Mina míanya nu tso wò AST ƒe sesẽme ŋu. (Aspartate Transferase - AST) Nukae ema fia?

Ðewohĩ èkpɔ asixɔxɔ aɖe si woyɔna be AST le ʋudodokpɔ ŋuti nyatakaka aɖe me, alo èse ɖɔkta aɖe ƒo nu tso eŋu. Eyata, ɖewohĩ èle eŋu bum be, "Nukae AST fia?" Mègatsi dzi o, mina míaƒo nu tso eŋu bɔbɔe. Abe alesi nàƒo nu kple xɔ̃wò ene.

Nukae nye AST? Kpuie ko la,...

AST nye ŋkɔ kpui si wotsɔ na enzyme si nye Aspartate Transferase . Wogayɔnae ɣeaɖewoɣi be Aspartate Aminotransferase . Fifia ɖewohĩ ànɔ ɖokuiwò biam be, "Nukae nye enzyme sia?"

Bu eŋu kpɔ, dɔwɔla sue gbogbo aɖewo le míaƒe ŋutilã me siwo kpena ɖe nu vovovowo ŋu be woawɔ dɔ nyuie. Enzymewo le nenema. Le nyateƒe me la, wonye protein ƒomevi aɖe. Enzyme sia si woyɔna be AST la le teƒe geɖe le míaƒe ŋutilã me. Aklã me koŋue wòle . Gake tsɔ kpe ɖe eŋu la, AST dɔlékui sia le lãkusi bubu geɖe abe dzi, ahɔhɔ̃, dɔgbo, ayiku, kple lãmekawo ene me. Gake zi geɖe la, ne míeƒo nu tso AST ŋu la, zi geɖe la, edo ƒome kple míaƒe aklã ƒe lãmesẽ.

Eyata nukae nye AST ʋudodokpɔ?

AST ʋudodokpɔ dzidzea AST ƒe agbɔsɔsɔ si le wò ʋu me. Zi geɖe la, ne míaƒe ŋutilã ƒe lãmenugbagbeviwo gblẽ la, AST dɔlékui sia ate ŋu aƒo ƒu ɖe ʋua me. Eyata AST ƒe agbɔsɔsɔ si sɔ gbɔ ɖe ʋu me nye dzesi be nane ate ŋu agblẽ le ŋutilãa me. Zi geɖe (gake menye ɣesiaɣi o) esia ate ŋu anye aklãdɔ.

Gake menye aklã me koe AST le o. Eyata esesẽna na ɖɔkta be wòanɔ te ɖe AST ƒe agbɔsɔsɔ ɖeɖeko dzi anya dɔléle ƒomevi si tututu le ŋuwò. Zi geɖe la, wowɔa AST dodokpɔa kpe ɖe dodokpɔ bubu geɖe ŋu. Le kpɔɖeŋu me, wowɔa esia abe aklã me enzyme panel (HFP) alo comprehensive metabolic panel (CMP) ƒe akpa aɖe ene . Esia wɔnɛ be nète ŋu dzidzea nu geɖe le ʋu ɖeka me eye nèkpɔa wò lãmesẽ bliboe.

Ŋkɔ bubu geɖewo le AST dodokpɔa ŋu:

• Aspartate ƒe dɔlékuiwutike (AST).
• Aspartate aminotransferase (AST) ƒe dɔlékuiwo ƒe dɔwɔwɔ.
• Serum Glutamic-Oxaloacetic Transaminase (SGOT) ƒe ʋumenugbagbeviɣidɔlékuiwo.
• SGOT.
• Aspartate transaminase ƒe atike.

Vovototo kae le AST kple ALT dome?

Ðewohĩ èse asixɔxɔ bubu si woyɔna be ALT kpe ɖe AST ŋu kpɔ. ALT (Alanine Transferase) nye enzyme bubu si wodzidzena le aklã me. Esiawo evea siaa dona ɖe ʋua me ne aklã me lãmenugbagbeviwo gblẽ.

