Ðe gastrin sɔ gbɔ ɖe wò dɔgbo me akpaa? Mina míaƒo nu tso (Hypergastrinemia) ŋu!

Ðe nèsena le ɖokuiwò me zi geɖe be yeƒe dɔgbo me mekɔna o, yeƒe lãme yɔ fũ, alo nuɖuɖumeŋusẽ ƒe kuxi bubuwo le ye ŋua? Ɣeaɖewoɣi la, nusi gbɔ esia tso ate ŋu anye be lãmetsi aɖe si woyɔna be `(Gastrin)` si wowɔna le wò ŋutilã me ƒe agbɔsɔsɔ sɔ gbɔ wu esi sɔ. Egbea, míaƒo nu tso nɔnɔme sia si woyɔna be `(Hypergastrinemia)` ŋu tsitotsito eye wòanɔ bɔbɔe ŋutɔ.

Nukae nye `(Hypergastrinemia)`? Mina míase egɔme pɛpɛpɛ!

Kpuie ko la, `(Hypergastrinemia)` fia be `(Gastrin)`, si nye lãmetsi si kpena ɖe míaƒe ŋutilã ŋu wòɖua nuɖuɖu, ƒe agbɔsɔsɔ sɔ gbɔ wu alesi wòhiã. Lãmenugbagbevi tɔxɛ aɖe si le dɔgboa ƒe gli si le míaƒe dɔgbo ƒe akpa si le anyime, si nye dɔgbo suea gbɔ, ye wɔa `(Gastrin)` lãmetsi sia. Míeyɔa esia be `(G lãmenugbagbeviwo)`.

Azɔ kpɔ ɖa, `(Gastrin)` lãmetsi siae gblɔna na míaƒe dɔgbo be, "Enyo, azɔ ɖe acid ɖa." Dɔgbo me acid sia, si nye `(gastric acid) le vevie na mí ŋutɔ. Elabena, dɔgbo me acid sia kpena ɖe mía ŋu míeɖua nuɖuɖu si míeɖuna eye míexɔa nunyiame siwo le nuɖuɖu ma me, le kpɔɖeŋu me `(amino acids)` kple proteins.

Ke hã, nusi ateŋu adzɔ ɖe `(Hypergastrinemia)` dzi la sesẽ vie wu. Ɣeaɖewoɣi la, ate ŋu ana dɔgbo me acid sɔ gbɔ akpa (`hyperchlorhydria`), eye ɣebubuɣiwo la, ate ŋu ana dɔgbo me acid (`hypochlorhydria`) nasɔ gbɔ akpa. Eyata alesi `(Hypergastrinemia)` akpɔ ŋusẽ ɖe dziwòe nɔ te ɖe atikewɔwɔ ƒe nɔnɔme bubu siwo le ŋuwò, amekoko siwo nèwɔ, kple atike siwo nèzãna dzi.

Amekawoe ate ŋu axɔ nɔnɔme sia wu?

Le nyateƒe me la, nɔnɔme sia si woyɔna be ``Hypergastrinemia'' ateŋu adzɔ ɖe amesiame dzi, metsɔ le ƒe alo ŋutsu alo nyɔnu nyenye me o. Eya ta enyo be mí katã míanya esia.

Nukae nye nusiwo gbɔ `(Hypergastrinemia)` tsona?

Nu geɖewo ateŋu ahe nɔnɔme sia vɛ, siwo dometɔ aɖewoe nye ``Hypergastrinemia.'' Nusiwo gbɔ wòtsona dometɔ aɖewo ɖea dɔgbo me acid ƒe wɔwɔ dzi kpɔtɔna, eye bubuwo dzia dɔgbo me acid ƒe wɔwɔ ɖe edzi. Na míalé ŋku ɖe eveawo ŋu ɖe vovo.

