Ðe wò ʋumenugbagbeviwo mele wɔwɔm nyuie oa? Mina míasrɔ̃ nu tso Myelodysplastic Syndrome (MDS) ŋu!

Ðe ɖeɖi tea ŋuwò eye ɖeɖi tea ŋuwò ɣesiaɣia? Ðe wòsesẽna na wò ɣeaɖewoɣi be nàgbɔ ya ne èwɔ dɔ vi aɖe gɔ̃ hãa? Alo ɖe nèdea dzesi abi kple ʋu le dodom le wò ŋutilã ƒe akpa sia akpaa? Togbɔ be èsusu be nusiawo nye nusiwo sɔ hã la, ɣeaɖewoɣi la, susu aɖe ate ŋu anɔ megbe na esia si ŋu wòle be nàtsi dzi ɖo vie. Egbea míele nu ƒom tso nɔnɔme mawo dometɔ ɖeka ŋu, si nye myelodysplastic syndrome.

Nukae nye myelodysplastic syndrome (MDS) ƒe dɔléle?

Azɔ mina míakpɔ nusi Myelodysplastic Syndrome (MDS) sia nye ɖa. Ame aɖewo hã yɔnɛ be Myelodysplasia. Nyitsɔ laa la, wogayɔe be Myelodysplastic Neoplasm. Kpuie ko la, enye kansa ƒomevi aɖe . Gake nusi dzɔna le esia me enye be lãmenugbagbevi vevi siwo wɔa ʋu le míaƒe ŋutilã me – míeyɔna wo be (hematopoietic stem cells) – metsina nyuie o, si fia be wometsina nyuie o. Lãmenugbagbevi siawo le míaƒe ƒumeŋuɖui me. Eyata kuxia dzea egɔme ne lãmenugbagbevi vevi siawo metsi nyuie o eye wozu ʋumenugbagbevi dzĩwo, ʋumenugbagbevi ɣiwo, kple ʋumenugbagbevi dzĩ siwo le lãmesẽ me.

Ne ʋumenugbagbevi siwo le lãmesẽ me mesɔ gbɔ na wò ŋutilã o la, àte ŋu adze nɔnɔme sesẽwo abe ʋusɔgbɔdɔ ene vɛ. Àte ŋu axɔ dɔlékuiwo hã zi geɖe eye ʋu nado le ŋuwò zi geɖe. Le ame aɖewo gome la, MDS ate ŋu agblẽ ɖe edzi eye wòava zu kansa si woyɔna be acute myeloid leukemia (AML) .

Nɔnɔme sia si woyɔna be MDS mebɔ kura o . Le United States la, edzea ame abe ene dzi le ame 100,000 ɖesiaɖe me ƒe sia ƒe. Ne wokpɔe be MDS le ŋuwò la, wò ɖɔktawo adze agbagba be yewoaɖe dɔlélea ƒe ŋgɔyiyi dzi akpɔtɔ, yewoaɖu wò dzesiwo dzi, eye yewoada kuxi ɖesiaɖe si ate ŋu ado mo ɖa.

MDS ƒomevi kawoe li?

Ðɔktawo ma MDS ƒe nɔnɔme sia ɖe ƒomevi vovovowo me. Woléa ŋku ɖe dodokpɔ geɖe me tsonu ŋu. Mina míalé ŋku ɖe nusiwo dodokpɔ mawo di ŋu:

