Ðe woate ŋu ada Suklidɔ Ƒomevi 2 lia keŋkeŋa? Mina míadi nyatakaka yeyetɔ kekeake!

Suklidɔ va zu dɔléle si bɔ ŋutɔ le ame geɖe dome le míaƒe dukɔa me. Ðewohĩ wò ƒomea me tɔ ɖeka, xɔ̃wò aɖe, alo wò ŋutɔ wò ŋutɔ gɔ̃ hãe nɔnɔme sia gblẽ nu le. Suklidɔ ƒomevi evelia koŋ nye lãmesẽkuxi sesẽ aɖe si dzea ame miliɔn 400 kple edzivɔ dzi le xexeame godoo. Ne womekpɔ edzi nyuie o la, ate ŋu ahe kuxi siwo me afɔku le abe ayiku ƒe gbegblẽ, nukpɔkpɔ ƒe gbegblẽ, dzidɔ, kple lãmetutudɔ ene vɛ. Togbɔ be atike ƒomevi siwo wu 30 ye li woatsɔ aɖu dɔléle sia dzi hã la, wo dometɔ aɖeke mate ŋu "adae" keŋkeŋ o. Gake... numekuku yeyewo ɖee fia be nɔnɔme sia ate ŋu atrɔ. Na míakpɔ alesi wòawɔe ɖa.

Nusi ŋu míebu tso suklidɔ ŋu ɣeyiɣi didi aɖee nye sia

Anɔ abe ƒe blaeve enye sia ene la, ne èbia eŋutinunyala aɖe tso suklidɔ ŋu la, agblɔ be nusi koŋ gbɔ esia tsonae nye ‘insulin ƒe dɔlélenutsiŋutete’. Kpuie ko la, insulin nye lãmetsi aɖe si míaƒe dɔgbo wɔna. Eƒe dɔ vevitɔe nye be wòaxɔ sukli (sukli) si dona tso nuɖuɖu si míeɖuna me atsɔe ade míaƒe ŋutilã ƒe lãmenugbagbeviwo me. Ɣemaɣie ŋusẽ sua lãmenugbagbeviawo si.

Bu insulin be enye safui, eye lãmenugbagbeviwo abe ʋɔtru ene. Insulin ye nye safui si ʋua ʋɔtrua ale be sukli nate ŋu age ɖe lãmenugbagbeviwo me.

Gake, amesi ŋu insulin ƒe dɔlélenutsiŋutete le ƒe lãmenugbagbeviwo mewɔa nu ɖe ​​insulin sia ŋu nyuie o. Ðeko wòle abe safui si le ʋɔtrua ŋu la xɔ dzo ene. Emegbe esi womate ŋu aʋu ʋɔa o ta la, ele be dɔgboa nawɔ insulin safui geɖe wu. Le ɣeyiɣi aɖe megbe la, dɔgboa va gbɔdzɔna le esi wòwɔa dɔ sesĩe alea ta. Ɣemaɣie suklidɔ ƒomevi evelia dzɔna. Esiae nye ŋutinya si míenya ɣeyiɣi didi aɖee nye sia.

Nu yeye vevitɔ kekeake si ŋu woke ɖo: Beta lãmenugbagbeviwo ƒe ŋutinya

Fifia dzɔdzɔmeŋutinunyalawo va kpɔe be menye insulin ƒe dɔmawɔmawɔ nyuie koe nye kuxia o. Kuxia ƒe afã mamlɛa le míaƒe beta lãmenugbagbeviwo me . Esiawoe nye lãmenugbagbevi siwo nɔa dɔgboa me eye wole abe dɔwɔƒe sue siwo wɔa insulin ene.

Beta lãmenugbagbevi siwo míaƒe ŋutilã hiã la ƒe akpa gãtɔ dzɔna le míaƒe agbe ƒe ƒe ʋɛ gbãtɔwo me. Gake wodzia ame aɖewo kple beta lãmenugbagbeviwo sɔ gbɔ wu ame bubuwo. Eyata ne insulin ƒe dɔlélenutsiŋutete va le wo si emegbe le woƒe tsitsime gɔ̃ hã la, woƒe beta cell dɔwɔƒewo ate ŋu awɔ insulin geɖe atsɔ axe fe ɖe eta.

Eyata, taɖodzinu gãtɔ kekeake fifiae nye be woadi atike si ate ŋu agbugbɔ beta lãmenugbagbevi siawo siwo le kukum la awɔ alo ana lãmenugbagbevi siwo le wo me nadzi ɖe edzi. Ne woate ŋu awɔ ema la, woate ŋu ada suklidɔ ƒomevi eve, ke menye be woaɖu edzi ko o.