Gake to vovo na AST la, ALT nye enzyme si le aklã me koŋ. AST le ŋutilã ƒe akpa bubu geɖe. Eyata wobua ALT ƒe agbɔsɔsɔ si dzi ɖe edzi be enye aklãdɔléle ƒe dzesi tɔxɛ aɖe wu AST ƒe agbɔsɔsɔ si dzi ɖe edzi . Gake ne ɖɔkta le aklã ƒe lãmesẽ me dzrom la, zi geɖe la, woléa ŋku ɖe AST kple ALT siaa ŋu ɖekae.

Nukatae wòhiã be woawɔ AST dodokpɔ?

Taɖodzinu vevitɔ si le AST dodokpɔ ŋue nye be wòade dzesi nusiwo gblẽ le lãmenugbagbevi siwo le míaƒe ŋutilã me ŋu. Esia kpena ɖe ame ŋu wòdea dzesi aklã me kuxiwo, vevietɔ ne lãmenugbagbevi siwo le aklãa me gblẽ, elabena AST ƒoa ƒu ɖe ʋua me. Azɔ hã, abe alesi míegblɔe va yi ene la, AST ƒe agbɔsɔsɔ ate ŋu adzi ɖe edzi ne lãmenugbagbeviwo gblẽ le ŋutilã ƒe akpa bubuwo gɔ̃ hã.

Ðɔkta ate ŋu abia tso asiwò be nàwɔ AST dodokpɔ (zi geɖe abe ƒuƒoƒo aɖe ƒe akpa aɖe ene) le susuwo abe:

1. Dodokpɔ hafi dzesiawo nadze

Afɔku le ame aɖewo ŋu be woaxɔ aklãdɔ. Ne afɔku siawo dometɔ aɖe le ŋuwò la, àte ŋu awɔ dodokpɔ sia atsɔ akpɔ wò aklã ƒe lãmesẽ hafi dzesiawo nadze. Afɔku siawo dometɔ aɖewoe nye:

• Ahanono fũu akpa.
• Aklãdɔléle ƒe amesinɔnɔ le ƒomea me.
• Suklidɔ.
• Lolo akpa (ami ƒe dzidziɖedzi le ŋutilã me).
• Atikewo dodo kple aŋe siwo ame bubuwo zãna.

Ɣeaɖewoɣi la, wotsɔa AST dodokpɔ dea Comprehensive Metabolic Panel (CMP) me abe lãmesẽ dodokpɔ si wowɔna edziedzi ƒe akpa aɖe ene, eyata ahiã be nàwɔ dodokpɔ sia ne mèle afɔku me be nàxɔ aklãdɔ o gɔ̃ hã.

2. Lé ŋku ɖe nɔnɔmea ŋu (Monitoring) .

Ne aklãdɔ le ŋuwò xoxo la, wò ɖɔkta ate ŋu aɖe gbe na AST dodokpɔ sia be wòakpɔe ɖa be ele nyonyom ɖe edzi, le gbegblẽm ɖe edzi, alo alesi wòle dɔ wɔm nyuie le atikewɔwɔ me hã. Azɔ hã, ne èle atike siwo ate ŋu agblẽ nu le aklã ŋu zãm la, wowɔa dodokpɔ sia hã be woakpɔe ɖa be atike la le aklã gblẽm hã.

3. Abe kpekpeɖeŋu le dɔlélewo didi me ene (Diagnosing) .

Ne aklãdɔ ƒe dzesiwo le ŋuwò la, woate ŋu ade AST dodokpɔ dodokpɔawo me be wòakpe ɖe ŋuwò nànya dɔlélea. Togbɔ be AST ƒe agbɔsɔsɔ ɖeɖe mate ŋu ade dzesi dɔléle aɖe o hã la, enye dɔléle aɖe didi ƒe akpa vevi aɖe.

Aklãdɔléle ƒe dzesi aɖewoe nye:

• Aɖuɖɔtoe kple/alo ʋuʋudedi.
• Dɔgbo ƒe vevesese (ƒodo me vevesese).
• Ŋutilã si le ʋuʋum.
• Jaundice (ŋutilã ƒe ɣie kple ŋku ƒe ɣie).
• Ðeɖiteameŋu ƒe seselelãme enuenu (ɖeɖiteameŋu).
• Nuɖuɖua mevivina o.

Amekae wɔa AST ʋudodokpɔa? Aleke wowɔnɛ?

