Momma yensua mogya mu kokoram a ɛntaa nsi a ɛba mogya mu ho ade? (Lymphocytic Leukemia Kɛse a Ɛyɛ Granular - LGL) .

So woate mogya mu kokoram bi a ɛyɛ nwonwa, nanso ɛntaa nsi koraa a ɛba mogya mu ho asɛm pɛn? Ebia woate w’adamfo bi a ɔwɔ bi ho asɛm. Anaasɛ ebia woate ho asɛm nkyɛe na woasusuw ho. Ɛnnɛ yɛbɛka mogya mu kokoram biako a ɛntaa nsi, nanso ɛho hia yiye ho asɛm. Wɔfrɛ no Large Granular Lymphocytic Leukemia (LGL). Ebia edin no bɛyɛ te sɛ nea ɛware kakra, nanso momma yɛmma ɛnyɛ mmerɛw.

Dɛn na LGL kyerɛ ankasa?

Sɛ yɛbɛka no tiawa a, LGL yɛ mogya mu kokoram bi a enyin nkakrankakra wɔ nipadua no mu, a enni sabea (a ɛkyerɛ sɛ ɛtra hɔ kyɛ). Ɛka mogya mu nkwammoaa fitaa soronko bi a ɛwɔ yɛn mogya mu. Yɛfrɛ saa nkwammoaa yi lymphocytes . So wunim sɛ lymphocytes yɛ yɛn nipadua mu ahoɔden a ɛko tia nyarewa no afã horow a ɛho hia yiye. Wɔte sɛ asraafo a wɔwɔ yɛn asraafo mu. Wɔn na wɔko tia mmoawa te sɛ mmoawa a wɔhyɛn yɛn nipadua mu, na wɔn na wɔyɛ nnuru a ɛko tia nyarewa a ɛbɔ yɛn ho ban fi nyarewa ho.

Enti, wɔ LGL mu no, nea ɛba ne sɛ nea wɔfrɛ no lymphocyte nkwammoaa yi, titiriw nkwammoaa ahorow abien a wɔfrɛ no Cytotoxic T cells anaa Natural Killer cells (NK nkwammoaa) no sesa wɔ ɔkwan a ɛnteɛ so esiane biribi nti na wofi ase kyekyɛ na ɛdɔɔso a wontumi nni so. Wɔfrɛ saa nkwammoaa a ɛnteɛ yi LGL nkwammoaa.

Saa tebea yi a wɔfrɛ no LGL no taa nyin brɛoo paa. Ɛno nti na wɔfrɛ no mogya mu kokoram a enni sabea no. Ɛtaa ba nnipa a wɔadi boro mfe 60. Nnuruyɛfo betumi asa LGL. Nanso ɛtɔ mmere bi a, tebea no betumi asan aba bio, na ebetumi ayɛ akwahosan ho haw a ɛtra hɔ kyɛ.

LGL ahorow atitiriw abien na ɛwɔ hɔ:

Wɔahu LGL tebea yi ahorow atitiriw abien. Wɔne:

1. T-cell kɛse a ɛyɛ granular lymphocytic leukemia (T-LGL) .

2. NK nkwammoaa mu lymphoproliferative yare a enni sabea (CLPD-NK) .

Wɔ nsɛm abien no nyinaa mu no, sɛnea yɛadi kan aka no, nea ɛba ne sɛ T nkwammoaa anaa NK nkwammoaa no bɛyɛ nea ɛnteɛ.

Saa tebea yi ka yɛn nipadua dɛn?

Ebia woresusuw nkɛntɛnso ko a yare a wɔfrɛ no LGL yi nya wɔ yɛn nipadua so no ho. Wiɛ, esiane sɛ eyi yɛ Chronic Lymphocytic Leukemia bi nti, saa LGL nkwammoaa a ɛnteɛ no kɔ nnompe mu ntini no mu na esiw mogya mu nkwammoaa a ɛfata a wɔyɛ wɔ hɔ no kwan. Ɛte sɛ afifide bɔne bi a ɛreba mu na agye afifide pa bi.

