E aʻo kākou e pili ana i nā Aromatase Inhibitors i hoʻohana ʻia i ka mālama ʻana i ka maʻi ʻaʻai umauma.

Ke haʻi aku kāu kauka iā ʻoe a i ʻole kekahi āu i ʻike ai he maʻi ʻaʻai umauma, ua ʻōlelo paha lākou i ka lāʻau lapaʻau hormone ma ke ʻano he koho lapaʻau. E hopohopo iki paha ʻoe ke lohe ʻoe i kēia. Akā, mai hopohopo. I kēia lā, ke kamaʻilio nei mākou e pili ana i kahi ʻano lāʻau lapaʻau kūpono loa i hāʻawi ʻia i nā poʻe me nā hunaola kanesa i maʻalahi i ka hormone estrogen (Estrogen Receptor-Positive a i ʻole ER+). Ua kapa ʻia kēia mau mea he Aromatase Inhibitors.

I ka ʻōlelo maʻalahi, he aha kēia mau mea hoʻopale Aromatase?

ʻAe, e wehewehe kākou i kēia. ʻO nā mea hoʻopaʻa aromatase, a i ʻole AI no ka pōkole, he papa lāʻau lapaʻau i hoʻohana pinepine ʻia i ka lāʻau lapaʻau hormone. Hoʻohana ʻia lākou e mālama i ka maʻi ʻaʻai umauma ER+, ʻoi aku hoʻi i nā wahine postmenopausal .

I kēia manawa, e nānā, he hormone koʻikoʻi ka estrogen no ko kākou kino, ʻoi aku hoʻi no ke olakino hānau ʻana o nā wahine. Eia nō naʻe, no kekahi mau hunaola maʻi umauma, ua like kēia hormone estrogen me ka meaʻai. ʻO ia hoʻi, ke loaʻa ka estrogen, ulu koke kēlā mau hunaola maʻi.

ʻO kēia kahi e komo mai ai nā lāʻau lapaʻau AI. ʻO ka hana a kēia mau lāʻau lapaʻau, ʻo ia ke ālai i kahi enzyme i kapa ʻia ʻo aromatase i loko o ko kākou kino. Hoʻololi kēia enzyme aromatase i nā hormones ʻē aʻe i estrogen. No laila, ke hoʻōki kēia lāʻau lapaʻau i ka hana ʻana o ka enzyme aromatase, e emi ana nā pae estrogen i loko o ke kino. A laila e nalowale kēlā mau cell cancer i kā lākou "meaʻai", e oki lākou i ka ulu ʻana, a ua kāohi ʻia ke kanesa. Maopopo iā ʻoe?

I ka ʻōlelo maʻalahi, ʻo ka hana a kēia lāʻau lapaʻau, ʻo ia ke kāohi ʻana i nā hunaola kanesa mai ka loaʻa ʻana o ka "wahie" a lākou e pono ai.

I nā kūlana hea e ʻōlelo ʻia ai kēia lāʻau lapaʻau?

Aia kekahi mau kūlana e paipai paha ai kāu kauka i kēia lāʻau "AI":

• Inā ua hana ʻia ʻoe i ke ʻoki kino no ka maʻi ʻaʻai umauma ER+, hāʻawi ʻia kēia lāʻau lapaʻau e hōʻemi i ka pilikia o ka hoʻi hou ʻana mai o ke kanesa .
• Inā ua pālahalaha ke kanesa i nā lymph node kokoke.
• Inā ua pālahalaha ke kanesa i nā ʻāpana ʻē aʻe o ke kino (e like me nā māmā, nā iwi, ka lolo, ke akepaʻa), kapa mākou i kēia he kanesa metastatic.
• Inā loaʻa iā ʻoe kēia maʻi ʻaʻai ER+ ma mua o ka menopause. I kēia manawa, ke hana mau nei kāu mau ovaries i ka estrogen, no laila e hāʻawi ʻia paha iā ʻoe nā lāʻau ʻē aʻe e kāohi i kēlā hormone estrogen me ka lāʻau AI.
• Inā loaʻa i ke kāne ka maʻi ʻaʻai umauma ER+. (ʻAe, loaʻa pū kekahi i nā kāne ka maʻi ʻaʻai umauma, a he haʻahaʻa hoʻi nā pae o ka estrogen i loko o ko lākou kino).
• Ua hōʻike kekahi mau noiʻi i ka poʻe me ka piʻi ʻana o ka pilikia o ka ulu ʻana i ka maʻi ʻaʻai umaumaUa ʻōlelo ʻia e kōkua kēia lāʻau lapaʻau i ka hōʻemi ʻana i kēlā pilikia, akā ʻaʻole i loaʻa i ka ʻae kūhelu.