• Ʋumenugbagbevi dzĩwo kple ʋumenugbagbevi ɣi siwo le lãmesẽ me kpakple ʋumenugbagbevi dzĩwo ƒe xexlẽme: Ne wò ʋumenugbagbevi dzĩwo mesɔ gbɔ o la, míeyɔnae be ʋusɔgbɔdɔ. Ðewohĩ ɖeɖi te ŋuwò ŋutɔ eye gbɔgbɔtsixe tsi ƒowò.
• Ʋumenugbagbevi siwo metsi o, alo blasts: Ʋuʋudedi siawo le abe ʋumenugbagbevi siwo metsi o ene. Woxɔa teƒe geɖe akpa le ƒumeŋuɖui me, si wɔnɛ be ʋumenugbagbevi siwo le lãmesẽ me ƒe wɔwɔme sesẽna. Ne ʋumenugbagbevi ɣi siwo le lãmesẽ me mesɔ gbɔ na wò o la, àte ŋu axɔ dɔlékuiwo zi geɖe. Eye ne ʋumenugbagbevi dzĩ siwo le lãmesẽ me mesɔ gbɔ na wò o la, ate ŋu asesẽ be nàdzudzɔ ʋudodo.
• Sideroblastwo ƒe ƒuƒoƒo:Esiawo nye ʋumenugbagbevi dzĩ siwo metsi o. Nusi le etɔxɛ le wo ŋue nye be le esi teƒe be woazã iron atsɔ awɔ hemoglobin la, wodzraa iron ɖo. Ènyaa, hemoglobin nye protein si kpena ɖe míaƒe ʋumenugbagbevi dzĩwo ŋu be woatsɔ oxygen ayi ŋutilã bliboa me. Gayibɔ le vevie na esia. Eyata ne dɔléleŋutinunyalawo kpɔ sideroblast siawo la, efia be wò ʋumenugbagbeviɣi mele dɔ wɔm nyuie o.
• Dzɔdzɔmeŋusẽ ƒe dɔmawɔmawɔ nyuie: Dzɔdzɔmenugbagbeviwo nye míaƒe lãmenugbagbeviwo ƒe akpa siwo me domenyiŋusẽfianuwo le. DNA ye wotsɔ wɔa domenyiŋusẽfianuwoe. Ne domenyiŋusẽfianu siawo mesɔ o la, efia be nane kpɔ ŋusẽ ɖe wò DNA dzi eye wòna domenyiŋusẽfianu siwo le wò ʋumenugbagbeviwo me trɔ.

Nukawoe nye myelodysplastic syndrome ƒe dzesiwo?

Ðo ŋku edzi be ɣeaɖewoɣi la, MDS ate ŋu anɔ ŋuwò evɔ màɖe dzesi aɖeke afia o. Le nɔnɔme mawo me la, wokpɔa nɔnɔmea le vo me le ʋudodokpɔ si wowɔna edziedzi me. Dzesi vevitɔ si ame geɖe kpɔnae nye ʋumenugbagbevi dzĩwo ƒe xexlẽme si medea ame dzi o, alo ʋusɔgbɔdɔ. Gake ʋusɔgbɔdɔ ƒe dzesiwo kple MDS ƒe dzesi bubuwo ate ŋu asɔ kple nɔnɔme bubu siwo mesẽ boo o ƒe dzesiwo.

Eyata ne ède dzesi tɔtrɔ siwo le ete dometɔ aɖe, vevietɔ ne womedzo le kwasiɖa ʋɛ aɖewo megbe o la, kpɔ egbɔ be yeyi ɖɔkta gbɔ.

• Ne èse le ɖokuiwò me be yemate ŋu agbɔ ya o (míeyɔa esia be gbɔgbɔtsixetsixe).
• Ne èse le ɖokuiwò me be yegbɔdzɔ alo ɖeɖi te ye ŋu vevie , eye ɖeɖiteameŋua nu metsina le ɖiɖiɖeme geɖe xɔxɔ vɔ megbe gɔ̃ hã o.
• Ne ède dzesii be wò ŋutigbalẽ le ɣie wu alesi wònɔna ɖaa. Ðewohĩ ne ŋutigbalẽ do viviti le ŋuwò la, ɖɔktaa akpɔe ɖa be amadede aɖe bu le wò ŋkume ƒe akpa si le ete, wò nu me, kple wò ŋɔti me hã.
• Ne èxɔ abi alo ʋu le dodom bɔbɔe wu alesi nèwɔnɛ ɖaa.
• Ne ède dzesi teƒe dzĩ suesuesue siwo le fli me le wò ŋutigbalẽ ŋu la, esiawo ate ŋu anye petechiae, ʋuka suesuesue siwo le ŋutigbalẽa te.
• Ne dzoxɔxɔ ƒe dɔlékuiwo xɔa wò zi geɖe la .

Nukae hea MDS vɛ?

Edze abe mɔ vevi eve li siwo dzi woato axɔ MDS ene. Ðekae nye to gomekpɔkpɔ le dɔwɔna aɖewo siwo nana dɔléle sia xɔxɔ ƒe afɔkua dzina ɖe edzi me. Bubue nye to domenyiŋusẽfianu ƒe nɔnɔme aɖewo nyinyi me.

