Aw ka ɲininkaliw jaabiw filɛ nin ye nin kuru in kan min man teli ka kɛ, n’a bɛ wele ko Paraganglioma!

Yala tuma dɔw la, i bɛ barika sɔrɔ k’a ye ko i bɛ sumaya kosɛbɛ, i dusukun bɛ ka wuli joona, i kunkolo bɛ ka wuli wa? Walima i b’a miiri ko i tansiyɔn bɛ ka wuli yɔrɔnin kelen kun tɛ wa? Hali n’i bɛ se k’a miiri ko ninnu ye fɛnw ye minnu kɛra k’a sɔrɔ u ma kɛ cogo si la, tuma dɔw la, kun wɛrɛ bɛ se ka kɛ o kɔfɛ. Paraganglioma ye o bana sugu dɔ ye min man teli ka sɔrɔ, nka a nafa ka bon ka a dɔn.

O la, nin paraganglioma ye mun ye?

N’an y’a fɔ cogo nɔgɔman na, paragangliomas ye kuru ye minnu man teli ka sɔrɔ, minnu bɛ sɔrɔ i fari la. Tuma caman na, u bɛ sɔrɔ karotidi joli sira kɛrɛfɛ, joli siraba dɔ min bɛ aw kɔ la, aw kunkolo ni aw kɔkolo nɛrɛmugumaw kɛrɛfɛ, walima aw farikolo yɔrɔ wɛrɛw la. o kuruw bɛ kɛ ni farikolokisɛ suguya kɛrɛnkɛrɛnnen dɔ ye min bɛ wele ko kuromafini selilu . O farikolokisɛw bɛ ɔrimɔni dɔw dilan minnu bɛ wele ko katekolaminiw , ka u bila ka don aw joli la.

Yala aw b’a dɔn ko sugunɛbaralabana minnu bɛ an ka sugunɛ sanfɛ, olu bɛ ɔrimɔni suguya caman dilan wa? O katekolaminiw ye ɔrimɔni ye minnu bɛ baara nafama caman kɛ an farikolo la. Yala i b’a dɔn u ye fɛn minnu ye wa?

• Aw dusukun tantanni.
• Tansiyɔn jiginni.
• Sukaro hakɛ (`joli sukaro`).
• An farikolo bɛ degunw jaabi cogo min na.

Katekolamini suguya minnu nafa ka bon olu ye:

• Dopamine (dopamine) ye.
• Epinefirini (an bɛ min wele fana ko adrénaline).
• Norepinefirini (a bɛ fɔ fana ko noradrenaline).

Hali ni paragangliomes tɛ bɔ sugunɛbara la, o kurukuruw bɛ bɔ farikolo yɔrɔ la min bɛ sugunɛbara la. O la, ka fara o paragangliomas kan, katekolamini ɔrimɔni fana bɛ se ka dalajɛ joli la. O waati de la taamasiɲɛ suguya caman bɛ daminɛ ka bɔ kɛnɛ kan.

Danfara jumɛn bɛ Paraganglioma ni Pheochromocytoma cɛ?

Nin tɔgɔ fila in bɛ se ka mɔgɔ hakili ɲagami dɔɔnin, tiɲɛ tɛ? Paraganglioma ni pheochromocytoma fila bɛɛ ye kuru ye minnu man ca, minnu bɛ bɔ kolosinsinnanw na minnu kofɔra ka tɛmɛ. Danfaraba min bɛ u fla ni ɲɔgɔn cɛ o ye u bɛ Kɛ yɔrɔ min na farikolo la.

Feochromocytomes bɛ sɔrɔ aw ka sugunɛbaralabana cɛmancɛ yɔrɔ la, o min bɛ wele ko sugunɛbilenni. Paragangliomas bɛ sɔrɔ sugunɛbara kɔkan. A ka ca a la, u bɛ sɔrɔ kɔkolo joli siraw walima nɛrɛmuguma kɛrɛfɛ. O de kama tuma dɔw la, paragangliomas bɛ wele ko ‘feochromocytomes extra-adrénales’.

Yala Paraganglioma ye kansɛri ye wa?

