An ka Radiopharmaceuticals dɔn cogo nɔgɔman na. O bɛna kɛ ko nafamaba ye i bolo!

N’a sɔrɔ i bɛ siran dɔɔnin n’i ye “radiopharmaceutiques” daɲɛ mɛn, ɔnhɔn? Daɲɛ "radioactive" bɛ na ni faratifɛn dɔ ye an hakili la o yɔrɔnin bɛɛ, nka ni a kɛra ka ɲɛ furakɛli la, u bɛ se ka dɛmɛba lase mɔgɔ ma. O la bi, an ka kuma u ye fɛn minnu ye, u bɛ baara kɛ cogo min na, ani u lakananen don cogo min na aw bolo.

Nin fura minnu bɛ kɛ ni arajo ye, olu ye mun ye? An k’a faamu cogo nɔgɔman na!

N’an y’a fɔ cogo nɔgɔman na, nin `(Radiopharmaceuticals)` fana ye fura suguya kɛrɛnkɛrɛnnen ye . Nka u bɛ ni radiyowaati dɔɔni ye, o kɔrɔ ye ko u ye radiyowaati ye. Aw kana aw hakili ɲagami, nin ye radiyowaati ye min bɛ kɔrɔsi, min tɛ mɔgɔ tɔɔrɔ. An ka dɔgɔtɔrɔw, n’o ye dɔgɔtɔrɔw ni kɛnɛyabaarakɛlaw ni ɲɔgɔn cɛ, olu bɛ baara kɛ ni o furaw ye walasa ka ja sɛgɛsɛgɛli kɛ nukiliya furakɛli la ani ka bana dɔw furakɛ, kɛrɛnkɛrɛnnenya la kansɛribana .

Miiri k’a filɛ, n’u b’a fɛ k’a dɔn ni fɛn dɔ bɛ i fari la, tuma dɔw la dɔgɔtɔrɔw bɛ fura dɔɔni di i ma ka min walima ka pikiri kɛ i la sani i ka sɛgɛsɛgɛli kɛ wa? Nin ye o ɲɔgɔnna fɛn ye. o fura kɛrɛnkɛrɛnnenw bɛ dilan ani ka dilan mɔgɔ kɛrɛnkɛrɛnnenw fɛ minnu kalanna kɛrɛnkɛrɛnnenya la , n' olu bɛ wele ko nukliyɛri furakɛlikɛlaw . O kɔfɛ , kɛnɛyabaarakɛlaw ni kɛnɛyabaarakɛlaw (RT) bɛ baara kɛ n’u ye walasa ka ja sɛgɛsɛgɛliw kɛ. Tuma dɔw la, kansɛri furakɛla minnu bɛ kɛ ni fiɲɛ ye , olu fana bɛ fura ninnu di u ma i n’a fɔ furakɛli.

Nin arajofura ninnu bɛ kɛ mun na?

Nin fura ninnu bɛ kɛ yɔrɔ fila de la kosɛbɛ. An k’a lajɛ u ye min ye.

1. Diagnostic Radiofurakɛli

arajofuraw bɛ kɛ tuma caman na nukiliya furakɛli ja sɛgɛsɛgɛliw la . An bɛ ninnu wele ko "dignostic radiopharmaceutiques". Etazuni dɔrɔn na, a jateminɛna ko o nukliyɛri fura sɛgɛsɛgɛli miliyɔn caman bɛ kɛ san o san. O la sa, i bɛ se ka miiri baara bɛ kɛ n’u ye kosɛbɛ cogo min na.

nin sɛgɛsɛgɛliw bɛ se ka a lajɛ ni farikolo yɔrɔw ni farikolo yɔrɔw bɛ baara kɛ ka ɲɛ . O bɛ kɛ nin cogo la:

Nin fura radiyowaati in hakɛ dɔɔni dɔrɔn de bɛ di aw ma walasa aw ka min, ka a fiyɛ, walima ka a pikiri kɛ. olu bɛ wele tuma dɔw la ko radiotracers . Fura radiyowazi hakɛ min bɛ di aw ma, o tɛna kojugu kɛ aw la. A hakɛ ka dɔgɔ kosɛbɛ. Nin fura in bɛ taa yɔrɔ la, gɛlɛya bɛ aw fari la yɔrɔ min na, ka a lajɛ. O kɔfɛ, kamera min bɛ mɔgɔ sɛgɛn kosɛbɛ, i n’a fɔ kamera gama, o bɛ fiɲɛ dɔn i fari la, ka ja dɔw dilan dɔgɔtɔrɔ bɛ se ka minnu ye.

Miiri k’a filɛ, nin fura in bɛ i n’a fɔ detekti dɔ bɛ taa farikolo kɔnɔ, ka gɛlɛya yɔrɔw sɔrɔ k’a jira an na ko “Gɛlɛya bɛ nin yɔrɔ in de la.”