Nusiwo hea dɔgbo me acid dzi ɖeɖe kpɔtɔ vɛ

Ne ``Hypergastrinemia`` dzɔ la, dɔgbo me acid ƒe wɔwɔme si sɔ ate ŋu aɖe akpɔtɔ le susu siawo ta:

• Atike siwo tsia dzidɔ alo GERD (Gastroesophageal Reflux Disease) nu: Ne èle atike siawo ƒomevi zãm ɣesiaɣi la , ema hã ate ŋu anye nusi gbɔ wòtso.
• Dɔgbo ƒe dɔléle si nɔa anyi didi: Esiae nye esime dɔgboa ƒe gli gbɔdzɔna vivivi eye wòzua abi le ɣeyiɣi aɖe megbe.
• Dɔdzẽ si le dɔgboa me: Esia hã ate ŋu adze edzi.
• `(H. pylori)` dɔlékui: `(Helicobacter pylori)` nye dɔlékui si ateŋu anɔ dɔgboa me. Dɔlékui sia hã nye nusi gbɔ `(Hypergastrinemia).` tsona
• Ayikuwo ƒe dɔmawɔmawɔ nyuie: Nɔnɔme sia ate ŋu adzɔ ne ayikuawo mele dɔ wɔm nyuie o.
• Proton Pɔmpi Mɔxenu (PPI) Zazã:PPI-tikewo (abe omeprazole ene) zazã ɣeyiɣi didi na dɔgbo ƒe dɔléle, acid reflux, nuɖuɖumadzroame, alo dɔgbo ƒe abi ƒe dɔléle hã nye nu vevi aɖe si gbɔ wòtsona.
• Vagotomy: Esia bia be woaɖe vagus nerve ƒe akpa aɖe ɖa. Lãmetsi sia tsoa ahɔhɔ̃a me yia dɔgboa me eye wòtsɔa dzesiwo yia dzi kple nuɖuɖumeŋusẽ. Hypergastrinemia ate ŋu adzɔ le amekoko sia megbe.

Nusiwo hea dɔgbo me acid ƒe dzidziɖedzi vɛ

Azɔ mina míalé ŋku ɖe nusiwo hea dɔgbo me acid ƒe dzidziɖedzi (Hypergastrinemia) vɛ ŋu:

• Antral G-cell hyperplasia (pseudo-Zollinger-Ellison ƒe dɔléle / Ps-ZES): Esia nye nɔnɔme si mebɔ o. Eɖi Zollinger-Ellison ƒe dɔlélea, gake dɔdzẽ siwo naa gastrin mele dɔgboa alo dɔgbo suea ƒe akpa gbãtɔ (duodenum) me o.
• Dɔgbo ƒe dodo: Nɔnɔme sia ate ŋu adzɔ ne mɔ si tso dɔgboa me yi dɔgbo suea me xe. Bu eŋu abe tsi ƒe pɔmpi si xe ene.
• Multiple endocrine neoplasia type-1 (MEN-1): Nɔnɔme sia nana ahɔhɔ̃mekawo ƒe dɔdzẽwo dona le adrenal glands, thyroid glands, alo parathyroid glands me.
• Retained antrum syndrome: Nɔnɔme sia ate ŋu ado mo ɖa ne wogblẽ dɔgboa ƒe akpa si le anyime (antrum) ƒe akpa sue aɖe ɖi le amekoko vɔ megbe be woaɖe dɔdzẽwo ɖa alo ada abiwo.
• Zollinger-Ellison ƒe dɔléle (ZES): Esia nye nɔnɔme si me dɔdzẽwo wɔa lãmetsi si nye gastrin wògbɔa eme. Nɔnɔme sia (ZES) ate ŋu ana dɔgbo naxɔ abi.

Nukae nye nɔnɔme si nye `(Hypergastrinemia)` ƒe dzesiwo?

Ne `(Hypergastrinemia)` le ŋuwò la, àte ŋu akpɔ dzesiwo abe:

• Ƒodo ƒe veve: Àte ŋu ase dɔgbo ƒe veve enuenu.
• Aɖuɖɔtoe si nɔa anyi didi: Aɖuɖɔtoe si nɔa anyi ŋkeke geɖe.
• Dɔdzẽ si le dɔgboa me: Esiawo ate ŋu anye dɔdzẽ alo dɔdzẽ siwo me dɔlékui aɖeke mele o.
• Dɔgbo ƒe abi: Abi siwo dona ne dɔgboa ƒe dɔdzẽ le ame ŋu.
• Nuɖuɖutomedɔléle sesẽ: Dɔdzẽ kple vevesese sesẽ le nuɖuɖutome.

Aleke ɖɔktawo wɔa dea dzesi dɔléle siae?