Eyi betumi de ɔhaw atitiriw abien aba:

• Neutropenia : Eyi yɛ granulocytes dodow a ɛso tew wɔ yɛn nipadua mu.Mogya mu nkwammoaa fitaa (granulocytes) (mogya mu nkwammoaa fitaa a abu so sen biara) dodow a ɛso tew. Sɛ saa nkwammoaa yi so tew a, tumi a yɛn nipadua no tumi ko tia nyarewa, anaa tumi a ɛko tia nyarewa no so tew. Eyi ma asiane a ɛwɔ hɔ sɛ obi bɛtaa anya ɔyare mmoawa no yɛ kɛse.
• Anemia : Ebia woate eyi ho asɛm. Monemia yɛ bere a nipadua no hwere mogya mu nkwammoaa kɔkɔɔ a ɛte apɔw dodow a ɛho hia no. Saa tebea yi betumi aba efisɛ LGL nkwammoaa nso nya mogya mu nkwammoaa kɔkɔɔ a wɔyɛ no so nkɛntɛnso. Sɛ mogya a ɛtɔ kɔ nipadua no mu ba a, wote nka sɛ woabrɛ na woabrɛ kɛse.

Hena na ɛda adi sɛ obenya saa yare yi?

LGL yɛ yare a ɛntaa nsi koraa ankasa. Sɛ wohwɛ wiase nyinaa a, wɔbɔ tebea yi ho amanneɛ wɔ nnipa bɛyɛ ɔpepem biako biara mu. Ɛno kyerɛ sɛ wɔ ɔman te sɛ Sri Lanka mu no, ebia ayarefo yi sua koraa. Mpɛn pii no, sɛ wohu yare yi a, ayarefo no adi mfe 60.

Dɛn ne sɛnkyerɛnne ahorow no? Yɛte eyi ase dɛn?

Nea ɛyɛ nwonwa kakra ni. Nnipa binom a wɔwɔ LGL betumi akɔ mfe pii a wonni sɛnkyerɛnne biara . Nhwehwɛmu bi daa no adi sɛ nnipa a wɔwɔ LGL no mu bɛyɛ nkyem abiɛsa mu biako nni sɛnkyerɛnne biara koraa bere a wohui sɛ wɔwɔ LGL no. Wohui sɛ wɔwɔ bi bere a mogya mu nhwehwɛmu a wɔyɛe esiane biribi foforo nti kyerɛe sɛ mogya mu nkwammoaa kɔkɔɔ dodow sua wɔ ɔkwan a ɛnteɛ so anaasɛ mogya mu nkwammoaa fitaa a wɔfrɛ no neutrophils sua no nkutoo.

Nanso, nsɛnkyerɛnne bi wɔ hɔ a ɛtaa ba a ɛkyerɛ sɛ ebia nnipa a wonya yare no ho sɛnkyerɛnne no behu:

• Ɔbrɛ ne ɔbrɛ a ɛtra so : Eyi ne LGL ho sɛnkyerɛnne a ɛtaa ba. Mpɛn pii no, eyi fi mogya a ɛtɔ kɔ nipadua mu a yɛadi kan aka ho asɛm no.
• Atiridiinini a ɛtaa ba ne ɔyare mmoawa a ɛsan ba : Mmoawa a wɔde nyarewa ba no betumi ama obi anya atiridiinini. Eyi fi nipadua no mu tumi a ɛko tia nyarewa a ayɛ mmerɛw.
• Splenomegaly: Eyi yɛ ahurututu, akwaa bi a ɛwɔ yɛn nipadua mu no a ɛtrɛw . Eyi betumi afi ɔyare mmoawa ne mogya a ɛtɔ kɔ nipadua mu ahorow bi mu.

Kae sɛ, sɛ wowɔ saa sɛnkyerɛnne ahorow yi ara kwa a, ɛnkyerɛ sɛ wowɔ LGL. Ebetumi ayɛ nyarewa afoforo pii ho sɛnkyerɛnne nso. Enti, sɛ worehyia biribi a ɛte sɛɛ a, ɛbɛyɛ papa sɛ wobɛkɔ oduruyɛfo nkyɛn akɔhwehwɛ afotu.

So tebea afoforo bi wɔ hɔ a ɛbata LGL ho?

Yiw, wɔahu sɛ nnipa pii a wɔwɔ LGL wɔ nyarewa afoforo a nipadua no tumi ko tia nyarewa . Ɛne sɛ, tebea horow a yɛn nipadua no ankasa nipadua mu tumi a ɛko tia nyarewa no tow hyɛ yɛn ankasa nkwammoaa a ɛte apɔw so. Eyinom mu no, ntini mu yare na abu so sen biara.