Nin ye misali dɔw ye minnu b’a jira cogo min na arajofuraw bɛ kɛ ka bana sɛgɛsɛgɛ:

• Fluorine-18 : Nin ye radiotracer ye min bɛ kɛ ka caya PET sɛgɛsɛgɛliw la (Positron Emission Tomography scans).
• Technetium 99m : Nin ye fɛn ye min bɛ kɛ ka caya nukliyɛri furakɛli la. A bɛ kɛ ka kolo, sugunɛ baara ani sugunɛ baara sɛgɛsɛgɛ.
• Xenon-133 : Nin ye fura ye min bɛ kɛ ni radiyo ye, aw bɛ min fiyɛ. A bɛ di ka fogonfogon baarakɛcogo lajɛ (fogonfogon baarakɛcogo sɛgɛsɛgɛli).
• Rubidium-82 : Nin ye fura ye min bɛ di aw ma jolisira fɛ (IV). A bɛ kɛ ka dusukun fasa cogoya lajɛ (myocardial imaging).

2. Furakɛcogo minnu bɛ kɛ ni arajo furaw ye

Sisan, an ka kuma fura ninnu bɛ kɛ cogo min na furakɛli la. Ninnu ni minnu bɛ kɛ ka bana sɛgɛsɛgɛ, olu tɛ kelen ye dɔɔni. arajofura minnu bɛ kɛ furakɛli la , olu bɛ fiɲɛ barikamaba bɔ ani ka selilɛri faga . O bɛ kɛ walasa ka farikolokisɛ kɛnɛmanw faga, kɛrɛnkɛrɛnnenya la kansɛribanakisɛw .

O fura ninnu bɛ i n'a fɔ "bounty hunters". O kɔrɔ ye ko u bɛ kansɛribanakisɛw sɔrɔ ka kɛnɛyaji lase o farikolokisɛw ma k’a ɲɛsin u ma . O ni kɛnɛma fiɲɛ furakɛli tɛ kelen ye , o min bɛ baara kɛ ni masin ye walasa ka fiɲɛbɔlanw ci ka bɔ i farikolo kɔkan. Nka o furakɛli radiyofuraw bɛ baara kɛ k’a ɲɛsin u ma ni u bɛ laɲini kɛ.

Nin foro in, n’o ye furaw tali ye minnu bɛ kɛ ni radiyo ye furakɛli kama, o ye ko kura ye. Ɲininikalaw bɛ ka nafa kura Sɛgɛsɛgɛ hali bi u la. U dalen b’a la ko furakɛli minnu bɛ kɛ ni radiyo ye , olu jɔyɔrɔ ka bon kosɛbɛ kansɛri furakɛli la don nataw la.

Radiyofura jumɛnw bɛ kɛ ka kansɛri furakɛ?

``Radiopharmaceuticals`` suguya caman bɛ yen dɔgɔtɔrɔw bɛ minnu kɛ ka kansɛri furakɛ. I n'a fo:

• PLUVICTO® (lutetium Lu 177 vipivotide tetraxetan): Nin ye fura ye min dagalen don Ameriki dumuniko ni furako ɲɛmɔgɔso fɛ (FDA). A bɛ kɛ ka ɲɛgɛnɛsira kansɛri furakɛ (PSMA-positive metastatic castration-resistant prostate cancer - PSMA-positive mCRPC).
• LutatheraTM `(LutatheraTM - Lutetium Lu 177 dotatate)`: Bamako, Mali.Nin fana ye fura ye min dabɔra FDA fɛ. A bɛ kɛ ka farikolojidɛsɛ dɔw furakɛ (somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors) minnu bɛ sɔrɔ kɔnɔbara la, banakɔtaa la ani kɔnɔbara la.
• Iyode-131 : Nin ye iyode radiyowazi furakɛli suguya fɔlɔ ye. A bɛ se ka sɔgɔsɔgɔninjɛ kansɛri dɔw furakɛ ani Graves ka bana dɔw, a bɛ fɔ fana ko jolidɛsɛbana.
• Radium-223 : O bɛ se ka kɛ kosɛbɛ kolotugudaw furakɛli la minnu bɛ sɔrɔ ni ɲɛgɛnɛsira kansɛri jɛnsɛnna (a bɛ taa yɔrɔ wɛrɛw la) kolo la. Ameriki FDA ye yamaruya di Dichloride Radium-223 (XofigoTM) ma o baara kama.

Ka fara o kan, furakɛli suguya damadɔ wɛrɛw bɛ kɛ kɛnɛyaso la sisan kansɛri suguya wɛrɛw kan.

Arajofura minnu bɛ kɛ ka caya, olu ye jumɛnw ye?

I n’a fɔ an y’a fɔ cogo min na ka tɛmɛ, Technetium-99m ye radiyofura ye, dɔgɔtɔrɔw bɛ min kɛ ka caya. A bɛ kɛ fɔlɔ ka ɲɛsin ja sɛgɛsɛgɛliw ma minnu bɛ kɛ ni bana ye. A bɛ dɛmɛ ka "ye" ninnu na:

• Fogonfogon la (joli bɔli) aw fogonfogon la.
• Joli bɛ woyo aw ka joli siraw la (Vascular perfusion).
• Kolow.
• Mikorokaridi farikolo yɔrɔ.
• Ɲɛjibɔlanw (glandes lacrimales).
• Thyroïde glande (sɔgɔsɔgɔninjɛ).