Be ɖɔktawo nate ŋu anya hypergastrinemia nyuie la, ele be woanya acid agbɔsɔsɔme si le wò dɔgboa me. Wodzidzea gastrin ƒe agbɔsɔsɔ si le wò ʋu me hã.

• Hafi dodokpɔ sia nadze egɔme la, wò ɖɔkta agblɔ na wò be nàtsi nu adɔ (mègaɖu nu o) hena ɣeyiɣi aɖe .
• Azɔ hã, ne ènye ``(PPI)`` zãla la, .Ele be nàdzudzɔ atike ma nono abe kwasiɖa ɖeka ene do ŋgɔ na dodokpɔa.
• Emegbe, woɖea wò ʋu eye wokpɔa wò Gastrin ƒe agbɔsɔsɔ. Ɣeaɖewoɣi la, woate ŋu axɔ ʋu siawo zi geɖe gbesiagbe, le ŋkeke geɖe me, be woakpɔe ɖa be wò Gastrin ƒe agbɔsɔsɔ trɔ hã.

Ne wò ɖɔkta susui be hypergastrinemia la, ate ŋu aɖe gbe be woawɔ dodokpɔ bubuwo atsɔ aɖe dɔléle bubuwo ɖa. Esiawo dometɔ aɖewoe nye:

• Secretin stimulation test: Esia bia be woana lãmetsi aɖe si woyɔna be secretin, si wò dɔgbo sue (duodenum) ƒe akpa gbãtɔ wɔna la dodo na wò. Ne wò gastrin ƒe agbɔsɔsɔ dzi ɖe edzi ŋutɔ zi ɖeka la, ate ŋu anye Zollinger-Ellison ƒe dɔlélea ƒe dzesi.
• Dɔgbo ƒe pH dodokpɔ: Esia léa ŋku ɖe acid ƒe agbɔsɔsɔ si le wò dɔgbo me ŋu. Ne pH mede 2 o la, ate ŋu anye Zollinger-Ellison ƒe dɔlélea ƒe dzesi hã.

Aleke wodaa Hypergastrinemia?

Atikewɔwɔ na hypergastrinemia nɔ te ɖe nusi gbɔ wòtso dzi.

• Dɔgbo me kansa, nuɖuɖutome ƒe xexe, ayikudɔ, kple nɔnɔmewo abe `(MEN-1)` kple `(ZES)`: Ne woda nɔnɔme siawo (zi geɖe to amekoko me) la, `(Hypergastrinemia)` ƒe dzesiwo hã nu yina.
• Atrophic gastritis (ACG) kple H. pylori dɔlékui: Woate ŋu atsɔ dɔlékuiwutikewo ada nɔnɔme siawo.
• Proton-pump inhibitors (PPIs): Ne èle PPI nom la, zi geɖe la, hypergastrinemia la nu ayi le ŋkeke atɔ̃ va ɖo adre me le atikeawo zazã vɔ megbe.
• Retained antrum syndrome: Ne woɖe antral tissue si susɔ le dɔgboa ƒe akpa si le ete la ɖa la, ate ŋu aɖe dɔgboa me acid si sɔ gbɔ wu si dona la dzi akpɔtɔ.

Nu vevitɔ kekeakee nye be nàƒo nu kple wò ɖɔkta tso atike nyuitɔ kekeake si nàzã na wò nɔnɔmea ŋu.

Ðe mate ŋu aɖe afɔku si le `(Hypergastrinemia)` me dzi akpɔtɔa?

Ne ènye atike siwo wua acid alo PPI zãla ɣeyiɣi didi aɖe la, afɔku li be nàxɔ hypergastrinemia. Eyata ele vevie be nàƒo nu kple wò ɖɔkta tso alesi nàwɔ akpɔ afɔku sia gbɔe ŋu.

Ne `(Hypergastrinemia)` le ŋunye la, nukae mate ŋu akpɔ mɔ na? Nukae dzɔna ne womewɔ atike nɛ o?

