So wo yafunu a ɛyɛ wo yaw no nyɛ yafunu mu mmoawa kɛkɛ? Momma yɛnka GIST (Gastrointestinal Stromal Tumor) ho asɛm!

So ɛtɔ mmere bi nso a wo yafunu yɛ wo yaw, anaa wo yafunu yɛ wo yaw, anaasɛ wote nka sɛ wo mu yɛ duru? Ɛtɔ da bi a yɛsusu sɛ aduane bi nye, "gastric upset", anaasɛ "flatulence" kɛkɛ. Nanso, susuw ho hwɛ, ɛtɔ mmere bi a asɛm bi a anibere wom kɛse betumi aba wɔ sɛnkyerɛnne nketenkete a ɛte saa akyi. Saa nneɛma no biako, a ɛnyɛ nea abu so saa, nanso ɛho hia yiye sɛ yehu fa kokoram tebea ho ne GIST, a egyina hɔ ma Gastrointestinal Stromal Tumor . Momma yɛnka eyi ho asɛm nkɔ akyiri kakra, nanso ɛnyɛ den koraa, ɛyɛ?

Dɛn ne saa yafunu mu stromal tumor (GIST) yi?

Sɛ yɛbɛka no tiawa a, GIST yɛ kokoram akisikuru a ɛba wo aduan mu afasu mu —wo nipadua no fã a aduan ne anonne fi w’ano kɔ wo yafunu mu na afei ɛfa wo dwensɔtwaa mu ma wɔyam. Sɛ yɛbɛka no pɛpɛɛpɛ a, saa akisikuru yi hwe ase wɔ nea nnuruyɛfo frɛ no ‘ soft tissue sarcoma ’ mu.

Afei susuw ho hwɛ, GIST akisikuru bi yɛ nketewa paa, te sɛ pɛnsere a wɔde popa anaa pea. Sɛ ɛyɛ akisikuru ketewaa bi a, ebia worenhu mpo anaasɛ worente ɛyaw biara. Nanso, bere kɔ so no, akisikuru bi fi ase nyin. Ɛno ne bere a saa GIST ahorow yi betumi afi ase de sɛnkyerɛnne ahorow ne akwahosan ho haw afoforo aba wo so. Mpɛn pii no, nnuruyɛfo sa GIST tebea yi denam oprehyɛn a wɔyɛ de yi akisikuru anaa akisikuru no fi hɔ koraa no so.

Wɔfrɛ tebea yi GIST sɛn?

Nokwarem no, GIST yɛ kokoram a ɛntaa nsi koraa . Sɛ wɔde toto aman afoforo a ɛwɔ wiase mpo ho a, ɛte saa ara. Sɛ nhwɛso no, wɔ ɔman te sɛ United States mu no, afe biara nnipa foforo 4,000 kosi 6,000 pɛ na wohu sɛ wɔanya GIST. Enti wubetumi asusuw sɛnea tebea yi ho yɛ na no ho. Ɛno nti na ɛho hia sɛ wohu, sɛnea ɛbɛyɛ a sɛ wuhu yare no ho sɛnkyerɛnne bi a, wubetumi ahwehwɛ aduruyɛ mu afotu ntɛm.

Dɛn ne GIST ho sɛnkyerɛnne ahorow?

Sɛnea yɛadi kan aka no, sɛ GIST akisikuru no sua koraa a, ebia worenhu sɛnkyerɛnne biara. Mpɛn pii no, wohu GIST akisikuru bi wɔ akwanhyia mu bere a wɔreyɛ nhwehwɛmu te sɛ yafunu mu nhwehwɛmu, anaasɛ bere a wɔreyɛ oprehyɛn foforo no.

Nanso, bere a akuru no yɛ kɛse, anaasɛ egyina faako a ɛwɔ so no, sɛnkyerɛnne ahorow bi betumi ada adi. Eyinom ne sɛnkyerɛnne ahorow a ɛtaa ba:

• Yafunu a ɛyɛ wo yaw anaasɛ wo ho nyɛ wo dɛ a wobɛte nka . Eyi betumi ayɛ te a wote nka sɛ wo ho ayɛ wo ma anaa biribi a akɔhyɛ wo yafunu mu ara kwa.
• Mogya a ɛwɔ wo nsu mu anaa wo nsu a mogya ayɛ mu ma. Ɛtɔ da bi a, nsuo no tumi yɛ tuntum tuntum, na ɛno nso yɛ mogya a ɛretu wɔ nipadua no mu ho sɛnkyerɛnne.
• Akisikuru kyerɛ sɛ worenkɔ dwensɔtwaa mu nna pii.
• Berɛ biaraƆbrɛ ne ɔbrɛ a wɔte nka kɛse . Te sɛ nea nkwa nni nipadua no mu.
• Wo mu duru a wobɛtew a wommɔ mmɔden.
• Anorexia kyerɛ sɛ ɔmpɛ sɛ odidi.
• Mogya a wɔfe . Eyi yɛ sɛnkyerɛnne a anibere wom kakra.

