N'a sɔrɔ aw ye "sulfa furaw" ko mɛn. Laala dɔgɔtɔrɔ dɔ ye kiribi dɔ di aw ma walasa aw ka a kɛ aw fari la, a ko: “Nin ye sulfa fura ye.” Sulfonamide ye mun ye tigitigi? Yala u ye banakisɛfagalanw dɔrɔn de ye wa ? Ayi, maana ka jan kosɛbɛ ka tɛmɛ o kan. An ka se nin ko in kuncɛlen ma bi.
N’an y’a fɔ cogo nɔgɔman na, o sulfonamide ninnu ye mun ye?
Sulfonamides ye fura suguya dɔ ye min bɛ dilan ni fɛn dilannenw ye, o kɔrɔ ye ko laboratuwaraw kɔnɔ. U tɛ sɔrɔ u yɛrɛ la. Fura suguya minnu bɛ nin fura suguya in na, olu bɛɛ bɛ ni “kisɛ” ye u ka kemikaliya la. O de y’a to u bɛ wele ko “sulfonamides.”
Sisan, an k’a lajɛ o kow bɛ baara kɛ cogo min na. Kɛrɛnkɛrɛnnenya la ni a dira banakisɛw ma, fura ninnu bɛ min kɛ, o ye ka banakisɛw bali ka fɛn dɔ dilan min bɛ wele ko " folate ", u mago bɛ min na. an b' a dɔn fana ko folate ye witamini B9 ye . Aw ye miiri dɔrɔn, nin balofɛn in min bɛ wele ko folate, o nafa ka bon banakisɛw ka ɲɛnamaya ani ka jɛnsɛn. O la ni sulfonamide furaw donna fari la, u bɛ taa banakisɛw bali ka foli in dilan. A bɛ i n’a fɔ kɔngɔ bɛ mɔgɔ la ni dumuni tɛ, banakisɛw bɛ barika dɔgɔya dɔɔni dɔɔni ka sa.
“O tuma na fɛ, yala gɛlɛya tɛ an farikolo la wa?” i bɛ se ka miiri. Ayi, bawo anw, o kɔrɔ ye ko hadamadenw, an farikolo mago bɛ folate min na, an bɛ o sɔrɔ an bɛ dumuni minnu dun. An tɛ foli dilan an farikolo kɔnɔ. O la, a ka c’a la, fura in tɛ nɔ bila an farikolo yɔrɔw la o cogo la.
Sani penisilini ka sɔrɔ, san 1930 waatiw la, sulfonamides tun ye fura ɲumanw dɔ ye minnu bɛ sɔrɔ banakisɛfagalanw furakɛli la. O waati la , o fura ninnu ye dɛmɛ don ka dɔ bɔ banakisɛfagalanw ka saya hakɛ la ni danfaraba ye. Nka bi, u tɛ kɛ banakisɛw dɔrɔn de la. fura minnu bɛ nin kalasi in na , olu bɛ kɛ bana caman wɛrɛw la .
Sulfonamidiw bɛ kɛ bana jumɛnw na?
Fɔlɔ, u tun bɛ kɛ ka banakisɛw furakɛ ani k’u kunbɛn kosɛbɛ. Nka bi, nin fura suguya in jiginna kosɛbɛ. Sulfonamides bɛ kɛ ka bana caman furakɛ, i n’a fɔ sukarodunbana suguya 2, tansiyɔn jiginni, sidabanakisɛ, ani melanoma, farikansɛri suguya dɔ.
An k’a lajɛ fura wɛrɛ minnu bɛ nin kulu in na ani u bɛ kɛ bana minnu na. Walasa ka nɔgɔya don an na, an bɛna o kow tila tilayɔrɔ fila ye.
1. Sulfonamide minnu bɛ kɛ banakisɛfagalanw ye
Olu ye furaw ye minnu bɛ di banakisɛfagalanw ma kosɛbɛ.
| Banakisɛfagalan suguyaw : sulfonamides |
|---|
| Mafenidi (Sulfamylon®) ye . |
| Sulfadiazene (Silvadene® walima Thermazene®) – (a ka ca a la a bɛ kɛ jeninida la) . |
| Sulfametizɔli (sulfametizole). |
| Sulfisoxazole (Sulfisoxazole) bɛ sɔrɔ |
| Sulfasalazine (Azulfidine®) – (A bɛ kɛ fana ka kɔnɔbolibana furakɛ) . |
| Sulfadoxine – (a bɛ kɛ ka sumayabana furakɛ) . |
2. Sulfonamide minnu tɛ banakisɛfagalanw ye
Ninnu tɛ furaw ye minnu bɛ banakisɛw faga. U bɛ kɛ ka bana damadɔ wɛrɛw furakɛ. Nin lisi in ka jan dɔɔni, nka a bɛ hakilina di aw ma fura suguya in bonya kan.
| Dɔrɔgu Tɔgɔ | Baara minnu bɛ kɛ ni a ye |
|---|---|
| Asetohɛksamidi, Kuloroporopamidi, Tolazamidi, Tolbutamidi | Sukarodunbana suguya 2 |
| Furosemidi (Lasix®), Bumetanide, Torsemide, Kuloritalidɔni, Idrokulorotiazidi, Indapamidi | Sugunɛ furaw bɛ kɛ ka funu furakɛ min bɛ sɔrɔ tansiyɔn jiginni fɛ ani dusukun tantanni fɛ. |
| Selɛkɔkisibi (Celebrex®) . | Joli dimi ni funu cogoyaw i n’a fɔ jolidɛsɛ. |
| Darunawiri (Prezista®) (Duranawiri) (Prezista®) . | Fura min bɛ sidabanakisɛ furakɛ. |
| Sumatriptan (Imitrex®) ye . | Kungolodimi kama. |
| Sildenafili (Viagra®, Revatio®) ye fura ye. | Cɛyabana ni fogonfogon la tansiyɔn jiginni. |
| Tamsulosini (Flomax®) ye . | Ni sugunɛ gɛlɛyaw bɛ sɔrɔ sugunɛbaralabana bonya fɛ (banakisɛ min bɛ bɔ sugunɛbilenni na). |
| Zonisamidi (Zonegran®) ye . | Kɔnɔboli minnu bɛ sɔrɔ kɔnɔboli fɛ. |
Yala a bɛ se ka kɛ ka faritanabana sɔrɔ sulfonamides la wa?