Zi geɖe la, amesi wona hehee etɔxɛe be wòaɖe ʋu, si woyɔna be ʋukaŋutinunyala, ye xɔa ʋu sia. Gake lãmesẽdɔwɔla ɖesiaɖe si wona hehee be wòano ʋu ate ŋu awɔ esia. Emegbe woɖoa kpɔɖeŋua ɖe dodokpɔxɔ aɖe. Afimae atikewɔƒe ƒe dzɔdzɔmeŋutinunyala aɖe léa ŋku ɖe kpɔɖeŋua ŋu eye wòzãa mɔ̃ tɔxɛwo (analyzers) tsɔ dzidzea AST ƒe agbɔsɔsɔ.

Ðe nane li si wòle be mawɔ hafi adoe kpɔa?

• Nutsitsidɔ: Ne wò AST dodokpɔ nye Comprehensive Metabolic Panel (CMP) ƒe akpa aɖe la, woate ŋu abia tso asiwò be nàtsi nu adɔ (mègaɖu nu alo ano naneke o negbe tsi ko) gaƒoƒo 10-12 hafi nàdo wò ʋu kpɔ. Gake ne AST dodokpɔa koe nèle wɔwɔm alo Aklã ƒe Dɔwɔnu (HFP) ko la, zi geɖe la, mehiã be nàtsi nu adɔ o. Gake la,Wɔ ɖe wò ɖɔkta ƒe mɔfiamewo dzi pɛpɛpɛ.
• Atikewo Ŋuti Nyatakakawo: Ele be nàgblɔ atikewo, vitaminwo, kple kpeɖeŋutɔtike siwo katã nèzãna na wò ɖɔkta. Atike aɖewo ate ŋu akpɔ ŋusẽ ɖe AST ƒe agbɔsɔsɔ dzi. Wò ɖɔkta ate ŋu abia tso asiwò be nàdzudzɔ wo nono ŋkeke ʋɛ aɖewo do ŋgɔ na dodokpɔa, negbe ɖe wogblɔ na wò ko hafi. Mègadzudzɔ atike aɖeke nono wò ɖɔkta ƒe aɖaŋuɖoɖo manɔmee gbeɖe o.

Nukae dzɔna ne èdo ʋu?

Esia le bɔbɔe ŋutɔ.

• Ànɔ zikpui dzi. Emegbe woakpɔ ʋuka si sɔ le wò alɔnu (zi geɖe la, le abɔta te, le eme).
• Ne wonya ke ɖe ʋukaa ŋu ko la, wokɔa teƒea hewua dɔlékuiwo.
• Emegbe, wotsɔa aŋe sue aɖe dea ʋuka ma me eye woɖea ʋu. Esia ate ŋu ave ame vie, abe anyidi ɖu wò ene.
• Ne wotsɔ aŋea de eme vɔ la, woƒoa ʋu sue aɖe nu ƒu ɖe dodokpɔmɔ̃ me.
• Ne èƒo ʋu si sɔ na dodokpɔa nu ƒu vɔ la, ɖe aŋea ɖa eye nàtsɔ kotoku alo gaze aɖe aƒoe ɖe teƒe si ʋua le dodom le be ʋua natɔ te.
• Emegbe wotsɔa aŋɔ ƒoa teƒea eye wowua dɔa nu.

Zi geɖe la, dɔ sia katã mexɔa aɖabaƒoƒo atɔ̃ o.

Nukae dzɔna le ʋudodo vɔ megbe?

Ne woɖo ʋua ɖe dodokpɔxɔa vɔ la, woakpɔ emetsonuwo le abe ŋkeke ɖeka alo eve ene megbe. Ɣeaɖewoɣi la, ate ŋu axɔ ɣeyiɣi didi vie. Wò ɖɔkta agblɔ emetsonuwo na wò ne wova.

Ðe afɔku aɖe le esia mea?

Ʋudodokpɔ nye dodokpɔ si bɔ ŋutɔ eye wòle vevie. Afɔkuawo le sue ŋutɔ. Ðewohĩ abi kple abi aɖewo anɔ afisi woɖe ʋua le. Gake ema nu ayi kaba.

Nukae AST dodokpɔa me tsonu fia?

