Ua ʻike anei ʻoe e loli ana ke ʻano o kou mau lima, kou mau wāwae, a i ʻole kou helehelena? Malia paha he paʻa pinepine ke apo āu e ʻaʻahu nei, a ua loli paha ka nui o kou kāmaʻa? ʻAʻole kēia he mau mea wale nō, he mau hōʻailona paha ia o kahi maʻi kakaʻikahi akā koʻikoʻi paha i kapa ʻia ʻo acromegaly . Mai hopohopo, e kamaʻilio mākou e pili ana i kēia me nā kikoʻī a me ka maʻalahi i kēia lā.
He aha ka Acromegaly? I ka pōkole...
ʻO ka Acromegaly kahi maʻi i hoʻokumu ʻia e nā pae kiʻekiʻe o kahi kemika i kapa ʻia ʻo Growth Hormone (GH) i loko o kou kino. ʻO ka maʻamau, hana ʻia kēia hormone ulu (GH) e ka pituitary gland , kahi gland nui e like me ka pī ma ke kumu o ko mākou lolo. Eia nō naʻe, i ka acromegaly, hana nui ʻia kēia hormone ma muli o kahi puʻupuʻu i loko o ka pituitary gland a i ʻole ma kahi ʻē aʻe o ke kino.
Ua ʻike anei ʻoe he ʻāpana liʻiliʻi akā koʻikoʻi loa ka pituitary gland. Hoʻokuʻu ia i ʻewalu mau hormones, ʻo kekahi o ia mau mea ka hormone ulu (GH).
He aha ka hormone ulu (GH) no mākou?
ʻO ka Hormone Ulu, i ʻike ʻia hoʻi ʻo Human Growth Hormone (hGH) a i ʻole Somatotropin , he hormone kūlohelohe ia. He mea nui ia no ka ulu ʻana o nā ʻāpana like ʻole o ko kākou kino a no ke kiʻekiʻe i ka wā kamaliʻi. Eia nō naʻe, i ko kākou wā ʻelemakule, ma hope o ka pani ʻana o nā epiphyses o ko kākou mau iwi, pono mau ko kākou kino i kēia GH. ʻIke anei ʻoe i ke kumu? Kōkua ia i ka mālama ʻana i ke ʻano olakino o ko kākou mau iwi, ka cartilage, a me nā ʻōpū o loko, a kōkua i ka metabolism, ʻoiai ka mālama ʻana i ko kākou mau pae glucose koko ma nā pae kūpono.
No laila, inā piʻi nui ka hormone ulu o ke kino (GH) ma hope o ka wā makua, hiki ke loaʻa nā pilikia e like me ke ʻano o ka iwi, ka hoʻonui ʻia ʻana o nā ʻōkana, a me ka piʻi ʻana o ke kō koko (hyperglycemia) .
He aha ka ʻokoʻa ma waena o ka acromegaly a me ka gigantism?
Hoʻokumu ʻia nā mea ʻelua e ka hoʻonui ʻia ʻana o ka hormone ulu (GH). Eia nō naʻe, aia ka ʻokoʻa i ka mea e hoʻopilikia ai ke ʻano. Hoʻomohala nā pākeke i ka acromegaly. Hoʻomohala nā keiki i ka gigantism .
Inā piʻi aʻe ka nui o ka hormone ulu (GH) i nā keiki ma mua o ka pani ʻana o nā papa ulu i loko o ko lākou mau iwi (ʻo ia hoʻi, ma mua o ka pau ʻana o ka wā ʻōpiopio), e ulu lākou i ke kiʻekiʻe ʻē aʻe. Ua kapa ʻia kēia he gigantism. He mea kakaikahi ia ma mua o ka acromegaly. Ua kapa pū kekahi mau kauka iā ia he "pediatric acromegaly."
Eia nō naʻe, inā piʻi aʻe kāu mau pae hormone ulu (GH) ma hope o ka pani ʻana o kāu mau papa ulu, ʻaʻole ʻoe e ulu kiʻekiʻe. Eia nō naʻe, hiki i kēlā hormone keu ke hoʻopilikia i ke ʻano o kou mau iwi, ka nui o kou mau kino, a me nā mea olakino ʻē aʻe. Ua kapa ʻia kēlā ʻano he acromegaly.
ʻO wai ka mea e loaʻa pinepine ai ka acromegaly?
