Atike si wozãna na dɔgbo ƒe dɔléle kple dɔgbo ƒe dɔléle! Mina míasrɔ̃ nu tso Proton Pump Inhibitors (PPIs) ŋu pɛpɛpɛ!

Ðe dzimeve alo akɔtave hã zi geɖea? Alo ɖe ɖɔktaa gblɔ be "gastritis"? Atike ƒomevi aɖe si ɖɔktawo ŋlɔna zi geɖe le nɔnɔme mawo me la woyɔna be `(Proton Pump Inhibitors)`. Ne míegblɔe tẽ la, ɖewohĩ míayɔe hã be "atike na dɔgbo ƒe dɔléle." Eyata, egbea míaƒo nu tso `(Proton Pump Inhibitors)` alo PPIs ŋu kpuie.

Nukatae míehiã PPI siawo? Nukae dzɔna ɖe dɔgbo me acid dzi?

Kpuie ko la, `(Proton Pump Inhibitors)` nye atike ƒomevi aɖe si ɖea acid si dona le wò dɔgbo me dzi kpɔtɔna, si fia be acid si le dɔgboa me dzi kpɔtɔna . Fifia ɖewohĩ èle eŋu bum be, "Oo, viɖe kae le dɔgbo me acid ŋu? Menyo o." Menye nyateƒee o. Dɔgbo me acid le vevie ŋutɔ na míaƒe ŋutilã. Aɖi siae kpena ɖe mía ŋu míeɖua nuɖuɖu siwo míeɖuna. Menye ema ɖeɖeko o, ke dɔgbo me aɖi sia hã kpena ɖe ame ŋu wògblẽa dɔlékui siwo gblẽa nu le ame ŋu siwo míeɖuna kple nuɖuɖu le manyamanya me.

Gake ɣeaɖewoɣi la, kuxiwo dzea egɔme ne dɔgbo me acid ƒe agbɔsɔsɔ dzi ɖe edzi akpa, alo ne acid la yi teƒe bubu wu alesi wòle be wòanɔ. Ele abe nyagbɔgblɔ be "Ne edzi ɖe edzi la, aɖi gɔ̃ hã anye aɖi." Ɣemaɣie dɔgbo ƒe abi (`ulcers`), alo abe alesi míeyɔnae ene la, "gastritis ulcers" ateŋu adzɔ. Nu bubuwo abe dzimeve kple vivisese le ŋɔti me hã ate ŋu adzɔ. Ɣemaɣie atike siawo siwo woyɔna be PPI kpena ɖe mía ŋu. Wozãa wo vevietɔ na kuxi siwo nɔa anyi didi siwo ku ɖe dɔgbo me acid ŋu.

Dɔléle ka ƒomevie wozãa PPI siawo na?

Ðɔktawo zãa atike siawo ƒomevi (Proton Pump Inhibitors) koŋ tsɔ daa nɔnɔmewo abe míaƒe nuɖuɖumeŋusẽ ƒe akpa aɖewo, siwo nye dɔgbowo kple nuɖuɖutome, siwo dɔgbo me acid hena vɛ kple woƒe dɔdzẽ ene. Na míakpɔ nusiwo wonye ɖa:

• GERD alo Chronic Acid Reflux Disease: Ðe dzi gbãna zi geɖea? Ðe vivi aɖe le wò ŋɔti mea? Emae nye nusi GERD nye. Kpuie ko la, acid si le wò dɔgbo me ye dona ɖe wò nuɖuɖutome. Esia ate ŋu agblẽ nu le wò nuɖuɖutome ƒe akpa si woyɔna hã be nuɖuɖutome ƒe dɔléle si nye erosive esophagitis ŋu. PPI-wo wɔa dɔ to dɔgbo me acid ƒe wɔwɔ dzi ɖeɖe kpɔtɔ kple ɣeyiɣi nana wò nuɖuɖutome be wòahaya me.
• Dɔgbo kple dɔgbo ƒe abi: Dɔgbo kple dɔgbo me abi nye abi siwo ate ŋu atso dɔgboa me acid gbɔ, si ate ŋu agblẽ nu le dɔgboa ƒe ametakpɔnu ŋu. Woate ŋu ahe abi vɛ le dɔgbo suea ƒe akpa gbãtɔ (si woyɔna be duodenum) hã. PPI-tikewo ate ŋu akpe ɖe ame ŋu wòada abi siawo. Tsɔ kpe ɖe eŋu la, vevesesenutsitike aɖewo, vevietɔ atike siwo me steroid mele o (NSAID) do ƒome kple afɔku si le abi xɔxɔ me. Numekukuwo ɖee fia be amesiwo noa NSAID edziedzi la dometɔ siwo ade 30% xɔa abi edziedzi. PPI-tikewo ate ŋu akpe ɖe ame ŋu be woaxe mɔ ɖe abi nu ahada gbe le wo ŋu.
• H. pylori ƒe dɔléle:Esia nye dɔlékui ƒomevi aɖe si ate ŋu anɔ míaƒe dɔgbo me. Dɔlékui sia ate ŋu ana dɔgbo naxɔ abi hã. Ne ɖɔktawo le H. pylori dɔlékui aɖe dam la, wonaa PPI kpe ɖe dɔlékuiwutikewo ŋu. Esia le alea elabena PPI-wo trɔa dɔgboa ƒe pH, si wɔnɛ be dɔlékuiwutikewo wua dɔlékuiawo nɔa bɔbɔe.
• Zollinger-Ellison ƒe dɔléle: Esia nye dɔléle si mebɔ o. Le nɔnɔme sia me la, dɔdzẽ ƒomevi aɖewo (`tumors`) dona le ŋutilã me eye wònana ŋutilãa wɔa lãmetsi aɖe si naa dɔgbo me acid sɔ gbɔ akpa. Esia wɔnɛ be dɔgbo me acid sɔa gbɔ akpa. Wozãa PPI hã tsɔ daa dɔléle sia.