Dɔwɔna siwo woate ŋu atsɔ asɔ kple MDS

• Esi wodo atike alo keklẽŋusẽdɔdamɔnu na wò le kansa aɖe si va yi ta. Ðɔktawo yɔa esia be MDS (tMDS) si do ƒome kple atikewɔwɔ. Zi geɖe la, tMDS ƒe dzesiwo dzena abe ƒe atɔ̃ va ɖo adre ene le atikewɔwɔ vɔ megbe.
• Kansadɔlékui aɖewo, siwo dometɔ aɖewoe nye atamadzudzɔ, nudzodzoeviwutikewo, kple atike siwo wotsɔna tsia kansa nu abe benzene ene, ƒe amedzidzedze.
• Ga kpekpewo abe mercury alo lead ene zazã.

Domenyinu ƒe nɔnɔme siwo ate ŋu ado ƒome kple MDS

Ame siwo ŋu dɔlélea le dometɔ 4% va ɖo 15% nyi domenyiŋusẽfianu ƒe nɔnɔme siwo dzia woƒe dɔlélea xɔxɔ ƒe afɔku ɖe edzi. Nɔnɔme mawo dometɔ aɖewoe nye:

• Fanconi ʋusɔgbɔdɔ: Esia nye domenyiŋusẽfianu ƒe nɔnɔme si mebɔ o si me wò ƒumeŋuɖui mewɔa ʋumenugbagbevi siwo le lãmesẽ me wòsɔ gbɔ o.
• Dyskeratosis congenita: Esia nye domenyiŋusẽfianu ƒe nɔnɔme bubu si mebɔ o. Le afisia hã la, wò ƒumeŋuɖui mewɔa ʋumenugbagbevi siwo le lãmesẽ me wòsɔ gbɔ o.
• Diamond-Blackfan ʋusɔgbɔdɔ: Esia nye ʋumenugbagbeviɣidɔ si mebɔ o si me wò ƒumeŋuɖui mewɔa ʋumenugbagbevi dzĩ siwo sɔ o.

Aleke wokpɔa dɔléle si nye myelodysplastic syndrome?

Ðɔktawo wɔa afɔɖeɖe geɖe tsɔ dea dzesi MDS dɔléle sia:

• Ʋu Xexlẽme Blibo (CBC) kple vovototodedeameme dodokpɔ: Woxɔa ʋu le asiwò eye wodaa wò ʋumenugbagbevi dzĩwo kple ɣiwo kpɔna. Exlẽa ʋumenugbagbevi ɣi ƒomevi ɖesiaɖe ƒe xexlẽme hã.
• Ʋu si wotsɔna ƒoa ʋu le lãme na ame: Esia léa ŋku ɖe tɔtrɔ siwo va le ʋumenugbagbevi siwo le wò ʋu me ƒe lolome, ƒomevi, nɔnɔme, kple lolome ŋu, kpakple ne iron sɔ gbɔ ɖe wò ʋumenugbagbevi dzĩwo me akpa hã.
• Lãmenugbagbeviwo ƒe domenyiŋusẽfianu me dzodzro: Atikewɔwɔ me dɔléleŋutinunyala léa ŋku ɖe ʋu aɖe ŋu le nusuekpɔmɔ̃ me be yeakpɔe ɖa be tɔtrɔ aɖewo va le wò ʋumenugbagbeviɣiwo ƒe domenyiŋusẽfianu me hã.
• Ƒumeŋuɖui ƒe lãmenugbagbeviwo ɖeɖe: Be ɖɔktaa nate ŋu awɔ dodokpɔ sia la, etsɔa aŋe si me do le dea wò akɔtaƒu me, tsɔa ƒumeŋuɖui, ʋu, kple ƒu ƒe kpɔɖeŋu aɖe, eye wòléa ŋku ɖe eŋu le nusuekpɔmɔ̃ me.

Nukawoe nye myelodysplastic syndrome ƒe afɔɖeɖewo?