Sɛ woanya saa sɛnkyerɛnne ahorow yi mu biako anaa nea ɛboro saa bere tiaa bi a, nyansa wom sɛ wobɛkɔ oduruyɛfo nkyɛn akɔhwɛ wo, sen sɛ wubesusuw ho kɛkɛ sɛ, "Dɛn ne ɛno?"

Dɛn ne nneɛma a ɛde GIST ba?

Mpɛn pii no, GIST ba bere a nsakrae, anaa nsakrae bi aba awosu mu abɔde bi a wɔfrɛ no KIT mu wɔ yɛn nipadua mu no. Susuw ho sɛ saa KIT awosu mu abɔde yi te sɛ ɔbɔfo ketewaa bi a ɔka kyerɛ nkwammoaa bi a ɛwɔ yɛn aduan mu nhyehyɛe mu sɛ "wɔnkyekyɛ na wɔnnɔɔso." Enti, sɛ sintɔ bi wɔ saa awosu mu abɔde yi mu a, saa nkwammoaa no fi ase kyekyɛ na ɛdɔɔso ntɛmntɛm dodo a wontumi nni so. Saa akuru anaa GIST no ba bere a saa nkwammoaa no nyin a wontumi nni so no. Saa awosu mu nsakrae yi taa ba bere a wɔawo yɛn akyi, wɔ yɛn nkwa nna mu. Ɛnyɛ biribi a wonya fi awofo hɔ ma mmofra.

Saa KIT awosu mu abɔde yi ka kyerɛ nkwammoaa sɛ wɔnyɛ protein bi a wɔfrɛ no KIT CD117 . Saa protein yi kanyan nkwammoaa a ɛwɔ aduan mu no mu paapae. Wɔ GIST mu no, saa adeyɛ yi nkɔ yiye, na ɛma akisikuru ba.

Nanso, ɛwom sɛ ɛntaa nsi koraa de, nanso awo mu tebea horow bi betumi ama asiane a ɛwɔ hɔ sɛ obi benya GIST no ayɛ kɛse kakra. Tebea horow yi bi ne:

• Abusua mu GIST yare: Eyi ho yɛ na koraa. Nea ɛkɔ so wɔ ha ne sɛ KIT awosu mu abɔde mu sintɔ bi fi awofo hɔ kɔ mmofra hɔ. Sɛ eyi ba a, asiane a ɛwɔ hɔ sɛ obi benya GIST no kɔ soro. Afei nso, GIST betumi aba wɔ mfe a esua sen sɛnea ɛtaa yɛ no mu na akisikuru bɛboro biako betumi aba.
• Neurofibromatosis type 1: Eyi nso yɛ awosu mu yare. Ɛma nkwammoaa ahorow bi nyin a wontumi nni so na ɛyɛ akisikuru wɔ nipadua no afã horow. GIST yɛ akisikuru biako a ebetumi aba wɔ saa kwan yi so.
• Carney-Stratakis syndrome: Eyi nso yɛ tebea a ɛntaa nsi koraa, a wonya fi awo mu. Nnipa a wɔwɔ saa tebea yi nso wɔ asiane kɛse mu sɛ wobenya GIST sen afoforo.

Ɔkwan bɛn so na wohu GIST?

Sɛ wokɔ oduruyɛfo nkyɛn a ɔwɔ sɛnkyerɛnne ahorow a yɛaka ho asɛm wɔ atifi hɔ no a, obedi kan abisa wo wo sɛnkyerɛnne ahorow no ho asɛm, bere tenten a ɛwɔ hɔ, na afei wayɛ nipadua mu nhwehwɛmu . Eyi kyerɛ nneɛma te sɛ wo yafunu a wobɛte nka.

