Farikolo Lafasabagaw: An ka Banakisɛfagalanw dɔn cogo nɔgɔman na!

Yala i delila ka miiri garadi fitininw na minnu bɛ an farikolo kɔnɔ wa? A bɛ iko an yɛrɛ ka kɛlɛbolo fitinin. Ni an banana walima ni fɛn dɔ i n’a fɔ baga donna an fari la, olu de bɛ na ɲɛfɛ ka kɛlɛ kɛ walasa k’an kisi. O cɛfarin fitininw ye an bɛ min wele ko antibodies , walima ``Antibodies'' tubabukan na. O tɔgɔ wɛrɛ ye ``Immunoglobuline'' ye.

Antigènes ni anticorps ye mun ye? U bɛ kɛlɛ daminɛ cogo di?

N’an y’a fɔ cogo nɔgɔman na, ` Antigène` ye fɛn o fɛn ye min bɛ kojugu kɛ an farikolo la, min bɛ bɔ kɛnɛma. Miiri k’a filɛ, son dɔ be donna i ka so kɔnɔ. O son in ye `Antigen` ye. O sonw bɛ se ka na ni cogoya caman ye:

• Banakisɛw
• Virus (banakisɛfagalanw).
• Funteni
• Alɛrijini (alrégènes).
• Baganw ka baga
• Tosini suguya wɛrɛw

Sisan, ni nin `(Antigène)` binkannikɛla in donna farikolo la, an farikolo tangalanw b'a dɔn o yɔrɔnin bɛɛ. An ka sigida b'a faamu ko "Oh... an tɛ mɔgɔ min dɔn, o bɛ na yan, wa nin tigi tɛ an dɔ ye." O waati de la an ka kɛlɛbolo, `` Anticorps`` , bɛ wele ka don Fasokan2009-09_enterneti_kalanni.dis.html,#5417333 ye farikolojɔlifɛn kɛrɛnkɛrɛnnenw ye minnu bɛ dilan an ka farikolo tangalanw fɛ. Olu bɛ taa o `(Antigen)` minɛ, k'a tiɲɛ, k'a dɛmɛ ka bɔ farikolo la. A bɛ iko i ye o son minɛ k'a di polisiw ma.

O banakisɛfagalanw bɛ bɔ min? U bɛ farikolo yɔrɔ jumɛn na?

Banakisɛfagalanw bɛ dilan ni joli kuru finman suguya kɛrɛnkɛrɛnnen dɔ ye an fari la. u bɛ wele ko selilu B . Ni ``antigène'' dɔ nana ka B-cell dɔ gosi, o B-cell bɛ tila ka selilɛri caman wɛrɛw dilan. A bɛ i n'a fɔ ``fotokopi''. An bɛ o selilu kura ninnu wele ko `` plasma cellules''. O joli-sira-funu de la, farikolo tangalan miliyɔn caman bɛ bɔ ka bɔ an joli ni an ka nɔgɔw la.

Banakisɛfagalan minnu bɛ Bɔ o cogo la, olu tɛ yɔrɔ kelen dɔrɔn na an farikolo la.

• An fari la
• Fogonfogon la
• Ɲɛji kɔnɔ
• Ni sɔgɔsɔgɔninjɛ ye
• Ni denba bɛ sin di den ma, kɛrɛnkɛrɛnnenya la a daminɛ na, nɔnɔmugu min bɛ wele ko colostrum , o banakisɛfagalan caman bɛ sɔrɔ o la. O de kama sin dili bɛ dɔ fara den ka se ka banaw kunbɛn . O kɔrɔ ye ko den bɛ lakanani sɔrɔ ba fɛ.

An ye nin banakisɛfagalan monoklɔni minnu mɛn, olu ye jumɛnw ye?

dɔgɔtɔrɔw bɛ kuma fɛn minnu kan nin donw in na , olu dɔ ye banakisɛfagalanw ye minnu bɛ wele ko monoclonal anticorps . Ninnu tɛ banakisɛfagalanw ye minnu bɛ sɔrɔ an farikolo la. U ye banakisɛfagalan suguya dɔ ye min bɛ dilan laboratuwari kɔnɔ. U dabɔra ka fɛn kelen kɛ i n’a fɔ an yɛrɛ ka farikolo tangalanw bɛ min kɛ. U dabɔra ka bin antigène kɛrɛnkɛrɛnnen dɔrɔn de kan. Nin furakɛli fɛɛrɛ inA bɛ fɔ fana ko `Immunothérapie`.

Bana jumɛnw bɛ se ka furakɛ ni farikolojidɛsɛbanakisɛ kelenw ye?