Arajofura wɛrɛw minnu bɛ kɛ ka caya, olu dɔw ye:

• 18F Fluorodeoxyglucose `(18F Fluorodeoxyglucose - FDG)`
• Galiyɔmu-68 DOTATATE
• Galiyɔmu-68 PSMA `(Galiyɔmu-68 PSMA)`
• 18F PSMA `(18F PSMA)`
• Iyode 123 `(Iyode 123)`

O la sa, yala nin furakɛlifɛn minnu bɛ kɛ ni arajo ye, olu farati tɛ tiɲɛ na wa?

Nin ye ɲininkali ye min bɛ mɔgɔ caman bolo. Ni aw bɛ baara kɛ ni u ye ka ɲɛ, ni u furakɛra ka ɲɛ, arajofuraw tɛ farati la. Aw ka kɛnɛyabaarakɛla ni/walima kɛnɛyaji kansɛri dɔgɔtɔrɔ bɛna baara kɛ ni nukilila furakɛlikɛla ye walasa ka a dɔn ni radiyofura hakɛ min bɛ aw di aw ma , o bɛnnen don ani ko a farati tɛ . O la sa, hami foyi tɛ yen.

I n’a fɔ fura bɛɛ, kɛnɛyaji furakɛli bɛ se ka kɔlɔlɔ dɔw lase mɔgɔ ma . Nka, a ka ca a la fura in nafa ka bon ka tɛmɛ a farati kan. Aw ka dɔgɔtɔrɔ bɛna nin kɔlɔlɔ ninnu ɲɛfɔ aw ye sani aw ka furakɛli daminɛ.

Hali ni furakɛli minnu bɛ kɛ ni arajo ye, olu bɛ kɛ kabini san tan caman nukiliya furakɛli ja la, u daminɛna kɔsa in na dɔrɔn ka kansɛri furakɛ. Ɲininikɛlaw bɛ ka sɛgɛsɛgɛli kɛ hali bi, o furaw bɛ kansɛribanakisɛw laɲini cogo min na ani k’u faga. Ni aw b’a fɛ ka kunnafoni sɔrɔ furakɛli fɛɛrɛw kan minnu bɛ kɛ ni radiyo ye kansɛri furakɛli la, aw bɛ kuma aw ka dɔgɔtɔrɔ fɛ. U nisɔndiyalen don k’i dɛmɛ.

A laban na, fɛn nafamabaw minnu ka kan ka to i hakili la

Okey, donc, ka bɔ an ye kuma min fɔ, ninnu ye fɛnba minnu ye i ka kan ka to i hakili la:

• fura minnu bɛ kɛ ni radiyo ye , olu ye fura suguya kɛrɛnkɛrɛnnen ye min bɛ radiyowaatiw kɔlɔsi .
• Olu bɛ kɛ ka caya ka ɲɛsin bana sɛgɛsɛgɛli ma (misali la, PET sɛgɛsɛgɛli, kolo sɛgɛsɛgɛli) ani ka bana dɔw furakɛ, kɛrɛnkɛrɛnnenya la kansɛri .
• Sɛgɛsɛgɛli la, olu bɛ kɛ i n'a fɔ ``Radiotracers'', ka farikolo yɔrɔw " jira" gɛlɛyaw bɛ yɔrɔ minnu na.
• Furakɛliw la, olu bɛ dɛmɛ ka kansɛribanakisɛw laɲini ani ka u tiɲɛ .
• fura ninnu farati tɛ ni u dira dɔgɔtɔrɔ ka kɔlɔsili ɲuman kɔnɔ . I n’a fɔ a bɛ kɛ cogo min na fura bɛɛ la, kɔlɔlɔ misɛnniw bɛ se ka sɔrɔ a la, nka a ka ca a la a nafa ka bon ka tɛmɛ u kan.
• Nin baara in, kɛrɛnkɛrɛnnenya la kansɛri furakɛli la, o bɛ ka yiriwa hali bi , wa yiriwali caman wɛrɛw bɛ se ka jira don nataw la.

O la, siɲɛ wɛrɛ n'i ye ``(Radiopharmaceutical)'' dɔ ko mɛn, i bɛ faamuyali ɲuman sɔrɔ sisan a ye min ye ani a bɛ kɛ min na, ɔnhɔn? Ni ɲininkali wɛrɛw bɛ aw fɛ, aw kana siga ka dɔgɔtɔrɔ ɲininka tuma bɛɛ.

` Furakɛcogo minnu bɛ kɛ ni radiyo ye, Nukilila furakɛli, Kansɛri furakɛli, Scans, Radiothérapie, Sɛgɛsɛgɛli