Zi geɖe la, nyatakaka siwo gbɔna kpena ɖe AST me tsonu ŋu le ʋudodokpɔ ŋuti nyatakaka me:

• Ʋudodokpɔa ƒe ŋkɔ (woyɔnae be AST).
• AST ƒe agbɔsɔsɔ (asixɔxɔ) si le wò ʋu me.
• Dodokpɔ ma ƒe didime si sɔ.
• Eɖanye wò emetsonua sɔ alo mesɔ o (si lolo alo le sue).

Nukae nye AST ƒe didime si sɔ?

AST ƒe didime si sɔ ate ŋu ato vovo vie tso dodokpɔxɔ ɖeka me yi bubu gbɔ. Nusi bɔ si sɔ gbɔe nye 8 va ɖo 33 U/L (units/litre) . Gake ele vevie be nàlé ŋku ɖe didime si sɔ ŋu le wò nyatakakaa me.

Azɔ hã, ɖo ŋku edzi be AST ƒe ɖoɖo "si sɔ" ɖeka aɖeke meli si wɔa dɔ na amesiame o. AST ƒe agbɔsɔsɔ si le lãmesẽ me ate ŋu ato vovo le nuwo abe:

• wò ƒexɔxɔ.
• Wò nyɔnunyenye/ŋutsunyenye.
• Wò duɖimekeke.
• Wò kpekpeme.

Wò ɖɔkta abu nusiawo katã ŋu eye wòatso nya me le nusi ado tso eme ŋu.

Nukae wòfia ne nye AST ƒe agbɔsɔsɔme sɔ gbɔ?

Ne AST ƒe agbɔsɔsɔ dzi ɖe edzi la, ate ŋu anye aklãdɔléle ƒe dzesi.Ne ʋudodokpɔ bubuwo, vevietɔ esiwo ku ɖe aklã ŋu hã mesɔ o la, anɔ eme be aklãdɔ le ŋuwò. Gake abe alesi míegblɔe va yi ene la, AST ƒe agbɔsɔsɔ ate ŋu adzi ɖe edzi hã ne lãmenugbagbevi siwo le ŋutilã ƒe akpa bubuwo gblẽ, vevietɔ le aklã me.

AST ƒe agbɔsɔsɔ si dzi ɖe edzi ate ŋu afia aklãdɔléle ƒe nɔnɔmewo abe:

• Aklã ƒe gbegblẽ si aha sesẽ hena vɛ.
• Aklãdɔléle.
• Aklã ƒe abi (Cirrhosis).
• Atike siwo gblẽa nu le aklã ŋu (siwo me aɖi le) nono.
• Aklã me dɔdzẽ alo aklã me dɔdzẽ.
• Ʋu si yia aklã me dzi ɖe kpɔtɔ (Liver Ischemia) (esia ate ŋu ana aklã ƒe lãkusiwo naku).

Tsɔ kpe ɖe eŋu la, nɔnɔme siwo medo ƒome kple aklã tẽ o hã ate ŋu ana AST ƒe agbɔsɔsɔ nadzi ɖe edzi:

• Iron ƒe ƒoƒo ɖe ŋutilã me fũ akpa (Hemochromatosis) (esia gblẽa nu le dzi, aklã, kple dɔgbo ŋu).
• Dzidɔ (Dzitodzito me Dɔléle).
• Mononucleosis nye dzoxɔxɔ.
• Lãmetsiwo ƒe dɔlélewo.
• Dɔdzẽ si le dɔgboa me (Pancreatitis).

Tsɔ kpe ɖe nusiawo ŋu la, AST ƒe agbɔsɔsɔ hã ate ŋu adzi ɖe edzi hena ɣeyiɣi aɖe le nudzɔdzɔwo abe:

• Dzobibi goglowo.
• Ʋuʋudedi.
• Amekoko alo dɔdamɔnu siwo ku ɖe dzi ŋu.
• Amekoko.
• Kamedede sesẽ.
• Ne èfɔ fu.

Nu vevitɔe nye be AST ƒe agbɔsɔsɔ si dzi ɖe edzi mefia kokoko be dɔléle sesẽ aɖe le ŋuwò o. Nu bubu geɖewo ate ŋu akpɔ ŋusẽ ɖe esia dzi. Wò ɖɔkta alé ŋku ɖe ʋudodokpɔ bubuwo, wò atikewɔwɔ ŋutinya, kple nu bubu ɖesiaɖe ŋu atsɔ aƒo nya ta.

