Ðe viwò hã le ANA dodokpɔ wɔma? (ANA Test) Mègatsi dzi o, mina míaƒo nu tso esia ŋu!

Esi ɖɔkta gblɔ na wò be ehiã be woawɔ `(ANA Dodokpɔ)` na viwò sue la, ànya se le ɖokuiwò me be vɔvɔ̃ ɖo ye vie, alo? "Nukae nye dodokpɔ sia? Nukatae wole esia wɔm? Ðe nane gblẽ le vinyea ŋua?" Enye nusi sɔ be nyabiase siawo tɔgbe nava susu me na wò. Esia tae míesusu be míaƒo nu tso `(ANA Dodokpɔ)` sia ŋu le mɔ bɔbɔe aɖe nu egbea, le mɔ si gɔme nàte ŋu ase nu.

Nukae nye ANA dodokpɔ sia?

Kpuie ko la, `(ANA Dodokpɔ)` nye dodokpɔ si léa ŋku ɖe nane si woyɔna be `Antinuclear Antibodies` ƒe anyinɔnɔ le viwò ƒe ʋu me hã. Enyo, fifia ɖewohĩ èle eŋu bum be nukae nye nuklia dɔlékuiwutike siawo hã.

Mina míaƒo nu tso dɔlékuiwutikewo ŋu gbã . Tsɔe be asrafo suewo ƒe ƒuƒoƒo aɖe le míaƒe ŋutilã me. Ame siawoe wɔa avu kple dɔlékuiwo, abe dɔlékuiwo kple dɔlékuiwo ene, siwo gena ɖe míaƒe ŋutilã me hekpɔa mía ta tso dɔlélewo me. Míeyɔa asrafo siawo be dɔlékuiwutikewo. Esiawo nye protein ƒomevi aɖe si míaƒe ʋumenugbagbevi ɣiwo wɔna.

Gake ɣeaɖewoɣi la, míaƒe dɔlélenutsiŋutete gblẽna. Le esi teƒe be dɔlékuiwutike siawo nadze dutatɔwo ƒe amedzidzelawo dzi la, wodzea mía ŋutɔwo ƒe lãmenugbagbevi siwo le lãmesẽ me dzi dzedze gɔme. To mɔ sia dzi la, woyɔa dɔlékuiwutike siwo dzea mía ŋutɔwo ƒe lãmenugbagbeviwo dzi vodadatɔe be autoantibodies .

Fifia, Antinuclear Antibodies siawo nye autoantibodies ƒomevi mawo dometɔ ɖeka. Esiawo tɔa ŋku nucleus si le míaƒe lãmenugbagbeviwo me koŋ. Ènyaa, nucleus la le abe lãmenugbagbevi ƒe mɔ̃ si dzi wokpɔna ene. Mɔfiame siwo katã ku ɖe lãmenugbagbevi, si nye DNA ŋu la le eme. Eyata ne Antinuclear Antibodies siawo sɔ gbɔ le ʋua me la, míaƒe dɔlélenutsiŋutete ate ŋu adze mía ŋutɔwo míaƒe ŋutilã dzi dzedze gɔme. Esiae nye nusi míeyɔna be Autoimmune Disease .

Gake nu vevi aɖe si dzi wòle be míaɖo ŋkui lae nye esi. ``(ANA Dodokpɔ)`` si nye ``(Positive)``, si fia be ANA le ʋua me, mefia ɣesiaɣi be dɔlélenutsiŋutete ƒe dɔléle aɖe le eme o. Ame siwo le lãmesẽ me abe 30% ene ate ŋu akpɔ ANA ƒe agbɔsɔsɔ aɖe le woƒe ʋu me. Azɔ hã, ANA ƒe agbɔsɔsɔ ate ŋu adzi ɖe edzi le dɔlékui aɖewo ƒe dɔlékuiwo xɔxɔ me alo ne wole atike aɖewo zãm.

Nukae ANA dodokpɔa kpena ɖe ame ŋu wòkea?

