Shin cutar ta sake dawowa bayan maganin cutar kansa? Bari mu yi magana game da DLI (Donor Lymphocyte Infusion)

Yaya za ka ji idan aka yi maka babban magani kamar dashen ƙashi don cutar kansar jini kuma ka yi tunanin, "Komai ya lafa yanzu," sannan ka ji cewa cutar kansa ta dawo? Abin yana da ban tausayi da kuma baƙin ciki ƙwarai. Amma kada ka yanke ƙauna. A yau muna magana ne game da magani na musamman wanda zai iya taimakawa a irin wannan yanayi. Ana kiransa DLI, wanda ke nufin Donor Lymphocyte Infusion.

A taƙaice, menene DLI?

To, bari mu faɗi haka a taƙaice. Lymphocytes wani nau'in farin jini ne a cikin jininka. Suna kama da sojoji a jikinmu. Su babban ɓangare ne na tsarin garkuwar jikinmu, suna yaƙi da ƙwayoyin cuta na ƙasashen waje, cututtuka, da ƙwayoyin cutar kansa.

Yanzu, DLI (Donor Lymphocyte Infusion) wata hanya ce da ake ɗaukar wasu daga cikin waɗannan lymphocytes daga mai ba da gudummawa mai lafiya wanda a baya ya ba da gudummawar ƙashin ku (ƙwayoyin halitta) kuma aka yi masa allura a jikin ku. Waɗannan sabbin, masu lafiya da ƙarfi 'sojoji' suna neman da kuma lalata duk wani ƙwayar cutar kansa da ta rage da ke ɓoye a jikin ku. Wannan shine babban burin wannan maganin.

A waɗanne yanayi ne ake ba da shawarar maganin DLI?

Likitan ku zai iya gaya muku game da wannan maganin idan ciwon daji na jini ya dawo (ya sake dawowa) bayan an yi masa dashen ƙashi.

Ga wasu daga cikin cututtukan da ake yawan amfani da su wajen maganin DLI:

• Ciwon sankarar myeloid mai tsanani (AML)
• Ciwon sankarar lymphocytic na yau da kullun (CLL)
• Ciwon sankarar myeloid na yau da kullun (CML)
• Myeloma Mai Yawa
• Myelodysplasia (MDS)
• Lymphoma na NonHodgkin

Yaya kuke shiryawa don wannan maganin?

Kafin fara maganin DLI, likitanka zai duba ka a hankali, ya tattauna alamominka, sannan ya yi odar gwaje-gwaje da dama.

• Binciken ƙwayoyin cuta na ƙashi: Ana ɗaukar ƙaramin samfurin ƙashi don duba duk wani ƙwayoyin cutar kansa da suka rage.
• Cikakken Kididdigar Jini (CBC):Suna duba adadin ƙwayoyin halitta a cikin jini.
• Gwaje-gwajen aikin koda da hanta.

Idan biopsy ya nuna cewa matakin ƙwayoyin cutar kansa yana da yawa sosai, likitanka zai iya yanke shawarar ba ka maganin chemotherapy kafin DLI. Wannan yana nufin rage yawan ƙwayoyin cutar kansa da kuma ƙara nasarar maganin DLI.

Ta yaya ake samun ƙwayoyin lymphocyte daga mai bayarwa?

Wannan wani abu ne na musamman da ke faruwa. Mai bayarwa wanda ya ba ka rai, wato, mai bayarwa wanda ya ba ka ƙashin ƙashi, shi ma yana taimakawa da wannan. Ana saka ƙaramin bututu (catheter) a cikin jijiyar hannunsa sannan a ɗauki wani jini. Wannan jinin yana ratsa ta wata na'ura ta musamman. Abin da wannan injin yake yi shi ne raba ƙwayoyin lymphocyte da muke buƙata kawai, sannan a mayar da sauran jinin zuwa jiki ta hanyar jijiyar da ke ɗayan hannun mai bayarwa. Wannan tsari ana kiransa apheresis . Wani lokaci, lokacin da ka fara bayar da ƙashin ƙashi, ana iya ɗaukar wasu daga cikin waɗannan ƙwayoyin lymphocyte a daskare su don amfani daga baya.