O ye gɛlɛya ye min bɛ mɔgɔ caman kan. Nin kuru ninnu, n’u bɛ wele ko paragangliomas , olu bɛ se ka kɛ kansɛri ye (bana jugu) walima kansɛri tɛ min na (bana jugu).Ni an y’a fɔ k’a jɛya, paragangliomas 20% ɲɔgɔn ye kansɛri ye.

Nka gɛlɛya min bɛ yan, o ye ko tuma dɔw la, a ka gɛlɛn dɔgɔtɔrɔw ma k’a dɔn ni kuru ye kansɛri ye walima ni kansɛri tɛ. O kɔrɔ ye ko hali ni opereli ye kuru bɔ ka a farikolo yɔrɔ sɛgɛsɛgɛ ni mikroskɔpu ye, tuma dɔw la, a tɛ se ka fɔ ka jɛya. O la, a ka ca a la, paraganglioma bɛ jate kansɛri ye nin ko ninnu na:

• Ni kuru jɛnsɛnna lamini yɔrɔw la (o bɛ wele ko `paraganglioma jɛnsɛnni sigida la`).
• Ni a jɛnsɛnna farikolo yɔrɔ janw na, i n’a fɔ aw fogonfogon walima aw kolo (o bɛ wele ko `metastasized`).
• Ni a seginna ka na a furakɛcogo fɔlɔ kɔfɛ ka kɛnɛya (o bɛ wele ko `segin`).

Ni kansɛri don, a bɛ jɛnsɛn cogo di?

Ni nin paraganglioma in ye kansɛri ye, a taamasiɲɛw kɛcogo jɔnjɔn tɛ yen. O nɔ na, ​​a ɲɛfɔlen don nin cogo la:

• Paraganglioma localisé : Tumu bɛ yɔrɔ kelen dɔrɔn de la.
• Paragangliome régionale : Kansɛri jɛnsɛnna ka taa ɲɛgɛnɛsiraw la walima farikolo yɔrɔ wɛrɛw la a daminɛ yɔrɔ kɛrɛfɛ.
• Paraganglioma metastatique : Kansɛri jɛnsɛnna aw farikolo yɔrɔ wɛrɛw la, i n’a fɔ aw ka sugunɛ, aw fogonfogon, aw kolo, walima aw ka ɲɛgɛnɛsira yɔrɔjanw. Kansɛribana paragangliomas 35% ni 50% cɛ bɛ se ka jɛnsɛn (ka taa yɔrɔ wɛrɛw la) o cogo la.
• Paraganglioma segin-segin : Kansɛri seginna ka na a furakɛlen kɔfɛ ka kɛnɛya. A bɛ se ka kɛ a tun bɛ yɔrɔ min na fɔlɔ, walima a bɛ se ka kɛ farikolo yɔrɔ wɛrɛ la.

O nɔnɔ ninnu bɛ falen teliya la cogo di?

A ka ca a la, paragangliomas bɛ bonya dɔɔni dɔɔni kosɛbɛ. Nka, o bɛ se ka ɲɔgɔn ta mɔgɔ kelen-kelen bɛɛ la. Mɔgɔ dɔw bɛ se ka bonya joona dɔɔni.

O ko bɛ nɔ bila jɔn de la kosɛbɛ?

Nin bana in, n’o bɛ wele ko paraganglioma , o bɛ se ka kɛ mɔgɔ si hakɛ bɛɛ la. Nka, a ka ca mɔgɔw la minnu si bɛ san 30 ni san 50. Ani fana, a 10% ɲɔgɔn bɛ sɔrɔ denmisɛnw na.

Paraganglioma ka teli ka kɛ cogo di?

Tiɲɛ na, nin ye kuru ye min man ca kosɛbɛ. Jateminɛ na, a jateminɛna ko mɔgɔ fila ɲɔgɔn dɔrɔn de bɛ paragangliomas sɔrɔ miliyɔn kelen kɔnɔ. O la sa, i bɛ se ka miiri nin ko in man ca cogo min na.

Paraganglioma taamasiɲɛw ye jumɛnw ye?

Paragangliomas taamasiɲɛw bɛ sɔrɔ tumu fɛ ka adrénaline walima noradrenaline kofɔlen caman bɔ aw joli la. Nka, paraganglioma dɔw tɛ nin ɔrimɔni wɛrɛ bɔ, o la, u tɛ taamasiɲɛ foyi lase mɔgɔ ma (u bɛ wele ko taamasiɲɛ tɛ minnu na).

