Ðe wò ʋumenugbagbevi dzĩwo sɔ gbɔa? Mina míaƒo nu tso Thrombocytosis ŋu!

Ðe wokpɔe hã be ʋumenugbagbevi dzĩwo sɔ gbɔ ɖe wò ʋu mea? Alo ɖe dɔléle sia le ame aɖe si nènya ŋua? Enye nusi sɔ be nàtsi dzodzodzoe vie ne èse nya sia tɔgbe. Gake megatsi dzi o, egbea míaƒo nu tso nɔnɔme sia si woyɔna be Thrombocytosis ŋu le mɔ bɔbɔe aɖe si gɔme nàte ŋu ase nu.

Nukae nye ʋumenugbagbeviɣidɔ? Kpuie ko la...

Kpuie ko la, ʋumenugbagbeviɣidɔ nye ne ʋumenugbagbevi dzĩwo sɔ gbɔ ɖe wò ʋu me. Fifia ɖewohĩ èle biabiam be, “Nukae nye ʋumenugbagbevi dzĩwo?” Nyabiase vevi aɖe ŋutɔe nye ema!

Ʋumenugbagbevi dzĩwo nye lãmenugbagbevi sue ƒomevi aɖe si le míaƒe ʋu me. Woƒe dɔ vevitɔe nye be woadzudzɔ ʋudodo ne ʋu le dodom, abe ne abi le eŋu ene. Wowɔa nu abe tɔdzisasrã sue aɖe ene.

Gake nukae adzɔ ne ʋumenugbagbevi dzĩwo ƒe xexlẽme dzi ɖe edzi akpa? Wò ʋu ate ŋu aƒo eye wòalé ɖe nu ŋu. Le nɔnɔme sesẽ aɖewo me la, ʋumenugbagbevi dzĩ siawo siwo sɔ gbɔ ate ŋu ana ʋuka siwo me afɔku le nadzɔ ɖe ʋukawo me. Esia ate ŋu ana nɔnɔmewo abe ʋusɔgbɔdɔ alo dzidɔ ene ƒe afɔkua nadzi ɖe edzi .

Gake menye Thrombocytosis ƒe dɔlélewo katãe nye esiwo me afɔku le sɔsɔe o. Alesi dɔlélea nu sẽe, kple ne èhiã atikewɔwɔ alo mèhiãe o, nɔ te ɖe nusi gbɔ wòtso dzi.

Ʋumenugbagbeviɣidɔ ƒomevi vevi eve li:

Ẽ, ɖɔktawo de dzesi dɔléle sia ƒomevi vevi eve. Mina míaƒo nu tso ema ŋu vie.

1. Ʋumenugbagbeviɣidɔ Vevie (ET) alo Ʋumenugbagbeviɣidɔ Gbãtɔ

Esia nye ʋumenugbagbeviɣidɔ si mebɔ o. Edzɔna ne wò ƒumeŋuɖui – ʋumenugbagbeviɣidɔwɔƒe si le wò ƒuwo me – wɔ ʋumenugbagbevi dzĩwo fũ akpa. Bu eŋu kpɔ, ƒumeŋuɖui sia mee wowɔ ʋumenugbagbevi siwo le míaƒe ŋutilã me ƒe akpa gãtɔ. Ame si ŋu ʋumenugbagbeviɣidɔ vevi aɖe le la ƒe ʋumenugbagbevi dzĩwo sɔa gbɔ le mɔ si mesɔ o nu le esi wògblẽ le ʋumenugbagbevi dzĩwo wɔwɔ ƒe ɖoɖo sia ŋu ta.

Wobua nɔnɔme sia si woyɔna be ET (Essential Thrombocythemia) , be enye dɔléle si bɔ wu le ʋumenugbagbeviɣi si woyɔna be Myeloproliferative Neoplasm (MPN) me.

