An ka opsonization (opsonization) kɛcogo dɔn min bɛ an farikolo lafasali dɛmɛ.

I ka kɛnɛ wa? Bi an bɛna kuma taabolo kabakoma dɔ kan min nafa ka bon kosɛbɛ, min bɛ kɛ an farikolo kɔnɔ. A bɛ iko fɛn kɛrɛnkɛrɛnnen dɔ min bɛ an farikolo lafasaliw dɛmɛ. N’a sɔrɔ i ye nin kuma in mɛn, wa a bɛ wele ko opsonization. N’i ​​y’o dɔn, i bɛna a faamu an farikolo bɛ baara kɛ cogo min na cogo kabakoma na.

Opsonization ye mun ye?

N’an y’a fɔ cogo nɔgɔman na, opsonization ye fɛɛrɛ ye min bɛ an ka farikolo tangacogo dɛmɛ. A bɛ baara kɛ ni tumu juguw dɔnni ye ani ka u tiɲɛ, i n’a fɔ banakisɛw (i n’a fɔ banakisɛw ni banakisɛw), walima an yɛrɛ ka farikolokisɛw minnu sara walima minnu tiɲɛna. Aw ye miiri aw farikolo tangalanw na iko jɛkulu kɛrɛnkɛrɛnnen min bɛ aw farikolo lakana. U bɛ to ka aw farikolo kɔlɔsi, ka fɛn o fɛn ɲini min bɛ se ka kojugu walima bana lase aw ma.

An farikolo tangalanw yɔrɔw danfaralenw – farikolo yɔrɔw, farikolokisɛw, farikolojɔlifɛnw, kemikɛlifɛnw – olu bɛɛ bɛ baara kɛ ɲɔgɔn fɛ. Yɔrɔ dɔw bɛ taa farikolo lamini ka binkannikɛlaw ɲini. Dɔ wɛrɛw bɛ fɛnw tiɲɛ minnu bɛ kojugu kɛ farikolo la. O waati de la farikolojɔlifɛn minnu bɛ wele ko opsonins , olu bɛ na u dɛmɛ. O opsonin ninnu bɛ tumuw datugu ka ‘marka’ kɛ u la. O kɔ, farikolo tangalan farikolokisɛ tɔw bɛ se k’u dɔn nɔgɔya la ani k’u tiɲɛ. Opsonization (opsonization) kɛcogo bɛ farikolokisɛ salenw ni minnu bɛ ka sa, banakisɛfagalanw, ani hali kansɛribanakisɛw taamasiyɛn.

Opsonin ye mun ye?

An bɛ ‘opsonins’ wele ko farikolojɔlifɛn suguya caman kulu. U ka baara kunba ye ka siri farikolokisɛw ni fɛnw na i n’a fɔ banakisɛw , ani ka farikolokisɛ suguya kɛrɛnkɛrɛnnen dɔ dɛmɛ an ka farikolo tangacogo la – an b’u wele ko fagositɛriw – k’u dɔn ani k’u ‘munumunu’. Miiri k’a filɛ i n’a fɔ ka dumunifɛn dɔ diyabɔ ani k’a jira ka ɲɛ cogo la min b’a to i b’a fɛ k’a dun.

Opsonin dɔw bɛ pan hɔrɔnya la an joli walima an ka nɔgɔji la. Dɔw bɛ dilan ni an farikolo tangalanw bɛ baara kɛ, ka bɔ farikolojɔlan wɛrɛw la. Tuma caman na, fɛn minnu bɛ i n’a fɔ farikolo tangalanw , n’a sɔrɔ aw ye minnu mɛn, olu fana bɛ kɛ opsoninw ye ka u to baara nafama wɛrɛw kɛli la.

O farikolokisɛw, n’u bɛ wele ko fagocytes , olu bɛ ɲɔgɔn sɔrɔ ni opsoninw ye i n’a fɔ bɔrɔ. O kɔ fɛ, u b’o bɔgɔdaga Kɛ k’u b’a fɛ ka fɛn min Tiɲɛ, k’o Minɛ k’a Tiɲɛ. O de y’a to opsoninw bɛ wele fana ko ‘bridging molecules’. Yala i y’a faamu wa?