Aleke atike siawo siwo woyɔna be PPI wɔa dɔe? Ewɔ nuku ŋutɔ, alo?

Tsɔe be "mɔ̃" vi aɖe le míaƒe dɔgbo me si wɔa acid. Míeyɔa mɔ̃ sia be ``hydrogen-potassium ATPase pɔmpi'', alo ``proton pɔmpi'' kpuie. Abe alesi tsipɔmpi hea tsi yia dzi ene la, proton pɔmpi siae wɔa atike si hiã be woatsɔ awɔ dɔgbo me acid.

Eyata nusi `(Proton Pump Inhibitors)` alo PPI siawo wɔnae nye be woatɔ te proton pɔmpia ƒe dɔwɔwɔ hena ɣeyiɣi aɖe . Eyae nye be "woxea mɔ nɛ", si fia be wodoa nu ɖe ​​eme. Emegbe dɔgbo me acid ƒe wɔwɔ dzi ɖena kpɔtɔna.

Gake esia mexea mɔ na dɔgbo me acid ƒe wɔwɔ keŋkeŋ o ɖe, alo? Acid si sɔ gbɔ ɖe asiwò be nàte ŋu aɖu nuɖuɖu. Ne èno PPI abe ŋkeke atɔ̃ ene ɖe wo nɔewo yome la, dɔgbo me acid ƒe wɔwɔ dzi aɖe akpɔtɔ abe 65% ene. Acid 35% susɔea sɔ gbɔ be woatsɔ aɖu nuɖuɖu.

Nukae nye PPI siawo?

Woate ŋu aƒle PPI siawo dometɔ aɖewo le atikedzraƒe (OTC) le atikedzraƒe atikewɔmɔnu manɔmee, gake esiwo sesẽ wu dometɔ aɖewo hiã be woaŋlɔ atike na wo tso ɖɔkta gbɔ (Rx ɖeɖeko).

PPI siwo woate ŋu ano kple ɖɔkta ƒe atikewɔmɔnu alo esi womeŋlɔ nɛ o (OTC kple Rx):

• Esomeprazole (Nexium®) ƒe atike .
• Lansoprazole (Atike si Wozãna Do Ŋgɔ®) .
• Omeprazole (Prilosec®) ƒe dɔlékuiwutike .
• Omeprazole/sodium bicarbonate (Zegerid®) ƒe dɔlékuiwutike .

PPI siwo woate ŋu akpɔ ne ɖɔkta ƒe atikewɔmɔnu koe li (Rx ɖeɖeko):

• Dexlansoprazole (Dexilant®) ƒe atike .
• Pantoprazole (Protonix®) ƒe atike .
• Rabeprazole (AcipHex®) ƒe atike .

Aleke mawɔ ano atike sia? Agbɔsɔsɔme nenie wòle be mano?

Atike siawo nɔa atikekui alo atikekui ƒe nɔnɔme me. Ètsɔa wo toa nu me. Atike aɖe le atikekui ƒomevi aɖewo me si woate ŋu atsaka ɖe nuɖuɖu me, abe akɔɖumi ene, eye emegbe woanoe. Esia nye kpekpeɖeŋu gã aɖe na amesiwo ƒe atikekuiwo mimi sesẽna.