Menye ɖeko Ðɔktawo zãa `(ANA Dodokpɔ)` tsɔ ɖoa ​​kpe edzi nenye be dɔlélenutsiŋutete ƒe dɔléle aɖe li alo meli o. Gake dodokpɔ sia me tsonu ate ŋu akpe ɖe mía ŋu míanya dɔléle si ƒomevi ate ŋu anɔ ɖevi ŋu. Dɔlélenutsiŋutete ƒe dɔléle geɖewo li siwo ateŋu ana woawɔ `(ANA Dodokpɔ)`. Mina míalé ŋku ɖe wo dometɔ aɖewo ŋu kpuie:

• Lãmetsiŋusẽ si woyɔna be Lupus Erythematosus (SLE): .Ame geɖe nya esia be "Lupus." Esia nye dɔléle si dɔlélenutsiŋutete wɔna si nana ŋutilã ƒe akpa vovovowo, abe ƒunukpeƒewo, ŋutigbalẽ, ayikuwo, kple dzi ene, xɔa abi. Dzesiawo dometɔ aɖewoe nye dzoxɔxɔ, ɖeɖiteameŋu, ƒunukpeƒeveame, kple ŋutigbalẽ ƒe abi siwo biã, siwo kɔ (vevietɔ abi siwo le abe kpakpaluʋui ene le mo).
• Scleroderma: Esia nye dɔléle si mebɔ o. Le nɔnɔme sia me la, ɖevia ƒe ŋutigbalẽ kple lãmenugbagbevi siwo le ŋutilãa me la va nɔa ƒoƒom vivivi eye wosẽna. Menye ŋutigbalẽa ɖeɖekoe esia ate ŋu agblẽ o, ke ate ŋu agblẽ nu le ŋutinu ememetɔwo abe nuɖuɖumeŋusẽ, lãkusi, ayiku, kple dzi hã ŋu.
• Polymyositis: Esia nye dɔléle si gblẽa nu le lãmekawo ŋu. Enaa lãmekawo xɔa abi eye wogbɔdzɔna. Zi geɖe la, egblẽa nu le lãmeka siwo te ɖe akɔta ŋu.
• Dermatomyositis: Nɔnɔme sia ƒe dzesiwo sɔ kple polymyositis, gake ehea ŋutigbalẽ ƒe kuxiwo hã vɛ. Le kpɔɖeŋu me, àte ŋu axɔ ŋutigbalẽ ƒe ʋuʋu, avuvu, alo aŋutiɖiɖi.
• Mixed Connective Tissue Disease (MCTD): Le esia me la, dɔléle etɔ̃awo katã, lupus, scleroderma, kple polymyositis, ƒe dzesiwo ate ŋu adze ɖekae alo ɖe wo nɔewo yome le ɣeyiɣi aɖe me.
• Juvenile Idiopathic Arthritis (JIA): Esia nye ƒunukpeƒetetedɔ ƒomevi aɖe si dzea ɖevi suewo dzi. Menye ɖevia ƒe asiwo, asibidɛwo, kple klowo ƒe ƒunukpeƒewo koe wòate ŋu agblẽ o, ke ɣeaɖewoɣi la, ŋkuwo, lãkusiwo, kple dzi hã.
• Sjögren ƒe Dɔléle: Le nɔnɔme sia me la, lãkusi siwo naa tsi nɔa ŋkuwo kple nu me la gblẽna. Esia fia be ɖevia ƒe ŋkuwo kple nu me ƒuna. Esia le alea elabena dɔlélenutsiŋutete dzea lãkusi siawo dzi.

Fifia àteŋu akpɔ alesi gbegbe `(ANA Dodokpɔ)` le vevie. Gake ne ɖɔkta da dɔ abe lupus ene la, wowɔa dodokpɔ bubuwo be woakpɔ alesi atike la le dɔ wɔm nyuie. Womewɔa `(ANA Dodokpɔ)` la ɣesiaɣi be woatsɔ alé ŋku ɖe dɔlélea ƒe nɔnɔme ŋu o.

Nukatae mía vi ahiã ANA dodokpɔ?

Fifia àte ŋu anɔ eŋu bum be, dzesi ka ƒomevie ana ɖɔkta naɖo aɖaŋu be nàwɔ `(ANA Dodokpɔ)` sia? Ne viwòa le dɔléle aɖe si dɔlélenutsiŋutete wɔna ƒe dzesiwo ɖem fia la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàwɔ dodokpɔ sia.

Nukae nye dɔléle siawo siwo dɔlélenutsiŋutete hena vɛ ƒe dzesiwo?

Togbɔ be dzesi siawo ate ŋu ato vovo hã la, ɖewo li siwo bɔ:

• Asrã si nɔa ame ŋu enuenu.
• Kpakpaluʋui ƒe nɔnɔme ƒe ʋuʋudedi dzĩ le mo.
• Sese le eɖokui me be ɖeɖi te ye ŋu ŋutɔ, sese le ame ɖokui me be agbe mele ye si o (Extreme fatigue).
• Ƒunukpeƒewo ƒe sesẽ kple woƒe vuvu.
• Lãmetsiwo ƒe vevesese.

