , ebia ɛne gastrin wɔ abusuabɔ.
• Sɛ wowɔ yafunu mu sɛnkyerɛnne bi, anaa tebea horow a ɛnyɛ yiye bere a wɔde sa wo no a, oduruyɛfo betumi asɔ wo gastrin dodow ahwɛ.
• Ɛtɔ mmere bi a, gastrin dodow a ɛkɔ soro no betumi ayɛ aduruyɛ mu tebea bi ho sɛnkyerɛnne, enti sɛ wowɔ sɛnkyerɛnne ahorow a, ɛho hia sɛ wohwehwɛ aduruyɛfo afotu.

Enti, Gastrin yɛ ade ketewaa bi nanso tumi wom a ɛyɛ adwuma komm wɔ yɛn nipadua mu. Eyi a wubehu no bɛyɛ nea ɛho hia paa ma w’akwahosan. Sɛ wowɔ nsɛmmisa foforo biara a, ntwentwɛn wo nan ase sɛ wubebisa wo duruyɛfo.

` Gastrin, hormone, aduan a wɔyam, yafunu mu acid, yafunu mu akisikuru, GERD, hypergastrinemia