Hafi nàno atike la, ele be nàxlẽ mɔfiame siwo le agbalẽvi la dzi nyuie.Ɣemaɣie nàkpɔ emetsonu siwo de pɛpɛpɛ wu. PPI aɖewo li siwo wòle be nàno gaƒoƒo afã alo gaƒoƒo ɖeka hafi aɖu nu, le ƒodo ƒuƒlu me. Ne èno wo ɣemaɣi la, ɣeyiɣi sua atike la si be wòawɔ dɔ hafi wò dɔgbo nadze acid dodo gɔme ne èle nu ɖum.

Wò ɖɔkta koe ateŋu agblɔ atike agbɔsɔsɔme si tututu nèhiã (`dose`) kple zi nenie wòle be nànoe gbesiagbe na wò. Aŋlɔ atike si ana nàɖu wò dzesiwo dzi evɔ mɔnukpɔkpɔ suetɔ kekeake nasu asiwò be wòagblẽ nu le ŋuwò. Le ame aɖewo gome la, atikekui ɖeka nono hafi aɖu ŋdinu sɔ gbɔ. Le ame bubuwo gome la, enono zi eve gbesiagbe, hafi woaɖu ŋdinu kple hafi aɖu fiẽnu, ate ŋu asɔ gbɔ. Ɣeaɖewoɣi la, enono ŋkeke eve ɖesiaɖe ate ŋu asu.

Le ɣeyiɣi aɖe megbe la, ahiã be nàɖe wò atikeawo ƒe agbɔsɔsɔ dzi akpɔtɔ. Wò ɖɔkta aɖo aɖaŋu na wò le esia hã ŋu.

Ɣeyiɣi didi kae wòxɔna hafi PPI siawo wɔa dɔ?

Ne wozã PPI-tike vɔ la, ate ŋu axɔ tso gaƒoƒo 24 va ɖo ŋkeke ene hafi woase eƒe ŋusẽkpɔɖeamedzi bliboa gɔme.

Ne dzimeve alo akɔta le veve sem kasia eye nèhiã gbɔdzɔe kaba la, anyo wu be nàzã atike si wua acid (abe Digene, Acidex) alo histamine blocker (H2 blocker) (abe Pepcid® alo Tagamet® ene) wu PPIs. Tsɔe be kasia dzi gbãna na wò ne èɖu nuɖuɖu si me wodea nu ʋeʋĩiwoe vɔ. Ekema, atike ma tɔgbe nono ana gbɔdzɔe ame le aɖabaƒoƒo ʋɛ aɖewo alo gaƒoƒo ʋɛ aɖewo me. Gake eƒe ŋusẽkpɔɖeamedzi menɔa anyi didi abe PPIwo ene o.

PPI-wo nyo wu ne dɔgbo me acid ƒe kuxi siwo nɔa anyi didi, siwo nɔa anyi didi le ŋuwò.

Ðe nugbegblẽ aɖewo li ne wozã PPI siawoa?

Kuxi gã aɖeke menɔa ame akpa gãtɔ ŋu ne wole PPI zãm o. Gake abe atike ɖesiaɖe ene la, woate ŋu ahe nugbegblẽ aɖewo vɛ. Esiawo dometɔ aɖewoe nye:

• Dɔgbo ƒe vevesese
• Miléle
• Dɔmetɔtrɔ
• Taɖuame
• Nu ƒuƒu
• Taɖuame
• Asrã
• Ʋuʋudedi/Gas
• Tagbɔdɔléle si me kɔ
• Ʋuʋudedi kple ʋuʋudedi
• Ʋuʋudedi

Togbɔ be zi geɖe la, wobua PPI be wole dedie hã la, numekulawo kpɔe be woate ŋu ahe afɔku aɖewo vɛ, vevietɔ ne wozã wo ɣeyiɣi didi . Mina míalé ŋku ɖe nusiwo wonye ŋu:

• Clostridioides difficile (C. diff) dɔlékui: PPI ate ŋu atrɔ dɔlékui nyui kple gbegblẽ ƒe dadasɔ le wò dɔgbo me, si ana dɔlékuiwo abe C. diff ene xɔxɔ ƒe afɔku nadzi ɖe edzi.
• Ƒu ƒe gbagbã: PPI ate ŋu aɖe wò ŋutilã ƒe ŋutete be wòaxɔ calcium, si nye mineral si kpena ɖe míaƒe ƒuwo ŋu wòsẽna la dzi akpɔtɔ. U.S. Nuɖuɖu Kple Atike Ŋuti Dɔwɔƒe (FDA) xlɔ̃ nu be PPI ate ŋu ana akɔta, asibidɛ, alo akɔta ƒe gbagbã ƒe afɔkua nadzi ɖe edzi.
• Ayikudɔléle:Esiawo ate ŋu ana ayikudɔléle si nɔa anyi didi (CKD) xɔxɔ ƒe afɔkua nadzi ɖe edzi, alo ana nɔnɔme siwo li fifia nagado gã ɖe edzi.
• Nunyiame ƒe veve: PPI ate ŋu aɖe wò dɔgbo sue ƒe ŋutete be wòaxɔ magnesium alo vitamin B12 dzi akpɔtɔ. Magnesium nye mineral si kpena ɖe míaƒe lãmekawo kple lãmekawo ŋu wowɔa dɔ nyuie. Vitamin B12 le vevie na míaƒe lãmekawo kple ʋumenugbagbevi dzĩwo.