Ne dzesi siawo dometɔ ɖeka alo esi wu nenema le ɖevia ŋu la, ɖɔkta ateŋu awɔ ``ANA Dodokpɔ'' atsɔ aku nu me yi ŋgɔe.

Aleke wowɔa ANA dodokpɔae?

Enyo, azɔ mina míakpɔ alesi wowɔa `(ANA Dodokpɔ)` sia ɖa. Le nyateƒe me la, esia le abe ʋudodokpɔ edziedzi ene. Woɖea ɖevia ƒe ʋu ƒe kpɔɖeŋu eye wodzidzea antinuclear antibodies `(ANA)` ƒe agbɔsɔsɔ si le eme.

Mɔnu tɔxɛ aɖe li si wozãna zi geɖe na esia, si woyɔna be Indirect Immunofluorescence Assay (IFA) . Ɣeaɖewoɣi la, wogayɔa mɔnu sia be Fluorescent Antinuclear Antibody (FANA) dodokpɔ.

Esiae dzɔna le IFA mɔnua me: Dɔléleŋutinunyala aɖe tsɔa ɖevia ƒe ʋumenugbagbeviɣi (ʋua ƒe akpa si nye tsi) dea glass slide si woate ŋu akpɔ le nusuekpɔmɔ̃ me la dzi. Emegbe wotsɔa dɔlékuiwutike tɔxɛ aɖe si klẽna, alo si me keklẽ le, kpena ɖe eŋu. Fluorescent antibodies siawo, ne ANA le kpɔɖeŋua me la, alé ɖe lãmenugbagbevi mawo ŋu. Emegbe ne dɔléleŋutinunyala la lé ŋku ɖe slide la ŋu le nusuekpɔmɔ̃ tɔxɛ aɖe me la, lãmenugbagbevi siwo me ANA le la aklẽ.

Ðe wòhiã be nàdzra viwòa ɖo hafi adoe kpɔa?

Dzadzraɖo tɔxɛ aɖeke mehiã na `(ANA Dodokpɔ)` sia o. Ðevia ate ŋu aɖu nu ahano nu le mɔ si sɔ nu le dodokpɔa gbe. Gake ele vevie ŋutɔ be ne viwòa le atike aɖewo zãm la, ele be nàgblɔe na ɖɔktaa godoo . Elabena atike aɖewo ateŋu ana `(ANA Test)` ƒe emetsonuwo nanye `(Positive). Ne nya aɖe le mia alo viwòa si ku ɖe esia ŋu la, bia ɖɔktaa.

Nukae dzɔna le dodokpɔa wɔɣi?

Wowɔa esia le mɔ si nu woɖea ʋu edziedzi le la nu. Ðɔkta alo dɔnɔdzikpɔla akpɔ ʋuka nyui aɖe le ɖevia ƒe alɔnu. Emegbe, woate ŋu atsɔ elastic-ka sue aɖe aƒo xlã alɔnu, alo woate ŋu abia tso ɖevia si be wòamimi woƒe alɔnu. Emegbe, wokɔa teƒe si woaɖe ʋua le eye wotsɔa aŋe sue aɖe dea ʋukaa me.

Ðevia ate ŋu ase le eɖokui me be yeƒe lãme le ƒoƒom vie ne wotsɔ aŋea de eme heɖee. Ne woƒo ʋua nu ƒu ɖe dodokpɔmɔ̃ alo nugoe me vɔ la, woɖea aŋe si wotsɔ blae la ɖa eye woɖea aŋea ɖa. Àte ŋu ase veve vie le afisi wofɔ ʋua le.

Mègatsi dzi o, dɔ sia katã mexɔa aɖabaƒoƒo atɔ̃ o.

Nukae dzɔna le dodokpɔa megbe?

Ne woɖe ʋua vɔ la, ɖɔkta alo dɔnɔdzikpɔla atsɔ kotoku alo gaze aɖe aɖo afisi woɖe ʋua le la dzi eye wòazi edzi. Esia ate ŋu akpe ɖe ame ŋu be ʋu si dona le ame ŋu, abi, kple abi ƒe ƒoƒo dzi naɖe akpɔtɔ. Emegbe woatsɔ aŋe si le dzadzɛ eye wòaƒu la asisi ɖe teƒea. Emegbe woaɖo ʋua ɖe nudokpɔƒe.

Ðe afɔku aɖewo le dodokpɔ sia mea?

Afɔku gã aɖeke mele ʋudodokpɔ me o . Viwòa ate ŋu ase veve alo abi aɖe le afisi woɖe ʋua le. Gake vevesesea alo abi si wòxɔ la nu ayi kaba .

Aleke míase ANA dodokpɔ ƒe nyatakakaa gɔmee?

