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Let's learn about Nitroglycerin Sublingual Powder, a medicine used for sudden chest pain.

MBBS
Medically Reviewed by MBBS ✓ Medically Reviewed
📅 Updated: Jul 14, 2026 • ⏱ 7 min read • Editorial policy
Let's learn about Nitroglycerin Sublingual Powder, a medicine used for sudden chest pain.
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Have you ever had a sudden, squeezing pain in your chest? For some, this pain spreads down your arms, shoulders, and neck. In medical terms, we call this angina. Today, we are talking about a special medicine that doctors prescribe for use in times like these. That is nitroglycerin powder, which is given to dissolve under the tongue. This is a medicine that helps in times like these like a lifesaver. So, let's see what it is, how to use it, and what things to be careful about.

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Simply put, what is nitroglycerin?

Nitroglycerin is a medicine that is given to prevent and treat chest pain, that is, angina. Think of the arteries that carry blood to your heart as water pipes. Sometimes, when these pipes become narrow, the heart does not get the amount of blood it needs. That's when that chest pain comes.

This nitroglycerin medicine works by widening the narrowed blood vessels (relaxing blood vessels). This makes it easier for the heart to pump blood. Just like widening a busy road makes it easier for vehicles to pass. This means the heart doesn't have to work as hard, and the pain gradually decreases. This is a medicine that belongs to a group of drugs called nitrates.

Things you need to tell your doctor before taking this medicine

Before your doctor prescribes this medication, he or she will need to have a complete picture of your health. So, if you have any of the conditions listed below, be sure to tell your doctor .

  • If you have anemia .
  • If you have a history of bleeding in the brain or a head injury.
  • If you have other heart conditions.
  • If you have liver disease.
  • If you have an allergic reaction to nitroglycerin or any other medicine, food, or dye.
  • If you are pregnant or trying to get pregnant.
  • If you are a mother who is breastfeeding.

Based on this information, the doctor will decide whether this medicine is suitable for you or not, and how to give it.

How exactly do you use this drug?

It is very important to know how to use this correctly, because it is used in an emergency.

The most important thing is to use this as soon as the chest pain starts . Even before that, sit down . Because some people can feel dizzy after taking the medicine. This can reduce the chance of falling.

Okay, now let's see how to do it step by step:

1. Prepare the packet: Hold the medicine packet upright. The notch on the top of the packet and the red arrow line should be facing up. Now, add a layer of the powder to the bottom of the packet and gather all the powder into the bottom.

2. Put it in your mouth: Hold the packet by the slit and bring it as close to your mouth as possible. Now tear the packet along the red arrow.

3. Place under the tongue: Lift your tongue and place all the powder from the packet in the space under your tongue.

4. Close your mouth: Quickly close your mouth tightly and breathe normally through your nose.

5. Be patient: Let this powder dissolve under your tongue. Do not rinse your mouth, spit, or swallow for 5 minutes.

Now is the most important part:

  • You should usually feel relief within 5 minutes of taking the first dose.
  • If the pain does not subside after 5 minutes or if it seems to be getting worse, call an ambulance immediately or go with someone to the nearest hospital Emergency Department (ETU).
  • You can take another dose after 5 minutes while waiting for the ambulance or on the way to the hospital.
  • Remember, do not take more than 3 doses within 15 minutes.

If your doctor has given you different instructions, always follow those instructions.

Possible side effects of the medicine

Like any medication, nitroglycerin can cause some side effects. Some of these are serious, while others are common. It is important to be aware of these.

Classification of side effects
Serious side effects that you should report to your doctor immediately
Allergic reactions Skin rash, itching, swelling of the face, lips, tongue or throat.
Symptoms of MethemoglobinemiaSevere headache, unusual weakness, difficulty breathing, nausea, vomiting, rapid heartbeat, blue skin or lips.
Increased pressure around the brain Severe headache, blurred vision, vision changes, nausea, vomiting.
Low blood pressure Dizziness, fainting, blurred vision.
Slow heartbeat Dizziness, fainting, altered level of consciousness, difficulty breathing.
Increased chest pain (Angina) Increasing pain, pressure, or tightness in the chest, neck, back, or arms.
Side effects that are usually not serious, but should be reported to the doctor if they persist:
Dizziness It may occur when you first start taking the medicine.
Flushing The face and neck area becomes red and feels warm.
Headache It is a common side effect for many people.

What to do if you take too much medicine?

If you think you have taken more medicine than you think, immediately call the National Poisons Information Centre at the Colombo National Hospital or go to the nearest Emergency Treatment Unit (ETU) .

Bad things to use with this medicine

This is very important. Nitroglycerin is a drug that can have very dangerous effects when combined with certain other medications. Do not take nitroglycerin for any reason , especially if you are taking any of the medications listed below.

  • Erectile Dysfunction Medications: Avanafil, Sildenafil (known as Viagra), Tadalafil, Vardenafil. These can cause a dangerous and life-threatening drop in blood pressure if taken with nitroglycerin.
  • Ergot alkaloids: Some medications used for migraines, such as Dihydroergotamine and Ergotamine.
  • A drug called Riociguat .

This list is not complete, so tell your doctor about all the medications you take (including vitamins and herbal remedies).

Other things to be careful about

  • Keep this medicine with you at all times . You never know when or where chest pain will strike.
  • You may feel drowsy or dizzy after taking this medicine. Therefore , avoid activities that require alertness, such as driving or operating machinery .
  • When getting up from a sitting position or getting out of bed, don't stand up suddenly . Stand up slowly. Be especially careful if you are elderly.
  • Do not take over-the-counter cough, cold, or pain medications without first consulting your doctor. Some medications can increase your blood pressure.

💡 Take-Home Message

  • Nitroglycerin powder is used for sudden chest pain (angina). Take it as soon as the pain starts.
  • Always sit in a safe place before taking the medicine.
  • Place the powder under your tongue and let it dissolve for 5 minutes without swallowing or rinsing your mouth.
  • If the pain does not subside within 5 minutes of the first dose or if it increases, seek emergency medical attention (ETU) immediately.
  • Never use nitroglycerin with erectile dysfunction medications (such as Sildenafil/Viagra). It is very dangerous.
  • It is very important to inform your doctor about all the medications you are taking.
❓ FAQ

FAQ

Evidence-based clinical answers to common patient questions

What to do if you take too much medicine?

If you think you have taken more medicine than you think, immediately call the National Poisons Information Centre at the Colombo National Hospital or go to the nearest Emergency Treatment Unit (ETU) .

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⚠️ Important: Medical articles and information on Nirogi Lanka are strictly for educational and awareness purposes and do not substitute professional medical advice, diagnosis, or treatment. Always consult a qualified physician for any medical concerns.