Bio nso, tebea afoforo pii betumi abata LGL ho:

• Anemia : Yɛaka eyi ho asɛm pɛn. Nnipa binom mogya so tew kɛse na ehia sɛ wɔde mogya ma na ama wɔn mogya mu nkwammoaa kɔkɔɔ dodow akɔ so atra hɔ. Nnipa binom a wɔwɔ LGLMogya a ɛtɔ kɔ mogya mu bi a wɔfrɛ no hemolytic anemia nso betumi aba. Wɔ eyi mu no, sɛ́ anka wɔbɛtew mogya mu nkwammoaa kɔkɔɔ a wɔyɛ so no, wɔsɛe mogya mu nkwammoaa kɔkɔɔ a ɛwɔ hɔ dedaw no.
• Lymphocytosis : Eyi yɛ mogya mu nkwammoaa fitaa a wɔfrɛ no lymphocytes dodow a ɛkɔ soro wɔ mogya no mu. Wɔtaa hu saa mogya mu nkwammoaa a ɛkɔ soro yi wɔ nnipa a wɔwɔ mogya mu nkwammoaa a ɛma mogya tu, mogya mu nkwammoaa a ɛma mogya tu, anaa ɔyare mmoawa a wɔde nyarewa ba no mu.

Dɛn ne nea ɛde LGL ba ankasa?

Eyi yɛ biribi a nnuruyɛfo nnya nte ase yiye. Wonnya nhuu nea ɛde LGL ba ankasa . Nanso, wogye di sɛ abusuabɔ bi da mogya mu kokoram tebea yi ne yɛn nipadua mu tumi a ɛko tia nyarewa, nyarewa a nipadua no tumi ko tia nyarewa, ne kokoram ahorow afoforo no dwumadi ntam.

• Nnipa a wɔwɔ LGL no mu bɛyɛ 30% wɔ nyarewa afoforo a nipadua no tumi ko tia nyarewa, te sɛ ntini mu yare.
• 25% kosi 30% foforo betumi anya lymphoma foforo anaa kokoram foforo.
• Afei nso, nnipa pii a wɔwɔ LGL no wɔ nsakrae wɔ wɔn awosu mu. Titiriw no, nkwaadɔm mu nsakrae wɔ awosu mu nkwaadɔm abien a wɔfrɛ no STAT3 ne STAT5B mu. Saa awosu mu nkwaadɔm abien yi di dwuma titiriw wɔ nkwammoaa mu ahoɔden a ɛko tia nyarewa ne ɔkwan a nkwammoaa fa so kyekyɛ na ɛdɔɔso no mu.

Ɔkwan bɛn so na nnuruyɛfo hu yare yi?

Nnuruyɛfo de mogya mu nhwehwɛmu ne awosu mu nhwehwɛmu di dwuma titiriw de hu LGL. Sɔhwɛ ahorow a wɔtaa yɛ no bi ni:

• Complete blood count (CBC) with differential : Eyi kan nkwammoaa ahorow a ɛwɔ wo mogya mu nyinaa, titiriw mogya mu nkwammoaa fitaa ahorow biara a wowɔ no dodow.
• Peripheral blood smear : Nea ɛka eyi ho ne sɛ wɔbɛhwɛ mogya bi wɔ afiri a wɔde hwɛ nneɛma nketenkete mu na wɔakan LGL nkwammoaa dodow a ɛwɔ mogya no mu.
• Flow cytometry : Eyi yɛ nhwehwɛmu a wɔyɛ wɔ aduruyɛdan mu a wɔde hwehwɛ nkwammoaa su mu. Wɔtaa de sɔhwɛ yi di dwuma de hu mogya mu kokoram ahorow na wɔkyekyɛ mu.
• Immunophenotyping : Eyi hwehwɛ sɛ wɔfa mogya anaa ntini ahorow na wɔhwehwɛ mu hwɛ sɛ ebia agyiraehyɛde pɔtee bi wɔ nkwammoaa no ani anaa. Wobetumi de saa agyiraehyɛde ahorow yi ahu nyarewa ahorow bi.
• T-cell receptor (TCR) gene rearrangement analysis : Eyi fa mogya anaa nnompe mu ntini bi na ɛhwehwɛ ɔhaw biara a ɛwɔ awosu mu nkwaadɔm a ɛhwɛ sɛnea T-cells yɛ adwuma no so.
• Awosu mu nhwehwɛmu : Wubetumi nso asɔ nkwaadɔm mu nsakrae a ɛwɔ STAT3 ne STAT5B awosu mu nkwaadɔm a yɛadi kan aka ho asɛm no mu ahwɛ.