Bio nso, wo duruyɛfo betumi ahyɛ sɛ wɔnyɛ nhwehwɛmu afoforo pii de kyerɛ sɛ ebia wowɔ GIST, ne kɛse, ne sɛ ebia atrɛw anaa. Wɔn titiriw ne:

• Endoscopy a ɛwɔ soro: .Nea ɛka eyi ho ne sɛ wode afiri ketewaa bi a wɔde mfoninitwa afiri ketewaa bi fa w’anom bɛhyɛ mu na woahwehwɛ wo menewa mu, wo menewa (aduan paipu), ne wo yafunu mu. Eyi ma wutumi hu tẽẽ sɛ biribi te sɛ akisikuru bi wɔ hɔ anaa.
• CT scan: Eyi de X-ray twa wo yafunu mu mfonini a ɛkɔ akyiri. Eyi betumi aboa ma wɔahu akuru no kɛse ne baabi a ɛwɔ.
• Positron emission tomography (PET) scan: Eyi nso yɛ scan soronko bi. Ɛboa ma wohu sɛnea kokoram nkwammoaa no yɛ adwuma ne sɛ ebia atrɛw akɔ nipadua no afã afoforo anaa.
• Biopsy: Eyi ne sɔhwɛ a wɔde kyerɛ sɛ wowɔ GIST anaa. Nea ɛka eyi ho ne sɛ wobeyi ntini ketewaa bi afi akuru no mu na wɔama ɔyare ho ɔbenfo bi de afiri a wɔde hwɛ nneɛma nketenkete ahwɛ mu . Eyi bɛboa ma wɔahu sɛ ɛyɛ GIST anaa biribi foforo. Ɛtɔ mmere bi a wobetumi ayɛ biopsy no bere koro no ara mu ne endoscopy no.

Ɔkwan bɛn so na wɔsa GIST?

Onipa titiriw a ɔsa GIST ne kokoram ho ɔyaresafo . Wɔtaa de oprehyɛn a wɔde yi akisikuru no na ɛyɛ GIST. Nanso, ayaresa ko a ɛfata wo no begyina nea nhwehwɛmu ahorow no ahu so. Eyi kyerɛ sɛ nnuruyɛfo bɛhwɛ nneɛma te sɛ akisikuru no kɛse, baabi a ɛwɔ, ne sɛ ebia atrɛw (atrɛw) afi baabi a edii kan fii ase anaa.

Nhwɛsoɔ:

• Sɛ akuru no sua koraa a, ebia wo oncology oprehyɛn ho ɔyaresafo no betumi ayi afi hɔ koraa denam oprehyɛn so. Afei, ebia ayaresa foforo biara ho nhia.
• Nanso sɛ akisikuru no sõ yiye anaasɛ ɛwɔ baabi a ɛyɛ den sɛ wɔbɛyɛ oprehyɛn a, ebia wo kokoram ho ɔyaresafo no besi gyinae sɛ ɔbɛma wo aduru bi a wɔfrɛ no targeted therapy de atew akisikuru no so ansa na wɔayɛ wo oprehyɛn. Saa nnuru yi de wɔn ani si nneɛma pɔtee bi a ɛboa ma GIST nkwammoaa no nyin so na ɛtow hyɛ so. Eyi ma akisikuru no so tew na ɛma ɛyɛ mmerɛw sɛ wɔbɛyɛ no oprehyɛn. Ɛtɔ da bi a, wobetumi atoa saa ayaresa ahorow a wɔde wɔn ani asi so yi so wɔ oprehyɛn akyi de asiw GIST kwan sɛ ɛrensan mma bio.

Kae sɛ ɛnyɛ GIST ayarefo nyinaa na wonya ayaresa koro. Wo nnuruyɛfo kuw no ne wo besusuw ayaresa nhyehyɛe a eye sen biara a wɔbɛyɛ ama wo tebea no ho.

Dɛn ne ayaresa no mu nsunsuanso bɔne?

Sɛnea ɛte wɔ aduruyɛ biara ho no, GIST ayaresa betumi de nsunsuanso bɔne bi aba.

Nneɛma bɔne bi a ebetumi afi ayaresa a wɔde wɔn ani asi so mu aba:

• Akwanside a wɔde siw kwan
• Ɔyare a ɛma obi dwensɔ (yafunu mu yaw) .
• Ɔbrɛ ne ɔbrɛ
• Ntini mu akisikuru
• Akisikuru (te nka sɛ wofe) .