2. Ʋumenugbagbeviɣidɔ si wɔa nu alo ʋumenugbagbeviɣidɔ evelia

Esiae nye Thrombocytosis ƒomevi si bɔ wu. Esiae nye esime wò ŋutilã wɔa ʋumenugbagbevi dzĩ geɖe le nɔnɔme bubu, dɔlékui, abixɔxɔ, amekoko, alo aɖuɖɔtoe ɖeɖeɖa ta. Kpuie ko la, wò ŋutilã wɔa nu ɖe ​​nu bubu aɖe ŋu eye wòdzia ​​eƒe ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ ɖe edzi. Nu siaZi geɖe la, ʋumenugbagbeviɣidɔ si wɔa dɔ ɖe ame dzi la nɔa anyi ɣeyiɣi kpui aɖe, si fia be ne wonya kpɔ nusi gbɔ wòtso gbɔ ko la, ʋumenugbagbevi dzĩwo ƒe xexlẽme gatrɔna yia nɔnɔme si sɔ me.

Amekae xɔa ʋumenugbagbeviɣidɔ?

Wokpɔa dɔléle sia zi geɖe le amesiwo xɔ wu ƒe 60. Azɔ hã, woka nya ta be wokpɔa ƒomevi aɖe si woyɔna be Essential Thrombocythemia (ET) le nyɔnuwo ŋu zi gbɔ zi eve wu ŋutsuwo.

Nukawoe hea ʋumenugbagbeviɣidɔ vɛ?

Susu siwo tae ƒomevi eve siwo ŋu míeƒo nu tsoe va yi hã to vovo.

Nusiwo Hea Thrombocythemia Vevie (ET) vɛ .

Essential Thrombocythemia (ET) nye domenyiŋusẽfianu ƒe dɔléle si woxɔ. Menye nane si wodzi wò kplii o. domenyiŋusẽfianu aɖewo siwo kpɔa gome le ʋumenugbagbevi dzĩwo wɔwɔ me ƒe tɔtrɔ, alo tɔtrɔ, gbɔe wòtsona. Esia wɔnɛ be wò ƒumeŋuɖui wɔa ʋumenugbagbevi dzĩwo fũ akpa.

Ame siwo ŋu Essential Thrombocythemia (ET) le ƒe afã kple edzivɔ ƒe domenyiŋusẽfianu ƒe tɔtrɔ le JAK2 domenyiŋusẽfianu me. Dzɔdzɔmeŋusẽ ƒe tɔtrɔ le CALR alo MPL domenyiŋusẽfianuwo me hã bɔ.

Dzɔdzɔmeŋutinunyalawo mete ŋu de dzesi nusi tututu hea domenyiŋusẽfianu ƒe tɔtrɔ siawo vɛ haɖe o, gake numekuku le eŋu yi edzi.

Nusiwo Hea Reactive Thrombocytosis vɛ

Esia ƒomevi dzɔna elabena wò ŋutilã wɔa ʋumenugbagbevi dzĩ geɖe le nɔnɔme vovovowo ta. Alo, ɣeaɖewoɣi la, ate ŋu atso esi ʋumenugbagbevi dzĩ xoxowo ƒoa ƒu ɖe wo nɔewo yome le esi teƒe be woatsrɔ̃ le agbɔsɔsɔ si sɔ nu ta hã.

Nusiwo ate ŋu ahe Reactive Thrombocytosis vɛ dometɔ aɖewoe nye esi :

• Ʋusɔgbɔdɔ , vevietɔ ʋusɔgbɔdɔ si me iron mele o.
• Ʋumedɔléle bubuwo.
• Kansa ƒomevi aɖewo .
• Dɔlékuiwo, abe aklãdɔ ene .
• Dzoxɔxɔ ƒe nɔnɔmewo – nɔnɔme siwo hea dɔdzẽ vɛ le ŋutilã me, abe ƒunukpeƒetetedɔ ene.
• Abixɔxɔ .
• Ayiku ƒe dɔmawɔmawɔ nyuie .
• Atike aɖewo.
• Amekoko, vevietɔ ƒodo ƒe dɔwɔwɔ.
• Aɖuɖɔtoe ɖeɖeɖa.
• Vitamin B12 ƒe anyimanɔmanɔ dada.