Taamasiɲɛ minnu ka teli ka yeYe:

• Tansiyɔn jiginni barikama (tansiyɔn jiginni).
• Kunkolodimi.
• Sumaya kojugu kun tɛ a la.
• Dusukun tantanni teliyalen, min tɛ kɛ cogo la, min ka bon fo dusukun tantanni bɛ se ka mɛn.
• K’a ye ko i farikolo bɛ yɛrɛyɛrɛ.

Ka fara ninnu kan, taamasiɲɛ dɔw fana bɛ yen minnu man ca :

• Ka kɛ i ɲɛ jɛman ye kosɛbɛ ka tɛmɛ i delila ka i ɲɛda cogoya kan.
• Dusukunnata ni/walima fɔɔnɔ.
• Kɔnɔboli.
• Kɔnɔja.
• Sukaro hakɛ caya joli la (sukarodunbana).
• Tansiyɔn jiginni barikama min bɛ kɛ sababu ye ka ɲɛnamini bila mɔgɔ la ni aw jɔlen don (o bɛ wele ko tansiyɔn jiginni orthostatique).
• Ka kɛ mɔgɔ fariman ye kun tɛ.

Mɔgɔ dɔw bɛ se ka nin taamasiɲɛ ninnu sɔrɔ tuma caman na, walima u bɛ se ka pɛrɛn. Miiri k’a filɛ, tuma dɔw la, foyi tɛ foyi la, o kɔ, o taamasiɲɛw bɛ barika bɔ, o kɔ, u bɛ tunu waati dɔ kɔfɛ. O de y’a to a bɛ tɛmɛn tuma dɔw la ka o dɔn.

Mun bɛ paraganglioma bila mɔgɔ la?

A ka ca a la, sababu kɛrɛnkɛrɛnnen tɛ paragangliomas (paragangliomes) la. O kɔrɔ ye k’u bɛ Kɛ k’a sɔrɔ u ma Kɛ k’a sɔrɔ u ma Kɛ k’a sɔrɔ u ma Kɛ. Nka, mɔgɔ 25% fo 35% ɲɔgɔn bɛ paragangliomas sɔrɔ ka a sababu kɛ jamu bana dɔ ye min bɛ boli denbayaw kɔnɔ (bana min bɛ sɔrɔ ciyɛn fɛ). O cogoya dɔw ye:

• Sindrom multiple endocrine neoplasie 2, suguya A ni B (MEN2A ni MEN2B)).
• Von Hippel-Lindau (VHL) ka bana.
• Neurofibromatose suguya fɔlɔ (NF1).
• Paragangliome héritage (banakisɛfagalan) min bɛ sɔrɔ cɛya la.
• Carney-Stratakis dyad (o la, paraganglioma bɛ se ka kɛ ni kɔnɔbara basigilen kuru (GIST) ye).
• Carney triad (o bɛ se ka kɛ paraganglioma, GIST, ani fogonfogon kuru suguya dɔ ye min bɛ wele ko fogonfogonlabana).

Paraganglioma bɛ sɔrɔ cogo di?

Paraganglioma sɛgɛsɛgɛli bɛ se ka gɛlɛya barisa a ye kuru ye min man teli ka sɔrɔ, wa tuma dɔw la a tɛ taamasiɲɛ foyi lase mɔgɔ ma. Tuma dɔw la, dɔgɔtɔrɔw bɛ paragangliomas sɔrɔ k’u to sɛgɛsɛgɛliw kɛli la kun wɛrɛ la.

Dɔgɔtɔrɔ bɛ se ka sigasiga paraganglioma la, a kɛlen kɔ ka nin ko ninnu jateminɛ:

• Aw ka furakɛli tariku dafalen, kɛrɛnkɛrɛnnenya la ni aw ka denbaya kɔnɔ mɔgɔ dɔ delila ka feochromocytoma walima paraganglioma sɔrɔ.
• Farikolo ni furakɛli sɛgɛsɛgɛli dafalen.
• Taamaʃyɛn dɔw cogoya. Misali la, ni tansiyɔn jiginni bɛ aw la min tɛ se ka kunbɛn furakɛlicogo ɲumanw fɛ.

Kɔrɔbɔli jumɛnw bɛ kɛ o kama?