Zi geɖe la, exɔa ŋkeke ʋɛ aɖewo hafi ANA dodokpɔ ƒe nyatakakaa va ɖona. Ɣeaɖewoɣi la, ne ɖɔktaa wɔ dodokpɔ bubuwo hã la, aƒo wo katã me tsonu nu ƒu ahaɖe wo me na wò.

ANA Dodokpɔ ƒe nyatakaka aɖe ƒo nu tso nu etɔ̃ koŋ ŋu: Gɔmeɖeɖe, Titer ƒe asixɔxɔ, kple Fluorescent Pattern.

Nya vevi siwo le nyatakakaa me

Gɔmeɖeɖe - Ðe wònye nu gbegblẽ alo nu nyuia?

• Nu gbegblẽ: Esia fia be womekpɔ ANA le ɖevia ƒe ʋu me o. Ne nenemae la, ke anɔ eme be dɔléle si dɔlékuiwutikewo ƒe dɔlélenutsiŋutete wɔna le ɖevia ŋu o.
• Nu Nyui: Esia fia be wokpɔ ANA le ɖevia ƒe ʋu me. Ne nenemae la, ke ate ŋu adzɔ be dɔléle aɖe si tso dɔlélenutsiŋutete gbɔ nanɔ anyi, gake ehiã be woawɔ dodokpɔ geɖe wu atsɔ aɖo kpe edzi.

Nukae nye titer ƒe asixɔxɔ?

``Titer`` ƒe asixɔxɔ sia gblɔa dɔlékuiwutike agbɔsɔsɔme si le ɖevia ƒe ʋu me na wò. Wokpɔ esia ale: Dɔléleŋutinunyala la tsia ɖevia ƒe ʋu ƒe akpa si nye tsi si me protein sɔ gbɔ ɖo (plasma) to dzetsi (dzetsi) vi aɖe dede eme me. Abe alesi míetsɔa tsi ƒoa cordial ne míele aha wɔm ene.

Gbã la, wotsɔa ʋumenugbagbeviɣi ƒe akpa 40 kple dze ƒe akpa 1 tsakana (1:40). Emegbe wogadea tsi tsakatsaka sia me (e.g. 1:80, 1:160, 1:320). Wodoa kpɔɖeŋu ɖesiaɖe si woɖe tsi me kpɔna be ANA hã le eme hã. Woŋlɔa tsi mamlɛtɔ si fia ANA ``Positive`` abe ``Titer`` ƒe asixɔxɔ le nyatakakaa me ene. Le kpɔɖeŋu me, asixɔxɔ si nye 1:160 fia be ANA ƒe agbɔsɔsɔ si lolo wu 1:80. Zi geɖe la, womebua asixɔxɔ si nye 1:40 alo esi mede nenema o be eɖe dzesi o.

Nukae fluorescent ƒe nɔnɔme fia?

Ne ANA le eme la, ne wotsɔ nusuekpɔmɔ̃ kpɔ lãmenugbagbeviawo la, woɖea nɔnɔme aɖe fiana, si le abe ʋuʋudedi ene. Kpɔɖeŋu sia ate ŋu ana nànya dɔléle si ame ŋutɔ ƒe dɔlélenutsiŋutete ate ŋu adze le ŋuwò . Kpɔɖeŋu ƒomevi vovovowo li:

• Homogeneous: Nucleus bliboa klẽna ɖekae. Esiae nye kpɔɖeŋu si bɔ wu. Ate ŋu adzɔ le dɔléle ɖesiaɖe si dɔlélenutsiŋutete wɔna me, gake ebɔ vevietɔ le lupus alo Sjögren ƒe Dɔléle me.
• Speckled: Le esia me la, nucleus la dzena abe dometsotso suewo alo ƒuƒu siwo le keklẽm le goawo katã me ene. Esia ate ŋu afia dɔléle vovovowo hã, siwo dometɔ aɖewoe nye lupus kple Srogens syndrome.
• Centromere: Afi siae wokpɔa ANA ƒe amadede le domenyiŋusẽfianuwo ŋu le. Zi geɖe la, nɔnɔme sia do ƒome kple dɔléle si nye Scleroderma.
• Nuklia ƒe dɔwɔwɔ:Le go sia me la, wokpɔa ANA ƒe amadede ƒo xlã nucleolus (afisi wowɔa ribosomes le lãmenugbagbevi la me) le nucleus la me. Esia ate ŋu ado ƒome kple nɔnɔmewo abe scleroderma, Srogens syndrome, kple mixed connective tissue disease (MCTD) ene. Ate ŋu anye alakpa nu nyui aɖe si dona tso eme ɣeaɖewoɣi.
• Nusiwo le gota: Le esia me la, wokpɔa ANA ƒe amadede le nucleus ƒe goawo ŋu. Zi geɖe la, esia doa ƒome kple lupus.