Nusiwo gbɔ wòtsona zi geɖe koe le xexlẽdzesi sia me. Nu bubu geɖewo ate ŋu ahe Reactive Thrombocytosis vɛ .

Nukae nye ʋumenugbagbeviɣidɔ ƒe dzesiwo?

Zi geɖe la, amesiwo ƒe ʋumenugbagbeviɣidɔ sɔ gbɔ la mekpɔa dzesi aɖeke o, ne mede ɖeke o la, womekpɔnɛ le eƒe gɔmedzedze o. Ne Reactive Thrombocytosis , le ŋuwò la, àte ŋu akpɔ atikewɔwɔ me nɔnɔme si gbɔ wòtso ƒe dzesiwo.

Gake ne dzesiwo dze la, zi geɖe la, wodo ƒome kple ʋu si dona le wò ŋutilã me le mɔ si mesɔ o nu kple ʋu ƒe sisi le wò ŋutilã me. Àte ŋu akpɔ dzesiwo abe:

• Taɖuame .
• Woate ŋu aƒoe bɔbɔe.
• Sese le eɖokui me be gbɔdzɔgbɔdzɔ, taɖuame, alo tagbɔsesẽ.
• Ʋu si dona le ŋɔti, nu, kple aɖuwo me.
• Ʋu si dona le dɔgboa alo dɔgbo me.

Ame aɖewo siwo ŋu Essential Thrombocythemia (ET) le ate ŋu axɔ dɔléle aɖe si woyɔna be Erythromelalgia . Esia nana asiwo kple afɔwo sea veve, vuvu, eye wobiãna. Woate ŋu akpɔ asiwo kple afɔwo hã ƒe ʋuʋu kple ʋuʋudedi.

Le nɔnɔme sesẽwo me la, ʋumenugbagbeviɣidɔ ate ŋu ana ʋu nado le ƒodo me le mɔ si mesɔ o nu (e.g., Budd-Chari syndrome ) eye wòana ʋusɔgbɔdɔ alo dzidɔ ƒe afɔkua nadzi ɖe edzi .

Aleke wokpɔa ʋumenugbagbeviɣidɔ?

Esi wònye be zi geɖe la, ʋumenugbagbeviɣidɔ mehea dzesiwo vɛ o ta la, kpeɖodzi gbãtɔ si le asiwòe nye ne ʋudodokpɔ edziedzi (e.g., Complete Blood Count – CBC ) ɖee fia be ʋumenugbagbeviɣidɔ dzi ɖe edzi.

Woɖe ʋumenugbagbeviɣidɔ gɔme be ʋumenugbagbevi dzĩ siwo wu 450,000 le ʋu suesuesue ɖeka me. Ne wò ʋumenugbagbevi dzĩwo sɔ gbɔ la, anɔ eme be wò ɖɔkta aɖe gbe be woagado ʋu kpɔ le kwasiɖa ʋɛ aɖewo megbe be yeakpɔe ɖa be ʋumenugbagbeviɣia gakpɔtɔ le dzidzim ɖe edzi hã. Zi geɖe la, ʋumenugbagbeviɣidɔ ƒe dzidziɖedzi zi ɖeka eye emegbe wògatrɔna va ɖoa nɔnɔme si sɔ me menyea kuxi o. Gake agbɔsɔsɔ si nu sẽ atraɖii ate ŋu afia be atikewɔwɔ me nɔnɔme aɖe le ame si.

Le reactive thrombocytosis gome la, dzesidede nɔnɔme si gbɔ wòtso (e.g., iron deficiency anemia , kansa, dɔlékui) ate ŋu akpe ɖe ɖɔktawo ŋu woakpɔe ahakpɔ egbɔ. Gake ne ɖɔktaa mete ŋu ke ɖe nu evelia ma tɔgbe ŋu o la, woagawɔ dodokpɔ bubuwo akpɔe ɖa be Essential Thrombocythemia (ET) le ŋuwò hã.

