Mina míasrɔ̃ nu tso Anterior Pituitary Gland (Adenohypophysis) ŋu ko: si nye dziɖula sue si le míaƒe ahɔhɔ̃ me!

Èbu dɔ agbɔsɔsɔme si míaƒe ŋutilã ƒe akpa sue aɖe wɔna ŋu kpɔa? Teƒe wɔnuku mawo dometɔ ɖekae nye anterior pituitary gland si ŋu míele nu ƒom tsoe egbea. Ame aɖewo hã yɔnɛ be ``Adenohypophysis``. Abe saŋkuƒoha ƒe kplɔla ene la, lãkusi sia ƒe dɔe nye be wòawɔ lãmetsi siwo kpɔa ŋusẽ ɖe ŋutilãa ƒe dɔ vevitɔwo dometɔ geɖe dzi eye wòɖea wo ɖa.

Eyata nukae nye ŋgɔgbe lãkusi sia?

Kpuie ko la, esiae nye wò lãkusi ƒe ŋgɔgbekpa. Pituitary gland nye lãkusi sue aɖe si lolo abe pea ene, si le wò ahɔhɔ̃ ƒe gɔme, le hypothalamus te tututu. Esia nye wò lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe akpa aɖe. Eyae nye akpa si kpɔa lãkusi vovovo siwo le ŋutilãa me ƒe dɔwɔwɔ dzi.

Tsɔe be akpa eve le wò lãkusi me: ŋgɔgbe lãkusi (emae nye ŋgɔgbe lãkusi si ŋu míele nu ƒom tsoe egbea) kple megbe lãkusi. Anterior lobe siae wɔa lãmetsiŋusẽ siwo ade ade (6) eye wòɖea wo ɖe go yia ŋutilãa me. Lãmetsiŋusẽ siawoe nye nusiwo míaƒe ŋutilã:

• Tsitsi (míetsina) .
• Metabolism (ŋutilã ƒe ŋusẽ wɔwɔ, nuwo ƒe dzobibi) .
• Vidzidzi (ŋutete be woadzi vi) .
• Nuteɖeamedzi ƒe ŋuɖoɖo
• No nana (na vidadawo) .

Wokpɔa ŋusẽ ɖe nu vevi geɖewo dzi. Togbɔ be ele sue hã la, vovo mele eŋu o eye ŋusẽ le eŋu ŋutɔ!

Eyata nukawoe nye lãmetsiŋusẽ tɔxɛ siwo ŋgɔgbe lãkusia wɔ?

Lãmetsiŋusẽ vevi ade ye nye dɔmemegã sue sia. Na míalé ŋku ɖe nusiwo wonye kple nusi wowɔna ŋu.

1. Adrenocorticotropic Hormone (ACTH): Esiae ʋãa wò adrenal glands be woawɔ cortisol, si woyɔna hã be "stress hormone," kple lãmetsi bubuwo. Esia le vevie ŋutɔ le ɣeyiɣi kpatawo me, abe ne èle vɔvɔ̃m ene.

2. Follicle-stimulating hormone (FSH): Le ŋutsuwo gome la, eʋãa vidzidɔwo be woawɔ tsinyenye. Le nyɔnuwo gome la, eʋãa azigolowo be woatsi, adzra wo ɖo ɖe azigolo ŋu, eye wòwɔa lãmetsi si nye estrogen.

3. Luteinizing Hormone (LH): Ne nyɔnue nènye la, LH doa ŋusẽ azigolowo be woawɔ progesterone. Ne ŋutsue nènye la, eʋãa ame be wòawɔ testosterone.

4. Amegbetɔ ƒe Tsitsi ƒe Lãmetsiŋusẽ (HGH): Esia le vevie na ɖevi suewo ƒe tsitsi. Ekpena ɖe wo ŋu wotsina eye lãmekawo nɔa wo ŋu. Le ame tsitsiwo gome la, ekpena ɖe ame ŋu be lãmekawo kple ƒuwo nanɔ lãmesẽ me, eye wòkpɔa ŋusẽ ɖe alesi wodzraa ŋutilã me ami ɖoe dzi.

5. Prolactin ƒe atike:Lãmetsi sia doa ŋusẽ notsi wɔwɔ ne vidada dzi vi vɔ. Ate ŋu akpɔ ŋusẽ ɖe dzinukpɔkpɔ, vidzidzi (vidzidzi ƒe ŋutete), kple gbɔdɔdɔ ƒe dɔwɔwɔ hã dzi.