Ɔwɔ, i bɛ se. N’a sɔrɔ aw ye mɔgɔw mɛn k’a fɔ ko: “Ne fari tɛ sɔn sulfa furaw ma.” Diɲɛ jamanaden 3% ni 8% cɛ faritanabana tɛ sulfa fura suguya dɔw la. Nka nin ni penisilini faritanabana bɛ taa ɲɔgɔn fɛ.
Min nafa ka bon, o ye nin ye: k’a sababu kɛ aw faritanabana tun bɛ sulfonamide fura kelen na, o kɔrɔ tɛ ko aw faritanabana tun bɛ fura tɔw bɛɛ la minnu bɛ nin fura in kɔnɔ. Nin ye fɛn ye dɔgɔtɔrɔw bɛ sɔn min ma sisan.
O la, ni faritanabana tun bɛ aw la ka kɔrɔ sulfonamide dɔ la, aw ye aw jija ka o fɔ aw ka dɔgɔtɔrɔ ye sani aw ka fura kura daminɛ. A bɛna se ka fura wɛrɛ bɛnnen dɔ fɔ aw ye.
Nin fura suguya in nafa ye mun ye?
I n’a fɔ fura tɔw bɛɛ, sulfonamides bɛ se ka nafa ni kɔlɔlɔ dɔw lase a ma. Olu kunbabaw ye:
- Banakisɛfagalanw tali : Ni aw bɛ banakisɛfagalan kelen ta ka mɛn, banakisɛ dɔw bɛ se ka o fura kɛlɛ. O kɔrɔ ye ko fura tɛ baara kɛ o banakisɛw kan tuguni. O bɛ se ka kɛ ni sulfonamides fana ye.
- A nɔ bɔli banakisɛ dɔw la: Banakisɛ suguya dɔw bɛ se ka fura ninnu kɛlɛ u yɛrɛ la.
- Kɔnɔnatumu jugumanw : Ninnu man ca kosɛbɛ , nka mɔgɔ dɔw bɛ se ka faritanabana jugumanba sɔrɔ i n’a fɔ Stevens-Johnson ka bana ani farikolojidɛsɛ toxic .
Nin kɔlɔlɔ ninnu bɛ se ka ɲɔgɔn ta kosɛbɛ mɔgɔ ni mɔgɔ cɛ ani fura ni fura. O la, aw ka dɔgɔtɔrɔ ye kunnafoni sɔrɔyɔrɔ ɲuman ye fura minnu bɛ aw bolo, a nafaw ni a faratiw kan. Aw ye a ɲininka o ko la.
Yala BactrimTM fana ye sulfonamide ye wa?
Ɔwɔ, a yɔrɔ dɔ la. Sulfamethizole bɛ BactrimTM la, o ye sulfonamide suguya dɔ ye. Ka fara o kan, fura wɛrɛ fana bɛ a la min bɛ wele ko trimethoprim. U fila bɛ baara kɛ ɲɔgɔn fɛ.
Yala Celebrex® fana ye sulfonamide ye wa?
Awɔ. Celecoxib (a bɛ fɔ a ma tuma caman na ni a tɔgɔ ye ko Celebrex®), o min bɛ kɛ ka jolidɛsɛ dimi furakɛ, o fana ye sulfonamide ye.
Nin fura in bɛ se ka kɛ sababu ye ka kirisiw sɔrɔ sugunɛ na wa?
Ɔwɔ, sulfa fura dɔw bɛ se ka kɛ sababu ye ka kristalɛw sɔrɔ sugunɛ na. Nka, o tɛ kɔlɔlɔ ye min ka teli ka sɔrɔ. Aw ka dɔgɔtɔrɔ bɛna aw laadi ni aw bɛ fura min ta, o bɛ se ka kɛ sababu ye ka nin bana in bila mɔgɔ la ani aw bɛ se ka min kɛ walasa ka a kunbɛn (misali la, aw bɛ ji caman min).
Take-Home cikan
- Sulfonamides tɛ banakisɛfagalanw dɔrɔn ye. U ye fura suguya caman ye minnu bɛ kɛ ka bana suguya caman furakɛ.
- Nin fura suguya in bɛ kɛ bana caman na, k’a ta banakisɛw la ka taa a bila sukarodunbana na, tansiyɔn jiginni, ani kunkolodimi.
- Farikoloɲɛnajɛ bɛ se ka kɛ sulfa furaw la. Nka, ni faritanabana bɛ i la suguya kelen na, o kɔrɔ tɛ ko faritanabana bɛna kɛ i la furaw bɛɛ la minnu bɛ o kulu kɔnɔ.
- Sani aw ka fura kura si daminɛ, aw ye aw jija ka furakɛli bana wɛrɛw fɔ aw ka dɔgɔtɔrɔ ye ani fura faritanabana minnu tun bɛ aw la ka tɛmɛ.
Sulfonamide, sulfafura, sulfonamides, banakisɛfagalan, fura faritanabana, Stevens-Johnson ka bana, Bactrim, Celebrex, Lasix
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