Yaya ake samun maganin DLI?

Wannan yana jin kamar wani abu mai sauƙi kamar ba ku maganin saline.

1. Likita ko ma'aikaciyar jinya za su saka ƙaramin bututu (catheter) a cikin jijiyar hannu ko ƙirji.

2. Sannan, za a haɗa fakitin da ke ɗauke da ƙwayoyin lymphocyte da aka raba daga mai bayarwa zuwa wannan bututun sannan a saka shi cikin jininka.

3. Wannan aikin yana ɗaukar kimanin mintuna 30 .

4. Idan an gama aikin, sai a cire bututun.

Wani lokaci za ka iya ba da allurai da dama kamar haka tsawon makonni ko watanni da dama.

Idan aka shigar da sabbin ƙwayoyin halitta cikin jiki ta wannan hanyar, ɗaya daga cikin mafi mahimmancin abubuwa ana kiransa da graft vs. tumor effect (GvT) . Wannan yana nufin cewa waɗannan ƙwayoyin halitta masu lafiya (graft) daga mai bayarwa suna neman sauran ƙwayoyin cutar kansa (ƙari) a jikinka, suna kai musu hari, kuma suna lalata su. Ta haka ne ciwon daji ke ɓacewa gaba ɗaya.

Menene fa'idodi da haɗarin maganin DLI?

Babban fa'idodin wannan

A da, idan ciwon daji ya dawo bayan an yi masa dashen ƙashi, zaɓin da ya rage shi ne a sake yin wani dashen ƙashi. Amma haɗarin rikitarwa ya fi yawa idan aka yi masa dashen ƙashi na biyu. DLI hanya ce mai kyau, mai ƙarancin haɗari don rage ciwon daji ba tare da magungunan rage garkuwar jiki ba.

Hadarin da ka iya faruwa da rikitarwa

Kamar yadda yake a duk wasu magunguna, akwai wasu haɗari. Ƙungiyar likitocinku za ta sa ido sosai kan waɗannan.

Me za a yi idan matsaloli suka taso?

Kada ku damu. Akwai magunguna ga duk waɗannan.

• Idan GvHD ta faru: Likitanka zai rubuta magungunan rage garkuwar jiki .
• Idan ƙwayoyin jininka sun yi ƙasa: Ƙananan ƙwayoyin jinin fararen jini sau da yawa suna ɓacewa da kansu. Idan ba haka ba, akwai magunguna don magance su. Ana iya ba da ƙarin jini idan ya cancanta don magance ƙananan ƙwayoyin jinin ja da platelets.

Bayan magani da kuma game da nasara

Yi magana da likitanka game da tsawon lokacin da zai ɗauka kafin ya dawo daidai bayan magani. Za ku buƙaci a ci gaba da bin diddigin ku akai-akai da kuma gwajin jini.

Nasarar wannan magani na iya bambanta daga mutum zuwa mutum. Akwai abubuwa da dama da ke shafarsa:

• Matakin Ciwon daji.
• Lafiyar garkuwar jikinka.
• Nau'in dashen da aka yi a baya.
• Ko an yi maganin chemotherapy kafin DLI ko ba a yi ba.

Shin DLI magani ne na rigakafi?

Ee, DLI magani ne na rigakafi.Wani nau'in magani ne. Domin abin da kake yi shi ne samar wa tsarin garkuwar jikinka ƙwayoyin T masu lafiya daga waje don taimaka masa yaƙar cutar kansa. Wannan abin alfahari ne kwarai da gaske.

DLI, Jiko na Lymphocyte mai bayarwa, ciwon daji, cutar sankarar bargo, dashen ƙashi, GvHD, immunotherapy, maganin ciwon daji a Sri Lanka, ciwon daji na jini, dashen ƙashi