Ua noʻonoʻo paha ʻoe i ka nui o ka hana i loko o kou kino, me ka ʻike ʻole ʻoe? E noʻonoʻo e pili ana i ia mea, kou puʻuwai e kuʻi ana, kou hanu ʻana, kou hoʻomanaʻo ʻana i kahi helehelena āu i ʻike ai, kou neʻe ʻana i kou mau lima a me kou mau wāwae... ʻAʻole hana wale ʻia kēia mau mea a pau. Ma hope o kēia mau mea a pau he mau ʻelele kemika liʻiliʻi. I kēia lā, e kamaʻilio mākou e pili ana i kekahi o kēlā mau ʻelele koʻikoʻi loa i loko o ko mākou kino. ʻO acetylcholine kona inoa, a i ʻole (ACh) no ka pōkole.
No laila, ʻo wai kēia acetylcholine (ACh)?
I ka ʻōlelo maʻalahi, ʻo ka acetylcholine (ACh) kahi ʻano kemika i kapa ʻia he neurotransmitter. E noʻonoʻo iā ia e like me kahi pilina kelepona ma waena o ko mākou lolo a me ke koena o ko mākou kino. No laila, ua like kēia mau (neurotransmitters) me nā 'ʻelele' e lawe ana i nā leka i mua a i hope ma o kēlā pilina.
He neurotransmitter hoʻonāukiuki ʻo Acetylcholine. ʻO ia hoʻi, hele kēia ʻelele i ke kelepona aʻalolo aʻe a "hoʻāla iā ia," "hāʻawi iā ia i kahi hoʻoikaika maikaʻi," me ka ʻōlelo ʻana, "ʻAe, ʻo kou manawa kēia, e lawe i kēia leka i mua."
Loaʻa kona inoa mai nā mea ʻelua i hana ʻia ai. He hui acetyl a me kahi meaʻai i kapa ʻia ʻo choline. Hiki iā mākou ke loaʻa i kēia choline mai ka meaʻai. Loaʻa ia i nā mea e like me nā yolks hua manu, soy, a me nā mea kanu a me nā nati. Hana ʻia hoʻi e ko mākou akepaʻa.
Hana ʻo Acetylcholine i nā hana koʻikoʻi he nui i loko o ko kākou kino. He mea nui loa ia no ka neʻe ʻana o nā ʻiʻo manawaleʻa . He kuleana nui nō hoʻi ia i nā hana o ka lolo e like me ka hoʻomanaʻo, ka noʻonoʻo ʻana, a me ke aʻo ʻana i nā mea hou .
Pehea e hana ʻia ai kēia i loko o ko kākou kino?
Loaʻa iā kākou kahi enzyme i loko o ko kākou kino i kapa ʻia ʻo 'choline acetyltransferase'. E noʻonoʻo e like me ke kuke. ʻO kēia enzyme ka mea e hoʻohui i ka choline i ʻōlelo ʻia ma mua a me ka hui acetyl e hana i ka ʻelele acetylcholine (ACh) ʻono. Hana ʻia kēia kaʻina hana ma nā wēlau o ko kākou mau hunaola nerve.
ʻAe, e nānā kākou pehea e hele ai kēia leka.
Ma hope o ka hana ʻia ʻana o ka acetylcholine (ACh), mālama ʻia ia ma ka hopena o kahi pūnaewele nerve, e like me kahi puʻu o nā leka ma ke keʻena leka. Hoʻokuʻu ʻia kēia ACh i mālama ʻia ke hiki mai kahi leka mai ka lolo.
A laila lele kēia ACh i loko o kahi hakahaka liʻiliʻi ma waena o nā hunaola nerve ʻelua. Ua kapa ʻia kēia hakahaka ʻo ka synaptic cleft. E noʻonoʻo e like me kahi leka e lele ana ma waena o kahi muliwai.
Aia i loko o ke aʻalolo nā wahi kūikawā e hopu ai i kēia ACh e hiki mai ana. I ka pololei, ua like ia me ke kī e kūpono ana i kahi kī. Kāhea mākou i kēia mau mea loaʻa. ʻElua ʻano nui o nā mea loaʻa no ka acetylcholine:
1. Nā mea hoʻokipa nikotinic
2. Nā mea hoʻokipa Muscarinic
Ke hoʻopaʻa ka kī ACh i kekahi o kēia mau kī Ibi ʻelua, e hoʻouna ʻia ka leka i ke kelepona aʻe. Ma kēia ʻano, e hele ka leka mai ke kelepona a i ke kelepona a hiki i kahi kūpono (no ka laʻana, he ʻiʻo).
