G-CSF (Granulocyte-Colony Stimulating Factor) ye mun ye? Mun na a nafa ka bon kansɛri furakɛli la?

N’a sɔrɔ i ye mɔgɔ dɔ ye i ka denbaya kɔnɔ, i somɔgɔ dɔ walima i teri dɔ la min bɛ ka kansɛri furakɛ. Aw ka kan ka furakɛli min bɛ wele ko "Chimiothérapie" o ko mɛn ni aw bɛ o furakɛli sugu kɛ. N’a sɔrɔ aw b’a dɔn fana ko nin chimio furakɛli in senfɛ, joli kuru finman minnu bɛ banaw kɛlɛ farikolo la, olu hakɛ bɛ dɔgɔya. O cogo la, nin barokun in kɔnɔ, an bɛna kuma fura kɛrɛnkɛrɛnnen dɔ kan, dɔgɔtɔrɔw bɛ min kɛ walasa ka an farikolo tangacogo dɛmɛ. O ye G-CSF ye.

G-CSF ye mun ye tigitigi?

N’an y’a fɔ cogo nɔgɔman na, G-CSF ye fura ye min bɛ an farikolo dɛmɛ ka joli kuru finman caman dilan , kɛrɛnkɛrɛnnenya la suguya min bɛ wele ko “neutrophils”.

Miiri k’a filɛ, an farikolo be komi jamana dɔ. O tuma na fɛ, o neutrophils ninnu bɛ i n’a fɔ sɔrɔdasi minnu bɛ o jamana kɔnɔ. O sɔrɔdasi minnu bɛ wele ko neutrophils, olu de bɛ kɛnɛma banakisɛw kɛlɛ, o kɔrɔ ye ko juguw i n’a fɔ banakisɛw ni banakisɛw, k’an tanga banaw ni banakisɛw ma. O la sa, mun bɛ kɛ ni o sɔrɔdasi ninnu dɔgɔyara? An ka jamana, n’o ye an farikolo ye, banaw bɛ kɛ nɔgɔya la.

Hali n’a bɛ Se ka Kɛ ko G-CSF tɔgɔ in ka gɛlɛn dɔɔnin, n’an y’a kɔrɔ Tiɲɛ, a ka nɔgɔn kosɛbɛ.

• Granulocyte : Nin ye tɔgɔ ye min bɛ di joli kuru finman suguya dɔ ma. Neutrophils fana ye granulocyte suguya dɔ ye.
• Koloni-Stimulating Factor: Nin ye fɛn ye min bɛ selilu "kama" walima "wuli". I n’a fɔ izini ɲɛmɔgɔ bɛ baara di baarakɛlaw ma cogo min na, o farikolojɔli dumuni in bɛ taa an kolotugudaw la k’a fɔ ko: “O bɛ ɲɛ, aw bɛ neutrophils dilanni daminɛ sisan.”

O la, fura in min bɛ wele ko G-CSF, o bɛ min kɛ, o ye a bɛ taa kolotugudaw la , o min ye an kolo kɔnɔ yɔrɔ ye min bɛ i n’a fɔ ɛponji, wa a b’a fɔ yen jirisunw ye ko “aw cɛw ka kan ka teliya ka kɛ neutrophils ye, ani neutrophils minnu bɛ yen, olu ka kan ka tila ka caya.”. O kɔfɛ, nin neutrophil sɔrɔdasi kura minnu dabɔra, olu bɛ fara joli kan, ka baara daminɛ walasa k’an lakana.

G-CSF bɛ kɛ cogo jumɛnw na?

G-CSF bɛ kɛ ka caya ka bana dɔ furakɛ ani k’a kunbɛn min bɛ wele ko “neutropenie”. Neutropenie ye joli la jolisegindumuni hakɛ dɔgɔyali ye dɔrɔn ka tɛmɛ a cogo kɔrɔ kan.

Kansɛri furakɛli la (Chimiothérapie) .