Nin banakisɛfagalan suguya min dilannen don ni fɛn dilannenw ye, n’o bɛ wele ko `(Monoclonal Antibodies)`, o bɛ kɛ ka bana suguya caman furakɛ. Sabula `(Monoclonal Anticorps)` kelen-kelen bɛɛ bɛ dilan ka `(Antigène)` kɛrɛnkɛrɛnnen dɔ laɲini. Misali damadɔw filɛ nin ye:

• Kansɛri suguyaw
• Jolibanaw i n’a fɔ sɔgɔsɔgɔninjɛ
• Dusukunnabana dɔw
• Sklerose multiple (MS) bana .
• Kɔnɔnatumuw (banakɔtaa sɔgɔsɔgɔninjɛ) .
• Lupus (Lupus) ye
• Crohn ka bana ye
• Psoriasis, o ye faritanabana ye
• Aw bɛ farikolo yɔrɔw cili banbaliya dabila

Yala farikolo tangalan suguya dɔw bɛ yen wa? U ye mun ye?

Ɔwɔ, farikolo tangalanw bɛɛ tɛ kelen ye. U tilalen don suguba 5 ye ka da u sigiyɔrɔ n’u baarakɛcogo kan. Sugu kelen-kelen bɛɛ tɔgɔ Dara tubabukan sɛbɛnni dɔ kan. Daɲɛ `Immunoglobulin` bɛ surunya ani `Ig` bɛ fara nin sɛbɛn in ɲɛfɛ.

1. IgG : Nin ye banakisɛfagalan suguya ye min ka ca an joli ni farikolojidɛsɛ wɛrɛw la. Olu de b’an tanga fɔlɔ banakisɛw ma i n’a fɔ banakisɛw ni banakisɛw. Min nafa ka bon kosɛbɛ, o ye ko nin `IgG` banakisɛfagalan ninnu bɛ se ka ba denso tigɛ ka den tanga den kɔnɔbara la.

2. IgA : Olu bɛ sɔrɔ kosɛbɛ an ka ninakiliyɔrɔ (nu, dawolo, fogonfogon) ani dumunikɛminɛnw (banakɔtaa) kɔnɔ. U bɛ sɔrɔ fana daji, ɲɛji ani sinji la. U bɛ dɛmɛ ka banakisɛw bali ka don fari la sani u ka se ka don farikolo la.

3. IgM : Ni banakisɛ donna farikolo la, o `IgM` banakisɛfagalan ninnu de bɛ fɔlɔ ka kɛlɛ kɛ . U bɛ sɔrɔ joli ni nɔgɔji la.

4. IgE : Nin banakisɛfagalan suguya in sen bɛ faritanabanaw de la kosɛbɛ . IgE hakɛ bɛ bonya ni farikolo bɛ fɛnw kɛ i n’a fɔ mugu ni buguri. U bɛ parazitiw fana kɛlɛ.

5. IgD : Ko caman bɛ ka kalan hali bi nin farikolojɔlifɛn ninnu kan, nka a bɛ da a la sisan ko u bɛ dɛmɛ ka B-cellw baara. U bɛ sɔrɔ dɔɔni dɔɔni joli la.

O banakisɛfagalanw dilannen don ni mun ye tiɲɛ na? U ɲɛda bɛ cogo di?

banakisɛfagalanw ye farikolojɔli dumuni suguya dɔ ye . banakisɛfagalan kelen-kelen bɛɛ bɛ kɛ ni polipɛtidi naani ye . Polipɛtidiw ye cakɛdaw ye minnu bɛ kɛ ni asidi aminiki fila walima caman ye. O cakɛda fla bɛ Weele ko "cakɛda girinmanw" ani fla tɔw bɛ Weele ko "cakɛda nɔgɔmanw".

O cakɛda naani ninnu bɛ fara ɲɔgɔn kan ka kɛ tubabukan sɛbɛnnibolo ‘Y’ cogoya ye.O cogo de la banakisɛfagalan dɔ bɛ dilan. Miiri k’a filɛ, ‘Y’ sɛbɛnni sanfɛla bolo fila dakun fila tɛ kelen ye, wa asidi aminiki sinsinni o yɔrɔw la, o tɛ kelen ye banakisɛfagalan suguya kelen-kelen bɛɛ la. O danfara de y’a to banakisɛfagalan kelen-kelen bɛɛ bɛ se ka `(Antigène)` kɛrɛnkɛrɛnnen dɔ dɔrɔn de dɔn ka bin a kan. I n’a fɔ kilisi kelen-kelen bɛɛ bɛ bɛn kilisi kelen-kelen bɛɛ ma cogo min na.

An ka kuma dɔɔnin COVID Anticorps kan, wa?