Wɔ nhwehwɛmu ahorow yi akyi no, nipadua no mu tumi a ɛko tia nyarewaWobetumi ayɛ nhwehwɛmu afoforo te sɛ nnompe mu ntini mu nhwehwɛmu de ayi tebea afoforo te sɛ nipadua no mu tumi a ɛko tia nyarewa, ntini mu yare, myelodysplasia , ne myeloid mutations afi hɔ . Wobetumi ahwɛ immunoglobulin dodow ne monoclonal protein dodow nso.

Ɔkwan bɛn so na wɔsa LGL?

Momma yɛnka sɛ wowɔ T-LGL anaa CLPD-NK mogya mu kokoram, nanso wunni sɛnkyerɛnne biara . Sɛ ɛba saa a, ebia wo duruyɛfo bɛkamfo ɔkwan bi a wɔfrɛ no "ɔwɛn a wobɛtwɛn." Nea ɛka eyi ho ne sɛ wobɛkɔ so ahwɛ w’akwahosan so. Mpɛn pii no, wobɛyɛ mogya mu nhwehwɛmu asram kakraa biara de ahwɛ sɛ ebia sɛnkyerɛnne ahorow no bɛda adi anaa.

Wɔ wɔn a wɔwɔ sɛnkyerɛnne ahorow no fam no, wobetumi de nnuru a ɛma nipadua no tumi ko tia nyarewa ne steroids ama wɔn. Nnuruyɛfo betumi afi ayaresa bi ase akyi foforo, anaasɛ wobetumi afi ayaresa a ano nyɛ den ase. Esiane sɛ LGL yɛ yare a ɛntaa nsi nti, nnipa dodow no ara hwehwɛ oduruyɛfo a ne ho akokwaw wɔ saa yare yi mu.

So yentumi ntew yare yi a ɛba no so?

Nea ɛyɛ awerɛhow no, dabi, yɛrentumi nyɛ saa. Nnuruyɛfo da so ara nnim nea ɛde ba ankasa. Enti, ɛyɛ den sɛ yɛbɛka ɔkwan a yɛbɛfa so asiw ano. Nanso wɔahu sɛ nnipa a wɔwɔ nyarewa a nipadua no tumi ko tia nyarewa no wɔ asiane kɛse mu sɛ wobenya saa tebea yi. Enti, sɛ wowɔ saa nyarewa a nipadua no tumi ko tia nyarewa yi mu biako a, ɛyɛ papa sɛ wubebisa wo duruyɛfo sɛ ɛsɛ sɛ wohaw wo ho wɔ LGL ho anaa.

So LGL yɛ yare a edi awu?

Mpɛn pii no, LGL yɛ yare a enni sabea, na ɛnyɛ owu mpofirim . Nnipa a wɔwɔ T-LGL leukemia ne CLPD-LGL leukemia no mu bɛyɛ 75% tra ase mfe anum wɔ bere a wɔahu sɛ wɔanya bi no akyi. Nanso, nnipa a wɔwɔ mogya mu kokoram ahorow yi mu bɛyɛ 10% wuwu esiane nyarewa a emu yɛ den a ebetumi aba sɛ mogya mu kokoram no mu ɔhaw nti. Enti, ɛho hia paa sɛ wobɛbɔ wo ho ban afi nyarewa ho.

Mɛyɛ dɛn ahwɛ me ho? Ɔkwan bɛn so na me ne tebea yi tra ase?

Sɛ wowɔ LGL a, ebia worennya yare no ho sɛnkyerɛnne biara. Nanso, ɛho hia sɛ wohwɛ w’akwahosan nyinaa so, a nea ɛka ho ne sɛ wobɛkɔ akɔhwɛ wo daa . Sɛ́ ebia wowɔ yare no ho sɛnkyerɛnne anaasɛ wunni bi no, nyansahyɛ ahorow yi betumi aboa:

• Di aduan a ahoɔden wom : Di nam, mpataa, nnuaba, nhabannuru, ne aburow a ɛnyɛ den pii.
• Apɔw-mu-teɛteɛ daa : Paw apɔw-mu-teɛteɛ a ɛyɛ wo dɛ na ɛfata wo.
• Da yiye : Ahomegye a ɛfata ho hia yiye.
• Di adwennwen ho dwuma.: Yɛ nneɛma a ɛma w’ani gye, dwennwen nneɛma ho, yɛ yoga.
• Bɔ wo nipadua mu ahoɔden a ɛko tia nyarewa ho ban : Bisa wo duruyɛfo fa nnuru a wɔde bɔ wo ho ban ne nneɛma afoforo a wubetumi ayɛ de asiw nyarewa ano. Nneɛma a ɛnyɛ den te sɛ samina a wode bɛhohoro wo nsa ne mmeae a nnipa ahyɛ hɔ ma a wobɛtwe wo ho afi ho mpo betumi aboa.