Nneɛma bɔne a ɛtaa ba a ebetumi aba bere a wɔreyɛ oprehyɛn no:

• Nneɛma a wɔyɛ wɔ aduru a wɔde kum nipadua no ho (sɛ nhwɛso no, adwenemhaw, ɔfe) .
• Ɛyaw a ɛba baabi a wɔyɛ oprehyɛn no
• Mogya a ɛretu

Saa nsunsuanso bɔne yi to obiara ɔkwan koro so. Ebia nnipa binom behyia emu dodow bi, bere a afoforo nso rennya bi. Sɛ wote nka sɛ wo ho nyɛ wo dɛ a, hwɛ hu sɛ wobɛka akyerɛ wo duruyɛfo anaa ɔyarehwɛfo. Wobetumi adi nsunsuanso bɔne dodow no ara ho dwuma.

Sɛ mewɔ GIST a, dɛn na ɛsɛ sɛ mehwɛ kwan akyi?

Sɛ wowie ayaresa wie mpo a, wo oncologist bɛkɔ so ahwɛ wo. Wei kyerɛ sɛ wɔbɛka akyerɛ wo sɛ bra bɛba abɛhwɛ wo akyi bere ne bere mu ahwɛ sɛnea wo ho atɔ wo ne w’akwahosan nyinaa. Mpɛn pii no, saa nhyehyɛe ahorow yi yɛ asram abiɛsa kosi asia biara.

Wɔ saa nsrahwɛ yi mu no, wo duruyɛfoɔ bɛbisa wo wo yareɛ no ho nsɛnkyerɛnneɛ, ahwehwɛ wo mu, na ɔbɛtumi nso ayɛ nhwehwɛmu foforɔ te sɛ scan, de ahwɛ sɛ GIST no asan aba anaa sɛdeɛ ɛreyɛ n’ade wɔ ayaresa ho. Sɔhwɛ ahorow a wɔtaa yɛ no bi ne:

• CT scan a wɔyɛ wɔ mmerɛbo ne akyi berɛmo mu.
• MRI mfonini (Magnetic resonance imaging (MRI) mfonini) .
• PET scans de hu sɛnea wɔyɛ wɔn ade wɔ ayaresa ahorow a wɔde wɔn ani asi so ho.

Wo duruyɛfo na obesi mpɛn dodow a ɛsɛ sɛ woyɛ saa nhwehwɛmu ahorow yi ho gyinae, a egyina wo tebea no so.

Dɛn ne nkwagye dodow a ɛwɔ GIST mu?

Eyi yɛ asɛm a ɛyɛ nkate. Nkwa dodow a obi a ɔwɔ GIST nya no gu ahorow wɔ onipa biara mu. Nneɛma pii wɔ hɔ a ɛkɔ so kyerɛ eyi. Sɛ nhwɛso no, akisikuru no kɛse bere a wɔahu GIST, sɛnea ɛyɛ adwuma, w’akwahosan nyinaa, ne sɛnea akisikuru no yɛ n’ade wɔ ayaresa ho.

Sɛnea nsɛm a wɔaboaboa ano afi ahyehyɛde ahorow te sɛ U.S. Ɔman Kokoram Asoɛe (NCI) , kyerɛ no, nnipa a wɔwɔ GIST no mu bɛyɛ 85% da so ara te ase wɔ mfe anum akyi a wɔahu yare no.

Nanso, sɛ wuhu akontaabu te sɛ eyi a, ɛsɛ sɛ wode nneɛma kakraa bi tra w’adwenem:

• Eyinom yɛ akontaabu ara kwa: egyina nnipa pii a wɔanya GIST pɛn no suahu so. Ebia wo tebea no bɛyɛ soronko koraa. Sɛ nhwɛso no, mfe a woadi ne sɛ ebia wowɔ ayaresa tebea afoforo betumi aka dodow yi.
• Saa akontaabu ahorow yi yɛ abakɔsɛm mu de: wɔboaboa nsɛm ano bɛyɛ mfe anum biara. Enti, nkɛntɛnso a ayaresa a aba so foforo no anya no nka dodow yi ho. Sɛ wɔde ayaresa foforo di dwuma a, dodow yi betumi ayɛ papa mpo.
• Nkwa dodow a wonya ne nkwa nna yɛ nneɛma abien: Nkwa dodow nkyerɛ wo bere tenten a wobɛtra ase. Ɛyɛ den titiriw sɛ wobenya nkwa nna ho nsɛm ama nnipa a wɔwɔ GIST.