Ɔwɔ, COVID banakisɛw ye fɛn ye bɛɛ bɛ kuma min kan nin donw in na. Banakisɛfagalan minnu bɛ COVID-19 lase mɔgɔ ma, olu bɛ se ka sɔrɔ mɔgɔw joli la minnu kɛnɛyara ka bɔ bana in na, walima mɔgɔ minnu ye COVID-19 boloci ta. Hali ni COVID tun bɛ aw la ka kɔrɔ, ni aw ye boloci kɛ, o bɛna dɔ fara aw farikolo ka farikolo tangacogo kan, ka dɔ fara aw ka se kan ka aw yɛrɛ tanga banakisɛ ma.

Ne bɛ se k’a dɔn cogo di ni Covid banakisɛw bɛ ne la?

aw bɛ se k' a dɔn ni COVID banakisɛw bɛ aw la ni aw ye banakisɛfagalanw sɛgɛsɛgɛli kɛ . Nin sɛgɛsɛgɛli ninnu bɛ kɛ laboratuwariw la, furakɛliso dɔw la, ani aw ka dɔgɔtɔrɔ fana bɛ se k’u fɔ aw ye.

Covid banakisɛfagalanw bɛ mɛn farikolo la fo waati joli?

Sɛgɛsɛgɛliw bɛ senna hali bi, nka sɛgɛsɛgɛliw y’a jira ko mɔgɔ minnu kɛnɛyara COVID-19 fɛ, banakisɛfagalanw bɛ u la minnu bɛ mɛn kalo duuru fo kalo wɔɔrɔ ni kɔ . Sɛgɛsɛgɛli dɔ y’a jira ko mɔgɔ minnu kɛnɛyara COVID fɛ, “hakilila B selilɛriw” bɛ olu la minnu bɛ se ka to san caman kɔnɔ, wa o hakilijagabɔlanw bɛ se ka banakisɛ in laɲini joona ni a seginna.

Ninnu ye thyroglobuline banakisɛ suguya jumɛnw ye?

A ka ca a la, thyroglobuline banakisɛfagalanw bɛ sɔrɔ mɔgɔ minnu na, sɔgɔsɔgɔninjɛ gɛlɛya bɛ mɔgɔ minnu na, i n’a fɔ jolidɛsɛ bɛ minnu na (sɔgɔsɔgɔninjɛ hormone ka ca kojugu) walima jolidɛsɛ (thyroïde hormone ka dɔgɔn kojugu). O farikolojɔlifɛnw bɛ bin farikolojɔlifɛn dɔ kan min bɛ wele ko thyroglobuline (o ye thyroïde hormone ɲɛbila ye). O bɛ se ka sɔgɔsɔgɔninjɛ tiɲɛ.

Antithyroglobuline Antibody Test ye mun ye?

Ni dɔgɔtɔrɔ bɛ sigasiga ko gɛlɛya bɛ aw ka sɔgɔsɔgɔninjɛ la, a bɛ se ka yamaruya di nin thyroglobuline anticorps test in ma . Nin sɛgɛsɛgɛli in bɛ kɛ fana walasa ka sɔgɔsɔgɔninjɛ kansɛri taabolo kɔlɔsi furakɛli kɔfɛ.

Mun bɛ kɛ ni n ka sɛgɛsɛgɛli kɛra ni n ye?

Ni nin sɛgɛsɛgɛli in y’a jira ko joli-sira-funu-banakisɛ bɛ aw joli la, o kɔrɔ ye ko sɔgɔsɔgɔninjɛ bɛ se ka kɛ aw la. O cogoya dɔw ye:

• Ɲɛgɛnɛsiraw ka banakisɛfagalanw (hyperthyroïdie).
• Thyrothyroïdie (banakisɛfagalanw dɔgɔyali).
• Hashimoto ka bana
• Graves ka bana
• Sɔgɔsɔgɔninjɛ min bɛ wele ko subacute thyroïdie
• Lupus (Lupus) ye
• Sukarodunbana suguya fɔlɔ

O la, o autoanticorps ninnu ye mun ye?

Olu bɛ wele fana ko antinucléaire anticorps (ANAs). Autoanticorps ye farikolo tangalan suguya dɔ ye min bɛ bin farikolojɔli dumuni nafamaw kan an yɛrɛ farikolo kɔnɔ farikolokisɛ kɛnɛmanw nucléaires kɔnɔ. Miiri k’a filɛ i n’a fɔ an yɛrɛ ka lafasaliw bɛ bin an yɛrɛ ta kan. O farikolojɔlifɛnw bɛ fili farikolo la farikolojɔli dumuni kɛnɛmanw na k’a fɔ ko farati bɛ u la ani ko u tɛ mako ɲɛ. O de kosɔn, an farikolo bɛ daminɛ ka bin a yɛrɛ kan. Nin farikolojɔlifɛn ninnu hakɛ ka dɔgɔn kosɛbɛ mɔgɔ fanba la. Nka ni u hakɛ ka ca, a ka c’a la, o bɛ a jira ko farikolo tangalanw ka bana dɔ don .