Aw ka dɔgɔtɔrɔ bɛ se ka nin sɛgɛsɛgɛliw ni fɛɛrɛ ninnu kɛ walasa ka a dɔn ni paraganglioma bɛ aw la:

• Farikololajɛ: Aw ka dɔgɔtɔrɔ bɛna aw sɛgɛsɛgɛ ani ka aw ka kɛnɛya bɛɛ lajɛ, i n’a fɔ aw ka tansiyɔn. A bɛna ɲininkali kɛ fana aw ni aw ka denbaya ka furakɛli tariku la, kɛrɛnkɛrɛnnenya la gɛlɛya o gɛlɛya bɛ sɔrɔ ɔrimɔni fɛ.
• Sugunɛ sɛgɛsɛgɛli lɛri 24 kɔnɔ : O ye ka aw ka sugunɛ dɔ lajɛ lɛri 24 kɔnɔ ani ka sugunɛbilenni ɔrimɔni hakɛ jateminɛ min bɛ wele ko katekolamini. A bɛ fɛnw fana ɲini minnu bɛ sɔrɔ ni o ɔrimɔni ninnu tiɲɛna. Ni o katekolamini ninnu bɛ aw ka sugunɛ na ka tɛmɛ a hakɛ kan, o bɛ se ka kɛ paraganglioma taamasiɲɛ ye.
• Joli katekolamini sɛgɛsɛgɛliw : Nin sɛgɛsɛgɛli ninnu bɛ katekolamini hakɛ jateminɛ aw joli la. I n’a fɔ a fɔra cogo min na ka tɛmɛ, u bɛ fɛnw fana ɲini minnu bɛ bɔ ni o ɔrimɔni ninnu tiɲɛna. Ni ninnu bɛ joli la ka tɛmɛ u hakɛ kan, o bɛ se ka kɛ fana paraganglioma taamasiɲɛ ye.
• PET scan (positron emission tomography scan): PET scan ye ka furakisɛ (radiotracer) pikiri kɛ i fari la min tɛ mɔgɔ tɔɔrɔ (radiotracer) ani ka i farikolo yɔrɔw ni i farikolo yɔrɔw ja ta ni minɛn ye min bɛ wele ko PET scanner. Nin sɛgɛsɛgɛli in bɛ farikolokisɛw ni kurukuruw dɔn minnu bɛ baara kɛ kosɛbɛ, minnu bɛ furakisɛ in minɛ. O bɛ se ka dɛmɛ don ka a dɔn ni kɛnɛya gɛlɛya dɔ bɛ yen. Nin sɛgɛsɛgɛli in ka ɲi kɛrɛnkɛrɛnnenya la paraganglioma yɔrɔ dɔnni na.
• CT scan (ɔridinatɛri tomography scan): CT scan ye fɛɛrɛ ye min bɛ X-ray caman ta ka bɔ yɔrɔw la minnu tɛ kelen ye walasa ka ja caman dilan i farikolo kɔnɔna na. Dɔgɔtɔrɔ bɛ se ka a fɔ aw ye ko aw ka CT scan kɛ walasa ka dɛmɛ don ka kuru dɔ yɔrɔ dɔn (a ka ca a la a bɛ kɛ kɔ la).
• MRI scan (magnetic resonance imaging): MRI bɛ baara kɛ ni magnet ye, arajo fiɲɛw ani ɔridinatɛri ye walasa ka ja caman dilan i farikolo kɔnɔna na. Dɔgɔtɔrɔ bɛ se ka a fɔ aw ye ko aw ka MRI kɛ walasa ka kuru bɛ ​​yɔrɔ min na, o lajɛ ka ɲɛ.

Dɔgɔtɔrɔ ye paraganglioma sɔrɔ aw la kɔfɛ, u bɛ se ka sɛgɛsɛgɛli wɛrɛw kɛ walasa ka a dɔn ni a jɛnsɛnna aw farikolo yɔrɔ wɛrɛw la.

Yala sɛgɛsɛgɛli ka kan ka kɛ jamu kan wa?