Enti, mma dodow yi nnhyɛ wo so. Sɛ wowɔ nsɛmmisa bi a, bisa wo oncologist. Obetumi akyerɛkyerɛ sɛnea akontaabu ahorow yi fa wo tebea no ho.

Wobɛyɛ dɛn ahwɛ wo ho?

W’akwahosan nyinaa a wobɛhwɛ so no ne ade a eye sen biara a wubetumi ayɛ ama wo ho, bere a wɔreyɛ GIST ayaresa ne bere a woasa no akyi nyinaa.

• Didi yiye: Bɔ mmɔden sɛ wubedi nnuan ahorow a protein pii wom, srade nnim, ne pii sɛnea wubetumi. Fa nhabannuru, nhabannuru, ne nnuaba ka w’aduan da biara da ho. Aduan a ɛkari pɛ bɛma wo nipadua no anya ahoɔden ma ne ho atɔ no ntɛm.
• Nya apɔw-mu-teɛteɛ kakra: Sɛ woyare a, ebetumi ahaw wo. Bere a worenya ahoɔden afi ayaresa mu no, apɔw-mu-teɛteɛ a emu nyɛ den (te sɛ nantew) betumi aboa wo ma woatew adwennwen so. Nanso, ɛsɛ sɛ wo ne wo duruyɛfo kasa bere nyinaa ansa na woafi apɔw-mu-teɛteɛ foforo ase anaasɛ ansa na woasan afi apɔw-mu-teɛteɛ nhyehyɛe bi a na woreyɛ no ase.
• Kwati sigaretnom koraa: Sɛ wode tawa aduru biara (a ɛlɛtrɔnik sigaret ka ho) di dwuma a, ɛma asiane a ɛwɔ hɔ sɛ obi benya kokoram foforo no yɛ kɛse, na ɛma asiane a ɛwɔ hɔ sɛ GIST bɛsan aba bio no yɛ kɛse.

Ebia tebea te sɛ GIST remfa sɛnkyerɛnne atitiriw biara mma mfiase no. Sɛ woyɛ saa mpo a, ebia wubesusuw sɛ ɛyɛ aduan a wonnya nni anaa yafunu mu atiridii kɛkɛ. Enti, sɛ wuhu sɛ wowɔ kokoram akisikuru a ɛntaa nsi te sɛ eyi a, ebetumi ayɛ ahodwiriw kɛse. Sɛ wowɔ saa tebea yi a, gye bere kakra kyerɛkyerɛ wo ho wɔ yare a ɛntaa nsi yi ne ayaresa a wubetumi apaw ho. Mpɛn pii no, ayaresa betumi ama wo yare no ho sɛnkyerɛnne no afi hɔ na mpo asa GIST. Wobɛnya nsɛmmisa pii. Wo nnuruyɛfo kuw no bɛba hɔ abɛbua wɔn nyinaa na wɔaboa wo.

Nea etwa to no, nneɛma a ɛsɛ sɛ yɛkae

Ɛwom sɛ GIST yɛ biribi a ɛsɛ sɛ wusuro de, nanso ɛyɛ tebea a ebetumi afi mu aba pa sɛ wunim na wonya ayaresa wɔ bere a ɛsɛ mu a.

• Mma w’ani ngu so: Sɛ wowɔ yafunu mu yaw bi a ɛyɛ soronko a ɛkɔ so daa, mogya retu wo ho sɛnkyerɛnne, anaasɛ wo mu duru so tew a wontumi nkyerɛkyerɛ mu a, hwehwɛ aduruyɛfo afotu.
• Ɛho hia sɛ wohu yare no pɛpɛɛpɛ: Ɛho hia sɛ wɔyɛ nhwehwɛmu titiriw na ama wɔahu GIST. Enti, hwehwɛ adwene a oduruyɛfo titiriw bi nya.
• Ayaresa ahorow bi wɔ hɔ: Ayaresa ahorow a etu mpɔn wɔ hɔ a wɔde sa GIST, te sɛ oprehyɛn ne ayaresa a wɔde wɔn ani asi so.
• Ɛnyɛ wo nko ara: w’aduruyɛ kuw, w’abusua, ne wo nnamfo bɛboa wo wɔ akwantu yi mu.

Ade a ɛho hia sen biara ne sɛ wobɛkɔ so ayɛ den na woadi aduruyɛ mu afotu akyi.

` Yafunu mu stromal tumor, GIST, kokoram, aduan mu nhyehyɛe, KIT gene, oprehyɛn, ayaresa a wɔde wɔn ani asi so