Ðe wòle be matsi dzi ne nye AST ƒe dodokpɔa sɔ gbɔa?

Ne wò AST ƒe agbɔsɔsɔ sɔ gbɔ wu agbɔsɔsɔ si sɔ si wona le wò AST dodokpɔ ƒe nyatakaka me la, mefia kokoko be dɔléle aɖe le ŋuwò si hiã be woawɔ atike nɛ o. Ame aɖe si ƒe aklã le lãmesẽ me eye wòwɔa dɔ nyuie gɔ̃ hã ate ŋu akpɔ AST ƒe agbɔsɔsɔ si to vovo na esi sɔ. Esia ate ŋu atso susu geɖe ta, le kpɔɖeŋu me:

• wò ƒexɔxɔ.
• Wò nyɔnunyenye/ŋutsunyenye.
• Wò duɖimekeke.
• Wò nuɖuɖu.
• Kamedede.
• Atike siwo gblẽa nu le AST ƒe agbɔsɔsɔ ŋu nono.
• Èfɔ fu.

Wò ɖɔkta abu nu siawo katã ŋu, tsɔ kpe ɖe wò ʋudodokpɔ me tsonu bubuwo ŋu, eye wòatso nya me nenye be ehiã be woadoe kpɔ ake.

Ne nye AST ƒe dodokpɔ me tsonu mesɔ o la, ɖe wòahiã be wogadoe kpɔ akea?

Ẽ, ne wò AST ƒe agbɔsɔsɔ mesɔ o la, wò ɖɔkta ate ŋu aɖe gbe be woagawɔ dodokpɔ ʋɛ aɖewo kpee. Dodokpɔ siawo dometɔ aɖewoe nye:

• Gbugbɔ do ʋu si nye AST kpɔ.
• Ʋudodokpɔ bubuwo (e.g. ALT, Bilirubin).
• Nɔnɔmetatawo dodokpɔ (e.g. Ultrasound scan).
• Biopsy ƒe dɔwɔwɔ.

Ɣekaɣie wòle be maƒo ka na ɖɔktaa?

• Ne aklã ƒe gbegblẽ ƒe dzesiwo le ŋuwò (e.g. jaundice, dɔgbo ƒe vevesese) la, yɔ wò ɖɔkta enumake.
• Ne ènya xoxo be aklãdɔ le ye ŋu la, gblɔe na wò ɖɔkta ne dzesi yeyewo alo esiwo ɖea fu na wò va dze ŋuwò.
• Ne nya aɖe le asiwò ku ɖe wò AST ƒe dodokpɔ me tsonu ŋu la, mègavɔ̃ be yeabia wò ɖɔkta o.

Nu vevitɔ kekeake si wòle be wòanɔ susu me na wò (Take-Home Message) .

Enye nusi sɔ be nàtsi dzi vie ne èkpɔ asixɔxɔ si mesɔ o le ʋudodokpɔ ŋuti nyatakaka aɖe me. Gake ɖo ŋku edzi be esi wò AST ƒe agbɔsɔsɔ dzi ɖe edzi ta la, mefia be dɔléle aɖe le ŋuwò alo nèhiã atikewɔwɔ o. Nu geɖe ate ŋu akpɔ ŋusẽ ɖe AST ƒe agbɔsɔsɔ dzi. Ame siwo le lãmesẽ me abe ɖeka le 20 ɖesiaɖe me ate ŋu akpɔ emetsonu siwo to vovo na esiwo sɔ.

Wò ɖɔkta atso nya me nenye be ahiã be nàgawɔ dodokpɔ bubuwo atsɔ adi nusi gbɔ asixɔxɔ sia si mesɔ o tso alo mehiã o. Eyata, mègavɔ̃ be yeaƒo nu tso nya sia ŋu na wò ɖɔkta o. Wole afima be yewoakpe ɖe ŋuwò. See?

` AST, aklã, enzymes, ʋudodokpɔ, SGOT, aklãdɔ, lãmesẽ dodokpɔ