Hiki iā ia ke ulu i kēlā me kēia makahiki ma hope o ka wā ʻōpio. Eia nō naʻe, ʻike pinepine nā kauka iā ia i ka poʻe ma waena o 40 a me 50 mau makahiki, ʻo ia hoʻi, i ka makahiki waena.
Pehea ka maʻamau o kēia?
He maʻi laha ʻole ka Acromegaly. Ma kahi o 31 wale nō o 100,000 poʻe i ʻike ʻia me kēia maʻi. No laila, mai makaʻu nui, akā he mea nui e makaʻala i nā hōʻailona.
Pehea ka hopena o ka acromegaly i koʻu kino?
Ke loaʻa i kahi pākeke ka acromegaly, ʻo ia hoʻi, ke piʻi ka nui o ka hormone ulu (GH), hoʻomaka nā iwi, nā cartilage, nā ʻōkana o ke kino, a me nā ʻiʻo ʻē aʻe e hoʻonui i ka nui. Aia nā loli maopopo i ke ʻano . Eia kekahi laʻana:
- Ka hoʻonui ʻana o nā lima a me nā wāwae.
- Ka hoʻonui ʻia ʻana o nā pepeiao, nā lehelehe, a me ka ihu.
- ʻAuwae e kīkoʻo ana, lae i hoʻonui ʻia.
Hōʻailona ka hormone ulu (GH) i ko kākou akepaʻa e hana i kahi hormone ʻē aʻe i kapa ʻia ʻo Insulin-like Growth Factor 1 (IGF-1) . ʻO kēia hormone, i kapa ʻia ʻo IGF-1, kōkua maoli i ko kākou mau iwi a me nā ʻiʻo kino e ulu, a hoʻopilikia pū i ke ʻano o ko kākou kino e kāohi ai i ke kō koko (glucose) a me nā momona (lipids). No laila, ke piʻi aʻe nā pae GH, piʻi pū nā pae IGF-1. Hiki i kēia ke alakaʻi i nā maʻi e like me ka Type 2 Diabetes , High Blood Pressure (Hypertension) , a me ka maʻi puʻuwai .
E noʻonoʻo, e like me ka hoʻonele ʻana o ka wai i ka wai no ka manawa lōʻihi, ke kiʻekiʻe loa kēia mau hormones, he hopena like ʻole ko lākou i ke kino.
He aha nā kumu o ka acromegaly?
ʻO ke kumu maʻamau o ka acromegaly he puʻupuʻu i loko o ka pituitary gland. Ua kapa ʻia kēia he pituitary adenoma . Hoʻoulu kēia puʻupuʻu i ka pituitary gland e hoʻokuʻu i ka nui o ka hormone ulu (GH).
E heluhelu hou aʻe e pili ana i ka Pituitary Adenoma...
He ʻano maikaʻi ʻole kēia mau adenomas pituitary. ʻO ia hoʻi, ʻaʻole lākou he maʻi kanesa. ʻO ka hapa nui o nā puʻupuʻu e hoʻoulu ai i ka acromegaly e ulu mālie loa. No laila, ʻaʻole paha ʻoe e ʻike i kekahi mau hōʻailona o kēia GH keu no nā makahiki.
Ma muli o ka nui a me kahi o ka puʻupuʻu, hiki iā ia ke kaomi ma nā ʻāpana ʻē aʻe o ka pituitary gland a hoʻopilikia i nā hormones ʻē aʻe i hana ʻia e ka pituitary gland. Inā nui ka puʻupuʻu, hiki iā ia ke kaomi ma nā ʻāpana kokoke o ka lolo, e hoʻoulu ai i ka ʻeha poʻo a me nā pilikia ʻike .
He aha nā hōʻailona o ka Acromegaly?
Ke loaʻa i kahi pākeke ka acromegaly, hoʻopilikia ia i nā iwi a me nā ʻiʻo o ke kino, e ulu ai lākou i ke ʻano ʻē. Hiki i kēia ke hana i nā hōʻailona penei:
- Nā lima a i ʻole nā wāwae i hoʻonui ʻia: Malia paha e hoʻomaka ana kou mau apo e paʻa, a piʻi aʻe ka nui o kou kāmaʻa, ʻoiai ka laulā.