Dodokpɔ siawo ate ŋu anye:

• Ʋu si wotsɔna ƒoa ʋu le gota gome:Esia léa ŋku ɖe eŋu be ʋumenugbagbevi dzĩ siwo le wò ʋu me la dze abe ɖe womesɔ o hã.
• DNA/domenyiŋusẽfianu dodokpɔwo: Esia ate ŋu ade dzesi domenyiŋusẽfianu ƒe tɔtrɔwo abe JAK2 , siwo do ƒome kple ET (Essential Thrombocythemia) zi geɖe.
• Ƒumeŋuɖui ŋuti numekuku: Esia léa ŋku ɖe wò ƒumeŋuɖui ŋu be lãmenugbagbevi siwo mesɔ o hã le eme hã.

Aleke wodaa ʋumenugbagbeviɣidɔ?

Ne dzesi aɖeke mele ŋuwò o la, ɖewohĩ dodokpɔ edziedzi koe wòahiã.

Zi geɖe la, mehiã be woawɔ atike na ʋumenugbagbeviɣidɔ (secondary thrombocytosis) o. Zi geɖe la, ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ trɔna yia nɔnɔme si sɔ me ne nɔnɔme si na ʋumenugbagbevi dzĩwo ƒe xexlẽme sɔ gbɔ (abe abi, dɔlékui, alo nuwɔna ɖe amekoko ŋu) nya nu tso. Gake ne dzesiwo le ŋuwò la, wò ɖɔkta ada nusi gbɔ wòtso.

Ne Essential Thrombocythemia (ET) le ŋuwò eye dzesiwo le fu ɖem na wò la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàwɔ atike vovovowo, abe:

• Aspirin si mesɔ gbɔ o nono gbesiagbe: Àte ŋu ano aspirin gbesiagbe be ʋu nagaxe o. Zi geɖe la, agbɔsɔsɔ sue sia menaa dɔgbo ƒe dzi gbãna alo ʋu dona le ame ŋu o. Gake mègano aspirin edziedzi ne mèƒo nu kple wò ɖɔkta o.
• Atike siwo ɖea ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ dzi kpɔtɔna nono: Atikewo abe Hydroxyurea (adzɔnu ƒe ŋkɔwo: Droxia®, Hydrea®, Siklos®, Mylocel®) kple Anagrelide (atike ƒe ŋkɔ: Agrilyn®) ɖea ʋumenugbagbevi dzĩwo ƒe wɔwɔ ɖe ƒumeŋuɖui me dzi kpɔtɔna. Interferon alfa (si ƒe ŋkɔe nye: Multiferon®) xea mɔ na ʋumenugbagbevi dzĩ siwo mesɔ o la be woagama wo ahadzi ɖe edzi o.
• Dɔwɔwɔ na wò be woaɖe wò ʋumenugbagbevi dzĩwo ɖa: Ne wò ʋumenugbagbevi dzĩwo sɔ gbɔ ale gbegbe be ʋu ƒe sisi si ate ŋu ade wò agbe afɔku me la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàwɔ dɔ aɖe si woyɔna be ʋumenugbagbeviɣidɔ . Esia bia be nàzã mɔ̃ aɖe atsɔ akɔ ʋumenugbagbevi dzĩ siwo sɔ gbɔ ɖe wò ʋu me. Gake le ʋumenugbagbeviɣidɔ ƒe akpa gãtɔ me la , ʋumenugbagbeviɣidɔ mehiã o.

Vevietɔ: Mègadze atikewɔwɔ siawo dometɔ aɖeke gɔme alo adzudzɔ atikewɔlawo ƒe aɖaŋuɖoɖo manɔmee o. Ele be nàdzro nusianu me kple wò ɖɔkta eye nàwɔe le eƒe mɔfiafia te.