Fagositozi (fagocytose) taabolo ye mun ye?

Fagositozi (fagocytose) (fagocytose) (fagocytosis).O ye fɛɛrɛ ye min fɛ an farikolo bɛ fɛn juguw walima fɛn minnu man ɲi, olu tiɲɛ ani k’u ban. N’an y’a Fɔ cogo nɔgɔman na, a kɔrɔ ye ko ‘seliw bɛ fɛn dɔ Minɛ k’a Tiɲɛ’. O fɛnw bɛ se ka kɛ banakisɛw ye , dunanfɛnw, walima hali an yɛrɛ ka farikolokisɛw.

Mun bɛ tiɲɛ fagositɔsi la?

Fɛn minnu bɛ tiɲɛ fagositɔsi fɛ, olu dɔw filɛ nin ye:

• Banakisɛ suguya caman i n’a fɔ banakisɛw, banakisɛw ani ɲɛgɛnw.
• Kɔnɔnatumu minnu bananen don.
• Kɔnɔnatumu salenw, kɔrɔlenw, walima minnu tiɲɛna.
• Kansɛri banakisɛw.
• Kɔnɔnatumuw, walima selilu nɔgɔw.
• Jɛɲɔgɔnya (synapses) minnu bɛ farikolo yɔrɔw ni ɲɔgɔn cɛ minnu ka baara dɔgɔyara.

Daɲɛ min ye ‘fagositɔsi’ ye, o kɔrɔ ye ko ‘selilu dunni’. O farikolokisɛw, n’u bɛ wele ko fagocytes, olu bɛ o farikolokisɛw ni tumuw minɛ minnu man ɲi, walima k’u ‘dun’, k’u tiɲɛ. O kɔ, farikolo bɛ se ka bɔ u la nɔgɔya la. Kɔnɔnatumu suguya bɛɛ, i n’a fɔ makɔrɔfagaw , dendɛrɛsi selilɛriw , neutrophils , ani natural killer (NK) selilɛriw , olu bɛ baara kɛ ni opsonization kɛcogo ye walasa ka fɛnw sɔrɔ minnu man ɲi ani k’u bɔ yen.

Fagositɛriw bɛ taamasiɲɛ jumɛnw sɔrɔ?

O farikolokisɛw, n’u bɛ wele ko fagocytes , olu bɛ a latigɛ ni u bɛna fɛn dɔ munumunu walima ni u tɛna a munumunu ka da taamasiɲɛ suguya caman kan. O taamaʃyɛn sugu damadɔ bɛ yen:

• ‘Find-me’ taamasiɲɛw : Olu bɛ se ka kɛ farikolojɔlifɛnw ye walima fɛn wɛrɛw minnu bɛ fagositɛriw dɛmɛ ka farikolokisɛw walima banakisɛw sɔrɔ u b’a fɛ ka minnu tiɲɛ.
• Ne dun walima aw kana ne dun taamasiɲɛw: I n’a fɔ a tɔgɔ b’a jira cogo min na, o taamasiɲɛw b’a fɔ fagosi ye ni a ka kan ka fɛn dɔ dun walima ni a man kan ka min dun.
• Opsonins: An ye kuma ta nin ko in kan dɔrɔn. Olu ye farikolojɔlifɛnw ye minnu bɛ siri farikolokisɛw walima banakisɛw la ani k’a fɔ fagɔli ye ko a ka “o munumunu k’a tiɲɛ.” U fana bɛ Kɛ i n’a fɔ bɔrɔ, o b’a To fagosi bɛ nɔrɔ nɔgɔya la a b’a fɛ ka fɛn min Tiɲɛ.
• Opsonins négatifs: Olu bɛ o kɔfɛko kɛ. O kɔrɔ ye ko u bɛ fari faga walima k’a gɛlɛya fagosi ma ka fɛn dɔ minɛ k’a tiɲɛ.

Yala opsonization misali dɔw bɛ yen wa?

