Sometimes the aches and pains we experience are so severe, aren't they? There are times when even ordinary
painkillers don't relieve the pain. Today, we are going to talk about a special medicine that doctors recommend to control severe pain that cannot be controlled by other medications, or that is caused by people who cannot tolerate other painkillers.
What is this medicine called Celecoxib and Tramadol?
Simply put, this is a combination of two medications. That means it contains two main types of drugs in one pill. 1.
Celecoxib : This is a painkiller that belongs to the `(
NSAID )` group. `(NSAID)` stands for "Non-Steroidal Anti-Inflammatory Drug". This mainly works by reducing
inflammation in the body, which means
swelling and redness. 2.
Tramadol: This is a strong painkiller that belongs to the `(
opioid )` group. This works by blocking pain signals to the brain and reducing the feeling of pain. The combination of these two medications provides great relief in controlling
severe pain . Sometimes you can see this medicine under the brand name `SEGLENTIS`.
Things you need to tell your doctor before taking this medicine
Before starting this medication,
it is very important to give your doctor a complete description of your health condition. Especially if you have any of the following conditions, you should definitely tell them about it.
| Condition or habit | Description |
|---|
| Heart disease and blood vessel problems | Conditions such as a previous heart attack, stroke, high blood pressure, or heart failure. |
| Recent surgeries | If you have had heart bypass surgery (CABG) within the past two weeks. |
| Stomach and intestinal problems | If you have a history of stomach ulcers or intestinal bleeding. |
| Kidney or liver disease | Any medical condition related to kidney or liver function. |
| Breathing difficulties | Conditions such as asthma. |
| Brain-related problems | Conditions such as head injuries, brain tumors, and seizures. |
| Mental health problems | Thoughts of harming yourself, addiction to drugs or alcohol. |
| Use of other medications | If you have taken a medicine from the `(MAOI)` group (e.g. Marplan, Nardil, Parnate) within the past 14 days. |
| Lifestyle | If you drink alcohol frequently, use tobacco, or are dehydrated. |
| Pregnancy and breastfeeding | If you are pregnant, trying to get pregnant, or breastfeeding. |
| Allergies | If you have an allergy to Celecoxib, Tramadol, or any other medicine or food. |
How should I use the medicine?
Be aware of these points when using this medicine.
- Take this medicine with a glass of water .
- Take your medicine exactly as your doctor prescribes, at the right time . It's best if you can take it at the same time every day.
- You can take it before or after meals. However, if you experience stomach upset, take it with food .
- Never take more than the dosage prescribed by your doctor.
- If you are over 65, a lower dose is usually prescribed because the risk of side effects is higher.
Important: This medicine is for you only. Even if someone else has the same pain as you, do not give this medicine to them. It can be dangerous.
What if the dosage of the medicine increases? (Overdose)
If you think you have taken too much of this medicine,
immediately call the National Poisons Information Centre at the Colombo National Hospital, or go to the Emergency Treatment Unit (ETU) of the nearest hospital. This is something that should not be delayed.
What to do if you miss a dose of medication?
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time.
Never take two doses at once to make up for a missed dose. Other medications that may interact with this medicine
It can be dangerous to take some other medications while taking this medicine. So tell your doctor about all the medications you take, including vitamins and herbal products.
Drugs that should not be taken with this medicine (Absolutely Avoid)
| Cidofovir | Ketorolac |
| Linezolid | MAOIs (e.g. Marplan, Nardil, Parnate) |
| Methylene blue | Safinamide |
Other drugs and substances that may interact
| Alcohol | Other medications that cause drowsiness (e.g. Benzodiazepines) |
| Other NSAIDs (e.g., Aspirin, Ibuprofen, Naproxen) | Blood thinners |
| Medicines for blood pressure | Diuretics (medicines that remove water from the body) |
| Some medications for depression | Steroids (e.g. Prednisone) |
Things to keep in mind when using the medicine
If the pain doesn't subside...
Tell your doctor if your pain does not go away, if it gets worse, or if you have a new type of pain. Sometimes, as you continue to take this medicine, your body may develop a tolerance and need a higher dose to control the pain. This is normal, so talk to your doctor about it.
Drowsiness and driving
This medicine may cause
drowsiness and dizziness . Therefore
, do not drive or operate machinery until you know how this medicine affects you. These side effects may be worse if you take this medicine with alcohol.
Drug addiction
Since this is an opioid, even if you take it exactly as your doctor tells you, your body can become dependent on it over a long period of time. Therefore, when you need to stop taking this medicine, your doctor will gradually reduce the dose.
Do not stop suddenly. Be aware of serious risks
- Stomach bleeding: If you have stomach pain , black or tarry stools, or vomit blood that looks like coffee grounds, seek medical advice immediately.
- Heart attack and stroke risk: This medicine may slightly increase the risk of blood clots, heart attack, and stroke. If you experience symptoms such as chest pain, difficulty breathing, difficulty speaking, or weakness on one side of your body, go to the hospital immediately.
- Severe skin reactions: If you develop red, blistered, or peeling skin along with fever, body aches, or pain, tell your doctor immediately.
- During pregnancy:Taking this medicine after 20 weeks of pregnancy may harm the baby. Therefore, if you are pregnant or planning to become pregnant, you should talk to your doctor.
- When breastfeeding: If you are taking this medicine while breastfeeding, watch your baby carefully for unusual drowsiness or difficulty breathing. If you notice any of these, seek medical advice immediately.
What are the possible side effects of this medicine?
Like any medicine, this one can have side effects. Some are serious, some are common.
| Serious side effects that should be reported to the doctor immediately |
|---|
- Severe allergic reactions (swelling of the face, lips, tongue, difficulty breathing, skin rash)
- Slow or shallow breathing, excessive sleepiness.
- Vomiting blood, passing stool that is black or bloody.
- Symptoms of a heart attack (chest tightness, pain, difficulty breathing).
- Symptoms of a stroke (numbness/weakness on one side of the body, difficulty speaking, severe headache).
- Signs of liver or kidney damage (yellowing of the eyes/skin, decreased urine output).
- Seizures.
|
| Common side effects (if they persist, tell your doctor ) |
|---|
- Constipation - If you do not have a bowel movement for more than 3 days, tell your doctor .
- Dizziness, drowsiness
- Dry mouth
- Headache
- Nausea, vomiting
|
How do you store and dispose of the medicine?
Because this is a strong painkiller, store it
safely out of the reach of children and pets . It can be very dangerous if someone else accidentally uses this medicine. It is important to properly dispose of expired or no longer needed medicine.
- Ask your doctor about the correct way to remove these.
- Some pharmacies have programs that accept unwanted medications.
- If that's not possible, remove the pellets from the container, mix them with something like used coffee grounds, soil, or cat litter, put them in a sealable bag, and throw them in the trash.
Take-Home Message
- Celecoxib and Tramadol are powerful medications that are prescribed by a doctor only for severe pain that cannot be controlled by other painkillers.
- Before starting this medication, tell your doctor about all medical conditions you have and all medications you are taking.
- Avoid drinking alcohol while taking the medicine and avoid taking other medications that make you sleepy.
- Seek immediate medical attention if you experience a serious side effect such as stomach bleeding, difficulty breathing, or a severe allergic reaction.
- Avoid stopping the medication suddenly without medical advice.
- Always keep this medicine in a safe place out of the reach of children and dispose of unwanted medicines properly.
Celecoxib, Tramadol, painkiller, severe pain, side effects, opioid, NSAID, painkiller Sinhala, vedana nashaka
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