Ðe woate ŋu ada ʋumenugbagbeviɣidɔ keŋkeŋa?

Ʋumenugbagbeviɣidɔ Vevie (ET) .Fifia la, womekpɔ atike aɖeke na ʋumenugbagbeviɣidɔ o. Gake wò ɖɔkta ate ŋu akpe ɖe ŋuwò nàkpɔ nɔnɔmea gbɔ be wòaɖe ʋu ƒe sisi ƒe afɔkua dzi akpɔtɔ. Le reactive thrombocytosis (si tso nu evelia gbɔ) gome la, zi geɖe la, ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ trɔna yia nɔnɔme nyuitɔ me ne wonya da atike si gbɔ wòtso ko.

Ðe woate ŋu axe mɔ ɖe ʋumenugbagbeviɣidɔ nua?

Womate ŋu axe mɔ ɖe nɔnɔme geɖe siwo hea ʋumenugbagbeviɣidɔ vɛ nu o, siwo dometɔ aɖewoe nye Essential Thrombocythemia (ET) .

Ðe ʋumenugbagbeviɣidɔ ate ŋu ade ame ƒe agbe afɔku mea?

Ʋumenugbagbeviɣidɔ ƒe agbɔsɔsɔ si sɔ gbɔ menye agbe ƒe afɔku o, gake kuxi siwo ateŋu ado mo ɖa – abe ʋu ƒe sisi alo ʋu ƒe dodo vevie ene – ateŋu anye afɔku.

Nusiwo hea ʋumenugbagbeviɣidɔ vɛ ƒe akpa gãtɔ nyea ɣeyiɣi kpui aɖe ko, eye ƒã hafi wohea ʋu ƒe sisi vevie vɛ. Le Essential Thrombocythemia (ET) me la, afɔkua lolo vie. Gake wò ɖɔkta alé ŋku ɖe ŋuwò nyuie, aŋlɔ atike siwo hiã la na wò, eye wòawɔ dɔ siwo hiã be wòaxe mɔ ɖe ʋu ƒe sisi si me afɔku le nu. Eyata mègatsi dzi o.

Nukae nye mɔkpɔkpɔ na amesi ŋu ʋumenugbagbeviɣidɔ le?

Zi geɖe la, ʋumenugbagbeviɣidɔ si nye reactive thrombocytosis nu yina ne woda kuxi si gbɔ wòtso. Togbɔ be wò ʋumenugbagbevi dzĩwo ƒe xexlẽme ate ŋu adzi ɖe edzi hena ɣeyiɣi kpui aɖe (eye ɖewohĩ ɣeyiɣi didi aɖe le wò dɔgbo ɖeɖeɖa vɔ megbe) hã la, zi geɖe la, ʋumenugbagbeviɣidɔ evelia menaa ʋu ƒe sisi le mɔ si mesɔ o nu o.

Essential Thrombocythemia (ET) , alo ʋumenugbagbeviɣidɔ gbãtɔ ate ŋu ana ʋu nado vevie alo ʋu ƒe sisi ƒe kuxiwo nado mo ɖa. Atikewo nono be wò ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ nanɔ abe alesi wòle ene ate ŋu akpe ɖe ŋuwò nàxe mɔ ɖe esia nu. Gake le ƒe geɖe ƒe dɔlélea xɔxɔ vɔ megbe la, ƒumeŋuɖui ƒe fibrosis (ƒumeŋuɖui ƒe abi) ate ŋu adzɔ. Ame ʋɛ aɖewo siwo ŋu Essential Thrombocythemia (ET) le hã ate ŋu axɔ ʋumenugbagbeviɣidɔ .

Ɣekaɣie wòle be makpɔ nye ɖɔkta?

Wɔ ɖe wò ɖɔkta ƒe mɔfiamewo dzi pɛpɛpɛ ku ɖe zi nenie wòle be nàyi atikewɔƒe ƒe dodokpɔwo kple nenye be ele be woado ʋu kpɔ be woalé ŋku ɖe wò ʋumenugbagbevi dzĩwo ƒe xexlẽme ŋu.