Tiɲɛ na, opsonin suguya tan ni caman bɛ yen an farikolo bɛ baara kɛ ni minnu ye walasa ka laɲini suguya caman dɔn ani k’u ban. U damadɔw filɛ nin ye walasa aw ka se ka minnu dɔn:

• Banakisɛfagalanw: Banakisɛfagalanw ye an farikolo tangacogo yɔrɔ nafamaba ye. U bɛ i ko dawolo ni konnɛgɛ, .U kɛrɛnkɛrɛnnen don banakisɛ yɔrɔ kɛrɛnkɛrɛnnenw na (u bɛ wele ko antigènes) . Banakisɛfagalan minnu bɛ wele ko Immunoglobulin G (IgG) ani Immunoglobulin M (IgM) olu fana bɛ kɛ opsoninw ye.
• Fɛn minnu bɛ ɲɔgɔn dafa: Olu ye farikolojɔli dumuniw kulu ye minnu bɛ an farikolo tangacogo dɛmɛ. Protéines complémentaires suguya caman bɛ baara kɛ ɲɔgɔn fɛ walasa ka fagocyte cellules bilasira ka taa yɔrɔw la, u ka kan ka tiɲɛ yɔrɔ minnu na. C1q, C3, C3b , ani C4b bɛɛ ye opsonin suguyaw ye.
• Fosifatidilisɛrini sirili opsoninw : Fosifatidilisɛrini ye ‘ne dun’ taamasiɲɛ ye. Ni farikolokisɛw bɛ ɲini ka sa ( apoptose ), o taamasiɲɛ bɛ bɔ selilu kɔnɔ. Opsonin caman, i n’a fɔ Annexin A1 , Apolipoprotéine H , Del-1 , Gas6, ani Protéine S, olu bɛ se ka kɛ o la.
• Opsonin wɛrɛw : Ka fara ninnu kan, farikolojɔli dumuniw i n’a fɔ kaletikulini , fibronectin , ficolins (o ye patɔrɔn dɔnni furakisɛw ye), mannose-binding lectin , nɔnɔ tulu globulini (lactadherin) , ani pentraxins fana bɛ kɛ opsoninw ye. Hali ni o tɔgɔw bɛ se ka kɛ i n’a fɔ u ka gɛlɛn dɔɔnin, o tɔgɔw bɛɛ bɛ dɛmɛ don k’an farikolo lakana.

Opsonization bɛ mun kɛ fagocytose la?

I n’a fɔ an y’a fɔ cogo min na ka tɛmɛ, farikolokisɛ minnu bɛ wele ko fagocytes , olu bɛ banakisɛw ‘dun’ ani farikolokisɛ minnu mago tɛ an farikolo la, o min bɛ wele ko fagocytosis , walasa farikolo ka se k’u bɔ nɔgɔya la. O waati de la opsoninw bɛ na u dɛmɛ. Opsoninw bɛ seliluw ni binkannikɛlaw datugu u b’a fɛ ka minnu tiɲɛ. A bɛ i n’a fɔ ka tulumafɛnw fara dumuni dɔ kan walasa a ka diya ani ka diya. Ni fagositɛriw ye o ‘fɛn sumalenw’ ye, u b’a kɛ i n’a fɔ ‘a ka di’. (Tiɲɛ na, ‘opsonization’ daɲɛ bɔra Gɛrɛkikan daɲɛ dɔ la min kɔrɔ ye ‘ka dumuni duman kɛ’!)

Fagositɛriw bɛ sama ka taa o opsonin dacogo in na, o min bɛ sɔrɔ ka siri u minɛbagaw la.U bɛ baara kɛ ni yɔrɔw ye minnu bɛ wele ko opsonins walasa ka nɔrɔ a la. O cogo la, opsoninw bɛ i n’a fɔ foroko min b’u dɛmɛ k’o dumuni duman minɛ. O kɔ fɛ, fagosi bɛ o ‘dumuni’ sama ka don a kɔnɔ, k’a tiɲɛ, k’a ‘sɔgɔ’.

Opsonization bɛ kɛ cogo di?