- Nā loli i ke ʻano o ka helehelena: Ka puka ʻana a i ʻole ka hoʻonui ʻana o ka ʻauwae a me/a i ʻole ka lae.
- Ka hoʻonui ʻia ʻana o nā lehelehe, ka ihu, a me/a i ʻole ke alelo.
- Ka hou nui ʻana a i ʻole ka ʻili ʻaila.
- Ka hohonu ʻana o ka leo a me ka hāhā ʻana o ka leo.
Nā hōʻailona ʻē aʻe:
- Nā ʻeha poʻo
- ʻEha hui
- Nā loli o ka ʻike
- Hoʻonui ʻia ka hanana o nā ʻili liʻiliʻi
- ʻO ka mae ʻana ma nā lima
- ʻApnea hiamoe (apnea hiamoe)
- ʻO ka maʻi Carpal tunnel a i ʻole nā pilikia o ka iwi kuamoʻo.
Hoʻomaka pinepine nā hōʻailona acromegaly me ka lohi loa , i kekahi manawa i nā makahiki. No laila hiki ke paʻakikī ke ʻike i ka wā mua. ʻIke wale kekahi poʻe ua nui aʻe ko lākou mau lima ke paʻa ke apo a lākou e ʻaʻahu ai a loli paha ka nui o ko lākou kāmaʻa.
E noʻonoʻo, aia kekahi kanaka i kapa ʻia ʻo Nilanthi. Ua manaʻo ʻo ia ua paʻa kona apo mare no kekahi manawa i kēia manawa. ʻAʻole paʻa kona mau kāmaʻa e like me ka wā ma mua, ua paʻa iki lākou. Ua manaʻo ʻo ia ua ulu nui ʻo ia. Akā i ka manawa like, ke ʻōlelo nei kāna mau hoaaloha ua ʻokoʻa iki kona helehelena ma mua o ka wā ma mua, a ua nui iki kona ʻauwae. ʻO kēia nā mea liʻiliʻi e ʻike mua ʻia.
Inā loaʻa iā ʻoe kēia mau hōʻailona, he mea nui loa e kamaʻilio me ke kauka.
Pehea e ʻike ʻia ai ka Acromegaly?
Ma muli o ka lohi loa o ka ʻike ʻia ʻana o nā hōʻailona, i nā makahiki he nui, hiki ke paʻakikī iki ke ʻike.
Hiki i kāu kauka ke kuhikuhi iā ʻoe i kahi endocrinologist , he kauka loea i nā maʻi e pili ana i ka hormone. E hana ʻo ia i kahi hōʻailona ma muli o kou mōʻaukala olakino, ka hoʻokolokolo lapaʻau, a me nā hoʻokolohua kūikawā (e like me nā hoʻokolohua koko a me nā hoʻokolohua kiʻi).
He aha nā hoʻokolohua diagnostics?
Inā ua ʻike ʻia ʻoe me ka acromegaly, hiki i kāu kauka ke kauoha i nā hoʻokolohua hou aʻe e ʻike ai inā ua hoʻopilikia ke ʻano i nā ʻāpana ʻē aʻe o kou kino. Hiki i kēia mau mea ke komo pū me:
- He hoʻāʻo echocardiogram e nānā ai i nā pilikia puʻuwai.
- Nā hoʻokolohua hiamoe e ʻike ai inā e hanu ana ʻoe i ka wā hiamoe.
- Colonoscopy no ka nānā ʻana i ke olakino o ka colon.
- E nānā i ke olakino o ka iwi me kahi X-ray a i ʻole DEXA scan .
Pehea e mālama ʻia ai ka Acromegaly?
Aia kekahi mau koho lapaʻau no ka acromegaly. Ma muli o kou mau hōʻailona a me ke kūlana, e kuhikuhi kāu kauka i ka lāʻau lapaʻau kūpono iā ʻoe.
ʻO nā lāʻau lapaʻau i hoʻohana pinepine ʻia:
- ʻoki kino
- Lāʻau lapaʻau
- Hoʻōla radiation
ʻO ke ʻoki kino no ka Acromegaly
I nā hihia he nui, hiki i ke ʻoki kino ke hōʻemi nui a hoʻōla loa paha i nā hōʻailona o ka acromegaly. Hoʻohana pinepine nā kauka ʻoki kino i kahi ʻano hana i kapa ʻia ʻo ke ʻoki kino transsphenoidal , ʻo ia hoʻi ka hana ʻana i ke ʻoki kino ma o ka ihu a ma o ka sphenoid sinus (kahi hakahaka ma hope o nā ala ihu, ma lalo o ka lolo).