Nukae woawɔ ne ANA ƒe nyatakakaa nye nyuitɔ?

ANA dodokpɔ ƒe nyatakaka si nye ``Positive'' fia be antinuclear antibodies le ɖevia ƒe ʋu me. Esia ate ŋu afia be dɔléle aɖe si tso dɔlélenutsiŋutete gbɔ abe lupus ene le ɖevia ŋu.

Ke hã, abe alesi megblɔe va yi ene la, mègavɔ̃ be autoimmune dɔléle aɖe le viwò ŋu le esi ANA ƒe nyatakakaa nye ``Positive'' ta ko o. Ame geɖe siwo le lãmesẽ me ate ŋu akpɔ ANA le woƒe ʋu me. Azɔ hã, atike aɖewo kple dɔlékuiwo ƒe dɔléle ateŋu atrɔ ``ANA Dodokpɔ'' ƒe emetsonuwo.

Ne viwò ƒe `(ANA Dodokpɔ)` nye `(Positive)` la, zi geɖe la, ɖɔktaa awɔ dodokpɔ geɖe bubu hafi aɖo kpe dɔléle aɖe dzi. `(ANA Dodokpɔ)` ƒe emetsonuwo ɖeɖe mate ŋu anya nenye be dɔlélenutsiŋutete ƒe dɔléle aɖe li o. Be ɖɔktaa nanya ne dɔléle aɖe le ame ŋu loo alo mele eme o la, abu nu siwo gbɔna la katã ŋu:

• `(ANA Dodokpɔ)` (titer ƒe asixɔxɔ, kpɔɖeŋu) ƒe emetsonuwo.
• Dzesi siwo ɖevia ɖena fiana.
• Nusiwo nèkpɔna le viwòa ƒe ŋutilãmedɔdada me.
• Dɔdokpɔƒe dodokpɔ bubuwo me tsonu.

Nya vevi siwo wòle be nàbia ɖɔktaa

Ne ehiã be woawɔ ANA dodokpɔ na viwòa la, nya vevi aɖewo li nàte ŋu abia ɖɔktaa:

• Ðe wòhiã be ɖevia nadzra ɖo etɔxɛe ɖe `(ANA Dodokpɔ)` sia ŋua?
• Ðe wowɔa dodokpɔ bubuwo kpe ɖe `(ANA Dodokpɔ)` ŋua?
• Aleke ɖevi ƒe `(ANA Dodokpɔ)` me tsonu ate ŋu akpe ɖe ame ŋu wòase nusi gbɔ woƒe dzesiwo tso gɔme?
• Ðe wòhiã be woawɔ dodokpɔ siwo akplɔ ɖevia ɖo le dodokpɔ sia me tsonu nua?

Mlɔeba la, nu siwo dzi wòle be woaɖo ŋkui

Enye nusi sɔ be mia kple viwò miavɔ̃ vie eye miatsi dzimaɖi ne miekpɔe be ehiã be woawɔ ANA dodokpɔ na viwòa. Gake ɖo ŋku edzi be ʋudodokpɔ bɔbɔe aɖe si mexɔa aɖabaƒoƒo atɔ̃ o koe esia nye.

`(ANA Dodokpɔ)` ƒe emetsonuwo nye nu ɖeka ko si ŋu ɖɔkta buna ne ele nyametsotso wɔm tso dɔléle si dɔlékuiwutikewo tsona ŋu. Tsɔ kpe ɖe esia ŋu la, wobua nu bubu geɖewo ŋu, abe ɖevia ƒe dzesiwo, ƒomea ƒe atikewɔwɔ ŋutinya, kple dodokpɔ bubuwo me tsonu ene. Ke hã, `(ANA Dodokpɔ)` me tsonu ate ŋu ana kpeɖodzi veviwo be woatsɔ anya ne dɔléle si tsoa dɔlélenutsiŋutete gbɔ le ɖevia ŋu loo alo mele eŋu o. Eya ta mègavɔ̃ o eye nàtsɔ susu fafɛ adze ŋgɔ dodokpɔ sia. Bia nya ɖe sia ɖe si anɔ asiwò la ɖɔktaa.

` Ðeviwo ƒe lãmesẽ, ANA dodokpɔ, autoimmune dɔlélewo, ʋudodokpɔ, dɔlélewo didi, dɔlélenutsiŋutete, lupus