Esesẽna be nàgblɔ nusi nèsena le ɖokuiwò me ne èva nya be kansa le ye ŋu. Gake ne ɖɔktaa le nu ƒom tso atikewɔwɔ ŋu eye nèse nyawo abe ‘atikewɔwɔ’ ene la, esɔ be vɔvɔ̃ naɖo ŋuwò wu, nàdi be yeanya nu geɖe wu, eye nàtɔtɔ. Chemo-tike siwo wozãna wu tsɔ daa kansa dometɔ ɖekae nye ‘Taxane.’ Egbea, míaƒo nu tso esia ŋu bɔbɔe ŋutɔ, le mɔ si gɔme nàte ŋu ase nu, abe ɖe nèle nu ƒom na xɔ̃wò vevi aɖe ene.
Nuka tututue nye Taxane?
Kpuie ko la, taxanes nye atike siwo wozãna tsɔ daa dɔlékuiwoe ƒe hatsotso aɖe si wua kansa lãmenugbagbeviwo eye wodzudzɔa dɔdzẽ ƒe tsitsi. Atikewɔmɔnu bia be míatsɔ atike siawo akpe ɖe míaƒe ʋuka si zɔa mɔ to ŋutilã bliboa me be yeadi kansa lãmenugbagbeviwo ahagblẽ wo dome.
Nusi na taxane-tike siawo le etɔxɛe nye be atiwo mee wokpɔa wo tsoe le dzɔdzɔme nu. Woɖe wo tso ‘Yew’-ti ƒe aŋgba me gbã . Le nyateƒe me la, taxanes nye atike ƒomevi eve siwo woɖena tso numiemiewo me la dometɔ ɖeka. Ƒomevi bubue nye atikewo ƒe ƒuƒoƒo aɖe si woyɔna be ‘Vinca alkaloids’, siwo woɖe tso ‘Mella’ numiemie me.
Fifia la, dzɔdzɔmeŋutinunyalawo le nu srɔ̃m tso taxane siwo wokpɔna tso numiemie siawo me ƒe atikewo ƒe wɔwɔme ŋu eye wole dɔ wɔm gɔ̃ hã be yewoawɔ wo le nudokpɔƒewo.
Aleke atike sia wua kansa lãmenugbagbeviwoe?
Be míase esia gɔme la, ele be míase alesi kansadɔlékuiwo kakanae gɔme gbã. Kansa kakana ne woma kansa lãmenugbagbevi ɖeka ɖe eve me, eye woama ɖe ene me, eye emegbe wodzina ɖe edzi kabakaba. Le atikewɔwɔ me la, woyɔa alesi lãmenugbagbevi aɖe mãna ɖe eve me be mitosis .
Nusi taxane-tikewo wɔnae nye be wodoa kplamatse lãmenugbagbeviwo ƒe mama ƒe ɖoɖoa.
Tsɔe be ne lãmenugbagbevi aɖe ma la, ele be domenyiŋusẽfianu si le lãmenugbagbevi ma me la nama ɖe eve pɛpɛpɛ eye woaɖoe ɖe lãmenugbagbevi yeye eveawo. Nu aɖewo le lãmenugbagbevi la me siwo kpena ɖe ame ŋu le dɔ sia wɔwɔ me, abe ka sue siwo wotsɔ blaa nu ene. Woyɔa esiawo be microtubules . Esiawoe hea akpa siwo hiã na lãmenugbagbevi yeye eveawo dome.
Ne wotsɔ taxane-tikea yi ŋutilãa me la, enaa ka siawo siwo woyɔna be microtubules la sesẽna madzemadzee . Emegbe womate ŋu abla alo aʋu nyuie o. Eyata lãmenugbagbevi la mama ɖe eve me ƒe ɖoɖoa tɔa te le afã me. Ne womate ŋu awɔ mama sia o la, lãmenugbagbevi si dzila la kuna le ɣeyiɣi aɖe megbe.