6. Lãmetsiŋusẽ si doa ŋusẽ lãkusi (TSH): Esiae gblɔna na wò lãkusi be wòawɔ eya ŋutɔ ƒe lãmetsiwo ahaɖe wo ɖa. Thyroid lãmetsiwo le vevie ŋutɔ be míaƒe ŋutilã ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ nayi edzi.

Èkpɔa, aleke gbegbe woate ŋu awɔ dɔ vovovo geɖe le teƒe sue siae nye si!

Aleke ŋgɔgbe lãkusi wɔa dɔ kple ŋutinu bubuwoe?

Wò ŋgɔgbe lãkusi do ƒome kple wò ahɔhɔ̃ ƒe akpa aɖe si woyɔna be hypothalamus tẽ. Hypothalamus ɖea "lãmetsiŋusẽ siwo ɖea asi le" kple "lãmetsiŋusẽ siwo xea mɔ na" abe somatostatin kple dopamine ene ɖe ʋuka me to pituitary duct (akpa sue aɖe si le abe mɔ̃ ene si doa ka kple ahɔhɔ̃ kple pituitary gland) me. Lãmetsiŋusẽ siawo siwo ɖea asi le lãme na ame la doa ŋusẽ lãmetsi siwo le ŋgɔgbe lãkusia me alo xea mɔ na wo. Hypothalamus kple anterior pituitary gland le abe ame eve siwo le nu ƒom na wo nɔewo ɣesiaɣi hele nyatakakawo ɖɔlim ene.

Ne lãmetsiŋusẽwo do le ŋgɔgbe lãkusi me vɔ la, wowɔa nu kple ŋutinu, lãkusi, kple lãkusi bubu geɖe siwo le míaƒe ŋutilã me eye wokpɔa ŋusẽ ɖe wo dzi. Le kpɔɖeŋu me:

• Míaƒe ƒuwo, lãmekawo, kple míaƒe ememe ŋutinu bubuwo
• Adrenal Glands ƒe Ʋuʋudediwo
• Thyroid Gland (Ŋutilã ƒe Ʋuka).
• Azigolowo kple vidzidɔ (si nye vidzidzi ƒe lãkusiwo) .
• No me lãkusiwo (nu siwo naa notsi) .

Afika tututue ŋgɔgbe lãkusi sia le?

Abe alesi míegblɔe va yi ene la, wò lãkusi le wò ahɔhɔ̃ ƒe gɔme, le wò ŋɔti ƒe tɔdzisasrã megbe, le ``Hypothalamus.`` te tututu.Ele xɔ sue aɖe, alo kotoku me, le ƒu aɖe si le wò tagbɔ si woyɔna be sphenoid bone me. Ðɔktawo yɔa esia be ``Sella Turcica.``

Wò lãkusi ƒe lãkusi eve siwo do ƒome kple wo nɔewo. Aɖuɖɔtoe si le ŋgɔgbe la le ŋgɔgbe, eye wòdze ŋgɔ wò ta ƒe ŋgɔgbe. Aɖuɖɔtoe si le megbe la le megbe. Gake nukutɔe la, lãkusi si le ŋgɔgbe la lolo wu esi le megbe. Pituitary gland bliboa ƒe kpekpeme ƒe 80% lɔƒo le ŋgɔgbekpa sia me.

Kuxi kawoe ate ŋu ado mo ɖa le ŋgɔgbe lãkusi ŋu?

Esi lãmetsi sia wɔa lãmetsi vevi geɖewo ta la, kuxi ɖesiaɖe si le eŋu ate ŋu ahe lãmesẽkuxi vovovowo vɛ. Zi geɖe la, woate ŋu ama kuxi siawo ɖe hatsotso eve me:

1. Hypopituitarism: Esia fia be lãmetsiŋusẽ ʋɛ aɖewo koe nɔa lãkusia me wu alesi wòhiã.

2. Tagbɔdɔléle si gbɔ eme:Ema fia be lãkusia le lãmetsiŋusẽ geɖe wɔm wu alesi wòhiã.

Susu vevi geɖewo li siwo tae nɔnɔme eve siawo dzɔna zi geɖe ɖo:

• Pituitary gland tumors (adenomas): Zi geɖe la, esiawo nyea dɔdzẽ siwo menye kansa o (siwo me dɔlékui aɖeke mele o).
• Nusiwo gblẽ le ŋgɔgbe lãkusi, hypothalamus, alo pituitary duct ŋu: Esia ate ŋu atso afɔku, dɔlékui, alo ʋu ƒe dodo me (e.g., pituitary apoplexy).
• Domenyiŋusẽfianu ƒe nɔnɔmewo: Le kpɔɖeŋu me, nɔnɔmewo abe `(Multiple Endocrine Neoplasia - MEN)`.