Aia nā kikoʻī o ke ʻoki ʻana i ka nui a me kahi o ka puʻupuʻu. ʻO ka pahuhopu nui o ke ʻoki ʻana, ʻo ia ka wehe loa ʻana i ka puʻupuʻu e hoʻoulu ai i ka hana nui o ka hormone ulu (GH). Inā hiki i ke kauka lapaʻau ke wehe i kahi hapa nui o ka puʻupuʻu, ʻaʻole paha ʻoe e pono i kekahi lāʻau lapaʻau hou aʻe. Eia nō naʻe, inā ua wehe ʻia kahi hapa wale nō o ka puʻupuʻu, pono paha ʻoe i ka lāʻau lapaʻau a i ʻole ka radiation therapy e kāohi i nā hōʻailona a hōʻemi i ka hana ʻana o ka hormone ulu (GH).
Nā lāʻau lapaʻau no ka Acromegaly
Hiki i kāu kauka ke kuhikuhi i hoʻokahi lāʻau lapaʻau a i ʻole ka hui pū ʻana o nā lāʻau lapaʻau. Hana nā lāʻau lapaʻau ma nā ʻano like ʻole e hoʻomaʻamaʻa i nā pae hormone ulu (GH) o kou kino a hōʻemi i nā hōʻailona. I kekahi mau hihia, hāʻawi ʻia ka lāʻau lapaʻau a hiki i ka emi ʻana o ka puʻupuʻu, no laila hiki i ke kauka lapaʻau ke wehe palekana. Pono paha kekahi poʻe e lawe i ka lāʻau lapaʻau no ka wā lōʻihi e kāohi i nā pae hormone ulu (GH) a me nā hōʻailona.
Hiki ke ho'ōla loa ʻia ka acromegaly?
Hiki ke ho'ōla ʻia ka Acromegaly i kekahi manawa, akā ʻaʻole i nā manawa a pau. Ke wehe ʻia kahi puʻupuʻu pituitary e hoʻoulu ai i ka acromegaly ma ke ʻoki ʻana, ʻo ka nui o ka ho'ōla ʻana ma kahi o 85% no nā puʻupuʻu liʻiliʻi . No nā puʻupuʻu nui, aia ma waena o 40% a me 50%.
ʻAʻole hiki i nā lāʻau lapaʻau ke ho'ōla loa i ka acromegaly, akā hiki iā lākou ke hāʻawi i ka lāʻau palekana a lōʻihi .
Hiki ke pale ʻia ka acromegaly?
ʻO ka mea pōʻino, ʻaʻohe mea hiki iā ʻoe ke hana e pale aku i ka acromegaly. ʻAʻole maopopo i nā kānaka ʻepekema ke kumu o nā puʻupuʻu pituitary e hoʻoulu ai i ka acromegaly. Eia nō naʻe, manaʻoʻiʻo lākou he kuleana ko kekahi mau kumu genetic .
He aha ka wānana no ka acromegaly?
ʻO ke kūlana no kēia mea e pili ana i ke koʻikoʻi o ka maʻi a me ke ʻano o ka mālama ʻia ʻana o nā hōʻailona me ka lāʻau lapaʻau. ʻIke ka poʻe he nui i ka emi nui ʻana o nā hōʻailona ma hope o ka lāʻau lapaʻau.
Inā ʻaʻole mālama ʻia, hiki i ka acromegaly ke hoʻololi nui i kou helehelena a me ke ʻano o kou mau iwi. Hiki i kēia mau hōʻailona ke loaʻa ka hopena koʻikoʻi i kou manaʻo ponoʻī a me ke ʻano o ke ola. Kōkua nā hui kākoʻo i kekahi poʻe e kū i nā pilikia o ka acromegaly.
Hiki i ka Acromegaly ke hoʻoulu i nā pilikia olakino, e like me ka maʻi puʻuwai a i ʻole ka maʻi diabetes type 2, hiki ke hōʻemi i ke ʻano o ke ola a hoʻopōkole i ka manaʻolana o ke ola. No laila, he mea nui e ʻike i ke kauka inā loaʻa iā ʻoe nā hōʻailona a, inā ʻike ʻia, e hahai pono i kahi hoʻolālā lapaʻau.