Taxane-tikewo ɖua kansa dzi to ŋutete si le kansa lãmenugbagbeviwo si be woama ahatsi la dome gbegblẽ me.
Kansa ƒomevi kawoe wozãa taxane-tikewo na?
Taxanes nye atike vevi aɖe ŋutɔ si wozãna tsɔ daa kansa vovovowo. Wozãa esiawo dometɔ aɖewo abe kansa aɖewo dada gbãtɔ ene, eye wozãa bubuwo na kansa siwo kaka ɖe teƒe bubuwo.
| Kansa ƒomevi siwo wotsɔ Taxane da dɔe | |
|---|---|
| Kansa koŋue wozãna | |
| Azigolo me kansa | No me dɔdzẽ |
| Kansa ƒomevi bubu siwo woda | |
| Tsinyegoe me kansa | Vidzidɔ me kansa |
| Dɔgbo me dɔdzẽ | Ta kple kɔ me kansa |
| Dɔdzẽ si le ʋuka me | Aklã me dɔdzẽ (Non-small cell lung cancer) . |
| Vidzidɔ me kansa | Lãmetsiŋusẽ ƒe dɔléle |
Le go aɖewo me la, wonaa taxanes kpe ɖe atike bubuwo ŋu. Wò ɖɔkta atso nya me le atikewɔwɔ si nyo na wò nɔnɔmea ŋu.
Aleke wowɔa atike siae? Eye nukawoe nye eƒe nugbegblẽ le ame ŋu?
Alesi wowɔa atikewɔwɔae
Wodoa taxanes to ʋuka me (IV) . Wotoa cannula (catheter) dzi naa wo, si sɔ kple saline solution. Dɔdamɔnu sia ate ŋu axɔ gaƒoƒo ɖeka alo gaƒoƒo geɖe. Ðewohĩ ahiã be nàxɔ atike sia zi ɖeka le kwasiɖa me, alo zi ɖeka le kwasiɖa ʋɛ aɖewo ɖesiaɖe me. Wò ɖɔkta anɔ te ɖe wò nɔnɔmea dzi atso nya me le atikewɔwɔ ƒe ɖoɖowɔɖia ŋu.
Nusiwo wokpɔna zi geɖe ƒe nugbegblẽ le ame ŋu
Togbɔ be atike siwo wozãna tsɔ daa dɔlékuiwoe tɔa ŋku kansadɔlékui siwo ma kabakaba hã la, woate ŋu akpɔ ŋusẽ ɖe lãmenugbagbevi siwo le lãmesẽ me, siwo mãna kabakaba le míaƒe ŋutilã me hã dzi ɣeaɖewoɣi. Le kpɔɖeŋu me, nuwo abe míaƒe ɖa ƒe lãmenugbagbeviwo, ŋutigbalẽ me lãmenugbagbeviwo, kple ʋumenugbagbeviwo ene. Esia tae eƒe nugbegblẽ le ame ŋu dzɔna ɖo.