Ni a sɔrɔla ko paraganglioma bɛ aw la, a ka c’a la, aw ka dɔgɔtɔrɔ bɛna a fɔ aw ye ko aw ka laadilikan kɛ aw ka jamu kan walasa ka a dɔn ni bana dɔ bɛ aw la min bɛ sɔrɔ ciyɛn fɛ ani ni farati bɛ aw la ka kansɛri wɛrɛw sɔrɔ minnu bɛ tali kɛ o la.

Aw ka dɔgɔtɔrɔ bɛ se ka a fɔ aw ye ko aw ka jamu sɛgɛsɛgɛli kɛ nin ko ninnu na:

• Ni bana taamasiɲɛw bɛ aw walima aw ka denbaya kɔnɔmɔgɔ dɔ la minnu bɛ tali kɛ feochromocytoma héritage walima paraganglioma syndrome la.
• Ni taamasiɲɛ minnu b’a jira ko katekolamini hakɛ ka ca i joli la ka tɛmɛ a cogo kɔrɔ kan walima ni kansɛribana taamasiɲɛw bɛ aw la.
• Ni aw ye paraganglioma sɔrɔ sani aw ka san 40 sɔrɔ.

Ni aw ka jamu ladilikɛla ye jamu caman yeli ye aw ka sɛgɛsɛgɛli jaabiw la, a ka c’a la, a bɛna a fɔ aw ka denbaya kɔnɔmɔgɔ tɔw fana ye (hali mɔgɔ minnu taamasiɲɛ tɛ u la nka farati bɛ minnu na) fana ka sɛgɛsɛgɛli kɛ.

Paraganglioma bɛ furakɛ cogo di?

Paraganglioma furakɛli bɛ bɔ fɛn caman na, i n’a fɔ:

• Tumu hakɛ.
• Ni kuru in ye kansɛri ye (a jugumanba) walima a man ɲi (bana jugumanba).
• Ni bana taamasiɲɛw bɛ aw la ka a sababu kɛ katekolamini hakɛ caya ye.
• Yala kuru bɛ ​​yɔrɔ kelen dɔrɔn de la wa, walima a jɛnsɛnna (a bɛ taa yɔrɔ wɛrɛw la) farikolo yɔrɔ wɛrɛw la wa?
• Ni kuru in sɔrɔla a siɲɛ fɔlɔ la, walima ni a kɛnɛyara ka kɔrɔ ka sɔrɔ ka segin a kan.

Ni paraganglioma bɛ aw la min bɛ bana taamasiɲɛw lase aw ma ka a sababu kɛ ɔrimɔni tɛmɛnen ye, aw ka dɔgɔtɔrɔ bɛna furaw di aw ma walasa ka o taamasiɲɛw kunbɛn. O furaw bɛ se ka kɛ ninnu ye:

• Fura minnu bɛ aw ka tansiyɔn kunbɛn, misali la, alfa-blokantiw .
• Fura minnu bɛ aw dusukun tantanni to a cogo la, misali la beta-blokantiw .
• Fura minnu bɛ ɔrimɔni nɔw bali minnu bɛ bɔ ka tɛmɛ aw ka surɔfiyen gland (w) fɛ.

Paraganglioma furakɛli suguyaw ye:

• Opereli fɛ ka tumu bɔ.
• Furakɛli min bɛ kɛ ni fiɲɛ ye.
• Chimiothérapie (banakisɛfagalanw) furakɛli.
• Ablation furakɛli.
• Furakɛli min ɲɛsinnen don a ma.

Aw ni aw ka dɔgɔtɔrɔso jɛkulu bɛna furakɛli bolodacogo latigɛ min bɛ bɛn aw ni aw ka bana ma kosɛbɛ.

Opereli fɛ ka tumu bɔ

Paraganglioma furakɛli kunba ye opereli ye. Opereli kɛtuma na walasa ka kuru bɔ, aw ka operelikɛla bɛna a lamini yɔrɔw ni ɲɛgɛnɛsiraw lajɛ walasa ka a dɔn ni kuru jɛnsɛnna. Ni a kɛra, operelikɛla bɛna farikolo yɔrɔ min bananen don, o bɔ, ni a bɛ se ka kɛ.

Paraganglioma fanba bɛ se ka bɔ ni fɛɛrɛw ye minnu tɛ fɛn caman kɛ, i n’a fɔ opereli min bɛ kɛ ni laparoscopie ye . O ye ka tigɛ misɛnni damadɔw kɛ aw fari la ani ka kuru bɔ ni minɛn kɛrɛnkɛrɛnnenw ye. Nka, kuru belebelebaw bɛ se ka kɛ laada opereli dafalen ye.