Ma hope o ka hāʻawi ʻia ʻana o ka leka, aia kekahi e hoʻomaʻemaʻe i ke koena o ka ACh ma ia hakahaka. ʻO ia kahi enzyme i kapa ʻia ʻo 'acetylcholinesterase.' ʻO ka hana a kēia, ʻo ia ka wāwahi ʻana i ke koena o ka ACh a hoʻihoʻi iā ia i mau ʻāpana hou loa . A laila hiki ke hoʻohana hou ʻia kēlā mau ʻāpana e hana i nā ACh hou. Ua like ia me ka hoʻomaʻemaʻe ʻana i ke alanui ma hope o ka hāʻawi ʻia ʻana o ka leka a me ka ʻae ʻana i ka leka aʻe e hele mai.
He aha nā mea nui a ka acetylcholine (ACh) e hana ai i ko mākou kino?
He nui nā hana a Acetylcholine (ACh). ʻOkoʻa kāna hana ma muli o ka mea loaʻa e hoʻopaʻa ai. E nānā kākou i kāna mau hana nui.
| ʻAno Mea Hoʻokipa | Hana Nui |
|---|---|
| Ke hoʻopili ʻia me nā mea hoʻokipa muscarinic |
|
| Ke hoʻopili ʻia i nā mea hoʻokipa nicotinic |
|
Pili nā ʻano mea loaʻa ʻelua i nā mea āpau mai ka mālama ʻana i ko kākou mau hoʻomanaʻo, a hiki i ka hoʻokumu ʻana i nā hoʻomanaʻo hou, ka mālama ʻana iā lākou, a me ka hoʻomanaʻo ʻana iā lākou . He mea nui loa nō hoʻi lākou i ka lolo, no ko kākou nānā ʻana, ko kākou makemake e aʻo, a me ke kahua hiamoe hohonu i kapa ʻia ʻo REM (Rapid Eye Movement) hiamoe.
He aha nā maʻi e hiki ke loaʻa inā e hoʻemi ʻia kēia?
ʻO ka emi ʻana o ka pae o ka acetylcholine (ACh) i loko o ko kākou kino hiki ke alakaʻi i kekahi mau maʻi koʻikoʻi. ʻO nā mea nui:
- ʻO ka maʻi o Alzheimer: He maʻi kēia e hoʻopilikia nui ana i ka hoʻomanaʻo. Ua ʻike ʻia he haʻahaʻa loa ka pae o ka acetylcholine i loko o ka lolo o ka poʻe me ka maʻi o Alzheimer.
- Myasthenia gravis: He maʻi autoimmune kēia. ʻO ke ʻano kēia, hana kūʻē ka ʻōnaehana pale ponoʻī o ko mākou kino iā mākou. ʻO ka mea e hana ʻia ma ʻaneʻi, hele kā mākou mau antibodies a hōʻino i nā mea loaʻa acetylcholine (ACh) i loko o nā ʻiʻo. A laila, ʻaʻole hiki i ka ACh ke hoʻouna i ka leka, no laila e nāwaliwali mālie nā ʻiʻo.
- ʻO ka maʻi myasthenic Lambert-Eaton: Hoʻopilikia pū kēia i nā ʻiʻo. Akā ʻokoʻa ke kumu. ʻO ka mea e hana nei ma ʻaneʻi, ʻaʻole hoʻokuʻu nā hunaola nerve i ka ACh lawa.
Nā mea ʻē aʻe e pili ana i ka acetylcholine (ACh)
ʻO ka mea kaumaha, ua hoʻohana kekahi i ka ʻike o ka hana a ka acetylcholine e hōʻino i nā kānaka.
Eia kekahi laʻana, hana nā kinoea nerve e like me ka sarin a me kekahi mau insecticides ma ka hoʻopau ʻana i ka enzyme clearing acetylcholinesterase a mākou i kamaʻilio ai ma mua. ʻAe kēia iā ACh e hōʻiliʻili, e hoʻopōʻino ana i nā ʻiʻo a hiki i ka make.
Eia kekahi, ke ʻai ʻia, hoʻonui nui ka mea ʻawahia o ka nananana ʻeleʻele i nā pae ACh. Hiki i kēia ke kumu i ka ʻūmiʻi nui o nā ʻiʻo, ka ʻūmiʻi ʻana, a me ka maʻi lolo, a me ka make pū kekahi.