| Nusiwo wògblẽna le ame ŋu | Numeɖeɖe bɔbɔe aɖe |
|---|---|
| Neutropenia ƒe dɔléle | Neutrophils, si nye ʋumenugbagbevi ɣi ƒomevi aɖe si wɔa avu kple dɔlékuiwo le ŋutilãa me ƒe xexlẽme dzi ɖeɖe kpɔtɔ nana dɔlékuiwo xɔxɔ ƒe afɔkua dzina ɖe edzi. |
| Ahɔhɔ̃mekawo ƒe dɔléle si le gota | Lãmetsiŋusẽ ƒe gbegblẽ le abɔwo kple afɔwo ŋu. Esia ate ŋu ana abɔwo kple afɔwo natsi, woase veve, alo woagbɔdzɔ . |
| Taɖa ƒe ŋeŋe | Esia nye nugbegblẽ le ame ŋu si bɔ, gake ɖa agatsi ne wowu atikewɔwɔa nu. |
| Aɖuɖɔtoe kple ʋuʋudedi | Ebɔ le atikewɔwɔ ƒe ŋkekewo me. Wona atikewo be woatsɔ aɖu esia dzi. |
| Lãmetsiwo kple ƒunukpeƒewo ƒe vevesese | Ate ŋu anɔ veve sem le ŋutilãa me eye ƒunukpeƒewo nasẽ. |
| Ʋu ƒe sisi trɔna | Ʋu ƒe sisi ate ŋu akɔ alo aɖiɖi. |
| Ʋumenugbagbeviɣiwo dzi ɖe kpɔtɔ | Ʋumenugbagbevi dzĩwo ƒe ɖiɖi ate ŋu ahe ʋusɔgbɔdɔ vɛ eye ʋumenugbagbevi dzĩwo ƒe ɖiɖi (thrombocytopenia) ate ŋu ana ʋu nado le ame ŋu. |
Menye ame sia ame dzie nugbegblẽ le ame ŋu siawo dzɔna o. Azɔ hã, woate ŋu aɖu wo dometɔ geɖe dzi. Ele vevie ŋutɔ be nàna wò ɖɔkta alo dɔnɔdzikpɔlawo nanya nu tso vevesese ɖesiaɖe si nèse ŋu.
Ðe afɔku aɖewo le atikewɔwɔ sia mea?
Taxanes nye atike si wɔa dɔ ŋutɔ si na kansadɔnɔwo ƒe agbenɔƒe didi. Gake abe atikewɔmɔnuwo katã ene la, afɔku aɖewo li.
Ɣeaɖewoɣi la, nugbegblẽ le ame ŋu siwo míeyɔ ɖe etame ate ŋu anye nu sesẽwo. Le nɔnɔme mawo me la, wò ɖɔkta ate ŋu atso nya me be yeatrɔ wò atikewɔwɔ ƒe ɖoɖowɔɖi alo adzudzɔe hena ɣeyiɣi aɖe.
Nu vevi bubue nye be le ɣeyiɣi aɖe megbe la, kansadɔlékuiwo ate ŋu adze atike sia ‘zu numame na wo’ gɔme. Eyae nye be wova xɔa atikewo ƒe dɔlélenutsiŋutete . Emegbe atike la ƒe ŋusẽkpɔɖeamedzi ate ŋu aɖe akpɔtɔ. Gake ne edzɔ alea la, wò ɖɔkta atrɔ ɖe tiatiawɔblɔɖe abe atike vovovo siwo wotsɔ tsakae dodo kpɔ alo atikewɔwɔmɔnu bubu kafukafu ene ŋu.
Gbedasi si Wotsɔ Yi Aƒeme
- Taxane nye atike siwo wozãna tsɔ daa dɔlékuiwoe ƒe hatsotso sẽŋu aɖe ŋutɔ si woɖe tso numiemiewo me si xea mɔ na kansa lãmenugbagbeviwo ƒe mama.
- Esia daa kansa ƒomevi geɖe dzidzedzetɔe, siwo dometɔ aɖewoe nye no, azigolo, kple lãkusi.
- Nugbegblẽ le ame ŋu abe ɖa ƒe vuvu, lãmetutudɔ, kple ŋutilã ƒe vevesese ene ate ŋu ado mo ɖa, gake woate ŋu akpɔ wo dometɔ akpa gãtɔ gbɔ.
- Ele vevie ŋutɔ be nàgblɔ vevesese sue ɖesiaɖe si nàse le ɖokuiwò me le atikewɔwɔ me na wò ɖɔkta alo dɔnɔdzikpɔla .
- Kansa dada nye mɔzɔzɔ. Ðo ŋku edzi ɣesiaɣi be menye wò ɖeka koe le mɔzɔzɔ sia me o eye be atikewɔlawo ƒe ƒuƒoƒo bibi aɖe le asiwò be woakpe ɖe ŋuwò.
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