Nɔnɔme aɖewo siwo `Hypopituitarism` (lãmetsiŋusẽ ƒe anyimanɔmanɔ) hena vɛ:

Lãmetsiŋusẽ ɖeka alo esi wu nenema ƒe anyimanɔmanɔ ate ŋu ahe nɔnɔmewo abe:

• Adrenal ƒe dɔmawɔmawɔ nyuie evelia: Adrenal gland ƒe dɔmawɔmawɔ nyuie le ACTH lãmetsi si dzi ɖe kpɔtɔ ta.
• Tsitsi ƒe Lãmetsiŋusẽ ƒe Dɔmawɔmawɔ (GHD): Lãmetsiŋusẽ si nye HGH ƒe agbɔsɔsɔ dzi ɖena kpɔtɔna. Kpuie ko la, tsitsi ate ŋu atɔ te.
• Central hypogonadism: Gbɔdɔdɔ ƒe lãmetsiwo ƒe wɔwɔme dzi ɖe kpɔtɔ tso vidzidzi ƒe lãkusiwo (azigolo alo vidzidɔ) me le FSH kple/alo LH ƒe agbɔsɔsɔ si dzi ɖe kpɔtɔ ta.
• Central hypothyroidism: Tagbɔdɔléle si tso TSH lãmetsiŋusẽ si dzi ɖe kpɔtɔ ta.

Nɔnɔme aɖewo siwo `Hyperpituitarism` (lãmetsiŋusẽ ƒe agbɔsɔsɔ si dzi ɖe edzi) hena vɛ:

Lãmetsiŋusẽ ɖeka alo esi wu nenema ƒe dzidziɖedzi ate ŋu ahe nɔnɔmewo abe:

• Acromegaly: Nɔnɔme si mebɔ o si HGH si sɔ gbɔ ɖe ame tsitsiwo me hena vɛ. Le nɔnɔme sia me la, ƒuwo kple lãkusiwo tsina le mɔ si mesɔ o nu.
• Gigantism: Ðevi alo sɔhɛ tsitsi si ƒe kɔkɔme mesɔ o si ƒe lãmetsi si nye HGH sɔ gbɔ akpa. Esia hã mebɔ kura o.
• Cushing ƒe dɔléle: Lãmetsiŋusẽ si nye ACTH ƒe wɔwɔ fũ akpa nana adrenal glands wɔa cortisol si sɔ gbɔ akpa. Esia nye dɔléle ƒomevi aɖe si woyɔna be Cushing ƒe dɔléle.
• Hyperprolactinemia: Lãmetsiŋusẽ si nye prolactin ƒe wɔwɔ fũ akpa.
• Central hyperthyroidism: Thyroid gland si wɔa dɔ fũu akpa le TSH ƒe wɔwɔ fũ ta. Esia nye nusi mebɔ kura o si hea ʋumenugbagbeviɣidɔ vɛ.

Mina míasrɔ̃ nu vi aɖe tso Pituitary Adenomas ŋu.

Pituitary adenoma nye dɔdzẽ si dona le wò pituitary gland me. Gake mègatsi dzi o, zi geɖe la, esiawo nyea dɔdzẽ siwo tsina blewu, siwo menye kansa o (siwo me dɔlékui aɖeke mele o).

Gake adenoma siawo ate ŋu axe mɔ na pituitary cells siwo sɔ eye woaxe mɔ na wo be woagawɔ dɔ nyuie o. Esia ateŋu ahe ``Hypopituitarism`` (lãmetsiŋusẽ ƒe dɔwɔwɔ si mebɔ o), vevietɔ ne dɔdzẽa lolo. Ɣeaɖewoɣi la, dɔdzẽ siawo ateŋu awɔ lãmetsiŋusẽ bubuwo hã, si ateŋu ahe ``Hyperpituitarism`` (lãmetsiŋusẽ ƒe dzidziɖedzi) vɛ.