He aha nā pilikia e hiki mai ana inā ʻaʻole mālama ʻia?
Inā ʻaʻole mālama ʻia, hiki i ka acromegaly ke alakaʻi i nā pilikia e like me:
- ʻAno 2 diabetes
- Ke koko kiʻekiʻe (Hypertension)
- Maʻi puʻuwai
- Maʻi ʻiʻo puʻuwai (Cardiomyopathy)
- ʻO ka ʻāʻī o ke kino
- Nā polyps o ka kolona - Hiki i kēia ke lilo i maʻi ʻaʻai inā ʻaʻole mālama ʻia.
- Ka hāʻule ʻana o ke kino
He aha ke kūlana o ke ola o kekahi kanaka me ka acromegaly?
Aia kēia i ke koʻikoʻi o ka maʻi a inā he mau pilikia olakino ʻē aʻe, i hoʻokumu pinepine ʻia e ka acromegaly i mālama ʻole ʻia.
Inā ʻaʻole i kaohi pono ʻia kāu pae hormone ulu (GH) a loaʻa iā ʻoe nā maʻi ʻē aʻe e like me ka maʻi puʻuwai a me ka maʻi diabetes, hiki ke hoʻemi ʻia kou ola ma kahi o 10 mau makahiki.
Eia nō naʻe, inā loaʻa iā ʻoe ka acromegaly, ua mālama pono ʻia, a loaʻa iā ʻoe nā pae hormone ulu (GH) a me IGF-1 maʻamau, e ola paha ʻoe i kahi ola maʻamau.
Āhea wau e ʻike ai i ke kauka e pili ana i ka acromegaly?
Inā loaʻa iā ʻoe nā hōʻailona o ka acromegaly, he mea nui loa ia e kamaʻilio me ke kauka.
Inā ua ʻike ʻia ʻoe me ka acromegaly, pono ʻoe e ʻike pinepine i kāu kauka e hōʻoia i ka hana pono ʻana o kāu lāʻau lapaʻau.
He maʻi laha ʻole akā koʻikoʻi ka Acromegaly. ʻO ka nūhou maikaʻi, hiki ke mālama ʻia me ke ʻoki ʻana, ka lāʻau lapaʻau, a/a i ʻole ka radiation therapy. Inā ua ʻike ʻoe e ulu nui ana kou mau lima, nā wāwae, a/a i ʻole nā hiʻohiʻona o kou helehelena, e kamaʻilio me kāu kauka. Hiki iā ia ke holo i kekahi mau hoʻokolohua maʻalahi e ʻike ai inā ʻo kāu mau pae hormone ulu (GH) ke kumu o kāu mau hōʻailona.
ʻO ka mea hope loa, leka lawe i ka home
- He ʻano laha ʻole ka Acromegaly i nā pākeke i hoʻokumu ʻia e ka hoʻonui ʻia o ka hormone ulu (GH).
- ʻO nā hōʻailona paha e komo pū me ka pehu ʻana o nā lālā a me ka maka, ka hou nui ʻana, a me ka loli o ka leo . Hiki ke ʻike mālie ʻia kēia mau mea, no laila ʻaʻole paha ʻoe e ʻike iā lākou.
- ʻO ke kumu nui o kēia he puʻupuʻu, pinepine ʻaʻole ia he maʻi kanesa, e ulu ana i loko o ka pituitary gland.
- Hiki i ka ʻike mua ʻana a me ka mālama ʻana ke pale i nā pilikia he nui a hoʻomaikaʻi i ka maikaʻi o ke ola.
- Inā loaʻa iā ʻoe kēia mau hōʻailona, mai kānalua e ʻimi i ke aʻo lapaʻau. ʻO ia ka mea naʻauao loa e hana ai.
E hoʻomanaʻo, ʻo kēia ʻike no nā kumu ʻike wale nō. ʻAʻole loa e hoʻohana ʻia ma ke ʻano he pani no ka ʻōlelo aʻoaʻo lapaʻau. Inā he mau hopohopo olakino kou, e ʻoluʻolu e kūkākūkā me kahi loea lapaʻau kūpono.
ʻAcromegaly , Hormone ulu, Pituitary Gland, Gigantism, IGF-1, Maʻi hormonal, Endocrine
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