Ɣekaɣie wòle be mayi Dɔwɔƒe si Kpɔa Nudzɔdzɔ Kpatawo Gbɔ (ETU) ?

Ne èkpɔ ʋusɔgbɔdɔ alo dzidɔ ƒe dzesiwo la, ƒo ka na 1990 enumake alo yi kɔdzi ƒe xɔ si te ɖe ŋuwò kpata. Nya nu tso dzesi siawo ŋu.

Nya kawoe wòle be mabia nye ɖɔkta?

Àte ŋu abia wò ɖɔkta nyawo abe:

• Ðe wòle be matsi dzi ɖe nye ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ si sɔ gbɔ ŋua?
• Ðe wòahiã be mawɔ dodokpɔ geɖe wu be woagakpɔ nye ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ akea?
• Dodokpɔ kawoe wòahiã be mawɔ be manya nusi gbɔ nye Thrombocytosis tso?
• Atikewɔwɔ kawoe nèkafu?
• Tɔtrɔ kawoe mate ŋu awɔ le nye agbenɔnɔ me be makpɔ nɔnɔme sia gbɔ?

Ne wò ʋudodokpɔ me tsonu ɖee fia be wò ʋumenugbagbevi dzĩwo sɔ gbɔ la, mègatsi dzodzodzoe o. Wò ʋumenugbagbevi dzĩwo ate ŋu asɔ gbɔ le susu vovovowo ta. Susu siawo dometɔ geɖe mehiã be woawɔ atike na wo o. Gake ne wò ʋusɔgbɔdɔ dzina ɖe edzi ɣesiaɣi eye dzesiwo le ŋuwò la, wò ɖɔkta adze agbagba adi nusi gbɔ wòtso. Zi geɖe la, ŋkuléle ɖe nu ŋu nyuie kple atikewo zazã ate ŋu axe mɔ ɖe kuxi sesẽtɔ kekeake siwo dona tso ʋumenugbagbeviɣidɔ me nu.

Mlɔeba la, nusiwo dzi wòle be woaɖo ŋkui (Take-Home Message) .

Enyo, míeƒo nu geɖe tso Thrombocytosis ŋu egbea, alo? Mele mɔ kpɔm be èse esia gɔme nyuie.

Nu vevitɔe nye be mègatsi dzodzodzoe ne èva kpɔe be wò ʋumenugbagbevi dzĩwo sɔ gbɔ o. Menye Thrombocytosis ƒe dɔlélewo katãe nye afɔku o.

• Reactive Thrombocytosis ye nye esi bɔ wu, eye zi geɖe la, ɣeyiɣi kpui aɖe ƒe nu bubu aɖe gbɔe wòtsona. Esia hã anyo ɖe edzi ne wonya da dɔ na nusi gbɔ wòtso ma ko.
• Essential Thrombocythemia (ET) nye ƒomevi si mebɔ o si ate ŋu abia be woakpɔ egbɔ ɣeyiɣi didi.
• Kpɔ egbɔ be yewɔ dodokpɔ kple atikewɔwɔ siwo sɔ abe alesi wò ɖɔkta gblɔe ene.
• Mègaŋe aɖaba ƒu dzesi aɖeke dzi o. Di atikewɔla enumake, vevietɔ ne ʋu le dodom le ŋuwò si mebɔ o, abi le ŋuwò, ta le vevem vevie, akɔta le veve sem na wò, alo gbɔgbɔ sesẽ na wò.
• Ðo dze kple wò ɖɔkta gaglãa . Bia nya alo nya ɖesiaɖe si ŋu nètsi dzi ɖo.

Ðo ŋku edzi be menye wò ɖeka koe o. Ne atikewɔlawo ƒe mɔfiame kple kpekpeɖeŋu nyui le asiwò la, àte ŋu akpɔ nɔnɔme sia gbɔ nyuie eye nànɔ agbe si me lãmesẽ le.