So ebetumi aba sɛ wobɛtra ase sɛnea ɛte biara a tebea yi wɔ hɔ?

Mpɛn pii no, nnipa a wɔsa wɔn yare wɔ LGL ho no taa tra ase sɛnea ɛsɛ . Wobetumi atra ase akyɛ te sɛ obi a onni tebea no. Nanso, ɛho hia sɛ yɛkae sɛ ebia nnipa bi a wɔwɔ LGL wɔ mogya mu nyarewa a emu yɛ den dedaw a ɛka wɔn asetra pa.

Bere bɛn na ɛsɛ sɛ mekɔ oduruyɛfo nkyɛn?

Sɛ wunya sɛnkyerɛnne ahorow a ɛkyerɛ sɛ ebia wo tebea no reyɛ kɛse a, akyinnye biara nni ho sɛ ɛsɛ sɛ wokɔ wo duruyɛfo nkyɛn. Sɛ wɔresa wo yareɛ no ho sɛnkyerɛnne dedaw a, ɛsɛ sɛ wosan nso ka nsakraeɛ biara a wobɛhunu wɔ wo nipadua mu (sɛ nhwɛsoɔ no, sɛnkyerɛnne a ɛreyɛ kɛseɛ) kyerɛ wo duruyɛfoɔ .

Nsɛmmisa a ɛho hia bɛn na ɛsɛ sɛ wobisa oduruyɛfo no?

Esiane sɛ LGL yɛ yare a ɛntaa nsi saa nti, ɛyɛ ade a ɛfata sɛ wubenya nsɛmmisa pii wɔ ho. Nsɛmmisa bi a yɛwɔ anidaso sɛ ɛbɛboa wo ma woasua pii afa LGL ho ni:

• LGL bɛn na mewɔ?
• Dɛn ne ayaresa ahorow a wɔde sa eyi?
• So mehia ayaresa bɛboro biako?
• Mete nka sɛ me ho atɔ me yiye mprempren. So menya yare no ho sɛnkyerɛnne?
• Mewɔ nyarewa afoforo. So LGL bɛma wɔayɛ bɔne kɛse?

Nsuro da sɛ wubebisa nsɛm te sɛ eyinom. Wo duruyɛfo wɔ hɔ sɛ ɔbɛboa wo. Wɔasi wɔn bo sɛ wɔbɛkyerɛkyerɛ biribiara mu wɔ ɔkwan a wubetumi ate ase so.

Nea etwa to no, nneɛma a ɛsɛ sɛ yɛkae

Large granular lymphocytic leukemia (LGL) yɛ mogya mu kokoram a ɛntaa nsi a ɛka wo mogya mu nkwammoaa fitaa. Sɛ wowɔ saa tebea yi mpo a, ebia worenhu nsakrae biara wɔ wo nipadua mu a ebetumi ayɛ LGL ho sɛnkyerɛnne. Ɛtɔ mmere bi a, ebia sɛnkyerɛnne ahorow no renna adi mfe pii.

Nnuruyɛfo ntumi nsa saa tebea yi koraa. Nanso, ayaresa ahorow bi wɔ hɔ a ebetumi aboa ma wɔadi ne yare no ho sɛnkyerɛnne ahorow so. It is normal to feel shocked and scared when you hear that you have an incurable disease . Wo nnuruyɛfo bɛte nea enti a wote nka saa no ase.

Wɔn ani begye sɛ wɔbɛkyerɛkyerɛ nea wubetumi ayɛ de ahwɛ w’akwahosan so mprempren, ne nea sɛ yare no ho sɛnkyerɛnne bi ba a, wobɛhwɛ kwan. Sɛ wunim nea wobɛhwɛ kwan daakye a, ɛbɛma woanya ahotoso ne ahoɔden pii a wode bɛtra LGL. Enti, wo ne wo duruyɛfo nka nsɛmmisa a wowɔ nyinaa ho asɛm. Nya nsɛm a ɛfa ho. Ɛno ne ade a eye sen biara a wubetumi ayɛ wɔ bere a ɛte sɛɛ mu.

`LGL mogya mu kokoram, mogya mu kokoram, mogya mu nkwammoaa fitaa, lymphocytes, neutropenia, mogya a ɛtɔ kɔ nipadua mu, nipadua mu ahoɔden a ɛko tia nyarewa