Wogale nu srɔ̃m tso kadodo si le PPI-wo kple afɔku siawo dome ŋu. Gake zi geɖe la, ɖɔktawo kafui be nàzã atike si ƒe agbɔsɔsɔme le sue wu eye wòazã ɣeyiɣi kpuitɔ kekeake vaseɖe esime wò dzesiwo nanyo ɖe edzi. Esia aɖe afɔku si le afɔku siawo me dzi akpɔtɔ.

Ɣekaɣie wòle be makpɔ nye ɖɔkta?

Ne ɖɔkta aɖe ŋlɔ PPI na wò la, kpɔ egbɔ be yebia wò ɖɔkta ne nya aɖe le asiwò ku ɖe atikeawo nono, ɣeyiɣi si nàdzudzɔ, alo alesi nàɖe atikeawo zazã dzi akpɔtɔ ŋu.

Ne èle PPI nom le atikedzraƒe le atikedzraƒe eye nèse le ɖokuiwò me be yehiã wo gbesiagbe be yeaɖu yeƒe dzesiwo dzi la, ele be nàyi ɖɔkta gbɔ kokoko. Ate ŋu aɖo aɖaŋu na wò le atikeawo ƒe agbɔsɔsɔme kple ɣeyiɣi didi si tututu wòle be nàno ŋu.

Azɔ hã, ne èkpɔ afɔku siawo dometɔ aɖe la, yi ɖɔkta gbɔ enumake:

• Nulɔdɔ (ŋutilã ƒe ʋuʋu, bibi, vuvu) .
• Dzesi siwo fia be ayiku gblẽ (aɖuɖɔtoe si mebɔ o wu tsã, asiwo kple afɔwo ƒe vuvu, afɔkpodzi) .
• Magnesium ƒe anyimanɔmanɔ ƒe dzesiwo (ʋuʋudedi, dzi ƒe tsotso madzɔmadzɔ, lãmekawo ƒe ʋuʋu) .
• Vitamin B12 ƒe anyimanɔmanɔ ƒe dzesiwo (asi kple afɔ ƒe vevesese, lãmetutudɔ, ʋuʋudedi, taɖuame, tɔtɔ) .
• Ne ŋutigbalẽa biã, ʋuʋudedi, alo wòdze abe ɖe wòle ʋuʋum ene
• Ne aɖuɖɔtoe sesẽ aɖe le ŋuwò
• Ne asrã le ŋuwò

Eyata nukae nye gbedasi mamlɛtɔ si woatsɔ ayi aƒemee?

Dɔgbo me acid ƒe agbɔsɔsɔ fũ, alo eƒe nɔƒe si mesɔ o ate ŋu ave ame ŋutɔ. Ate ŋu agblẽ nu le wò nuɖuɖumeŋusẽ hã ŋu. Dzɔgbenyuietɔe la, atike geɖe li siwo ate ŋu akpe ɖe ŋuwò ne dzesi siawo le ŋuwò.

Ne èdi gbɔdzɔe ɣeyiɣi kpui aɖe la, antacid alo H2 blocker ye nyo wu. Gake ne dzi gbãna enuenu alo ƒodo me abi le ŋuwò la, wò ɖɔkta ate ŋu aŋlɔ PPI ƒomevi aɖe na wò. Atike siawo li ƒe geɖe eye wobua wo be wonye atike siwo le dedie eye wowɔa dɔ nyuie. Ame geɖe kpɔa gbɔdzɔe to atike siawo zazã me.

Nu vevitɔe nye be ele be woazã atike sia le ɖɔkta ƒe aɖaŋuɖoɖo te, le agbɔsɔsɔ si woŋlɔ nɛ me kple ɣeyiɣi si woɖo ɖi ko.Ne èdze agbagba be yeazãe le mɔ si nèdi nu la, kuxiwo ate ŋu ado mo ɖa. Eyata nunya anɔ eme be nàɖo to nya si ɖɔkta la gblɔna ɣesiaɣi eye nàno atike la ɖe edzi.

` PPIs, dɔgbo ƒe dɔléle, dɔgbo ƒe dɔléle, acid ƒe sisi, dɔgbo ƒe abi, omeprazole, pantoprazole