Antinucléaire anticorps (ANA) bɛ sɛgɛsɛgɛ cogo di?

joli sɛgɛsɛgɛli kunba min bɛ kɛ ka nin `ANA` ninnu lajɛ , o ye ` fluorescent antinucléaire anticorps test` ye . Nin sɛgɛsɛgɛli in na, dɔgɔtɔrɔw bɛ banakisɛfagalanw lajɛ minnu sɛbɛnnen don ni fluorescent ye mikroskɔpu fɛ, ka fluorescence fanga ni a kɛcogo dɔn. A ka ca a la, nin sɛgɛsɛgɛli in bɛ kɛ ka bana dɔw sɔrɔ i n’a fɔ lupu.

ANA sɛgɛsɛgɛli min kɛra ni ANA ye, o kɔrɔ ye mun ye?

Ni aw ye ``positive`` sɔrɔ ANA sɛgɛsɛgɛli la, o kɔrɔ tɛ ko farikolo tangalanw ka bana bɛ aw la, nka a bɛ se ka kɛ ko aw ka dɔgɔtɔrɔ bɛ se ka sɛgɛsɛgɛli kɛ ka taa a fɛ. Ni aw ye ``positive`` sɔrɔ, a ka c’a la, aw ka dɔgɔtɔrɔ bɛna a fɔ aw ye ko aw ka sɛgɛsɛgɛli wɛrɛw kɛ.

Min nafa ka bon kosɛbɛ, farikolo tangalanw ye an farikolo tangacogo ye cogo min na banakisɛw, faritanabanaw ani bagaw ma. An farikolo bɛ o farikolojɔli dumuniw dilan u yɛrɛ la. Tuma dɔw la, farikolo tangalan kelen minnu dilannen don laboratuwariw kɔnɔ, olu bɛ kɛ ka kɛnɛya gɛlɛya dɔw furakɛ, i n’a fɔ kansɛri, dusukunnabana ani sɔgɔsɔgɔninjɛ.

Fɛn minnu nafa ka bon kosɛbɛ i ka kan ka to i hakili la (Take-Home Message) .

O bɛ ɲɛ, o la, an ye kuma minnu fɔ, an ka olu dɔw lajɛ ka surunya, i ka kan ka minnu to i hakili la:

• Banakisɛfagalanw ye an farikolo lafasalifɛnw ye. U bɛ dɛmɛ don k’an tanga ni dunanw ka tumuw ni bagaw (antigènes) kɛlɛli ye.
• olu bɛ dilan joli kuru finman kɛrɛnkɛrɛnnenw fɛ minnu bɛ wele ko selilu B .
• Banakisɛfagalan suguya caman bɛ yen (IgG, IgA, IgM, IgE, IgD), u kelen-kelen bɛɛ bɛ baara kɛrɛnkɛrɛnnen kɛ.
• Banakisɛfagalanw (monoclonal anticorps) ye banakisɛfagalan suguya kɛrɛnkɛrɛnnen ye min dilannen don laboratuwari kɔnɔ. U bɛ kɛ ka bana suguya caman furakɛ, kansɛri fana sen bɛ o la.
• An bɛ COVID banakisɛw sɔrɔ banaw ni bolociw la.
• Tuma dɔw la, an ka farikolo tangalanw bɛ se ka baara kɛ an yɛrɛ farikolo la. olu bɛ wele ko autoanticorps . Olu bɛ se ka kɛ sababu ye ka farikolo tangalanw ka banaw lase mɔgɔ ma.

O la, aw bɛ se k’a ye ko nin cɛfarin fitinin ninnu minnu bɛ wele ko anticorps, olu nafa ka bon an farikolo la cogo min na. Olu de b’an tanga bana caman ma. Ni ɲininkali wɛrɛ bɛ aw fɛ o ko la, aw kana siga ka dɔgɔtɔrɔ ɲininka.

` Banakisɛfagalanw, Banakisɛfagalanw, Immunoglobuline, Antigène, Banakisɛfagalanw, B selilɛriw, Banakisɛfagalan monoklonaliw, COVID banakisɛfagalanw, Thyroglobuline Anticorps, Autoanticorps, ANA sɛgɛsɛgɛli