Opereli kɔfɛ, aw ka dɔgɔtɔrɔ bɛna katekolamini hakɛ lajɛ aw joli walima aw ka sugunɛ na. Ni katekolamini hakɛ seginna a cogo kɔrɔ la, o ye taamasiɲɛ ye min b’a jira ko paraganglioma selilɛriw bɛɛ bɔra.

Radiation Thérapie (radiation Thérapie) ye

Fiɲɛ furakɛli ye kansɛri furakɛli ye min bɛ kɛ ni fiɲɛbɔlanw ye minnu fanga ka bon walasa ka kansɛribanakisɛw faga walima k’u bali ka bonya. O bɛ kɛ ka sɔrɔ ka tiɲɛni dɔgɔya lamini farikolo yɔrɔ kɛnɛmanw na.

Fiɲɛdimi furakɛli suguya fila bɛ yen:

• Kɛnɛma kɛnɛya furakɛli : O ye ka baara kɛ ni masin ye min bɛ i farikolo kɔkan walasa ka fiɲɛ bila yɔrɔ la kansɛri bɛ yɔrɔ min na.
• Kɔnɔna furakɛli : O ye ka fɛnɲɛnamafagalan dɔ bila pikirijikɛlanw, kisɛw, nɛgɛw walima katetɛriw kɔnɔ, o kɔfɛ dɔgɔtɔrɔ bɛ o don kuru kɔnɔ walima a kɛrɛfɛ.

Aw ka dɔgɔtɔrɔ bɛ furakɛli suguya min fɔ ni fiɲɛ ye, o bɛ bɔ aw ka kansɛri yɔrɔ la, sigida la, yɔrɔ jan na, walima a seginna ka na. Dɔgɔtɔrɔw ka teli ka kɛnɛyaji furakɛli kɛ ni kɛnɛyaji ye ani/walima 131I-MIBG furakɛli walasa ka kansɛri banakisɛw furakɛ. 131I-MIBG furakɛli ye fɛɛrɛ ye min bɛ kɛ ka fɛnɲɛnamafagalan dɔ di kansɛribanakisɛ suguya dɔw ma, o kɔfɛ, o bɛ pikiri kɛ farikolo la ani a bɛ fiɲɛ min bɔ, o bɛ farikolokisɛw faga.

Chimiothérapie (banakisɛfagalanw) furakɛli

Paraganglioma min bɛ taa yɔrɔ wɛrɛw la, o furakɛcogo jɔnjɔn ye chimiothérapie ye. O ye furaw tali ye walasa ka kansɛribanakisɛw faga, ka u bali ka tila, walima ka u bali ka bonya. A ka ca a la, chimiothérapie bɛ kɛ jolisira fɛ. Hali ni a ka ca a la nin ye fura ɲuman ye, a bɛ se ka kɔlɔlɔ lase mɔgɔ ma.

Furakɛcogo min bɛ kɛ ni ablation ye

Ablation therapy ye furakɛli fɛɛrɛ ye min tɛ fɛn caman kɛ, a bɛ funteni caman walima funteni dɔgɔya kosɛbɛ walasa ka kuruw tiɲɛ. Ablation furakɛli minnu bɛ dɛmɛ ka kansɛribanakisɛw ni banakisɛfagalanw faga, olu ye:

• Radiofréquence ablation : O ye ka arajo fiɲɛw kɛ ka kansɛribanakisɛw ni farikolokisɛw ni farikolokisɛw sumaya ani ka u tiɲɛ. Arajo-fiɲɛw bɛ ci elekitorodew fɛ (minɛn misɛnnin minnu bɛ kuran ta).
• Cryoablation : Nin furakɛli in bɛ kɛ ni azote jilama walima gazi ɲuman jilama ye walasa ka kansɛribanakisɛw ni farikolokisɛ minnu tɛ cogoya la, olu sumaya ani ka u tiɲɛ.