Ðɔktawo ma nɔnɔmea ɖe akpa vovovowo me le afɔku si le dɔlélea me be wòava zu ʋumenugbagbeviɣidɔ sesẽ (AML) nu. Wozãa afɔkudzidzenu ƒe ɖoɖo aɖe si woyɔna be International Prognostic Scoring System (IPSS) . Nusiwo ŋu ɖɔktawo buna dometɔ aɖewoe nye esi:

• Eɖanye ʋusɔgbɔdɔ, ʋudodo, alo dɔlékuiwo ƒe dzesi aɖewo le ŋuwò o.
• Afɔku le eme be ʋumenugbagbeviɣidɔ nadze dziwò.
• Tɔtrɔ aɖewo le wò domenyiŋusẽfianu me.
• Eɖanye be èxɔ MDS le atikewɔmɔnu alo keklẽŋusẽdɔdamɔnu na wò le kansa ta vɔ megbe o.
• Wò ƒexɔxɔ kple wò lãmesẽ bliboa.

Aleke wodaa myelodysplastic syndrome ƒe dɔléleae?

Ðɔktawo bua nu geɖe ŋu ne wole ɖoɖo wɔm ɖe MDS dada ŋu:

• MDS ƒomevi si le asiwò.
• Eɖanye nɔnɔmewo abe ʋusɔgbɔdɔ, ʋusɔgbɔdɔ, alo dɔlékuiwo le ŋuwò le MDS ta o.
• Eɖanye be èxɔ MDS le atikewɔmɔnu alo keklẽŋusẽdɔdamɔnu na wò le kansa ta vɔ megbe o.
• wò ƒexɔxɔ.
• Wò lãmesẽ bliboa.

Myelodysplastic syndrome dada ate ŋu anye beléle si akpe ɖe ame ŋu kple atikewɔwɔ siwo gblẽa ʋumenugbagbevi siwo mele lãmesẽ me o dome .

Beléle si Kpena Ðe Ame Ŋu

Esia ate ŋu alɔ:

• Ʋudodo alo ʋudodo: Ne ʋusɔgbɔdɔ le ŋuwò la, àte ŋu ado ʋumenugbagbevi dzĩwo. Ne ʋudodo ƒe kuxiwo le ŋuwò la, woate ŋu ado ʋumenugbagbeviɣidɔ na wò.
• Erythropoiesis-stimulating agents (ESA): Atikewɔwɔ sia nana wò ʋumenugbagbevi dzĩ tsitsiwo ƒe agbɔsɔsɔ dzina ɖe edzi.
• Dɔlékuiwutikewo: MDS ate ŋu akpɔ ŋusẽ ɖe wò ʋumenugbagbevi ɣiwo dzi, si ana dɔlékuiwo xɔxɔ ƒe afɔku nadzi ɖe edzi. Eyata woate ŋu ana dɔlékuiwutikewo.

Dɔdamɔnu siwo woatsɔ aɖe ʋumenugbagbevi siwo mele lãmesẽ me o ɖa

Esia ate ŋu alɔ:

• Atikewɔmɔnu: Woate ŋu azã atikewɔmɔnu siwo wozãna na ʋumenugbagbeviɣidɔ sesẽ (AML) la ke na esia.
• Dɔlélenutsiŋutete ƒe dɔdamɔnu: Wozãa atikewɔwɔ sia na MDS ƒomevi sue aɖewo. Dɔdamɔnu sia tea dɔlélenutsiŋutete si wɔa dɔ fũu akpa la ɖe to eye ate ŋu akpe ɖe ame ŋu be ʋudodo ƒe hiahiã dzi naɖe akpɔtɔ.
• Lãmenugbagbeviwo dodo na ame: Esia bia be nàtsɔ lãmenugbagbevi siwo tso gbɔwò alo ame aɖe gbɔ, aɖɔli wò ŋutɔ wò ʋumenugbagbevi siwo wɔa ʋu. Woɖea lãmenugbagbevi siawo tso wò ʋu alo ƒumeŋuɖui me. Wodzraa lãmenugbagbevi siawo ɖo ɖe nufamɔ̃ me esime nèle atikewo zãm, emegbe wotsɔa wo ƒua gbe eye wogatsɔa wo dea wò ŋutilã me to ʋuka me. Emegbe woɖea mɔ na lãmenugbagbevi siawo be woatsi le wò ŋutilã me eye woawɔ ʋumenugbagbevi yeyewo.