Taabolo suguya caman bɛ yen minnu bɛ kɛ sababu ye ka opsonization (opsonization) bila mɔgɔ la. Olu kunbabaw ye:

• Banakisɛfagalanw ka jaabi bangenen : An farikolo la, farikolojɔli dumuniw i n’a fɔ C3, olu bɛ banakisɛw, banakisɛw walima ɲɛgɛnw yɔrɔw dɔn ani ka u siri u la. Nin ye opsonization (opsonization) sen kelen ye. O ye lafasali fɛɛrɛ ye an farikolo bɛ bange ni min ye.
• Banakisɛfagalanw ka jaabi ladamu : Banakisɛfagalanw bɛ banakisɛfagalanw dɔn ka bɔ banakisɛw, banakisɛw walima binkannikɛla jugu wɛrɛw la minnu tun dɔnna ka kɔrɔ. I n’a fɔ dakun ni kilisi, olu bɛ bɛn ɲɔgɔn ma walasa ka antigène-anticorps complexe dɔ dilan . O kɔfɛ, furakisɛ dafalenw bɛ siri o fɛnɲɛnɛma in na ka banakisɛ walima selilɛri datugu ni opsonin caman ye. Nin ye fɛn ye an farikolo bɛ min kalan waati tɛmɛnen kɔfɛ.
• ‘Ne dun’ taamasiɲɛw: Ni farikolokisɛw tiɲɛna walima ni u surunyana ka sa, u bɛ taamasiɲɛw ci farikolo tangalanw ma walasa u ka ‘ne halaki’. Opsoninw bɛ o taamasiɲɛw dɔn ka u siri u la.

Fɛn damadɔ bɛ o wale kelen-kelen bɛɛ la, wa u bɛɛ bɛ na ɲɔgɔn fɛ walasa k’an ka farikolo tangacogo baara.

Mun na opsonization nafa ka bon?

Aw b’a dɔn, banakisɛw ye nanbarakɛlaw ye kosɛbɛ. Ikomi u ka kan ka kisi, u b’a ɲini ka dogo an ka farikolo tangalanw na walima k’u yɛrɛ tanga. O waati de la opsonization (opsonization) taabolo bɛ kɛ nafama ye kosɛbɛ. A bɛ fagositɛriw dɛmɛ u ka banakisɛ dogolen sɔrɔ nɔgɔya la, ka nɔrɔ a la, ka laban k’a tiɲɛ.

O cogo kelen na, an yɛrɛ ka farikolokisɛw bɛ baara kɛ ni opsonization ye walasa k’a fɔ farikolo tangalanw ye ko: ‘bana bɛ ne la,’ ‘Ne tiɲɛna,’ walima ‘Ne bɛna sa.’ Ni farikolo ye o taamasiɲɛ in sɔrɔ, a b’a dɔn k’o farikolokisɛw bɔ a la.

N’an y’a fɔ cogo nɔgɔman na, opsonization bɛ i n’a fɔ kumaɲɔgɔnya fɛɛrɛ nafamaba min b’an farikolo to kɛnɛya la. Ni o tun tɛ, a tun bɛna gɛlɛya an ka farikolo tangacogo ma ka baara kɛ ka ɲɛ.

Gɛlɛya minnu bɛ opsonization na, yala olu bɛ se ka bana bila mɔgɔ la wa?

Ɔwɔ, tiɲɛ yɛrɛ la. Fagositɔsi bɛ se ka tiɲɛ ka a sababu kɛ jamu dɔw ka bana ye , fura dɔw tali, walima sababu wɛrɛw. DafalanFarikoloɲɛnajɛ dɛsɛw ni farikolo tangalanw ka bana wɛrɛw bɛ se ka fɛn caman Changer an farikolo bɛ fɛn minnu dɔn, minnu ye kojugu ye ani minnu tɛ kojugu ye. Miiri k’a filɛ nin ye:

• A bɛ se ka kɛ aw ka fagocytes cellules tɛ se ka fɛn juguw tiɲɛ i n’a fɔ cellules tiɲɛnenw, banakisɛw ani banakisɛw. O fɛn jugu ninnu bɛ se ka dalajɛ farikolo la o kɔ ka bana bila mɔgɔ la.
• N’o tɛ, aw ka fagosibanakisɛw bɛ se ka fɛnw tiɲɛni daminɛ minnu man kan ka tiɲɛ, i n’a fɔ farikolokisɛ kɛnɛmanw. A bɛ iko i yɛrɛ ka kɛlɛbolo bɛ bin a yɛrɛ kan.