Furakɛcogo min ɲɛsinnen don a ma

Furakɛli laɲininen ye furakɛli fɛɛrɛ ye min bɛ furaw walima fɛn wɛrɛw kɛ ka kansɛribanakisɛ kɛrɛnkɛrɛnnenw dɔrɔn de kɛlɛ, k’a sɔrɔ a ma tiɲɛni kɛ farikolokisɛ kɛnɛmanw na. Dɔgɔtɔrɔw bɛ furakɛli laɲinitaw kɛ walasa ka paragangliomas yɔrɔjanw ni minnu bɛ segin ka na, olu furakɛ.

Ɲininikalaw bɛ ka tirosini kinase balilan dɔ sɛgɛsɛgɛ sisan min bɛ wele ko sunitinib.Fura suguya dɔ bɛ ka sɛgɛsɛgɛ walasa k’a dɔn a bɛ se ka paragangliomas yɔrɔjanw furakɛ cogo min na. Tirosini kinase inhibitor furakɛli ye furakɛli suguya ye min bɛ kɛ ni laɲini ye, min bɛ tumuw falenni jɔ.

Yala paraganglioma (paraganglioma) sɔrɔli bɛ se ka bali wa?

A fɔ man di nka, paragangliomas tɛ se ka bali. Nka ni bana dɔw bɛ i la minnu bɛ sɔrɔ ciyɛn fɛ ani ni jamu dɔw bɛ i la minnu bɛ i bila farati la paragangliomas sɔrɔli la, jamu ladilikanw bɛ se k’i dɛmɛ ka paragangliomas sɛgɛsɛgɛ ani a bɛ se ka kɛ i bɛ se k’u minɛ joona.

Aw bɛ kuma aw ka dɔgɔtɔrɔ fɛ ni aw somɔgɔw (balimakɛw ni bangebagaw) ye paraganglioma walima pheochromocytoma sɔrɔ, ani/walima ni nin jamu bana ninnu dɔ bɛ aw la:

• Neoplasie endocrine multiple 2 ka bana.
• Von Hippel-Lindau (VHL) ka bana.
• Neurofibromatose suguya 1 ye.
• Paragangliome héritage (banakisɛfagalan) min bɛ sɔrɔ cɛya la.
• Carney-Stratakis ka kuluba.
• Carney ka mɔgɔ saba.

Pronostic ye mun ye nin ko in na?

Paragangliomas, o kɔrɔ ye ko a kɛnɛyali ni a ka ɲɛnamaya cogoya, o bɛ danfara ka kɛɲɛ ni fɛn caman ye. Olu dɔw ye:

• Tumu bɛ yɔrɔ min na aw fari la ani a bonya hakɛ.
• A kɛra kansɛri ye wo, a kɛra a jɛnsɛnna farikolo yɔrɔ wɛrɛw la wo.
• Yala opereli ye kuru bɔ wa, ni o kɛra, kuru hakɛ joli bɔra opereli senfɛ wa?

Paraganglioma fitini bɛ mɔgɔ minnu na, ni o ma jɛnsɛn farikolo yɔrɔ wɛrɛw la (a ma taa yɔrɔ wɛrɛw la) , olu ka ɲɛnamaya san duuru kɔnɔ, o bɛ se 95% ɲɔgɔn ma. Nka, paraganglioma bɛ mɔgɔ minnu na, ni o seginna furakɛli fɔlɔ kɔfɛ walima ni a jɛnsɛnna farikolo yɔrɔ wɛrɛw la (a bɛ taa yɔrɔ wɛrɛw la), olu ka san duuru ɲɛnamaya hakɛ bɛ se 34% ni 60% cɛ

Ani fana, paraganglioma juguman dɔw bɛ yen, hali n’u ma jɛnsɛn yɔrɔ jan, opereli tɛ se ka bɔ u la pewu barisa u jɛnsɛnna ka se yɔrɔ jan ma lamini farikolo yɔrɔw la. O cogo la, adɛrɛnalini ni noradrenaline bɔli kojugu bɛ se ka kɛ farati ye, wa a furakɛli ka gɛlɛn.

Min nafa ka bon kosɛbɛ, o ye ko paragangliomas, a kɛra kansɛri ye wo, a kɛra kansɛri tɛ wo, ni a ma furakɛ, o bɛ se ka gɛlɛyabaw lase mɔgɔ ma, hali minnu bɛ se ka mɔgɔ ka ɲɛnamaya bila farati la, ka a sababu kɛ u bɛ adɛrɛnalini ni noradrenaline hakɛ caya kojugu.