Anterior pituitary adenomas ƒomevi geɖe li siwo wɔa lãmetsiŋusẽ (siwo wɔa dɔ):

• Prolactinoma: Ewɔa prolactin lãmetsi si sɔ gbɔ akpa. Esiae nye pituitary adenoma ƒomevi si bɔ wu.
• Somatotroph adenoma: Ewɔa tsitsi ƒe lãmetsi (GH) si sɔ gbɔ akpa.
• Corticotroph adenoma: Enaa ACTH lãmetsi si sɔ gbɔ wu.
• Thyrotroph adenoma: Enaa TSH lãmetsi si sɔ gbɔ akpa.
• Gonadotroph adenoma: Ewɔa LH kple FSH lãmetsi siwo sɔ gbɔ wu.

Ðe dodokpɔ aɖewo li siwo ate ŋu akpɔe ɖa be nye ŋgɔgbe lãkusi le lãmesẽ mea?

Ẽ, ne kuxi aɖe ƒe dzesiwo le ŋuwò le ŋgɔgbe lãkusi ŋu la, anɔ eme be wò ɖɔkta aɖe gbe be woalé ŋku ɖe lãmetsiŋusẽ ƒe agbɔsɔsɔ ŋu. Zi geɖe la, esiawo nyea ʋudodokpɔwo .

Ne wò ʋudodokpɔ me tsonu ɖe ​​nane si mebɔ o fia la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò abe MRI scan ene be woatsɔ alé ŋku ɖe wò ʋuka si me ʋu sina tona ŋu.

Eyata nukae míate ŋu awɔ be ŋgɔgbe lãkusi sia nanɔ lãmesẽ me?

Ne míagblɔe tututu la, màte ŋu axe mɔ ɖe pituitary gland ƒe kuxi siawo nu ɣesiaɣi o. Gake nu vevi ɖeka si nàte ŋu awɔe nye be nàlé be na wò ta. Ta ƒe abixɔxɔ, vevietɔ ahɔhɔ̃ me abi si gblẽa nu le ame ŋu (TBI) ate ŋu agblẽ nu le wò lãkusi si me ʋu sina tona ŋu. Ne edzɔ alea la, ate ŋu awɔ lãmetsiŋusẽ geɖe akpa alo ʋɛ akpa.

Nu siwo nàte ŋu awɔ atsɔ axe mɔ ɖe ta kple ahɔhɔ̃ ƒe abixɔxɔ nu dometɔ aɖewoe nye esi:

• Do zikpuimeka ɣesiaɣi ne èle ʋu me.
• Ʋukuku nyuie.
• Do gakuku ne èle gasɔ, dzokeke, alo kamedefefe siwo gblẽa nu le ame ŋu vevie wɔm.
• Ðe afɔ aɖewo be nàxe mɔ ɖe anyidzedze nu, vevietɔ ne èle afɔku gã aɖe me be nàdze anyi. Àte ŋu awɔ nuwo abe mɔxenuwo ɖeɖeɖa le wò aƒe me, azɔlizɔzɔ ƒe kpekpeɖeŋunu zazã, kple ŋkuléle ɖe nu ŋu nyuie ene.
• Ne ɖevi suewo le asiwò la, na woƒe fefewɔƒewo nanɔ dedie.

Ðo ŋku edzi be: Wò ŋgɔgbe lãkusi nye ŋutinu sue aɖe, gake ŋusẽ le eŋu, eye wòle vevie, si wɔa lãmetsiŋusẽ vovovo siwo kpɔa ŋusẽ ɖe míaƒe lãmesẽ ƒe akpa geɖe dzi.

Mlɔeba la, nu siwo dzi wòle be woaɖo ŋkui

Eyata, àte ŋu akpɔ alesi gbegbe ŋgɔgbe lãkusi sia le vevie le míaƒe ŋutilã me. Le ema ta la, ate ŋu asesẽ vie ɣeaɖewoɣi be woanya nenye be dzesi aɖewo tso kuxi aɖe si le lãkusi sia ŋu alo nu bubu aɖe gbɔ.

Nu vevitɔe nye be ne dzesi yeye aɖewo siwo mebɔ o va dze ŋuwò, alo ne ètsi dzi ɖe dzesi aɖe si le ŋuwò xoxo ŋu la, kpɔ egbɔ be yeyi ɖɔkta gbɔ eye yeƒo nu tso eŋu.Woate ŋu awɔ dodokpɔ bɔbɔe ʋɛ aɖewo atsɔ akpɔ wò lãmesẽ. Ne kuxi aɖe li la, woate ŋu ade dzesii ahadae kaba.

` Anterior pituitary, adenohypophysis, lãmetsiwo, pituitary gland, ahɔhɔ̃, lãmenugbagbeviwo ƒe dɔwɔwɔ, pituitary dɔlélewo