Simifura minnu bɛ kɛ kansɛri furakɛli la, olu dabɔra ka kansɛribanakisɛw faga minnu bɛ tila teliya la. Nka, o furaw tɛ se ka kansɛribanakisɛw dɔrɔn dɔn, nka u tɛ se ka farikolokisɛ kɛnɛmanw fana dɔn minnu bɛ tila joona an fari la. O la, ikomi neutrophils, minnu bɛ sɔrɔ kolotugudaw la, olu fana ye selilɛri suguya dɔ ye min bɛ tila teliya la, u fana bɛ tiɲɛ ni chimio furaw ye.

O bɛ i n’a fɔ binfagalan fiyɛli walasa ka binjuguw bɔ, nka a bɛ jiri ɲumanw fana tiɲɛ.

O de kama neutropenie ka teli kosɛbɛ chimiothérapie kɔfɛ. Ni nin bana in juguyara, hali bana misɛnni dɔ bɛ se ka mɔgɔ ka ɲɛnamaya bila farati la. O cogo la, dɔgɔtɔrɔw bɛ G-CSF fɔ walasa ka dɔ bɔ banakisɛ sɔrɔli la ani ka farikolo tangacogo segin a cogo kɔrɔ la.

Kɔnɔnatumuw cili la

Kansɛri ni jolidɛsɛ suguya dɔw la, a ka kan ka jirisunba dɔ ci. G-CSF bɛ kɛ ka kɔn nin wale in ɲɛ ani a kɔfɛ.

• Sani a ka jiginni kɛ : Ni G-CSF dira banabagatɔ ma, kolotuguda bɛ jirisunba caman bɔ ka u bila joli la. O kɔfɛ, dɔgɔtɔrɔw bɛ o jirisun kɛnɛmanw lajɛ ka bɔ joli la.
• Jiginni waati: O kɔfɛ, chimiothérapie walima radiation furakɛli hakɛ caman bɛ farikolo kɔnɔ farikolokisɛw bɛɛ tiɲɛ minnu tɛ cogo la.
• Jiginni kɔfɛ: A laban na, jirisun kɛnɛman minnu lajɛra ka kɔrɔ, olu bɛ segin ka don farikolo la. O farikolokisɛw bɛna kɛ kɔfɛ jolikisɛ kuraw ye minnu kɛnɛman don.

Ni aw ye jirisunw dibaga ye, a bɛ se ka kɛ fana ko aw ka kan ka G-CSF pikiri kɛ sani a ka kɛ.

Bana wɛrɛ minnu bɛ kɛ sababu ye ka neutrophils dɔgɔya

Neutrophils hakɛ fana bɛ se ka dɔgɔya ka a sababu kɛ bana dɔw ye minnu bɛ sɔrɔ bange waati (neutropenie congénitale jugumanba) walima ni a sababu tɛ dɔn (neutropenie idiopathique). O cogo la, G-CSF bɛ kɛ ka dɔ fara neutrophils hakɛ kan.

G-CSF suguyaw ani u dicogo

G-CSF bɛ sɔrɔ sugu la tɔgɔ suguya caman na. A suguya fla minnu bɛ Kɛ ka caya olu ye:

1. Filgrastim: Nin ye suguya ye min bɛ kɛ waati kunkurunnin kɔnɔ. A ka ca a la a ka kan ka kɛ don o don pikiri ye.

2. Pegfilgrastim : Nin ye fura suguya ye min bɛ mɛn sen na, o la a ka ca a la a bɛ se ka pikiri kelen dɔrɔn kɛ chimiothérapie siɲɛ fila cɛ.

O fura ninnu bɛ sɔrɔ tɔgɔ suguya caman na ani biyosimilɛriw. Misali la, aw ka dɔgɔtɔrɔ bɛ se ka tɔgɔw fɔ aw ye i n’a fɔ Neupogen®, Neulasta®, Nivestym® ani Zarxio®.

Fura in bɛ di farikolo ma cogo di?

a ka ca a la , G-CSF bɛ kɛ farikolo jukɔrɔ pikiri ye , nka a dɔw la , a bɛ se ka kɛ fana ka kɛ IV pikiri ye .