O gɛlɛya dɔw ye:

• Dusukunnabana (cardiomyopathie).
• Aw dusukun fasa funu (`myocardite`).
• Joli bɔli aw kunsɛmɛ na min tɛ se ka kunbɛn (joli bɔli kunsɛmɛ na).
• Ji bɛ caya aw fogonfogon la (fogonfogon la sɔgɔsɔgɔninjɛ).
• Dusukun tantanni (`dusukun tantanni`).
• Kuru bɔ.
• Koma.
• Saya.

Tuma jumɛn na ne ka kan ka taa dɔgɔtɔrɔso la?

Ni a sɔrɔla ko paraganglioma (paraganglioma) bɛ aw la, ni taamasiɲɛ sikɛlenw bɛ aw la, aw bɛ taa dɔgɔtɔrɔso la joona.

Ni aw ye paraganglioma taamasiɲɛw ye, i n’a fɔ tansiyɔn jiginni ani kungolodimi, aw bɛ kuma aw ka dɔgɔtɔrɔ fɛ. Ikomi paraganglioma man ca, a nafa ka bon hali bi ka tansiyɔn jiginni furakɛ, hali ni a ka ca a la a tɛ aw la.

Ni aw y’a ye ko aw somɔgɔw dɔ (balimakɛw, bangebagaw) dɔ bɛ ni jamu ye i n’a fɔ ``Multiple endocrine neoplasia 2 syndrome`` walima ``Von Hippel-Lindau (VHL) bana``, aw bɛ dɔgɔtɔrɔ ɲininka jamu sɛgɛsɛgɛli la, barisa o bɛ se ka dɔ fara aw ka paraganglioma sɔrɔli kan.

Aw ka kan ka ɲininkali jumɛnw kɛ aw ka dɔgɔtɔrɔ la?

Ni a sɔrɔla ko paraganglioma bɛ aw la, a bɛ se ka kɛ ko a bɛ aw dɛmɛ ka nin ɲininkali ninnu kɛ aw ka dɔgɔtɔrɔ la:

• Mun na ne ye paraganglioma sɔrɔ?
• Yala ne denw ni/walima ne somɔgɔw bɛ se ka paraganglioma sɔrɔ wa?
• Furakɛli suguya jumɛnw bɛ ne bolo?
• Furakɛli suguya wɛrɛw kɔlɔlɔ jumɛnw bɛ yen?
• Ne bɛ se ka ne ka bana taamasiɲɛw kunbɛn cogo di?

A laban na, fɛn minnu ka kan ka to an hakili la (Take-Home Message) .

Paraganglioma ye bana ye min man teli ka sɔrɔ, nka a nafa ka bon ka a dɔn. Ni bana taamasiɲɛw bɛ aw la minnu bɛ to sen na, minnu faamuyali ka gɛlɛn, kɛrɛnkɛrɛnnenya la tansiyɔn jiginni barikama, sumaya, walima dusukun tantanni teliya, hakilitigiyako don aw ka dɔgɔtɔrɔ ka ladilikan ɲini sanni aw k’u bɔ kɛnɛ kan k’a fɔ ko a kɛra fɛn ye min bɛ kɛ dɔrɔn.

Hali ni paraganglioma sababu tɛ dɔn tuma caman na, a ni cɛya bana dɔw bɛ tali kɛ ɲɔgɔn na. O la ni paraganglioma walima feochromocytoma ye aw ka denbaya kɔnɔ mɔgɔ dɔ sɔrɔ, jamu sɛgɛsɛgɛli bɛ se ka aw dɛmɛ ka aw ka farati dɔn, ani fana ni kɛnɛya gɛlɛya wɛrɛw bɛ se ka sɔrɔ aw la. Ni ɲininkali dɔw bɛ aw fɛ o ko la, aw kana siga ka kuma aw ka dɔgɔtɔrɔ fɛ. U bɛ yan walisa k’aw dɛmɛ.

` Paraganglioma, Paraganglioma, Feochromocytome, Chromaffin cellules, Catecholamines, Hormones, Tumuw, Kansɛri, Taamaʃyɛnw, Tansiyɔn jiginni, Bana minnu bɛ sɔrɔ jamu fɛ