Gɛlɛya mana kɛ fɛn o fɛn ye, a bɛ se ka kɛ sababu ye ka farikolo tangalanw ka banaw bila mɔgɔ la , i n’a fɔ lupus , walima hakilibanaw i n’a fɔ Alzheimer . Aw bɛ se ka banakisɛ caman sɔrɔ fana walima kansɛri sɔrɔli farati ka bon aw la.

Yala opsonization bɛ se ka kɛ ka banaw furakɛ wa?

Nin ye ɲininkali ɲumanba ye. Dɔgɔtɔrɔso dɔnnikɛlaw bɛ ka ɲinini kɛ kaban fɛɛrɛ minnu bɛ se ka kɛ ka baara kɛ ni nin opsonization kɛcogo in ye walasa ka banaw furakɛ. U jigi ye ka fɛɛrɛw tigɛ walasa k’an farikolo tangalanw dɛmɛ u kɛtɔ ka fɛn juguw opsonize walima ka farikolokisɛ kɛnɛmanw bali ka opsonize. Nin ɲinini in bɛ se ka dɛmɛ don ka banaw furakɛcogo labɛn i n’a fɔ:

• Kansɛri : A bɛ se ka kansɛribanakisɛw ‘taamaʃyɛn’ ani ka farikolo tangalanw dɛmɛ k’u tiɲɛ.
• Banakisɛfagalanw : Nin fɛɛrɛ in bɛ se ka nafa sɔrɔ kɛrɛnkɛrɛnnenya la banakisɛfagalan dɔw kɛlɛli la.
• Farikolo tangacogo jugumanw : U b’a ɲini ka farikolokisɛ kɛnɛmanw bali u ka kɛ ‘taamaʃyɛn’ ye ani ka dɔ bɔ farikolo ka se ka a yɛrɛ tiɲɛ.

O dɔrɔn tɛ, ɲininikɛlaw bɛ ka baara kɛ ni opsonization (opsonization) kɛcogo fana ye walasa ka bolociw ni farikolojidɛsɛ furakɛli kɛcogo sɛgɛsɛgɛ. O sɛgɛsɛgɛliw bɛ wele ko opsonophagocytic killing assays (OPKA) . O la, nin ye ɲininikɛyɔrɔ ye min bɛ layidu ta kosɛbɛ.

Fɛn damadɔ minnu ka kan ka to an hakili la waati kunkurunnin kɔnɔ

Okey, donc an ye kuma caman fɔ opsonization kan, tiɲɛ tɛ? O ye an ka farikolo tangacogo yɔrɔ nafamaba ye. A bɛ i n’a fɔ ka dancɛ sigi an farikolo kɔnɔ fɛn juguw ni farikolokisɛw cɛ minnu bɛ u tiɲɛ.

Yala aw hakili bɛ ne y’a fɔ cogo min na ko hali dumuni nafama minnu man di denmisɛnw ye, olu ka teli ka u dun ni aw ye dɔɔni dɔ fara u kan wa? O de ye opsonization (opsonization) ye. A bɛ a to o fagositɛriw ka...A tɛ ‘dumuni’ kɛ dɔrɔn ka diya selilɛriw ye, a bɛ ‘foroko’ fana di u ma u ka se ka min minɛ. O kɔ, u bɛ se ka taa a fɛ k’a dun!

O la, opsonization bɛ i n’a fɔ cɛfarin makuntɔ min bɛ dɛmɛ ka an farikolo kɛnɛya ani ka tanga banaw ma. O kɛcogo in bɛ ka kɛ ka ɲɛ, o de y’a to an tɛ bana tuma caman na. O la sa, yala nafa t’a la ka an janto dɔɔnin nin kabako kow la minnu bɛ kɛ an farikolo kɔnɔ wa? N jigi b’a kan ko nin dɔnniya in bɛna aw n’aw ka denbaya dɛmɛ ka to kɛnɛya la.

` Banakisɛfagalanw, opsonization, phagocytose, tumuw, farikolokisɛw, farikolo tangalanw, lafasali