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ʻO nā ʻano mea hoʻopaʻa aromatase i hoʻohana nui ʻia

Aia kekahi mau ʻano o kēia mau lāʻau lapaʻau "AI" ma ka mākeke. Na kāu kauka e koho i ka mea kūpono loa i kou kūlana.

Pehea e loaʻa ai iaʻu kēia lāʻau lapaʻau a pehea ka lōʻihi?

He lāʻau lapaʻau kēia "AI" e pono ai ʻoe e lawe i kēlā me kēia lā . I kekahi manawa, hoʻomaka ka lāʻau lapaʻau me kēia lāʻau. I kekahi manawa, hāʻawi mua paha kāu kauka iā ʻoe i kahi lāʻau hormone ʻē aʻe i kapa ʻia ʻo tamoxifen no kekahi mau makahiki a laila hoʻololi iā ʻoe i ka lāʻau lapaʻau "AI".

ʻO ka maʻamau, hoʻomau ʻia kēia lāʻau no kahi o ʻelima mau makahiki . Ma hope o ʻelima mau makahiki, inā ʻaʻohe ou hōʻailona o ka maʻi kanesa a he maʻamau nā hoʻokolohua, hiki iā ʻoe ke hoʻōki i ka lāʻau.

Eia nō naʻe, ua hōʻike kekahi mau noiʻi e hiki i ke kanesa ke hoʻi hou mai a hiki i 20 mau makahiki ma hope o ka mālama ʻia ʻana. Ua kapa ʻia kēia ʻo 'late recurrence'. No laila, he mea nui loa e kamaʻilio ākea me kāu kauka e pili ana i nā pilikia e pili ana i kou kūlana.

Nā pono o ka mālama ʻana a me nā hopena ʻaoʻao hiki

ʻO ka pōmaikaʻi nui o kēia lāʻau lapaʻau, ʻo ia ka hiki ke ho'ōla loa i ka maʻi ʻaʻai umauma ER+. Ua hōʻike ʻia nā noiʻi he 95% o ka poʻe i loaʻa i kēia lāʻau lapaʻau AI ma hope o ke ʻoki ʻana, ʻaʻole lākou e hoʻi hou mai ko lākou maʻi ʻaʻai i loko o 5 mau makahiki . He nūhou maikaʻi kēlā, ʻeā?

Akā, e like me nā lāʻau lapaʻau āpau, hiki i kēia ke loaʻa nā hopena ʻaoʻao. No ka mea, e like me kā mākou i kūkākūkā ai ma mua, ʻo ka estrogen kahi hormone e kōkua pū ana i ka mālama ʻana i ko mākou mau iwi a me ka puʻuwai olakino. No laila, ke hoʻohaʻahaʻa ʻoe i nā pae estrogen me kahi 'AI', hiki ke loaʻa kekahi mau hopena ʻaoʻao.

Pehea e hoʻoponopono ai i nā hopena ʻaoʻao?

Mai hopohopo i kēia mau hopena ʻaoʻao. ʻO ka mea nui loa, ʻo ia ke kamaʻilio me kāu kauka e pili ana iā lākou. ʻOiai inā he koʻikoʻi nā mea e like me ka ʻeha hui, ʻaʻole pono ʻoe e hoʻomanawanui. Hiki i kāu kauka ke hāʻawi iā ʻoe i nā hoʻonā. Eia kekahi laʻana:

• Hiki ke kuhikuhi ʻia nā lāʻau hoʻopau ʻeha, ʻoiai nā NSAID (e.g., ibuprofen).
• Inā paʻakikī iā ʻoe ke ʻae, hiki iā ʻoe ke hoʻololi i kahi ʻano AI ʻē aʻe ma kahi o ka AI āu e lawe nei.
• I kekahi mau hihia, hiki ke hoʻololi ʻia ʻo tamoxifen ma kahi o AI.

ʻO ka mea nui loa, ʻo ia ke hoʻomaopopo i kāu kauka e pili ana i kekahi pilikia, ma mua o ka hoʻoholo wale ʻana i nā hoʻoholo.

Āhea ʻoe e pono ai e kamaʻilio me ke kauka?

I nā hihia aʻe, e kamaʻilio me kāu kauka.

• Inā ʻoi aku ka ʻino o nā hopena ʻaoʻao ma mua o kou manaʻo.
• Inā ʻaʻole hāʻawi ka lāʻau lapaʻau i hāʻawi ʻia e ke kauka i kekahi hōʻoluʻolu mai nā hopena ʻaoʻao.
• Inā ʻike ʻoe i nā hōʻailona o ka hoʻi hou ʻana o ke kanesa (e laʻa me nā puʻupuʻu hou, ka ʻeha mau, ka paʻakikī o ka hanu ʻana) , e nīnau i kāu kauka i nā hōʻailona e makaʻala ai.