I loko o kahi pilikia e like me ka lāʻau make, ʻo ka mea maikaʻi loa e hana ai, ʻo ia ke hele koke i ka Emergency Treatment Unit (ETU) kokoke loa i ka haukapila . Inā pono, e hoʻokaʻaʻike aku nā kauka i ke Kikowaena ʻIke Lāʻau Make Lahui ma ka Halemai Lahui ʻo Colombo no ka ʻōlelo aʻo.
Aia kekahi mau lāʻau lapaʻau e pili ana i kēia?
ʻAe. Hoʻohana ʻia nā lāʻau lapaʻau e pili ana i ka acetylcholine e mālama i kekahi mau kūlana olakino.
ʻO ka papa nui o nā lāʻau lapaʻau ʻo ia nā 'cholinesterase inhibitors'. Hana kēia mau lāʻau lapaʻau ma ke kāohi ʻana i ka enzyme e wāwahi ana iā ACh. ʻAe kēia iā ACh e noho ma ka hakahaka ma waena o nā hunaola nerve no ka manawa lōʻihi, e hoʻonui ana i kāna hana. Hoʻohana ʻia kēia mau lāʻau lapaʻau (e laʻa me donepezil, rivastigmine) e mālama i nā kūlana i haʻahaʻa ai nā pae ACh, e like me ka maʻi Alzheimer a me ka myasthenia gravis .
ʻO kekahi laʻana ʻo Botulinum toxin , a i ʻole e like me kā mākou e ʻike nei, ʻo 'Botox'. Hana ia ma ke kāohi ʻana i ka hoʻokuʻu ʻia ʻana o ACh mai nā hopena aʻalolo. Hoʻomaha kēia i nā ʻiʻo ma mua o ka ʻaelike ʻana. Hoʻohana ʻia ia no nā kumu hoʻonani (e hōʻemi i nā wrinkles) a e mālama i nā kūlana e like me ka migraines.
Hiki iā kākou ke lawe i kēia ma ke ʻano pila? Hiki iā kākou ke loaʻa mai ka meaʻai?
ʻAʻole hiki ke lawe ʻia ʻo Acetylcholine (ACh) ma ke ʻano he pila. Eia nō naʻe, hiki ke lawe ʻia ka meaʻai e kōkua ai i ka hana ʻana, ʻo ia hoʻi ka choline, ma ke ʻano he mea hoʻohui. Ua manaʻoʻiʻo ʻia kekahi mau mea hoʻohui lāʻau lapaʻau, e like me Ginkgo biloba, e hoʻopilikia i nā pae ACh.
Akā eia kekahi mea āu e hoʻomanaʻo pono ai . Mai hoʻohana i nā mea hoʻohui me ka ʻole o ka nīnau mua ʻana i kāu kauka a kauka lāʻau paha . Hiki iā lākou ke launa pū me nā lāʻau lapaʻau ʻē aʻe āu e lawe nei, a i ʻole hiki iā lākou ke hōʻino iā ʻoe.
Akā hiki iā kākou ke loaʻa ka choline ma ke ʻano kūlohelohe mai ka meaʻai. ʻO kekahi o nā meaʻai nui i loaʻa ia mea:
- ʻAke pipi
- Nā hua manu
- Pipi
- Nā pīni soya, nā pīni moa
- Moa
- Iʻa cod
- Quinoa
- Nā halo, broccoli
- Waiū
Leka Lawe-Home
- ʻO Acetylcholine (ACh) kahi ʻelele kemika koʻikoʻi e kaohi ana i nā hana koʻikoʻi e like me ko mākou hoʻomanaʻo, ka neʻe ʻana o nā ʻiʻo, a me ka helu o ka puʻuwai.
- ʻO nā pae haʻahaʻa o kēia hiki ke alakaʻi i nā kūlana koʻikoʻi e like me ka maʻi Alzheimer a me ka myasthenia gravis.
- ʻO ka ʻai ʻana i kahi meaʻai kaulike, ʻoiai nā meaʻai i loaʻa ka choline, hiki ke kōkua iā ʻoe e loaʻa nā meaola e pono ai kou kino.
- Mai lawe i nā mea hoʻohui e hoʻomaikaʻi i ka hoʻomanaʻo a i ʻole no kekahi kumu ʻē aʻe me ka ʻole o ke aʻo ʻana a ke kauka. E kamaʻilio mau me kāu kauka.
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