Atikewɔwɔ siawo dometɔ ɖesiaɖe ate ŋu agblẽ nu le ame ŋu kple kuxi vovovowo. Ne èle atikewɔwɔ ƒe mɔnuwo ŋu bum la, ele vevie ŋutɔ be nàbia wò ɖɔkta tso mɔnu ɖesiaɖe ƒe nugbegblẽ le ame ŋu kple kuxi siwo dona tso eme ŋu.

Amesiwo ŋu myelodysplasia le ate ŋu akpɔ viɖe tso beléle si naa ame ƒe dziɖeɖi me . Beléle sia ate ŋu akpe ɖe ame ŋu woakpɔ MDS ƒe dzesiwo kple atikewɔwɔ ƒe nugbegblẽ le ame ŋu gbɔ. Eye vevietɔ la, ate ŋu akpe ɖe ŋuwò nàɖu nuteɖeamedzi si le agbenɔnɔ kple dɔléle si nɔa anyi didi alea me dzi.

Ðe woate ŋu ada myelodysplastic ƒe dɔlélea?

Mɔ ɖeka kolia si dzi woato ada MDS keŋkeŋ enye lãmenugbagbeviwo dodo na ame dzidzedzetɔe . Nublanuitɔe la, menye amesiamee ate ŋu awɔ atike sia o. Bia wò ɖɔkta nenye be ʋudodo sia ƒomevi sɔ na wò eye nenye be enye tiatia si ŋu wòle be nàbu.

Nukae nye ame si ŋu myelodysplastic syndrome le ƒe agbenɔƒe?

Myelodysplastic syndrome nye lãmesẽkuxi sesẽ aɖe si ate ŋu ahe nɔnɔme siwo ate ŋu ade ame ƒe agbe afɔku me vɛ.Azɔ hã, esia nye lãmesẽnya si sesẽ ŋutɔ, eye wògblẽa nu le amesiame ŋu le mɔ vovovowo nu. Wò ɖɔktae nye nyatakakatsoƒe nyuitɔ kekeake tso wò ame ɖekaɖekawo ƒe nɔnɔme kple alesi nàgblɔe ɖi ŋu.

Ðe woate ŋu axe mɔ ɖe myelodysplastic syndrome nua?

Ao, gake ne wose afɔku siwo le MDS xɔxɔ me gɔme la, ate ŋu akpe ɖe ɖɔktawo ŋu woakpɔ MDS ahadae kaba. Myelodysplastic syndrome do ƒome kple atikewɔmɔnu kple keklẽŋusẽdɔdamɔnu, kpakple atike aɖewo kple ga kpekpewo zazã. Ƒo nu tso wò atikewɔwɔ ŋutinya kple atikewo kple ga kpekpewo zazã kplikplikpli, ɣeyiɣi didi ɖesiaɖe ŋu na wò ɖɔkta. Woate ŋu akpe ɖe ŋuwò nàda wò ŋutɔ wò afɔkua kpɔ.

Aleke malé be na ɖokuinye?

MDS gblẽa nu le amesiame ŋu le mɔ vovovowo nu. MDS le ame aɖewo ŋu gake dzesi aɖeke mele wo ŋu o. Ne aleae wòle na wò la, wò ɖɔkta ate ŋu aɖo aɖaŋu be nàdo ʋu kpɔ ɣleti etɔ̃ ɖesiaɖe be nàlé ŋku ɖe tɔtrɔ siwo va le wò ʋumenugbagbevi dzĩwo me ŋu. Ne MDS le ŋuwò eye wole beléle si akpe ɖe ŋuwò, abe ʋudodo ene, xɔm la, ate ŋu ahiã be nàzã atike bubuwo atsɔ aɖe ʋudodo zi gbɔ zi geɖe dzi akpɔtɔ. Afɔɖeɖe aɖewo siwo nàte ŋu aɖe atsɔ ado alɔ wò atikewɔwɔe nye esi:

• Ne èzãa atamanuwo (siwo dometɔ aɖewoe nye atamanono kple vaping) la, dze agbagba nàdzudzɔ. Bia wò ɖɔkta tso atamanono dzi ɖeɖe kpɔtɔ ƒe ɖoɖowo ŋu.
• Lé kpekpeme si sɔ na ɖokuiwò.
• Di kamedede siwo doa dzidzɔ na wò eye nàwɔ wo zi geɖe alesi nàte ŋui.
• Ðo ŋku edzi be MDS nye dɔléle si nɔa anyi didi, eye ɖɔktawo ate ŋu adae gake womate ŋu adae o. Menye amesiame ase nusi me tom nèle gɔme o. Nuƒoƒo na ame bubu siwo to nɔnɔme mawo ke me abe wò ene ate ŋu akpe ɖe ŋuwò. Wò atikewɔlawo ƒe ƒuƒoƒo ate ŋu akpe ɖe ŋuwò nàkpɔ ɖoɖowo kple dɔwɔnu siwo le abe esiawo ene.

Togbɔ be MDS nye dɔléle si nɔa anyi didi hã la, mefia be ele be nànɔ agbe mɔkpɔkpɔ manɔmee o. Atikewɔwɔ aɖewo li siwo ate ŋu akpe ɖe ame ŋu wòaɖu nɔnɔmea dzi.

Ɣekaɣie wòle be mayi xɔ si me wowɔa dɔ kpata le?

Myelodysplastic syndrome ate ŋu ahe ʋusɔgbɔdɔ, ʋu ƒe dodo ƒe kuxiwo, kple dɔlékuiwo vɛ. Ele be nàyi xɔ si me wowɔa dɔ kpata le godoo ne:

• Ne dzoxɔxɔ si nye Celsius degree 38.3 (Fahrenheit 100.4) alo esi wu nenema le ŋuwò la, asrã nye dzesi be dɔlékui aɖe ate ŋu anɔ ŋuwò.
• Ne ʋu le dodom le ŋuwò le mɔ si dzi màte ŋu aɖu o nu.

Nya kawoe wòle be mabia nye ɖɔkta?

Esi wònye be myelodysplastic syndrome nye dɔléle si mebɔ o ta la, nyabiase geɖe ate ŋu anɔ asiwò tso eŋu. Nya aɖewo siwo nàte ŋu abia wò ɖɔktae nye esi:

• Ðe MDS nye kansaa?
• Aleke MDS kpɔa ŋusẽ ɖe dzinyee?
• Ðe nye MDS ahe lãmesẽkuxi sesẽwo vɛa? Ne nenemae la, ke ka ƒomevie?
• Dzesi aɖeke mele ŋunye o. Nukae mate ŋu awɔ be wòahe nɔnɔme siwo do ƒome kple MDS ƒe dzɔdzɔ ɖe megbe?

Gbedasi Mamlɛtɔ si Wotsɔ Yi Aƒeme

Ne myelodysplastic syndrome (MDS) le ŋuwò la, enye kansa ƒomevi aɖe si nye dɔléle si nɔa anyi didi. Dɔléle aɖeke mele bɔbɔe o, gake agbenɔnɔ kple dɔléle si nɔa anyi didi fia be woakpɔ ŋusẽ si wòate ŋu akpɔ ɖe seselelãme dzi la gbɔ. Gake agbenɔnɔ kple MDS mefia be ele be nàɖe asi le mɔkpɔkpɔ ŋu o. Atikewɔwɔ aɖewo li siwo ate ŋu akpe ɖe ame ŋu wòaɖu MDS dzi. Àte ŋu adze na dɔdamɔnu dodokpɔ si le atike yeyewo dim na myelodysplastic syndrome. Nu aɖewo hã li siwo nàte ŋu awɔ na ɖokuiwò. Bia wò ɖɔkta tso tɔtrɔ siwo nàwɔ le agbenɔnɔ me, abe nuɖuɖu nyuie kple kamedede ene ŋu. Nu siawo ate ŋu akpe ɖe ŋuwò nànɔ lãmesẽ me alesi nàte ŋui. Mègavɔ̃ gbeɖe o, eye mègakpe fu wò ɖeka o. Ðo dze kple wò ɖɔkta tso nusianu ŋu, eye nàxɔ kpekpeɖeŋu si nèhiã.

` Myelodysplastic syndrome, MDS, myelodysplasia, ʋumenugbagbeviɣidɔ, ƒumeŋuɖui, ʋusɔgbɔdɔ, ʋumenugbagbeviwo