Atike yeye siwo he mɔkpɔkpɔ vɛ

Esi dzɔdzɔmeŋutinunyalawo nɔ numekuku wɔm tso esia ŋu la, wokpɔ atike aɖe si ate ŋu akpe ɖe beta lãmenugbagbevi siawo ŋu woatsi. Woyɔa esia be harmine . Enye atike si le dzɔdzɔme nu le numiemie vovovowo me le xexeame godoo.

Atike sia si woyɔna be harmine wɔa dɔ to mɔxexe ɖe enzyme aɖe si woyɔna be DYRK1A nu le beta lãmenugbagbeviwo me. Ne woxe mɔ ɖe esia nu la, beta lãmenugbagbeviwo tea mama, dzidziɖedzi, eye woƒe lolome dzina ɖe edzi. Le dodokpɔ siwo wowɔ le sisiblisiwo ŋu me la, suklidɔléla siwo wona atike sia ƒe beta lãmenugbagbeviwo ƒe lolome dzi ɖe edzi zi gbɔ zi etɔ̃ ! Le ɣeyiɣi ma ke me la, sukli ƒe agbɔsɔsɔ le woƒe ʋu me hã gaɖo eƒe nɔnɔme si sɔ.

Gake, hafi esia nakpɔ dzidzedze le amegbetɔwo me nenema ke la, dzɔdzɔmeŋutinunyalawo kpɔe be nu bubu aɖe hiã. Eyata, wodo atike si nye harmine la kpɔ kple atike ƒe hatsotso bubu si wozãna xoxo na suklidɔ. Woyɔa atike ƒe hatsotso ma be GLP1R agonists . Ne ènye amesi noa suklidɔtike la, ɖewohĩ èse ŋkɔ siawo kpɔ: `(exenatide)`, `(liraglutide)`, `(lixisenatide)` nye atike siwo le hatsotso sia me dometɔ aɖewo. Wowɔa dɔ to beta lãmenugbagbeviwo ƒe dɔwɔwɔ kple insulin wɔwɔ ƒe dzidedeƒo me.

Eyata nukae dzɔ esi wotsɔ atike eve siawo ƒo ƒui? Nusiwo do tso eme wɔ nuku ŋutɔ!

Nusiwo do tso eme siawo na kakaɖedzi geɖe va le amewo si be atikewɔwɔmɔnu sia akpɔ dzidzedze le amegbetɔwo hã me.

Kuxi si le ŋgɔ eye nukatae esia le vevie?

Kuxi gãtɔ kekeake si li fifiae nye alesi woatsɔ atike tsakatsaka sia ayi beta lãmenugbagbeviwo gbɔ tẽ. Dzɔdzɔmeŋutinunyalawo le gbɔgblɔm be, "Agbalẽvi aɖe le mía si be míada gbe le beta lãmenugbagbeviwo ŋu, gake míenya adrɛs si tututu dzi míaɖoe ɖo o." Abe egbɔkpɔnu ene la, wole nane si woyɔna be monoclonal antibodies zazã ŋu bum . Esiawo le abe agbalẽɖoɖoɖa dɔwɔƒe si me nunya le si ate ŋu atsɔ míaƒe atikewo ƒe agbalẽvi ayi beta lãmenugbagbeviwo gbɔ tẽ ene.

Nukatae esia le vevie nenema gbegbe ɖo?

Bu eŋu kpɔ ko, suklidɔtike siwo li fifia la kpɔa sukli ƒe agbɔsɔsɔ le ʋu me dzi ko. Ne èdzudzɔ atikeawo nono la, dɔlélea agadze.

Nu ɖeka si gogo egbɔkpɔnu si anɔ anyi ɖaa vaseɖe fifiae nye amekoko si me woɖea ʋu le . Eyae nye amekoko be woaɖe lolo dzi akpɔtɔ. Zi geɖe la, esia nana suklidɔa nu yina. Gake le ame miliɔn 400 siwo le xexeame gome la, amekoko meɖea vi o. Exɔ asi, afɔku le eme, eye wòxɔa ɣeyiɣi didi hafi wòdaa gbe.

Gake ne atike yeye sia si wotsɔ tsaka kpɔ dzidzedze la, ate ŋu atrɔ ame miliɔn geɖe ƒe agbenɔnɔ le xexeame godoo. Menye ɖeko wòtsia dzesiwo nu o, ke egbugbɔa nusi gbɔ dɔlélea tso, si nye beta lãmenugbagbeviwo ƒe bu.