Has the doctor told you or someone close to you that you have Hepatitis C? Then don't worry about it. Because today there are very effective, modern medicines that can completely cure this disease. Today we are going to talk about a combination of two such medicines. The name of this medicine is Sofosbuvir and Velpatasvir. Let's see about this medicine, how to use it, and what we need to be careful about.
What kind of medicine is this? (What is this medication?)
Simply put, Sofosbuvir and Velpatasvir are a combination of two antiviral drugs. The main function of this is to eliminate the hepatitis C virus in our body. This medicine is usually given in combination with one or more other drugs for treatment.
One very important thing to remember: This medicine only works for the hepatitis C virus. It will not cure other viral infections, such as the common cold, flu, or cough. So, never use it for those things.
This medication may come under names like Epclusa on the market. But no matter what the name, it's important to follow your doctor's instructions.
Things you need to tell your doctor before taking medicine
Before starting this treatment, it is essential that your doctor is aware of your complete health condition. Because that information will determine the most suitable and safest treatment for you. Therefore, if you have any of the following, be sure to tell your doctor .
- Diabetes: If you have diabetes, this medication may cause changes in your blood sugar levels. Therefore, it is important to inform your doctor about this.
- Heart disease: If you have heart disease, tell us about it too.
- HIV or AIDS: It is essential to disclose these conditions if you have them.
- If you have had another organ transplant: For example, if you have had something like a kidney transplant, tell us about it.
- Other liver disease: It is very important to know if you have other liver diseases in addition to hepatitis C (for example, if you have previously had hepatitis B). We will talk more about that later.
- If you are pregnant or trying to get pregnant: Talk to your doctor about how this medicine will affect you during pregnancy and while breastfeeding.
- Breastfeeding: If you are breastfeeding, also mention that.
- Allergies: Be sure to tell your doctor if you have any allergies to Sofosbuvir, Velpatasvir, or any other medicine, food, or dye contained in this medicine.
How should I use this medicine?
The method of using the medicine is very simple, but it is very important to follow it exactly.
- Swallow this pill whole with a glass of water .
- You can take it with or without food. However, if you experience stomach upset, it is better to take it with a meal .
- The most important thing is to take the medicine at the prescribed time and at the prescribed intervals .
- Do not skip a dose of medicine for any reason . Even if you feel a little better, take the full dose of medicine prescribed by the doctor for the full duration. This is like a battle, you need to take the medicine exactly until the virus is completely defeated.
Should this medicine be given to children?
This medication can be prescribed to children as young as 6 years old in some selected cases. However, it requires special precautions. Therefore, if you are giving this medication to your child, discuss it carefully with your pediatrician.
What if I take too much medicine?
If you have any suspicion that you have taken more medicine than you think, do not panic and immediately call the National Poisons Information Centre at the Colombo National Hospital . Alternatively, go to the Emergency Treatment Unit (ETU) of the nearest hospital.
Please note: This medicine has been prescribed for you only. Do not share it with anyone else for any reason.
What to do if you miss a dose of medicine?
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Never take two doses at once, that is, a double dose.
Other drugs that may interact with this medicine (Interactions)
Some other medications you are taking can affect the way Sofosbuvir; Velpatasvir works. Therefore, it is very important to tell your doctor about all the medications you are taking (including vitamins, herbal products, and herbal remedies) . Below are some medications that may interact with this medicine.
| Drug type/condition | Examples |
|---|---|
| Heart rhythm medications | Amiodarone |
| Antacids | Drugs like Cimetidine, Famotidine, Omeprazole, Lansoprazole |
| Some antibiotics | Rifabutin, Rifampin, Rifapentine |
| Cholesterol-lowering medications | Atorvastatin, Rosuvastatin |
| Seizure medication | Carbamazepine, Phenobarbital, Phenytoin |
| Other medicines and herbs | Digoxin, Efavirenz, St. John's Wort, Tipranavir, Topotecan, Warfarin |
This list is not complete. So tell your doctor if you smoke, drink alcohol, or use other drugs.
Things to be careful about when taking medicine
- Regular medical check-ups: During your treatment, your doctor will call you to check on your progress. Be sure to go at those times. If your symptoms don't improve or get worse, tell your doctor . You may also need to have some blood work done during this time.
- Hepatitis B Warning: This is a very important point. If you have ever had Hepatitis B , you should tell your doctor. Because sometimes when you use this medicine, the old, cured Hepatitis B virus can become active (reactivate) in the body. Therefore, it is essential that your doctor is aware of this.
- Ribavirin and pregnancy: This medicine is sometimes given in combination with another medicine called ribavirin. Ribavirin can cause serious birth defects. Therefore, if you or your partner are trying to get pregnant, talk to your doctor about it and decide on a safe method of birth control.
- Diabetes and blood sugar: If you have diabetes, check your blood sugar levels regularly while taking this medication. If there are any changes, ask your doctor if you need to make any changes to your diet or diabetes medication.
Side effects that may occur due to medication
Like any medicine, this one can cause some side effects. Some of them are serious, some of them are common.
| Classification of side effects | |
|---|---|
| Serious side effects that require immediate medical attention | |
| Allergic reactions | Skin rash, itching, swelling of the face, lips or tongue. |
| Difficulty breathing | Difficulty breathing, feeling of tightness in the chest. |
| Other serious symptoms | Severe dizziness, depressed mood, feeling unusually tired or weak. |
| Side effects that are usually not serious, but should be reported to the doctor if they persist | |
| Headache | General headache. |
| Nausea | Feeling like you're sick to your stomach. |
| Stomach upset/bloating | Diarrhea |
| Other | Insomnia, fatigue, irritability. |
If you experience any other unusual symptoms not mentioned in this list, seek medical advice about that as well.
How do you store and dispose of the medicine?
- Keep this medicine out of the reach of children and pets .
- Store at room temperature, below 30 degrees Celsius (30°C).
- Never use expired medicine .
- Ask your doctor about the safest way to dispose of unused or expired medications. They may advise you to remove the pills from the container, mix them with something like used coffee grounds, soil, or cat litter, put them in a tightly sealed bag, and throw them in the trash. But never flush medications down the toilet without first checking with your doctor .
Take-Home Message
- Sofosbuvir; Velpatasvir is a very effective antiviral drug used to treat hepatitis C.
- Before starting treatment, tell your doctor about all your medical conditions and all other medications you are taking.
- Take the full amount of medication prescribed by your doctor, at the appointed time, and do not skip any meals.
- If you have previously had hepatitis B, it is essential to inform your doctor .
- If you experience any serious side effects such as difficulty breathing or allergic reactions, seek medical advice immediately.
- If you have any questions about this medication, don't be afraid to discuss it with your doctor.


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