• A bɛ se ka kɛ aw ka kan ka taa dɔgɔtɔrɔso la don o don walasa ka boloci kɛ.
• Walima, dɔgɔtɔrɔso baarakɛla dɔ bɛna aw walima denbaya kɔnɔmɔgɔ dɔ kalan ka jɛya boloci pikiri kɛcogo la so kɔnɔ. A man gɛlɛn o cogo la.

Yala bɛɛ mago bɛ G-CSF la wa?

Ayi, G-CSF tɛ di mɔgɔ bɛɛ ma minnu bɛ chimiothérapie kɛ walima minnu ka neutrophiles ka dɔgɔn. I n’a fɔ fura tɔw bɛɛ, nafa bɛ G-CSF la ka fara a kɔlɔlɔ dɔw kan. Aw ka dɔgɔtɔrɔ bɛna fɛn caman jateminɛ sani aw ka fura in sɛbɛn.

• i si hakɛ
• Aw ka kɛnɛya cogoya bɛɛ lajɛlen
• Kansɛri suguya min bɛ aw la
• Aw bɛ chimiothérapie suguya min ta
• Ni farikolojidɛsɛ taamasiɲɛw bɛ aw la kaban (i n’a fɔ sumaya) .

G-CSF nafaw ni a kɔlɔlɔ minnu bɛ se ka sɔrɔ

Ni G-CSF ka ɲi, aw k’aw hakili to a la ko a nafa ka bon kosɛbɛ ni faratiw ye.

Nafa kunbabaw:

• Banakisɛ jugumanba minnu bɛ se ka mɔgɔ ka ɲɛnamaya bila farati la, olu farati bɛ dɔgɔya kosɛbɛ.
• Neutrophils hakɛ dɔgɔyali bɛ se ka chimiothérapie bali ka mɛn walima ka dɔ bɔ a tata hakɛ la , o bɛ a to kansɛri furakɛli ka taa ɲɛ i n’a fɔ a labɛnna cogo min.

Kɔnɔnatumu kɔlɔlɔ minnu bɛ se ka sɔrɔ

Kɔnɔnatumu fanba bɛ kɛ waati dɔɔni kɔnɔ, wa u bɛ ban G-CSF jɔlen kɔfɛ.

Fɛn minnu ka kan ka to aw hakili la ni aw bɛ G-CSF ta

• Aw bɛ aw ka furakɛli tariku bɛɛ fɔ dɔgɔtɔrɔ ye. Aw ye aw jija ka a ladɔnniya bana wɛrɛ minnu bɛ aw la ani fura wɛrɛ minnu bɛ aw ta (witaminiw fana sen bɛ o la).
• A man ɲi ka G-CSF ta ni aw kɔnɔma don, ni aw b’a ɲini ka kɔnɔ ta, walima ni aw bɛ sin di den ma . Aw bɛ kuma aw ka dɔgɔtɔrɔ fɛ o ko la.
• Aw kana aw hakili ɲagami kɔlɔlɔw la. Ni aw ye kɔlɔlɔ dɔw sɔrɔ, aw bɛ o fɔ aw ka dɔgɔtɔrɔ walima dɔgɔtɔrɔso baarakɛla ye. U bɛna i dɛmɛ k’u ɲɛnabɔ.
• Aw bɛ aw ka joli sɛgɛsɛgɛliw kɛ a waati la. Aw ka dɔgɔtɔrɔ bɛna aw ka neutrophils hakɛ lajɛ ani ka a dɔn furakɛli ka kan ka kɛ waati hakɛ min na.

G-CSF ye dɛmɛnan ye min nafa ka bon kosɛbɛ kansɛri furakɛli la. A bɛ fanga caman di walasa ka chimiothérapie furakɛli kɛ farati ye ani ka ɲɛtaa sɔrɔ. Ni ɲininkali wɛrɛw bɛ aw fɛ o ko la, aw kana siga ka dɔgɔtɔrɔ furakɛbaga ɲininka.