Sometimes the pain we experience is so severe that it cannot be controlled with ordinary painkillers. For such severe pain, whether after an operation or due to a certain medical condition, doctors sometimes prescribe a special medication. One such medication is Oxymorphone. Since this is a very strong painkiller, it is very important that we know exactly about it.
What kind of medicine is this Oxymorphone?
Simply put, Oxymorphone is a medication that is used to relieve severe pain . Doctors usually prescribe it when other painkillers don't work, or when the body can't tolerate the medication.
This works by blocking the pain signals that travel to your brain. It belongs to a group of powerful painkillers called opioids . Therefore, you need to be very careful when using it.
Things you need to tell your doctor before taking medicine
Because this is a very powerful medication, it is very important to give your doctor a complete account of your health. Be sure to tell them if you have any of the following conditions:
- If you have a head injury or a brain tumor
- If you have a drug or alcohol addiction
- Heart disease, kidney disease, or liver disease
- Lung disease, asthma, or other breathing difficulties
- If you are a regular drinker
- If you have seizures
- Intestinal problems
- Difficulty urinating
- If you have used an MAOI antidepressant (e.g. Marplan, Nardil, Parnate) within the past 14 days
- If you are pregnant, trying to get pregnant, or are a breastfeeding mother
- If you have an allergic reaction to oxymorphone or any other medicine, food, or dye.
Based on this information, the doctor will decide whether this medicine is suitable for you or not and what dosage to give.
The correct way to use this medicine
It is essential to follow the doctor's instructions when using this.
- Swallow this pill with a glass of water.
- Take this on an empty stomach, about an hour before or two hours after a meal . Do not take it with food.
- Take your medicine at the right time, at the right intervals. Do not take more than the amount prescribed by your doctor.
- Do not stop taking the medication suddenly without your doctor's advice.
Attention:If you think you have taken too much of this medicine, go to the nearest hospital Emergency Department (ETU) immediately . Or call the National Poisons Information Centre at the Colombo National Hospital.
This medicine is for you only . Never share it with anyone else.
What if I miss a medication appointment?
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Never take a double dose.
Does this have any effect with other medications?
Yes, Oxymorphone is a drug that can interact with many other medications. Therefore, you should tell your doctor about all the medications you are taking (including vitamins and herbal remedies). It can especially interact with the following medications:
| Drug category | Description and examples |
|---|---|
| Alcohol | Any type of alcohol. |
| Sedatives and sleeping pills | Medication for anxiety or insomnia. |
| Medicines for allergies, coughs, and colds | Antihistamine medication. |
| Some medications for depression | Ex: amitriptyline, fluoxetine, sertraline |
| Other strong painkillers | Other opioid painkillers or cough syrups. |
| Anesthetic drugs | Anesthetics used for surgery. |
This list is not complete, so it's safest to tell your doctor about all the medications you take.
Things to keep in mind when taking this medicine
- Pain and Tolerance: Tell your doctor if your pain doesn't go away, gets worse, or you have a new type of pain. After taking this medicine for a while, you may find that the dose that worked before is no longer enough. This means you need a slightly higher dose to control your pain. This is called tolerance . This is normal, so don't worry. But you should tell your doctor about this.
- Addiction and body habituation: Your body becomes accustomed to this medicine. This does not mean that you are 'addicted' to it. Addiction is the use of a medicine for a purpose other than a medical reason. You have a medical reason for taking this medicine because you are in pain.
- Drowsiness and dizziness: This medicine may make you feel drowsy or dizzy. So avoid driving or operating machinery until you know how it affects you. Do these things slowly, as you may feel dizzy when you stand up or sit up too quickly. Avoid drinking alcohol altogether.
- Constipation: This medicine may cause constipation. If you do not have a bowel movement after 3 days, call your doctor.
- Naloxone: Naloxone is an emergency drug that is given to reverse the effects of an opioid overdose. It is important for family members who are with someone taking this drug to be aware of this. Even after Naloxone is given, immediate hospitalization is essential.
What are the possible side effects?
Like any medicine, this one can have side effects. If you experience any of the serious side effects listed in the table below, seek medical advice immediately.
| Type of side effect | Symptoms |
|---|---|
| Side effects that should be reported to your doctor immediately | |
| Allergic reactions | Skin rash, itching, swelling of the face, lips, tongue or throat. |
| Decreased activity of the central nervous system (CNS depression) | Slow or shallow breathing, excessive sleepiness, unconsciousness, confusion. |
| Decreased function of the adrenal glands | Nausea, vomiting, loss of appetite, unusual weakness, dizziness. |
| Low blood pressure | Dizziness, fainting, blurred vision. |
| Side effects that usually do not require medical attention (but tell your doctor if they persist or are bothersome) | |
| Obstruction | Constipation |
| Dizziness and drowsiness | Dizziness, Drowsiness |
| Dry mouth | Dry mouth |
| Nausea, vomiting, headache | Nausea, Vomiting, Headache |
How to keep medicine safe?
Because this is a very powerful medicine, it is your responsibility to keep it safe.
- Keep out of reach of children and pets. This medicine can be fatal if accidentally taken by a child or other adult.
- This is a drug that can be abused . Therefore, keep it locked in a safe place to protect it from theft.
- It is important to properly dispose of unused medication. If this is not possible, flush it down the toilet. This is to prevent the potential for fatal accidents if this medication falls into the wrong hands.
- Do not use the medicine after the expiration date.
Take-Home Message
- Oxymorphone is a powerful painkiller, so always take it exactly as prescribed by your doctor, and only in the prescribed amount .
- Tell your doctor about all your medical conditions and all other medications you are taking.
- Never share this medicine with anyone else . It is very dangerous and illegal.
- Avoid stopping the medication suddenly without your doctor's advice.
- If you experience severe side effects such as difficulty breathing, excessive drowsiness, or confusion, go to the ETU immediately .
- Always keep medicine in a safe place out of the reach of children.











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