Ne womeda hypergastrinemia nyuie o la, gastrin ƒe agbɔsɔsɔ si le ŋutilãa me gakpɔtɔ sɔ gbɔ. Numekulawo susui be esia ate ŋu ana kansa lãmenugbagbeviwo natsi. Le kpɔɖeŋu me:

• Ʋu me kansa: abe ʋumenugbagbeviɣidɔ, ʋumenugbagbeviɣidɔ, kple ʋumenugbagbeviɣidɔ ene.
• Nuɖuɖutome kansa
• Dɔdzẽ si le dɔgboa me

Azɔ hã, ɣeyiɣi didi ƒe `(Hypergastrinemia)` ateŋu ahe dɔgbo me dɔdzẽ `(gastric carcinoids)` alo `gastric adenocarcinoma` vɛ. `(gastric carcinoids)` ƒomevi eve li:

• Dɔgbo me dɔdzẽ ƒomevi I: Esiawo do ƒome kple nɔnɔme si nye chronic atrophic gastritis.
• Nyɔnuwo mee wòdzɔna wu.
• Woate ŋu akpɔe le teƒe geɖe le dɔgboa me.
• Mɔnukpɔkpɔ si li be kansa nadze ame dzi la le sue.
• Dɔgbo me dɔdzẽ ƒomevi II: Esiawo do ƒome kple nɔnɔme siwo nye ZES kple MEN-1.
• Ate ŋu adzɔ le ŋutsuwo kple nyɔnuwo siaa me.
• Woate ŋu akpɔe le teƒe geɖe le dɔgboa me.
• Ɣeaɖewoɣi la, ate ŋu atrɔ azu kansa (le 7% va ɖo 12%).

Nukae nye mɔkpɔkpɔ na amesi ŋu `(Hypergastrinemia)` le?

Ame si ŋu ``Hypergastrinemia`` le ƒe lãmesẽ ƒe nɔnɔme le etsɔme nɔ te ɖe nu geɖe dzi:

• Nusi gbɔ dɔlélea tso.
• Domenyiŋusẽfianu.
• Lãmesẽ ŋutinya.
• Agbenɔnɔ ƒe nɔnɔme.

Ke hã, ne wowɔ atike na ame nyuie la, amesiwo ŋu ``Hypergastrinemia'' le ateŋu anɔ agbe si le dɔ dzi, si sɔ.

`(Hypergastrinemia)` le ŋunye, aleke mawɔ akpɔ ɖokuinye dzi?

Ne èle atike siwo wua acid alo PPI nom ɣeyiɣi didi aɖe la, ele vevie be nàdo wò kpɔ edziedzi. Kpɔ wò ɖɔkta gbɔ hena aɖaŋuɖoɖo.

Ɣekaɣie wòle be makpɔ ɖɔkta?

Ne èkpɔ dzesi yeye siawo dometɔ aɖe, alo ne èse le ɖokuiwò me be yeƒe dzesi siwo li xoxo la le sesẽm ɖe edzi la, kpɔ egbɔ be yeyi ɖɔkta gbɔ eye woado ye kpɔ bliboe.

Nusiwo dzi wòle be woaɖo ŋkui kpuie

Enyo, ekema mina míaɖo ŋku nusi ŋu míeƒo nu tsoe dzi ko:

• Hypergastrinemia nye lãmetsi si nye gastrin ƒe dzidziɖedzi le ŋutilãa me.
• Lãmetsi sia (Gastrin) kpɔa ŋusẽ ɖe acid ƒe agbɔsɔsɔ si le dɔgboa me dzi (acid ate ŋu adzi ɖe edzi alo aɖiɖi).
• Susu geɖewo ateŋu anɔ anyi – nuwo abe `(PPI)`/antacids zazã atraɖii, `(H. pylori)` dɔlékui, dɔgbo ƒe dɔléle, `(Zollinger-Ellison ƒe dɔléle)`.
• Ðɔktawo dea dzesi esia to ``Gastrin'' ƒe agbɔsɔsɔ dodokpɔ me.
• Wotu atikewɔwɔ ɖe nusi gbɔ wòtso dzi.
• Mègaŋe aɖaba ƒu dzesiawo dzi o, elabena woate ŋu ava zu dɔdzẽ kple kansa ne womeda wo o! Di atikewɔlawo ƒe aɖaŋuɖoɖo enumake.

Mele mɔ kpɔm be nyatakaka sia aɖe vi na wò. Nɔ lãmesẽ me!

` Dɔgbo ƒe ʋusɔgbɔdɔ, Gastrin, Dɔgbo me acid, Nuɖuɖumeŋusẽ, Zollinger-Ellison ƒe dɔléle, H. pylori, PPI, Dɔgbo ƒe dɔléle, Dɔgbo ƒe dɔdzẽ